GREMLIN Database
PNBA - Para-nitrobenzyl esterase
UniProt: P37967 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 489 (451)
Sequences: 7924 (6160)
Seq/√Len: 290.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_N210_K4.0531.00
162_Q194_S4.0001.00
100_M186_F3.9271.00
31_K46_E3.7351.00
239_I246_K3.3871.00
305_G383_Y3.0991.00
186_F440_A2.9421.00
41_A160_L2.8741.00
101_V166_L2.8691.00
286_E290_K2.8521.00
192_G213_M2.6341.00
185_V195_I2.6161.00
210_K301_P2.6111.00
31_K43_E2.6011.00
103_I134_L2.5481.00
14_K53_D2.5341.00
214_E436_W2.5261.00
97_L128_E2.5211.00
170_R183_V2.4631.00
62_P252_A2.4591.00
385_F405_F2.3791.00
213_M302_L2.3531.00
10_Y45_P2.3331.00
126_Q434_S2.3261.00
163_A198_L2.3181.00
22_H89_A2.3081.00
37_W43_E2.3051.00
9_Q171_E2.2721.00
195_I211_A2.2671.00
179_D182_N2.2401.00
210_K443_G2.2201.00
286_E291_A2.1991.00
251_S254_D2.1951.00
104_H138_L2.1851.00
48_W52_L2.1671.00
453_P471_I2.1591.00
113_G135_N2.1401.00
250_V254_D2.1371.00
108_F194_S2.1141.00
7_T12_K2.1021.00
89_A130_I2.0951.00
34_V37_W2.0911.00
198_L204_A2.0881.00
12_K50_D2.0601.00
301_P379_P2.0531.00
101_V169_V2.0491.00
100_M440_A2.0371.00
132_V173_I2.0251.00
31_K45_P2.0031.00
108_F193_M2.0021.00
96_N179_D1.9931.00
33_P37_W1.9881.00
188_E307_T1.9771.00
101_V134_L1.9721.00
58_G84_Y1.9691.00
408_G433_Q1.9621.00
182_N209_Q1.9391.00
5_I12_K1.9111.00
99_V173_I1.8921.00
164_A167_K1.8841.00
188_E400_A1.8821.00
44_P164_A1.8781.00
42_P160_L1.8721.00
143_F158_G1.8691.00
174_S180_P1.8591.00
85_V134_L1.8581.00
162_Q198_L1.8421.00
286_E294_E1.7951.00
286_E296_A1.7721.00
134_L165_A1.7661.00
28_P84_Y1.7631.00
307_T402_E1.7521.00
103_I185_V1.7291.00
163_A283_T1.7291.00
129_V440_A1.7281.00
386_D464_I1.7261.00
13_V27_I1.7231.00
214_E402_E1.7051.00
127_G437_I1.7001.00
17_T22_H1.7001.00
227_A231_A1.6881.00
14_K51_V1.6821.00
196_A218_S1.6811.00
5_I14_K1.6761.00
434_S438_T1.6711.00
57_Y86_N1.6681.00
199_L211_A1.6611.00
126_Q433_Q1.6581.00
90_P97_L1.6531.00
347_Y360_D1.6411.00
212_I436_W1.6291.00
28_P52_L1.6281.00
24_W89_A1.6261.00
113_G133_T1.5951.00
311_G359_T1.5921.00
167_K207_L1.5901.00
371_A382_M1.5871.00
429_S433_Q1.5721.00
170_R181_D1.5711.00
25_K57_Y1.5641.00
126_Q430_H1.5641.00
136_Y190_A1.5601.00
209_Q301_P1.5531.00
120_G124_A1.5521.00
166_L183_V1.5381.00
92_T95_K1.5301.00
244_L248_H1.5271.00
61_C104_H1.5201.00
13_V52_L1.5111.00
432_I436_W1.4961.00
189_S399_H1.4911.00
108_F277_P1.4901.00
308_R386_D1.4801.00
141_F252_A1.4701.00
30_A164_A1.4581.00
379_P454_A1.4581.00
408_G429_S1.4451.00
8_T13_V1.4421.00
27_I87_V1.4361.00
123_L433_Q1.4311.00
29_Y104_H1.4201.00
140_P233_F1.4071.00
16_T55_T1.4001.00
96_N174_S1.3961.00
181_D209_Q1.3871.00
100_M129_V1.3831.00
406_V436_W1.3791.00
387_W425_V1.3671.00
302_L374_Q1.3641.00
188_E403_L1.3591.00
39_F157_L1.3581.00
254_D257_K1.3561.00
374_Q380_V1.3481.00
104_H113_G1.3471.00
102_W118_Y1.3321.00
341_E345_D1.3301.00
59_S79_S1.3191.00
196_A213_M1.3121.00
237_L250_V1.3111.00
214_E307_T1.3081.00
245_D249_T1.3041.00
134_L162_Q1.2941.00
5_I51_V1.2731.00
27_I85_V1.2711.00
198_L283_T1.2641.00
29_Y134_L1.2571.00
86_N133_T1.2551.00
40_K248_H1.2531.00
169_V183_V1.2471.00
59_S84_Y1.2431.00
140_P255_L1.2401.00
88_F120_G1.2361.00
120_G131_V1.2221.00
160_L282_K1.2211.00
342_K345_D1.2201.00
287_E290_K1.2111.00
167_K171_E1.2111.00
61_C82_C1.2091.00
42_P164_A1.2091.00
163_A204_A1.1951.00
323_S326_T1.1921.00
304_I371_A1.1911.00
60_I112_A1.1901.00
31_K164_A1.1891.00
104_H134_L1.1751.00
58_G135_N1.1731.00
60_I78_Q1.1711.00
84_Y113_G1.1691.00
12_K51_V1.1651.00
214_E406_V1.1611.00
304_I367_A1.1561.00
290_K293_A1.1561.00
212_I303_L1.1501.00
398_F401_L1.1481.00
166_L185_V1.1481.00
32_P84_Y1.1481.00
371_A380_V1.1451.00
53_D56_A1.1451.00
118_Y188_E1.1431.00
32_P37_W1.1311.00
147_S151_E1.1281.00
159_L197_A1.1241.00
163_A167_K1.1241.00
13_V48_W1.1221.00
184_T210_K1.1211.00
11_G48_W1.1131.00
402_E436_W1.1111.00
426_K430_H1.1071.00
203_A282_K1.1061.00
160_L283_T1.1041.00
237_L258_A1.1031.00
306_T367_A1.1001.00
428_L465_L1.0941.00
290_K294_E1.0911.00
195_I213_M1.0891.00
211_A302_L1.0871.00
236_V261_Q1.0851.00
31_K37_W1.0841.00
102_W403_L1.0831.00
214_E383_Y1.0821.00
438_T442_T1.0811.00
14_K55_T1.0781.00
88_F133_T1.0771.00
98_P441_K1.0641.00
232_A235_Q1.0641.00
205_K298_S1.0631.00
431_T469_I1.0611.00
32_P81_D1.0611.00
62_P79_S1.0581.00
103_I162_Q1.0571.00
438_T447_T1.0521.00
129_V437_I1.0521.00
13_V54_A1.0491.00
202_P285_P1.0481.00
37_W40_K1.0441.00
464_I472_E1.0441.00
206_G300_I1.0361.00
182_N440_A1.0351.00
184_T212_I1.0301.00
199_L302_L1.0261.00
437_I441_K1.0241.00
163_A203_A1.0231.00
124_A131_V1.0171.00
61_C246_K1.0161.00
36_Q248_H1.0161.00
16_T25_K1.0141.00
164_A171_E1.0131.00
128_E441_K1.0101.00
123_L131_V1.0091.00
190_A194_S1.0071.00
167_K203_A1.0051.00
52_L58_G0.9951.00
359_T364_W0.9951.00
209_Q443_G0.9901.00
291_A296_A0.9881.00
131_V407_F0.9881.00
154_S157_L0.9841.00
122_K125_A0.9801.00
336_G339_L0.9791.00
196_A370_Y0.9741.00
253_E257_K0.9711.00
98_P182_N0.9681.00
250_V255_L0.9671.00
280_D285_P0.9621.00
423_D426_K0.9541.00
299_G377_Y0.9501.00
336_G340_A0.9461.00
444_N451_N0.9441.00
352_E356_H0.9421.00
26_G86_N0.9411.00
188_E402_E0.9411.00
438_T444_N0.9401.00
113_G134_L0.9391.00
456_H459_T0.9371.00
252_A256_L0.9361.00
8_T175_A0.9321.00
306_T364_W0.9311.00
343_V347_Y0.9301.00
183_V208_F0.9291.00
311_G358_M0.9281.00
107_A189_S0.9231.00
85_V165_A0.9201.00
201_M283_T0.9191.00
421_I425_V0.9181.00
226_A230_S0.9171.00
196_A216_G0.9151.00
98_P179_D0.9081.00
106_G189_S0.9071.00
427_Q431_T0.9041.00
87_V132_V0.9001.00
9_Q172_N0.8961.00
16_T23_K0.8941.00
438_T446_S0.8911.00
306_T382_M0.8901.00
402_E406_V0.8901.00
22_H91_D0.8871.00
140_P144_L0.8871.00
228_S232_A0.8841.00
169_V173_I0.8821.00
324_Q328_D0.8821.00
108_F159_L0.8791.00
385_F402_E0.8791.00
62_P141_F0.8761.00
155_D160_L0.8751.00
40_K152_A0.8721.00
101_V183_V0.8721.00
184_T443_G0.8711.00
45_P164_A0.8711.00
453_P461_E0.8711.00
159_L283_T0.8701.00
193_M222_T0.8671.00
433_Q437_I0.8661.00
41_A157_L0.8631.00
285_P291_A0.8621.00
197_A284_L0.8601.00
299_G378_A0.8591.00
381_W445_P0.8571.00
172_N175_A0.8561.00
400_A403_L0.8541.00
30_A33_P0.8531.00
329_A333_Y0.8521.00
118_Y403_L0.8521.00
428_L432_I0.8501.00
389_P405_F0.8501.00
132_V169_V0.8481.00
199_L300_I0.8471.00
143_F159_L0.8461.00
406_V432_I0.8401.00
309_D355_I0.8371.00
422_T425_V0.8371.00
10_Y171_E0.8321.00
435_A438_T0.8311.00
102_W407_F0.8311.00
57_Y88_F0.8211.00
36_Q40_K0.8191.00
38_R80_E0.8181.00
435_A446_S0.8161.00
368_V382_M0.8161.00
20_G91_D0.8141.00
450_V463_L0.8141.00
10_Y47_V0.8131.00
183_V207_L0.8091.00
129_V186_F0.8081.00
243_Q246_K0.8081.00
281_P285_P0.8071.00
403_L407_F0.8060.99
44_P167_K0.8030.99
230_S234_L0.8020.99
427_Q430_H0.8020.99
36_Q245_D0.8000.99
108_F190_A0.7980.99
387_W428_L0.7980.99
170_R207_L0.7960.99
227_A230_S0.7960.99
424_E467_S0.7930.99
371_A455_Y0.7930.99
139_G259_A0.7920.99
301_P378_A0.7920.99
157_L160_L0.7920.99
280_D284_L0.7910.99
197_A277_P0.7880.99
310_E399_H0.7880.99
28_P48_W0.7860.99
246_K365_R0.7850.99
144_L230_S0.7840.99
332_E337_K0.7820.99
100_M436_W0.7810.99
96_N181_D0.7800.99
153_Y157_L0.7800.99
425_V428_L0.7790.99
20_G125_A0.7770.99
213_M304_I0.7730.99
197_A218_S0.7730.99
423_D427_Q0.7710.99
127_G441_K0.7710.99
13_V28_P0.7710.99
12_K49_E0.7710.99
193_M216_G0.7700.99
166_L198_L0.7690.99
232_A236_V0.7680.99
11_G52_L0.7650.99
57_Y114_S0.7600.99
405_F425_V0.7580.99
163_A207_L0.7580.99
37_W42_P0.7570.99
131_V186_F0.7570.99
106_G399_H0.7570.99
198_L208_F0.7520.99
194_S198_L0.7510.99
44_P171_E0.7500.99
213_M216_G0.7460.99
239_I250_V0.7460.99
146_L230_S0.7450.99
40_K43_E0.7420.99
231_A235_Q0.7400.99
62_P78_Q0.7390.99
141_F256_L0.7390.99
168_W172_N0.7390.99
387_W405_F0.7380.99
438_T445_P0.7380.99
371_A375_S0.7380.99
158_G194_S0.7370.99
364_W384_R0.7370.99
355_I359_T0.7350.99
337_K341_E0.7340.99
106_G111_G0.7330.99
173_I178_G0.7310.99
102_W188_E0.7300.99
29_Y84_Y0.7290.99
10_Y172_N0.7270.99
234_L237_L0.7260.99
85_V132_V0.7260.99
101_V165_A0.7260.99
81_D84_Y0.7250.99
217_A367_A0.7230.99
163_A201_M0.7230.99
444_N447_T0.7230.99
204_A208_F0.7230.99
103_I136_Y0.7210.99
326_T329_A0.7210.99
233_F255_L0.7200.99
19_N125_A0.7200.99
62_P256_L0.7200.99
342_K346_L0.7180.99
237_L247_L0.7170.99
328_D332_E0.7160.99
157_L248_H0.7160.99
144_L233_F0.7150.99
460_R474_D0.7090.99
308_R384_R0.7090.99
282_K285_P0.7080.99
104_H135_N0.7080.99
309_D312_Y0.7070.99
8_T12_K0.7040.99
197_A283_T0.7030.99
104_H111_G0.7030.99
462_T472_E0.7020.99
455_Y460_R0.7010.99
88_F124_A0.7010.99
105_G188_E0.7000.99
87_V173_I0.7000.99
327_L331_L0.7000.99
121_S125_A0.6990.99
328_D344_A0.6990.99
341_E344_A0.6970.99
330_A333_Y0.6960.99
310_E359_T0.6950.99
170_R209_Q0.6950.99
21_V124_A0.6930.98
170_R208_F0.6910.98
6_V176_F0.6910.98
185_V198_L0.6900.98
382_M462_T0.6900.98
193_M223_K0.6890.98
160_L203_A0.6870.98
367_A371_A0.6850.98
45_P48_W0.6850.98
182_N441_K0.6820.98
147_S150_N0.6810.98
438_T441_K0.6790.98
461_E471_I0.6790.98
185_V208_F0.6790.98
52_L84_Y0.6790.98
100_M212_I0.6780.98
108_F143_F0.6760.98
459_T473_N0.6740.98
92_T96_N0.6740.98
87_V169_V0.6720.98
105_G189_S0.6720.98
188_E214_E0.6700.98
127_G433_Q0.6680.98
29_Y165_A0.6680.98
99_V132_V0.6670.98
60_I114_S0.6660.98
57_Y133_T0.6650.98
315_F355_I0.6650.98
461_E473_N0.6650.98
405_F428_L0.6600.98
86_N113_G0.6570.98
340_A343_V0.6560.98
234_L239_I0.6540.98
464_I467_S0.6540.98
148_S227_A0.6540.98
167_K205_K0.6480.98
41_A154_S0.6470.98
359_T363_F0.6470.98
145_H155_D0.6450.98
106_G190_A0.6450.98
152_A248_H0.6450.98
21_V120_G0.6430.98
95_K128_E0.6410.97
431_T435_A0.6390.97
369_A373_A0.6380.97
314_F363_F0.6360.97
309_D397_A0.6320.97
339_L343_V0.6320.97
435_A465_L0.6300.97
203_A285_P0.6280.97
211_A300_I0.6280.97
220_T366_P0.6270.97
385_F432_I0.6260.97
158_G162_Q0.6250.97
236_V258_A0.6240.97
103_I166_L0.6240.97
149_F154_S0.6220.97
185_V211_A0.6200.97
195_I208_F0.6180.97
386_D466_D0.6180.97
226_A278_A0.6160.97
312_Y352_E0.6160.97
367_A382_M0.6140.97
143_F194_S0.6140.97
360_D364_W0.6140.97
325_E328_D0.6140.97
147_S227_A0.6120.97
186_F214_E0.6110.97
186_F303_L0.6100.97
28_P81_D0.6100.97
291_A294_E0.6100.97
159_L162_Q0.6090.97
9_Q175_A0.6080.97
186_F406_V0.6070.97
307_T397_A0.6060.96
201_M204_A0.6060.96
100_M214_E0.6060.96
27_I134_L0.6050.96
464_I470_T0.6020.96
185_V213_M0.6010.96
235_Q240_N0.6010.96
446_S451_N0.6010.96
148_S230_S0.6010.96
100_M131_V0.6000.96
239_I365_R0.5990.96
26_G54_A0.5960.96
225_Q228_S0.5960.96
328_D341_E0.5960.96
23_K119_D0.5950.96
403_L406_V0.5930.96
103_I195_I0.5930.96
436_W440_A0.5920.96
17_T91_D0.5890.96
147_S231_A0.5890.96
205_K299_G0.5890.96
136_Y194_S0.5880.96
97_L130_I0.5880.96
297_A374_Q0.5870.96
292_I297_A0.5860.96
23_K88_F0.5840.96
435_A450_V0.5840.96
107_A110_L0.5830.96
210_K439_F0.5830.96
231_A234_L0.5830.96
48_W51_V0.5830.96
85_V101_V0.5820.96
256_L259_A0.5800.96
129_V441_K0.5800.96
212_I439_F0.5800.96
36_Q249_T0.5800.96
33_P84_Y0.5780.95
240_N246_K0.5770.95
88_F131_V0.5770.95
103_I194_S0.5760.95
25_K86_N0.5760.95
150_N154_S0.5760.95
375_S380_V0.5760.95
166_L208_F0.5750.95
311_G315_F0.5750.95
435_A447_T0.5740.95
445_P452_W0.5730.95
304_I380_V0.5730.95
149_F152_A0.5720.95
246_K250_V0.5720.95
463_L469_I0.5690.95
338_P341_E0.5690.95
327_L335_L0.5690.95
313_L400_A0.5690.95
456_H460_R0.5680.95
312_Y398_F0.5670.95
120_G123_L0.5670.95
406_V433_Q0.5670.95
212_I406_V0.5670.95
159_L194_S0.5660.95
381_W454_A0.5640.95
312_Y396_K0.5640.95
136_Y143_F0.5620.95
375_S457_E0.5620.95
200_A291_A0.5610.95
374_Q378_A0.5610.95
385_F428_L0.5600.95
344_A348_P0.5600.95
87_V130_I0.5600.95
201_M206_G0.5580.94
144_L157_L0.5570.94
340_A344_A0.5570.94
105_G136_Y0.5560.94
105_G399_H0.5550.94
233_F250_V0.5550.94
183_V209_Q0.5540.94
462_T475_P0.5540.94
306_T384_R0.5530.94
376_H457_E0.5530.94
144_L155_D0.5530.94
446_S450_V0.5530.94
379_P444_N0.5520.94
340_A347_Y0.5520.94
364_W368_V0.5510.94
57_Y113_G0.5510.94
325_E329_A0.5510.94
311_G363_F0.5500.94
292_I295_G0.5490.94
61_C138_L0.5490.94
162_Q165_A0.5480.94
165_A183_V0.5470.94
226_A229_T0.5470.94
58_G113_G0.5470.94
218_S370_Y0.5460.94
312_Y395_N0.5440.94
102_W186_F0.5430.94
9_Q173_I0.5430.94
291_A297_A0.5430.94
195_I199_L0.5430.94
131_V440_A0.5420.94
202_P205_K0.5420.94
216_G367_A0.5410.94
106_G194_S0.5410.94
373_A376_H0.5390.93
186_F212_I0.5390.93
124_A127_G0.5370.93
422_T426_K0.5370.93
326_T332_E0.5360.93
337_K340_A0.5360.93
331_L334_L0.5350.93
10_Y13_V0.5350.93
179_D209_Q0.5340.93
120_G133_T0.5340.93
309_D396_K0.5330.93
237_L246_K0.5330.93
90_P130_I0.5320.93
288_P291_A0.5320.93
93_P96_N0.5320.93
311_G314_F0.5310.93
41_A282_K0.5300.93
257_K261_Q0.5290.93
140_P258_A0.5290.93
198_L201_M0.5290.93
15_G54_A0.5290.93
101_V162_Q0.5280.93
303_L439_F0.5280.93
330_A334_L0.5270.93
123_L186_F0.5270.93
184_T439_F0.5260.93
384_R464_I0.5260.93
122_K433_Q0.5250.93
332_E335_L0.5240.92
435_A445_P0.5240.92
196_A292_I0.5230.92
159_L277_P0.5230.92
17_T20_G0.5200.92
280_D283_T0.5200.92
309_D356_H0.5200.92
102_W133_T0.5190.92
435_A463_L0.5190.92
456_H461_E0.5180.92
289_E293_A0.5180.92
353_S357_M0.5170.92
12_K48_W0.5160.92
193_M197_A0.5150.92
329_A332_E0.5150.92
463_L471_I0.5140.92
80_E141_F0.5130.92
108_F197_A0.5130.92
159_L284_L0.5120.92
343_V348_P0.5120.92
410_L429_S0.5110.91
140_P259_A0.5100.91
193_M196_A0.5090.91
472_E475_P0.5080.91
167_K170_R0.5080.91
389_P401_L0.5080.91
372_S376_H0.5070.91
240_N243_Q0.5060.91
145_H227_A0.5040.91
118_Y402_E0.5040.91
233_F237_L0.5030.91
146_L244_L0.5030.91
8_T11_G0.5030.91
123_L407_F0.5020.91
466_D470_T0.5020.91
93_P97_L0.5020.91
307_T310_E0.5020.91
186_F436_W0.5020.91
381_W442_T0.5010.91
368_V372_S0.5010.91
236_V262_L0.5010.91
388_H397_A0.5000.91
204_A207_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tpkA 2 0.9816 100 0.163 Contact Map
1dx4A 1 0.9775 100 0.163 Contact Map
1ea5A 2 0.9836 100 0.175 Contact Map
4m0eA 2 0.9857 100 0.18 Contact Map
2bceA 1 0.9591 100 0.186 Contact Map
3bixA 3 0.9693 100 0.191 Contact Map
2ogtA 1 0.9264 100 0.194 Contact Map
1p0iA 2 0.9775 100 0.199 Contact Map
4fnmA 2 0.9796 100 0.2 Contact Map
2h7cA 4 0.9796 100 0.205 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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