GREMLIN Database
OAT - Ornithine aminotransferase
UniProt: P38021 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 401 (371)
Sequences: 20682 (12193)
Seq/√Len: 633.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_K73_D4.3011.00
216_A220_K3.8421.00
362_E396_H3.7951.00
36_W44_E3.4641.00
321_Y388_D3.1661.00
179_V214_E3.0371.00
31_E38_K3.0161.00
93_K304_E2.9561.00
310_K313_D2.7871.00
321_Y384_K2.7751.00
240_K246_W2.7521.00
331_S395_K2.7231.00
314_R318_L2.6391.00
383_S386_D2.5761.00
63_K308_D2.5101.00
66_Q70_D2.4841.00
48_M390_A2.3391.00
93_K307_E2.3311.00
175_P181_A2.3081.00
301_A304_E2.2971.00
63_K305_V2.2611.00
214_E217_A2.2541.00
36_W386_D2.2411.00
325_E391_I2.2261.00
30_S40_P2.1951.00
217_A221_E2.1641.00
61_H305_V2.1091.00
38_K44_E2.0941.00
317_E384_K2.0811.00
63_K301_A2.0611.00
325_E388_D2.0521.00
93_K300_I2.0391.00
136_E189_N2.0141.00
358_R361_E1.9771.00
90_F299_S1.9281.00
136_E172_K1.9261.00
183_R221_E1.9221.00
65_I69_K1.8991.00
389_W393_K1.8901.00
358_R362_E1.8591.00
323_K327_E1.8421.00
102_M274_R1.8181.00
320_E324_S1.8131.00
39_D43_N1.8051.00
43_N363_G1.7931.00
101_E274_R1.7801.00
274_R278_G1.7751.00
364_L393_K1.7721.00
305_V309_E1.7671.00
141_V175_P1.7471.00
194_L227_I1.7431.00
183_R187_T1.7381.00
335_K349_T1.7371.00
36_W389_W1.7331.00
325_E328_S1.7301.00
85_D89_P1.7221.00
323_K339_G1.6911.00
106_M268_S1.6821.00
97_L307_E1.6801.00
30_S74_K1.6771.00
92_E96_K1.6411.00
265_F295_A1.5941.00
113_V255_I1.5921.00
182_L215_A1.5891.00
177_G208_P1.5871.00
240_K316_L1.5761.00
68_L298_V1.5731.00
93_K96_K1.5521.00
33_L62_P1.5501.00
89_P300_I1.5491.00
68_L72_A1.5491.00
323_K344_I1.5301.00
318_L321_Y1.5161.00
358_R397_V1.5081.00
35_A386_D1.5021.00
193_F219_C1.5011.00
261_G267_I1.4981.00
195_F215_A1.4951.00
180_E184_Q1.4811.00
228_A244_C1.4661.00
70_D74_K1.4591.00
256_L269_C1.4541.00
174_I185_A1.4421.00
98_T271_A1.4411.00
183_R214_E1.4391.00
186_I224_V1.4381.00
318_L387_L1.4381.00
210_G213_Q1.4321.00
44_E389_W1.4271.00
138_I190_T1.4241.00
123_W276_I1.4211.00
256_L271_A1.4081.00
35_A381_I1.3971.00
115_S270_I1.3951.00
137_I192_A1.3881.00
314_R317_E1.3881.00
362_E397_V1.3821.00
216_A219_C1.3771.00
329_I395_K1.3761.00
62_P66_Q1.3721.00
216_A226_F1.3691.00
103_I271_A1.3671.00
359_L366_C1.3511.00
300_I304_E1.3431.00
95_A103_I1.3411.00
91_Y105_P1.3401.00
395_K399_R1.3391.00
241_T245_D1.3311.00
318_L384_K1.3291.00
187_T222_E1.3291.00
123_W279_V1.3231.00
139_A173_L1.3211.00
66_Q69_K1.3161.00
117_V137_I1.3141.00
301_A305_V1.3101.00
240_K245_D1.3071.00
325_E392_E1.3041.00
140_C211_F1.2981.00
321_Y325_E1.2981.00
267_I296_C1.2911.00
246_W340_R1.2881.00
329_I391_I1.2831.00
325_E395_K1.2801.00
313_D317_E1.2741.00
116_A255_I1.2601.00
33_L60_R1.2591.00
195_F212_L1.2571.00
39_D45_Y1.2571.00
31_E74_K1.2541.00
382_I387_L1.2521.00
244_C254_Y1.2491.00
180_E183_R1.2411.00
120_A227_I1.2371.00
113_V194_L1.2331.00
250_V273_D1.2281.00
29_I37_V1.2271.00
57_Q305_V1.2251.00
96_K307_E1.2211.00
193_F215_A1.2191.00
89_P304_E1.2131.00
67_A301_A1.2061.00
60_R65_I1.2031.00
386_D389_W1.1991.00
65_I73_D1.1951.00
183_R218_I1.1911.00
19_A22_Y1.1911.00
102_M278_G1.1901.00
331_S399_R1.1871.00
267_I299_S1.1821.00
61_H309_E1.1761.00
253_M272_A1.1731.00
304_E308_D1.1691.00
316_L320_E1.1681.00
213_Q217_A1.1671.00
65_I72_A1.1661.00
351_A354_P1.1491.00
247_D340_R1.1481.00
260_L267_I1.1461.00
179_V218_I1.1401.00
106_M270_I1.1401.00
68_L294_L1.1341.00
392_E396_H1.1261.00
210_G247_D1.1201.00
69_K72_A1.1171.00
260_L269_C1.1161.00
362_E393_K1.1121.00
236_G312_A1.1121.00
154_L194_L1.1121.00
154_L171_I1.1071.00
105_P296_C1.0961.00
305_V308_D1.0961.00
124_A191_A1.0941.00
389_W392_E1.0881.00
242_F256_L1.0871.00
36_W46_M1.0791.00
359_L393_K1.0781.00
213_Q248_G1.0771.00
35_A46_M1.0691.00
228_A249_I1.0651.00
364_L390_A1.0641.00
359_L397_V1.0621.00
324_S328_S1.0491.00
30_S85_D1.0471.00
253_M270_I1.0471.00
181_A184_Q1.0381.00
175_P178_D1.0321.00
384_K388_D1.0291.00
30_S42_G1.0281.00
172_K185_A1.0261.00
30_S38_K1.0191.00
90_F300_I1.0141.00
134_Q223_N1.0111.00
388_D392_E1.0091.00
63_K304_E1.0081.00
33_L44_E1.0061.00
225_L276_I1.0041.00
33_L38_K1.0021.00
93_K97_L1.0011.00
112_A255_I1.0011.00
359_L364_L1.0001.00
183_R217_A0.9921.00
110_A151_A0.9891.00
219_C224_V0.9871.00
28_V40_P0.9851.00
97_L241_T0.9841.00
119_A270_I0.9831.00
209_E213_Q0.9791.00
135_A189_N0.9771.00
217_A220_K0.9741.00
124_A133_N0.9741.00
176_Y207_P0.9671.00
262_G302_S0.9661.00
192_A227_I0.9561.00
312_A315_S0.9541.00
239_G245_D0.9521.00
357_E361_E0.9491.00
313_D316_L0.9441.00
136_E187_T0.9421.00
66_Q73_D0.9401.00
100_K254_Y0.9391.00
385_E388_D0.9321.00
327_E330_D0.9311.00
186_I190_T0.9301.00
63_K66_Q0.9281.00
117_V154_L0.9251.00
70_D297_A0.9241.00
183_R222_E0.9231.00
235_L306_L0.9231.00
46_M386_D0.9231.00
206_I340_R0.9201.00
197_P228_A0.9201.00
335_K347_E0.9161.00
56_N259_A0.9161.00
139_A194_L0.9131.00
347_E372_T0.9111.00
136_E190_T0.9091.00
57_Q302_S0.9061.00
116_A227_I0.9041.00
212_L247_D0.8981.00
314_R384_K0.8931.00
135_A170_G0.8911.00
57_Q64_I0.8911.00
297_A301_A0.8891.00
140_C176_Y0.8891.00
210_G214_E0.8871.00
306_L312_A0.8841.00
28_V88_G0.8811.00
319_G323_K0.8811.00
119_A272_A0.8781.00
123_W225_L0.8741.00
215_A226_F0.8731.00
48_M382_I0.8631.00
40_P85_D0.8621.00
140_C207_P0.8611.00
324_S327_E0.8601.00
218_I222_E0.8601.00
64_I298_V0.8591.00
46_M389_W0.8591.00
70_D73_D0.8561.00
97_L303_L0.8551.00
136_E170_G0.8491.00
306_L311_L0.8491.00
246_W316_L0.8431.00
35_A383_S0.8411.00
120_A192_A0.8381.00
328_S395_K0.8361.00
241_T312_A0.8321.00
336_E347_E0.8301.00
86_Q297_A0.8281.00
110_A148_T0.8251.00
220_K250_V0.8231.00
311_L315_S0.8211.00
198_I340_R0.8181.00
55_V262_G0.8151.00
233_T343_F0.8131.00
89_P93_K0.8131.00
63_K67_A0.8101.00
382_I390_A0.8051.00
86_Q300_I0.8041.00
94_T271_A0.8041.00
133_N189_N0.8021.00
120_A225_L0.8011.00
342_L382_I0.8011.00
321_Y324_S0.8011.00
312_A316_L0.8001.00
328_S331_S0.8001.00
345_G373_V0.7951.00
325_E387_L0.7871.00
317_E321_Y0.7831.00
338_R347_E0.7791.00
153_S168_L0.7781.00
122_R284_S0.7731.00
141_V173_L0.7711.00
174_I182_L0.7661.00
46_M390_A0.7661.00
181_A185_A0.7661.00
214_E218_I0.7651.00
244_C249_I0.7631.00
219_C226_F0.7621.00
337_V344_I0.7621.00
265_F294_L0.7611.00
124_A223_N0.7611.00
235_L303_L0.7591.00
356_C368_E0.7591.00
100_K250_V0.7591.00
174_I181_A0.7541.00
197_P212_L0.7471.00
90_F296_C0.7471.00
216_A249_I0.7461.00
223_N275_E0.7461.00
355_Y394_I0.7461.00
106_M112_A0.7451.00
86_Q89_P0.7441.00
235_L256_L0.7441.00
99_G244_C0.7441.00
238_T246_W0.7431.00
376_F394_I0.7421.00
200_G232_Q0.7411.00
339_G344_I0.7411.00
242_F254_Y0.7401.00
343_F377_A0.7391.00
34_G381_I0.7391.00
318_L342_L0.7391.00
186_I222_E0.7361.00
193_F224_V0.7311.00
235_L241_T0.7301.00
241_T307_E0.7291.00
195_F226_F0.7281.00
120_A253_M0.7251.00
103_I269_C0.7251.00
83_H88_G0.7241.00
86_Q296_C0.7191.00
150_L168_L0.7171.00
75_I78_T0.7151.00
190_T224_V0.7141.00
281_N284_S0.7141.00
182_L193_F0.7131.00
116_A253_M0.7121.00
317_E320_E0.7101.00
48_M364_L0.7081.00
117_V194_L0.7081.00
140_C174_I0.7041.00
213_Q247_D0.7031.00
53_S377_A0.7031.00
67_A298_V0.7021.00
275_E278_G0.7021.00
315_S319_G0.6961.00
35_A379_P0.6951.00
46_M364_L0.6941.00
287_S290_G0.6941.00
186_I218_I0.6931.00
84_N87_L0.6901.00
235_L260_L0.6861.00
113_V151_A0.6841.00
347_E373_V0.6831.00
348_L355_Y0.6811.00
236_G306_L0.6791.00
74_K85_D0.6781.00
97_L242_F0.6781.00
385_E389_W0.6761.00
86_Q90_F0.6761.00
107_N111_E0.6751.00
198_I238_T0.6711.00
244_C251_P0.6701.00
256_L260_L0.6701.00
390_A393_K0.6691.00
98_T254_Y0.6661.00
87_L91_Y0.6631.00
355_Y397_V0.6631.00
49_L367_K0.6631.00
43_N361_E0.6621.00
76_T265_F0.6611.00
100_K244_C0.6611.00
72_A294_L0.6601.00
119_A280_F0.6601.00
71_Q74_K0.6561.00
320_E323_K0.6561.00
209_E247_D0.6551.00
64_I262_G0.6551.00
35_A382_I0.6551.00
178_D181_A0.6541.00
314_R383_S0.6531.00
108_T111_E0.6521.00
218_I221_E0.6521.00
226_F249_I0.6511.00
209_E340_R0.6471.00
319_G339_G0.6471.00
95_A101_E0.6471.00
207_P210_G0.6461.00
88_G92_E0.6461.00
333_V349_T0.6451.00
276_I279_V0.6451.00
29_I32_A0.6441.00
355_Y359_L0.6441.00
359_L394_I0.6431.00
206_I339_G0.6431.00
231_I255_I0.6431.00
93_K303_L0.6411.00
37_V365_L0.6401.00
199_Q205_V0.6401.00
272_A277_L0.6391.00
118_K285_H0.6361.00
28_V83_H0.6351.00
71_Q86_Q0.6341.00
227_I253_M0.6321.00
67_A70_D0.6311.00
99_G250_V0.6311.00
393_K397_V0.6311.00
74_K86_Q0.6301.00
382_I386_D0.6301.00
273_D276_I0.6301.00
337_V346_V0.6271.00
374_I394_I0.6271.00
357_E360_K0.6271.00
220_K226_F0.6261.00
364_L389_W0.6261.00
321_Y387_L0.6251.00
391_I395_K0.6251.00
123_W275_E0.6241.00
348_L398_L0.6241.00
50_S377_A0.6221.00
184_Q187_T0.6211.00
138_I182_L0.6191.00
109_G231_I0.6191.00
98_T242_F0.6191.00
212_L228_A0.6161.00
200_G343_F0.6141.00
44_E393_K0.6141.00
355_Y374_I0.6131.00
119_A253_M0.6121.00
121_R166_P0.6121.00
90_F105_P0.6111.00
60_R72_A0.6111.00
158_E162_R0.6101.00
97_L240_K0.6061.00
57_Q311_L0.6051.00
315_S380_L0.6051.00
134_Q189_N0.6041.00
376_F390_A0.6021.00
134_Q224_V0.6011.00
124_A134_Q0.6011.00
62_P73_D0.6001.00
199_Q202_A0.5981.00
334_I398_L0.5981.00
325_E329_I0.5981.00
121_R149_M0.5971.00
56_N380_L0.5961.00
346_V394_I0.5961.00
315_S342_L0.5961.00
179_V183_R0.5951.00
316_L319_G0.5941.00
50_S379_P0.5931.00
322_F391_I0.5931.00
322_F344_I0.5921.00
32_A75_I0.5921.00
298_V301_A0.5921.00
197_P233_T0.5911.00
115_S285_H0.5901.00
393_K396_H0.5861.00
27_I30_S0.5861.00
198_I343_F0.5841.00
90_F267_I0.5841.00
67_A304_E0.5831.00
32_A37_V0.5811.00
33_L36_W0.5801.00
318_L382_I0.5791.00
89_P92_E0.5761.00
278_G282_P0.5741.00
356_C360_K0.5721.00
220_K275_E0.5721.00
182_L214_E0.5721.00
188_P222_E0.5701.00
140_C195_F0.5691.00
213_Q216_A0.5681.00
172_K190_T0.5681.00
322_F387_L0.5681.00
49_L365_L0.5671.00
19_A272_A0.5671.00
95_A271_A0.5671.00
182_L186_I0.5651.00
329_I392_E0.5631.00
338_R373_V0.5631.00
394_I398_L0.5621.00
180_E214_E0.5621.00
278_G281_N0.5621.00
318_L383_S0.5621.00
117_V150_L0.5621.00
72_A298_V0.5611.00
138_I174_I0.5601.00
176_Y199_Q0.5601.00
56_N306_L0.5601.00
144_F147_R0.5591.00
106_M111_E0.5571.00
350_E354_P0.5571.00
29_I75_I0.5571.00
338_R345_G0.5571.00
70_D301_A0.5521.00
235_L242_F0.5521.00
390_A394_I0.5511.00
46_M382_I0.5511.00
64_I302_S0.5501.00
30_S33_L0.5501.00
182_L218_I0.5481.00
387_L391_I0.5471.00
257_G268_S0.5461.00
139_A171_I0.5461.00
138_I185_A0.5431.00
142_G202_A0.5390.99
309_E314_R0.5380.99
321_Y391_I0.5350.99
303_L307_E0.5330.99
241_T306_L0.5290.99
187_T221_E0.5280.99
225_L253_M0.5280.99
99_G245_D0.5280.99
307_E310_K0.5270.99
98_T256_L0.5260.99
241_T303_L0.5260.99
156_S173_L0.5250.99
388_D391_I0.5240.99
27_I360_K0.5240.99
209_E248_G0.5220.99
292_N295_A0.5210.99
64_I301_A0.5200.99
232_Q343_F0.5200.99
207_P212_L0.5200.99
254_Y271_A0.5190.99
195_F228_A0.5180.99
215_A224_V0.5180.99
387_L390_A0.5170.99
314_R387_L0.5160.99
95_A100_K0.5160.99
68_L265_F0.5150.99
95_A98_T0.5140.99
253_M276_I0.5140.99
327_E337_V0.5130.99
179_V215_A0.5120.99
251_P254_Y0.5120.99
349_T352_A0.5100.99
346_V376_F0.5100.99
389_W396_H0.5090.99
216_A228_A0.5080.99
322_F390_A0.5080.99
333_V398_L0.5070.99
243_A247_D0.5070.99
396_H399_R0.5060.99
213_Q249_I0.5050.99
31_E44_E0.5050.99
360_K365_L0.5040.99
72_A76_T0.5040.99
28_V85_D0.5040.99
211_F215_A0.5040.99
379_P382_I0.5040.99
197_P244_C0.5010.99
65_I262_G0.5000.99
182_L211_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z7dA 2 0.9302 100 0.35 Contact Map
4uoxA 3 0.9875 100 0.353 Contact Map
3oksA 2 0.9751 100 0.363 Contact Map
4atqA 7 0.9776 100 0.367 Contact Map
4e3qA 3 0.98 100 0.367 Contact Map
2oatA 3 0.995 100 0.371 Contact Map
4nogA 2 1 100 0.374 Contact Map
3hmuA 2 0.98 100 0.378 Contact Map
4ffcA 4 0.9726 100 0.378 Contact Map
2epjA 2 0.9426 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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