GREMLIN Database
SP2P - Stage II sporulation protein P
UniProt: P37968 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 401 (359)
Sequences: 369 (334)
Seq/√Len: 17.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_H218_G8.4541.00
343_D347_Y5.9961.00
194_Y214_V5.4361.00
283_R364_D5.0981.00
258_R350_D4.8121.00
346_V350_D4.2881.00
258_R351_L4.1501.00
358_L377_A3.8371.00
323_L326_K3.6521.00
191_T238_D3.6331.00
265_L274_I3.5941.00
214_V277_I3.5011.00
220_M375_N3.4911.00
224_A375_N3.1770.99
312_E353_D3.1670.99
214_V275_I3.1210.99
312_E315_K2.9510.99
250_Y253_S2.8950.98
271_L274_I2.7710.98
306_K346_V2.7470.98
290_T295_S2.6640.97
262_K351_L2.5670.97
195_L204_P2.5320.96
226_E232_A2.5240.96
218_G234_V2.4280.95
360_F374_A2.3650.95
222_G234_V2.2400.93
315_K319_E2.2330.93
333_T373_A2.2160.92
324_M331_L2.1790.92
190_N215_T2.1720.92
314_Y373_A2.0420.89
188_T253_S2.0400.89
302_V380_V2.0220.88
298_R367_L2.0190.88
207_A215_T2.0150.88
74_N77_F1.9960.88
320_L384_M1.9910.87
303_V366_N1.8990.85
327_K379_D1.8820.84
360_F370_L1.8690.84
220_M371_Q1.8620.84
197_L370_L1.8570.83
303_V358_L1.8490.83
183_V230_I1.8390.83
355_A373_A1.8240.82
273_Y381_F1.8090.82
190_N239_I1.8000.81
297_A370_L1.7980.81
193_S367_L1.7840.81
221_F374_A1.7740.80
294_K372_R1.7710.80
306_K343_D1.7120.78
187_H234_V1.6780.77
264_A271_L1.6760.76
100_S298_R1.6730.76
321_H332_S1.6440.75
321_H335_V1.6430.75
323_L384_M1.6300.74
324_M332_S1.6210.74
51_S54_F1.6150.74
344_N362_G1.5810.72
300_A373_A1.5790.72
261_V374_A1.5790.72
220_M223_Q1.5770.72
301_F358_L1.5740.72
325_E330_G1.5370.70
191_T240_Q1.5160.69
220_M224_A1.5130.69
140_S143_P1.5130.69
221_F277_I1.4830.67
253_S349_Q1.4770.67
248_L256_E1.4600.66
197_L284_K1.4390.65
339_G343_D1.4320.64
316_I384_M1.4180.63
239_I260_V1.4090.63
287_T362_G1.3830.61
209_H212_A1.3770.61
102_N106_P1.3580.60
188_T315_K1.3520.60
194_Y221_F1.3210.58
196_P349_Q1.3200.58
209_H238_D1.3050.57
284_K295_S1.3020.57
221_F313_N1.2940.56
240_Q376_A1.2930.56
316_I354_R1.2830.55
27_I31_I1.2590.54
237_T353_D1.2530.54
223_Q227_S1.2450.53
366_N370_L1.2310.52
183_V382_S1.2280.52
367_L370_L1.2210.52
179_D266_A1.2140.51
30_L56_G1.2070.51
257_S352_T1.2020.51
194_Y217_V1.2010.51
175_Q180_K1.1930.50
324_M362_G1.1880.50
304_G345_G1.1810.49
314_Y366_N1.1620.48
319_E323_L1.1580.48
146_V149_E1.1470.47
184_F235_N1.1340.46
282_R300_A1.1310.46
217_V378_A1.1200.46
62_P373_A1.1060.45
191_T209_H1.1050.45
344_N363_V1.1020.45
264_A268_N1.1010.44
111_G133_Y1.0990.44
284_K362_G1.0970.44
107_R111_G1.0900.44
149_E154_N1.0900.44
191_T208_R1.0860.44
36_L292_K1.0790.43
264_A281_S1.0790.43
261_V351_L1.0790.43
224_A228_Q1.0770.43
297_A366_N1.0750.43
302_V305_K1.0730.43
186_Y348_N1.0730.43
195_L205_D1.0680.42
23_I27_I1.0660.42
198_L213_N1.0660.42
377_A381_F1.0640.42
233_T267_S1.0550.42
290_T293_G1.0510.41
206_M241_S1.0500.41
204_P207_A1.0470.41
70_L214_V1.0440.41
220_M275_I1.0430.41
345_G363_V1.0400.41
210_S236_K1.0400.41
181_K184_F1.0380.41
204_P283_R1.0360.41
214_V294_K1.0360.41
283_R363_V1.0340.40
305_K337_S1.0310.40
195_L207_A1.0240.40
235_N353_D1.0230.40
187_H256_E1.0220.40
349_Q352_T1.0210.40
318_S322_K1.0130.39
261_V360_F1.0110.39
284_K287_T1.0060.39
94_S98_A1.0040.39
217_V248_L1.0010.39
194_Y370_L0.9960.38
71_Q95_L0.9950.38
323_L383_E0.9930.38
374_A382_S0.9920.38
73_E193_S0.9890.38
303_V317_A0.9850.38
277_I342_G0.9840.38
188_T266_A0.9830.38
103_L110_L0.9780.37
181_K231_G0.9750.37
115_P334_G0.9660.37
287_T332_S0.9660.37
28_V227_S0.9650.36
191_T263_D0.9640.36
290_T382_S0.9550.36
120_F126_L0.9480.36
301_F345_G0.9460.35
115_P349_Q0.9410.35
343_D346_V0.9400.35
182_V230_I0.9360.35
38_G321_H0.9270.34
84_T214_V0.9220.34
309_N353_D0.9210.34
305_K343_D0.9190.34
124_I127_A0.9190.34
347_Y365_N0.9160.34
262_K325_E0.9130.34
188_T358_L0.9130.34
219_D236_K0.9130.34
215_T232_A0.9120.34
259_P262_K0.9080.33
70_L302_V0.9060.33
357_L369_E0.9040.33
125_L358_L0.9030.33
170_K271_L0.9020.33
360_F377_A0.9010.33
220_M367_L0.9010.33
148_E151_R0.9000.33
107_R127_A0.8990.33
128_G325_E0.8980.33
177_T222_G0.8970.33
314_Y343_D0.8970.33
234_V302_V0.8960.33
275_I284_K0.8940.33
110_L114_L0.8940.33
181_K268_N0.8940.33
105_D109_F0.8890.32
151_R158_I0.8880.32
27_I252_R0.8840.32
253_S306_K0.8810.32
87_S368_E0.8800.32
193_S215_T0.8770.32
206_M240_Q0.8760.32
73_E116_G0.8750.32
94_S205_D0.8750.32
358_L373_A0.8740.32
193_S302_V0.8720.31
190_N347_Y0.8710.31
193_S196_P0.8700.31
275_I354_R0.8700.31
124_I137_P0.8690.31
232_A286_D0.8680.31
77_F107_R0.8660.31
132_D135_N0.8620.31
109_F214_V0.8610.31
188_T194_Y0.8590.31
37_S57_I0.8570.31
296_Y376_A0.8540.30
293_G312_E0.8530.30
223_Q326_K0.8470.30
344_N364_D0.8460.30
184_F264_A0.8450.30
275_I367_L0.8450.30
214_V360_F0.8430.30
108_S137_P0.8400.30
38_G41_T0.8350.30
194_Y360_F0.8300.29
154_N158_I0.8260.29
33_I37_S0.8250.29
194_Y353_D0.8240.29
298_R333_T0.8230.29
291_I376_A0.8200.29
116_G268_N0.8200.29
126_L136_M0.8180.29
337_S356_L0.8180.29
359_E365_N0.8170.29
361_G365_N0.8170.29
252_R255_D0.8150.28
320_L335_V0.8130.28
190_N197_L0.8120.28
150_E161_Q0.8090.28
23_I26_F0.8070.28
164_Q325_E0.8070.28
111_G120_F0.8040.28
362_G385_Y0.7980.28
192_E279_R0.7980.28
189_H279_R0.7980.28
192_E254_Y0.7980.28
254_Y279_R0.7980.28
189_H192_E0.7980.28
189_H254_Y0.7980.28
188_T248_L0.7970.28
137_P140_S0.7960.28
239_I320_L0.7960.28
348_N351_L0.7940.27
65_V68_H0.7920.27
337_S354_R0.7920.27
288_T310_F0.7900.27
155_L158_I0.7890.27
250_Y302_V0.7840.27
317_A349_Q0.7830.27
265_L351_L0.7820.27
195_L198_L0.7800.27
182_V231_G0.7800.27
232_A388_A0.7800.27
182_V272_Q0.7790.27
54_F111_G0.7770.27
218_G308_K0.7770.27
282_R302_V0.7770.27
334_G364_D0.7770.27
117_F121_D0.7740.27
88_F265_L0.7720.26
234_V260_V0.7720.26
213_N230_I0.7710.26
205_D363_V0.7710.26
101_I133_Y0.7700.26
302_V349_Q0.7680.26
207_A240_Q0.7640.26
26_F31_I0.7630.26
63_G70_L0.7620.26
254_Y276_D0.7560.26
189_H276_D0.7560.26
276_D279_R0.7560.26
192_E276_D0.7560.26
194_Y259_P0.7540.26
139_E142_P0.7540.26
381_F385_Y0.7530.26
196_P332_S0.7500.25
262_K266_A0.7480.25
182_V383_E0.7480.25
198_L362_G0.7470.25
62_P368_E0.7470.25
310_F316_I0.7450.25
167_N356_L0.7440.25
299_V370_L0.7420.25
43_L59_E0.7410.25
46_E339_G0.7400.25
214_V320_L0.7400.25
274_I351_L0.7380.25
296_Y372_R0.7380.25
240_Q260_V0.7350.25
130_G139_E0.7350.25
71_Q78_A0.7310.25
60_E300_A0.7300.24
181_K385_Y0.7300.24
187_H190_N0.7270.24
109_F277_I0.7260.24
288_T313_N0.7250.24
157_E366_N0.7220.24
100_S382_S0.7200.24
173_P294_K0.7190.24
188_T259_P0.7180.24
197_L207_A0.7170.24
345_G364_D0.7160.24
208_R250_Y0.7150.24
127_A140_S0.7150.24
281_S289_A0.7130.24
197_L212_A0.7110.24
184_F275_I0.7110.24
77_F101_I0.7070.23
111_G320_L0.7000.23
273_Y298_R0.6990.23
248_L252_R0.6980.23
56_G66_F0.6980.23
277_I282_R0.6970.23
40_L75_H0.6960.23
194_Y249_N0.6930.23
130_G135_N0.6920.23
287_T296_Y0.6920.23
102_N293_G0.6890.23
217_V289_A0.6890.23
211_K371_Q0.6880.23
38_G49_P0.6870.23
249_N252_R0.6860.23
35_V210_S0.6770.22
187_H329_P0.6760.22
184_F187_H0.6760.22
187_H300_A0.6750.22
197_L275_I0.6750.22
279_R359_E0.6740.22
189_H361_G0.6740.22
192_E359_E0.6740.22
279_R361_G0.6740.22
254_Y359_E0.6740.22
192_E361_G0.6740.22
254_Y361_G0.6740.22
189_H359_E0.6740.22
53_S383_E0.6740.22
194_Y336_F0.6720.22
360_F373_A0.6700.22
274_I356_L0.6690.22
316_I360_F0.6610.21
238_D241_S0.6610.21
293_G369_E0.6610.21
320_L334_G0.6600.21
32_V222_G0.6580.21
132_D184_F0.6560.21
139_E302_V0.6550.21
44_R184_F0.6540.21
107_R130_G0.6530.21
127_A143_P0.6520.21
37_S42_S0.6470.21
275_I285_K0.6470.21
90_L223_Q0.6460.21
253_S275_I0.6450.21
314_Y346_V0.6450.21
334_G362_G0.6430.21
132_D138_A0.6420.21
303_V356_L0.6420.21
109_F139_E0.6410.21
207_A275_I0.6410.21
190_N218_G0.6400.21
27_I36_L0.6370.21
307_S353_D0.6370.21
157_E367_L0.6360.20
183_V290_T0.6350.20
120_F127_A0.6340.20
303_V345_G0.6290.20
359_E369_E0.6270.20
361_G369_E0.6270.20
311_E382_S0.6260.20
128_G142_P0.6260.20
324_M348_N0.6260.20
137_P196_P0.6260.20
63_G150_E0.6250.20
276_D359_E0.6250.20
276_D361_G0.6250.20
277_I344_N0.6240.20
289_A371_Q0.6220.20
24_F289_A0.6220.20
122_T336_F0.6210.20
192_E278_H0.6200.20
254_Y278_H0.6200.20
189_H278_H0.6200.20
304_G351_L0.6200.20
188_T274_I0.6170.20
287_T349_Q0.6160.20
144_S148_E0.6160.20
70_L172_P0.6160.20
240_Q250_Y0.6160.20
251_A272_Q0.6150.20
207_A216_L0.6150.20
190_N260_V0.6140.20
25_L61_L0.6140.20
25_L28_V0.6130.20
306_K350_D0.6130.20
328_Y379_D0.6070.19
83_Q162_Q0.6060.19
122_T152_E0.6060.19
339_G372_R0.6060.19
214_V236_K0.6050.19
217_V370_L0.6050.19
48_R188_T0.6040.19
167_N180_K0.6040.19
33_I46_E0.6010.19
307_S345_G0.6010.19
90_L270_N0.6000.19
218_G236_K0.5970.19
19_A24_F0.5950.19
105_D124_I0.5940.19
300_A333_T0.5930.19
229_G378_A0.5930.19
232_A301_F0.5930.19
239_I253_S0.5930.19
131_T355_A0.5920.19
310_F349_Q0.5920.19
29_S37_S0.5910.19
84_T157_E0.5900.19
268_N386_W0.5880.19
63_G381_F0.5860.19
188_T300_A0.5850.19
187_H222_G0.5840.19
131_T140_S0.5840.19
221_F232_A0.5800.18
224_A232_A0.5800.18
191_T194_Y0.5800.18
262_K316_I0.5790.18
269_K319_E0.5770.18
92_R183_V0.5770.18
348_N361_G0.5760.18
348_N359_E0.5760.18
332_S349_Q0.5750.18
115_P332_S0.5750.18
287_T345_G0.5750.18
336_F360_F0.5740.18
182_V271_L0.5740.18
348_N369_E0.5730.18
180_K347_Y0.5730.18
152_E156_A0.5730.18
257_S272_Q0.5710.18
39_V270_N0.5690.18
78_A354_R0.5680.18
21_K24_F0.5680.18
307_S352_T0.5680.18
319_E384_M0.5650.18
194_Y296_Y0.5650.18
90_L118_A0.5650.18
19_A29_S0.5640.18
177_T182_V0.5640.18
228_Q324_M0.5630.18
169_Q268_N0.5630.18
134_T145_K0.5630.18
216_L355_A0.5630.18
272_Q356_L0.5610.18
34_F42_S0.5610.18
319_E335_V0.5590.18
124_I128_G0.5590.18
181_K269_K0.5580.18
321_H334_G0.5580.18
94_S162_Q0.5560.17
259_P366_N0.5550.17
20_V33_I0.5550.17
292_K351_L0.5540.17
44_R48_R0.5520.17
32_V335_V0.5490.17
258_R370_L0.5490.17
108_S128_G0.5490.17
275_I356_L0.5480.17
301_F376_A0.5480.17
181_K233_T0.5470.17
78_A381_F0.5460.17
20_V27_I0.5450.17
23_I169_Q0.5450.17
175_Q182_V0.5450.17
108_S231_G0.5450.17
38_G43_L0.5440.17
28_V37_S0.5420.17
182_V385_Y0.5420.17
19_A30_L0.5420.17
193_S303_V0.5420.17
320_L323_L0.5400.17
86_S295_S0.5400.17
99_T325_E0.5390.17
296_Y373_A0.5390.17
306_K333_T0.5380.17
299_V371_Q0.5380.17
65_V70_L0.5370.17
187_H236_K0.5370.17
240_Q318_S0.5360.17
189_H280_D0.5360.17
192_E280_D0.5360.17
254_Y280_D0.5360.17
238_D343_D0.5350.17
275_I374_A0.5340.17
273_Y287_T0.5330.17
265_L275_I0.5330.17
174_K182_V0.5310.17
96_K103_L0.5300.17
289_A380_V0.5300.17
258_R357_L0.5290.17
256_E260_V0.5290.17
74_N151_R0.5280.17
167_N172_P0.5260.16
182_V376_A0.5260.16
57_I214_V0.5250.16
374_A378_A0.5240.16
131_T333_T0.5230.16
284_K363_V0.5180.16
194_Y241_S0.5170.16
101_I251_A0.5140.16
66_F383_E0.5110.16
57_I60_E0.5110.16
371_Q375_N0.5100.16
30_L36_L0.5100.16
177_T322_K0.5100.16
304_G344_N0.5080.16
225_L377_A0.5070.16
306_K345_G0.5060.16
20_V43_L0.5060.16
349_Q355_A0.5040.16
316_I348_N0.5040.16
300_A336_F0.5040.16
210_S213_N0.5030.16
303_V349_Q0.5020.16
292_K322_K0.5010.16
268_N342_G0.5010.16
129_Q136_M0.5010.16
39_V236_K0.5010.16
191_T363_V0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rn7A 1 0.4389 98.7 0.912 Contact Map
3czxA 2 0.4289 98.2 0.924 Contact Map
1jwqA 1 0.4214 97.7 0.933 Contact Map
3ne8A 2 0.4564 96.1 0.946 Contact Map
4lq6A 1 0.4514 96.1 0.946 Contact Map
3qayA 1 0.4264 95.5 0.948 Contact Map
1xovA 1 0.4564 93.7 0.953 Contact Map
2kogA 1 0.0998 55.1 0.969 Contact Map
1jqgA 1 0.7905 49.2 0.97 Contact Map
2bo9A 2 0.606 34.7 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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