SP2P - BACSU - GREMLIN Contacts

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SP2P - Stage II sporulation protein P

UniProt:	P37968	Sequences: MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLRPELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSINLEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEKQQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVGDMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIIDIHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTGVFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVNAASGETKKQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	401 (359)
Sequences:	369 (334)
Seq/√Len:	17.6

BACSU - SP2P

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
187_H	218_G	8.454	1.00
343_D	347_Y	5.996	1.00
194_Y	214_V	5.436	1.00
283_R	364_D	5.098	1.00
258_R	350_D	4.812	1.00
346_V	350_D	4.288	1.00
258_R	351_L	4.150	1.00
358_L	377_A	3.837	1.00
323_L	326_K	3.652	1.00
191_T	238_D	3.633	1.00
265_L	274_I	3.594	1.00
214_V	277_I	3.501	1.00
220_M	375_N	3.491	1.00
224_A	375_N	3.177	0.99
312_E	353_D	3.167	0.99
214_V	275_I	3.121	0.99
312_E	315_K	2.951	0.99
250_Y	253_S	2.895	0.98
271_L	274_I	2.771	0.98
306_K	346_V	2.747	0.98
290_T	295_S	2.664	0.97
262_K	351_L	2.567	0.97
195_L	204_P	2.532	0.96
226_E	232_A	2.524	0.96
218_G	234_V	2.428	0.95
360_F	374_A	2.365	0.95
222_G	234_V	2.240	0.93
315_K	319_E	2.233	0.93
333_T	373_A	2.216	0.92
324_M	331_L	2.179	0.92
190_N	215_T	2.172	0.92
314_Y	373_A	2.042	0.89
188_T	253_S	2.040	0.89
302_V	380_V	2.022	0.88
298_R	367_L	2.019	0.88
207_A	215_T	2.015	0.88
74_N	77_F	1.996	0.88
320_L	384_M	1.991	0.87
303_V	366_N	1.899	0.85
327_K	379_D	1.882	0.84
360_F	370_L	1.869	0.84
220_M	371_Q	1.862	0.84
197_L	370_L	1.857	0.83
303_V	358_L	1.849	0.83
183_V	230_I	1.839	0.83
355_A	373_A	1.824	0.82
273_Y	381_F	1.809	0.82
190_N	239_I	1.800	0.81
297_A	370_L	1.798	0.81
193_S	367_L	1.784	0.81
221_F	374_A	1.774	0.80
294_K	372_R	1.771	0.80
306_K	343_D	1.712	0.78
187_H	234_V	1.678	0.77
264_A	271_L	1.676	0.76
100_S	298_R	1.673	0.76
321_H	332_S	1.644	0.75
321_H	335_V	1.643	0.75
323_L	384_M	1.630	0.74
324_M	332_S	1.621	0.74
51_S	54_F	1.615	0.74
344_N	362_G	1.581	0.72
300_A	373_A	1.579	0.72
261_V	374_A	1.579	0.72
220_M	223_Q	1.577	0.72
301_F	358_L	1.574	0.72
325_E	330_G	1.537	0.70
191_T	240_Q	1.516	0.69
220_M	224_A	1.513	0.69
140_S	143_P	1.513	0.69
221_F	277_I	1.483	0.67
253_S	349_Q	1.477	0.67
248_L	256_E	1.460	0.66
197_L	284_K	1.439	0.65
339_G	343_D	1.432	0.64
316_I	384_M	1.418	0.63
239_I	260_V	1.409	0.63
287_T	362_G	1.383	0.61
209_H	212_A	1.377	0.61
102_N	106_P	1.358	0.60
188_T	315_K	1.352	0.60
194_Y	221_F	1.321	0.58
196_P	349_Q	1.320	0.58
209_H	238_D	1.305	0.57
284_K	295_S	1.302	0.57
221_F	313_N	1.294	0.56
240_Q	376_A	1.293	0.56
316_I	354_R	1.283	0.55
27_I	31_I	1.259	0.54
237_T	353_D	1.253	0.54
223_Q	227_S	1.245	0.53
366_N	370_L	1.231	0.52
183_V	382_S	1.228	0.52
367_L	370_L	1.221	0.52
179_D	266_A	1.214	0.51
30_L	56_G	1.207	0.51
257_S	352_T	1.202	0.51
194_Y	217_V	1.201	0.51
175_Q	180_K	1.193	0.50
324_M	362_G	1.188	0.50
304_G	345_G	1.181	0.49
314_Y	366_N	1.162	0.48
319_E	323_L	1.158	0.48
146_V	149_E	1.147	0.47
184_F	235_N	1.134	0.46
282_R	300_A	1.131	0.46
217_V	378_A	1.120	0.46
62_P	373_A	1.106	0.45
191_T	209_H	1.105	0.45
344_N	363_V	1.102	0.45
264_A	268_N	1.101	0.44
111_G	133_Y	1.099	0.44
284_K	362_G	1.097	0.44
107_R	111_G	1.090	0.44
149_E	154_N	1.090	0.44
191_T	208_R	1.086	0.44
36_L	292_K	1.079	0.43
264_A	281_S	1.079	0.43
261_V	351_L	1.079	0.43
224_A	228_Q	1.077	0.43
297_A	366_N	1.075	0.43
302_V	305_K	1.073	0.43
186_Y	348_N	1.073	0.43
195_L	205_D	1.068	0.42
23_I	27_I	1.066	0.42
198_L	213_N	1.066	0.42
377_A	381_F	1.064	0.42
233_T	267_S	1.055	0.42
290_T	293_G	1.051	0.41
206_M	241_S	1.050	0.41
204_P	207_A	1.047	0.41
70_L	214_V	1.044	0.41
220_M	275_I	1.043	0.41
345_G	363_V	1.040	0.41
210_S	236_K	1.040	0.41
181_K	184_F	1.038	0.41
204_P	283_R	1.036	0.41
214_V	294_K	1.036	0.41
283_R	363_V	1.034	0.40
305_K	337_S	1.031	0.40
195_L	207_A	1.024	0.40
235_N	353_D	1.023	0.40
187_H	256_E	1.022	0.40
349_Q	352_T	1.021	0.40
318_S	322_K	1.013	0.39
261_V	360_F	1.011	0.39
284_K	287_T	1.006	0.39
94_S	98_A	1.004	0.39
217_V	248_L	1.001	0.39
194_Y	370_L	0.996	0.38
71_Q	95_L	0.995	0.38
323_L	383_E	0.993	0.38
374_A	382_S	0.992	0.38
73_E	193_S	0.989	0.38
303_V	317_A	0.985	0.38
277_I	342_G	0.984	0.38
188_T	266_A	0.983	0.38
103_L	110_L	0.978	0.37
181_K	231_G	0.975	0.37
115_P	334_G	0.966	0.37
287_T	332_S	0.966	0.37
28_V	227_S	0.965	0.36
191_T	263_D	0.964	0.36
290_T	382_S	0.955	0.36
120_F	126_L	0.948	0.36
301_F	345_G	0.946	0.35
115_P	349_Q	0.941	0.35
343_D	346_V	0.940	0.35
182_V	230_I	0.936	0.35
38_G	321_H	0.927	0.34
84_T	214_V	0.922	0.34
309_N	353_D	0.921	0.34
305_K	343_D	0.919	0.34
124_I	127_A	0.919	0.34
347_Y	365_N	0.916	0.34
262_K	325_E	0.913	0.34
188_T	358_L	0.913	0.34
219_D	236_K	0.913	0.34
215_T	232_A	0.912	0.34
259_P	262_K	0.908	0.33
70_L	302_V	0.906	0.33
357_L	369_E	0.904	0.33
125_L	358_L	0.903	0.33
170_K	271_L	0.902	0.33
360_F	377_A	0.901	0.33
220_M	367_L	0.901	0.33
148_E	151_R	0.900	0.33
107_R	127_A	0.899	0.33
128_G	325_E	0.898	0.33
177_T	222_G	0.897	0.33
314_Y	343_D	0.897	0.33
234_V	302_V	0.896	0.33
275_I	284_K	0.894	0.33
110_L	114_L	0.894	0.33
181_K	268_N	0.894	0.33
105_D	109_F	0.889	0.32
151_R	158_I	0.888	0.32
27_I	252_R	0.884	0.32
253_S	306_K	0.881	0.32
87_S	368_E	0.880	0.32
193_S	215_T	0.877	0.32
206_M	240_Q	0.876	0.32
73_E	116_G	0.875	0.32
94_S	205_D	0.875	0.32
358_L	373_A	0.874	0.32
193_S	302_V	0.872	0.31
190_N	347_Y	0.871	0.31
193_S	196_P	0.870	0.31
275_I	354_R	0.870	0.31
124_I	137_P	0.869	0.31
232_A	286_D	0.868	0.31
77_F	107_R	0.866	0.31
132_D	135_N	0.862	0.31
109_F	214_V	0.861	0.31
188_T	194_Y	0.859	0.31
37_S	57_I	0.857	0.31
296_Y	376_A	0.854	0.30
293_G	312_E	0.853	0.30
223_Q	326_K	0.847	0.30
344_N	364_D	0.846	0.30
184_F	264_A	0.845	0.30
275_I	367_L	0.845	0.30
214_V	360_F	0.843	0.30
108_S	137_P	0.840	0.30
38_G	41_T	0.835	0.30
194_Y	360_F	0.830	0.29
154_N	158_I	0.826	0.29
33_I	37_S	0.825	0.29
194_Y	353_D	0.824	0.29
298_R	333_T	0.823	0.29
291_I	376_A	0.820	0.29
116_G	268_N	0.820	0.29
126_L	136_M	0.818	0.29
337_S	356_L	0.818	0.29
359_E	365_N	0.817	0.29
361_G	365_N	0.817	0.29
252_R	255_D	0.815	0.28
320_L	335_V	0.813	0.28
190_N	197_L	0.812	0.28
150_E	161_Q	0.809	0.28
23_I	26_F	0.807	0.28
164_Q	325_E	0.807	0.28
111_G	120_F	0.804	0.28
362_G	385_Y	0.798	0.28
192_E	279_R	0.798	0.28
189_H	279_R	0.798	0.28
192_E	254_Y	0.798	0.28
254_Y	279_R	0.798	0.28
189_H	192_E	0.798	0.28
189_H	254_Y	0.798	0.28
188_T	248_L	0.797	0.28
137_P	140_S	0.796	0.28
239_I	320_L	0.796	0.28
348_N	351_L	0.794	0.27
65_V	68_H	0.792	0.27
337_S	354_R	0.792	0.27
288_T	310_F	0.790	0.27
155_L	158_I	0.789	0.27
250_Y	302_V	0.784	0.27
317_A	349_Q	0.783	0.27
265_L	351_L	0.782	0.27
195_L	198_L	0.780	0.27
182_V	231_G	0.780	0.27
232_A	388_A	0.780	0.27
182_V	272_Q	0.779	0.27
54_F	111_G	0.777	0.27
218_G	308_K	0.777	0.27
282_R	302_V	0.777	0.27
334_G	364_D	0.777	0.27
117_F	121_D	0.774	0.27
88_F	265_L	0.772	0.26
234_V	260_V	0.772	0.26
213_N	230_I	0.771	0.26
205_D	363_V	0.771	0.26
101_I	133_Y	0.770	0.26
302_V	349_Q	0.768	0.26
207_A	240_Q	0.764	0.26
26_F	31_I	0.763	0.26
63_G	70_L	0.762	0.26
254_Y	276_D	0.756	0.26
189_H	276_D	0.756	0.26
276_D	279_R	0.756	0.26
192_E	276_D	0.756	0.26
194_Y	259_P	0.754	0.26
139_E	142_P	0.754	0.26
381_F	385_Y	0.753	0.26
196_P	332_S	0.750	0.25
262_K	266_A	0.748	0.25
182_V	383_E	0.748	0.25
198_L	362_G	0.747	0.25
62_P	368_E	0.747	0.25
310_F	316_I	0.745	0.25
167_N	356_L	0.744	0.25
299_V	370_L	0.742	0.25
43_L	59_E	0.741	0.25
46_E	339_G	0.740	0.25
214_V	320_L	0.740	0.25
274_I	351_L	0.738	0.25
296_Y	372_R	0.738	0.25
240_Q	260_V	0.735	0.25
130_G	139_E	0.735	0.25
71_Q	78_A	0.731	0.25
60_E	300_A	0.730	0.24
181_K	385_Y	0.730	0.24
187_H	190_N	0.727	0.24
109_F	277_I	0.726	0.24
288_T	313_N	0.725	0.24
157_E	366_N	0.722	0.24
100_S	382_S	0.720	0.24
173_P	294_K	0.719	0.24
188_T	259_P	0.718	0.24
197_L	207_A	0.717	0.24
345_G	364_D	0.716	0.24
208_R	250_Y	0.715	0.24
127_A	140_S	0.715	0.24
281_S	289_A	0.713	0.24
197_L	212_A	0.711	0.24
184_F	275_I	0.711	0.24
77_F	101_I	0.707	0.23
111_G	320_L	0.700	0.23
273_Y	298_R	0.699	0.23
248_L	252_R	0.698	0.23
56_G	66_F	0.698	0.23
277_I	282_R	0.697	0.23
40_L	75_H	0.696	0.23
194_Y	249_N	0.693	0.23
130_G	135_N	0.692	0.23
287_T	296_Y	0.692	0.23
102_N	293_G	0.689	0.23
217_V	289_A	0.689	0.23
211_K	371_Q	0.688	0.23
38_G	49_P	0.687	0.23
249_N	252_R	0.686	0.23
35_V	210_S	0.677	0.22
187_H	329_P	0.676	0.22
184_F	187_H	0.676	0.22
187_H	300_A	0.675	0.22
197_L	275_I	0.675	0.22
279_R	359_E	0.674	0.22
189_H	361_G	0.674	0.22
192_E	359_E	0.674	0.22
279_R	361_G	0.674	0.22
254_Y	359_E	0.674	0.22
192_E	361_G	0.674	0.22
254_Y	361_G	0.674	0.22
189_H	359_E	0.674	0.22
53_S	383_E	0.674	0.22
194_Y	336_F	0.672	0.22
360_F	373_A	0.670	0.22
274_I	356_L	0.669	0.22
316_I	360_F	0.661	0.21
238_D	241_S	0.661	0.21
293_G	369_E	0.661	0.21
320_L	334_G	0.660	0.21
32_V	222_G	0.658	0.21
132_D	184_F	0.656	0.21
139_E	302_V	0.655	0.21
44_R	184_F	0.654	0.21
107_R	130_G	0.653	0.21
127_A	143_P	0.652	0.21
37_S	42_S	0.647	0.21
275_I	285_K	0.647	0.21
90_L	223_Q	0.646	0.21
253_S	275_I	0.645	0.21
314_Y	346_V	0.645	0.21
334_G	362_G	0.643	0.21
132_D	138_A	0.642	0.21
303_V	356_L	0.642	0.21
109_F	139_E	0.641	0.21
207_A	275_I	0.641	0.21
190_N	218_G	0.640	0.21
27_I	36_L	0.637	0.21
307_S	353_D	0.637	0.21
157_E	367_L	0.636	0.20
183_V	290_T	0.635	0.20
120_F	127_A	0.634	0.20
303_V	345_G	0.629	0.20
359_E	369_E	0.627	0.20
361_G	369_E	0.627	0.20
311_E	382_S	0.626	0.20
128_G	142_P	0.626	0.20
324_M	348_N	0.626	0.20
137_P	196_P	0.626	0.20
63_G	150_E	0.625	0.20
276_D	359_E	0.625	0.20
276_D	361_G	0.625	0.20
277_I	344_N	0.624	0.20
289_A	371_Q	0.622	0.20
24_F	289_A	0.622	0.20
122_T	336_F	0.621	0.20
192_E	278_H	0.620	0.20
254_Y	278_H	0.620	0.20
189_H	278_H	0.620	0.20
304_G	351_L	0.620	0.20
188_T	274_I	0.617	0.20
287_T	349_Q	0.616	0.20
144_S	148_E	0.616	0.20
70_L	172_P	0.616	0.20
240_Q	250_Y	0.616	0.20
251_A	272_Q	0.615	0.20
207_A	216_L	0.615	0.20
190_N	260_V	0.614	0.20
25_L	61_L	0.614	0.20
25_L	28_V	0.613	0.20
306_K	350_D	0.613	0.20
328_Y	379_D	0.607	0.19
83_Q	162_Q	0.606	0.19
122_T	152_E	0.606	0.19
339_G	372_R	0.606	0.19
214_V	236_K	0.605	0.19
217_V	370_L	0.605	0.19
48_R	188_T	0.604	0.19
167_N	180_K	0.604	0.19
33_I	46_E	0.601	0.19
307_S	345_G	0.601	0.19
90_L	270_N	0.600	0.19
218_G	236_K	0.597	0.19
19_A	24_F	0.595	0.19
105_D	124_I	0.594	0.19
300_A	333_T	0.593	0.19
229_G	378_A	0.593	0.19
232_A	301_F	0.593	0.19
239_I	253_S	0.593	0.19
131_T	355_A	0.592	0.19
310_F	349_Q	0.592	0.19
29_S	37_S	0.591	0.19
84_T	157_E	0.590	0.19
268_N	386_W	0.588	0.19
63_G	381_F	0.586	0.19
188_T	300_A	0.585	0.19
187_H	222_G	0.584	0.19
131_T	140_S	0.584	0.19
221_F	232_A	0.580	0.18
224_A	232_A	0.580	0.18
191_T	194_Y	0.580	0.18
262_K	316_I	0.579	0.18
269_K	319_E	0.577	0.18
92_R	183_V	0.577	0.18
348_N	361_G	0.576	0.18
348_N	359_E	0.576	0.18
332_S	349_Q	0.575	0.18
115_P	332_S	0.575	0.18
287_T	345_G	0.575	0.18
336_F	360_F	0.574	0.18
182_V	271_L	0.574	0.18
348_N	369_E	0.573	0.18
180_K	347_Y	0.573	0.18
152_E	156_A	0.573	0.18
257_S	272_Q	0.571	0.18
39_V	270_N	0.569	0.18
78_A	354_R	0.568	0.18
21_K	24_F	0.568	0.18
307_S	352_T	0.568	0.18
319_E	384_M	0.565	0.18
194_Y	296_Y	0.565	0.18
90_L	118_A	0.565	0.18
19_A	29_S	0.564	0.18
177_T	182_V	0.564	0.18
228_Q	324_M	0.563	0.18
169_Q	268_N	0.563	0.18
134_T	145_K	0.563	0.18
216_L	355_A	0.563	0.18
272_Q	356_L	0.561	0.18
34_F	42_S	0.561	0.18
319_E	335_V	0.559	0.18
124_I	128_G	0.559	0.18
181_K	269_K	0.558	0.18
321_H	334_G	0.558	0.18
94_S	162_Q	0.556	0.17
259_P	366_N	0.555	0.17
20_V	33_I	0.555	0.17
292_K	351_L	0.554	0.17
44_R	48_R	0.552	0.17
32_V	335_V	0.549	0.17
258_R	370_L	0.549	0.17
108_S	128_G	0.549	0.17
275_I	356_L	0.548	0.17
301_F	376_A	0.548	0.17
181_K	233_T	0.547	0.17
78_A	381_F	0.546	0.17
20_V	27_I	0.545	0.17
23_I	169_Q	0.545	0.17
175_Q	182_V	0.545	0.17
108_S	231_G	0.545	0.17
38_G	43_L	0.544	0.17
28_V	37_S	0.542	0.17
182_V	385_Y	0.542	0.17
19_A	30_L	0.542	0.17
193_S	303_V	0.542	0.17
320_L	323_L	0.540	0.17
86_S	295_S	0.540	0.17
99_T	325_E	0.539	0.17
296_Y	373_A	0.539	0.17
306_K	333_T	0.538	0.17
299_V	371_Q	0.538	0.17
65_V	70_L	0.537	0.17
187_H	236_K	0.537	0.17
240_Q	318_S	0.536	0.17
189_H	280_D	0.536	0.17
192_E	280_D	0.536	0.17
254_Y	280_D	0.536	0.17
238_D	343_D	0.535	0.17
275_I	374_A	0.534	0.17
273_Y	287_T	0.533	0.17
265_L	275_I	0.533	0.17
174_K	182_V	0.531	0.17
96_K	103_L	0.530	0.17
289_A	380_V	0.530	0.17
258_R	357_L	0.529	0.17
256_E	260_V	0.529	0.17
74_N	151_R	0.528	0.17
167_N	172_P	0.526	0.16
182_V	376_A	0.526	0.16
57_I	214_V	0.525	0.16
374_A	378_A	0.524	0.16
131_T	333_T	0.523	0.16
284_K	363_V	0.518	0.16
194_Y	241_S	0.517	0.16
101_I	251_A	0.514	0.16
66_F	383_E	0.511	0.16
57_I	60_E	0.511	0.16
371_Q	375_N	0.510	0.16
30_L	36_L	0.510	0.16
177_T	322_K	0.510	0.16
304_G	344_N	0.508	0.16
225_L	377_A	0.507	0.16
306_K	345_G	0.506	0.16
20_V	43_L	0.506	0.16
349_Q	355_A	0.504	0.16
316_I	348_N	0.504	0.16
300_A	336_F	0.504	0.16
210_S	213_N	0.503	0.16
303_V	349_Q	0.502	0.16
292_K	322_K	0.501	0.16
268_N	342_G	0.501	0.16
129_Q	136_M	0.501	0.16
39_V	236_K	0.501	0.16
191_T	363_V	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rn7A	1	0.4389	98.7	0.912	Contact Map
3czxA	2	0.4289	98.2	0.924	Contact Map
1jwqA	1	0.4214	97.7	0.933	Contact Map
3ne8A	2	0.4564	96.1	0.946	Contact Map
4lq6A	1	0.4514	96.1	0.946	Contact Map
3qayA	1	0.4264	95.5	0.948	Contact Map
1xovA	1	0.4564	93.7	0.953	Contact Map
2kogA	1	0.0998	55.1	0.969	Contact Map
1jqgA	1	0.7905	49.2	0.97	Contact Map
2bo9A	2	0.606	34.7	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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