GREMLIN Database
LIPO - Lipoprotein LipO
UniProt: P37966 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 502 (396)
Sequences: 21060 (17718)
Seq/√Len: 890.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_T69_K3.8191.00
252_K256_D3.6311.00
114_W346_L3.4281.00
162_D308_I3.3721.00
411_Y414_D3.1781.00
37_T67_E3.0251.00
115_E142_E2.9511.00
249_T253_K2.9251.00
183_K257_E2.8661.00
161_T165_K2.8641.00
179_Y253_K2.8431.00
161_T310_D2.8351.00
64_T351_S2.8311.00
39_K69_K2.8161.00
253_K257_E2.8121.00
245_M413_E2.7111.00
54_S58_K2.5771.00
59_A62_K2.5101.00
174_T177_D2.4981.00
159_I310_D2.4881.00
66_K348_E2.4401.00
61_E67_E2.4081.00
77_S80_D2.3991.00
242_K246_D2.3891.00
138_S143_V2.3881.00
60_L351_S2.3101.00
351_S354_D2.2921.00
131_E135_K2.2801.00
345_E348_E2.2731.00
183_K187_E2.2671.00
117_S142_E2.2611.00
177_D180_E2.2291.00
164_L283_V2.2201.00
413_E417_T2.2151.00
180_E184_A2.2131.00
162_D166_N2.1821.00
58_K62_K2.1371.00
55_P58_K2.1171.00
420_F424_K2.1161.00
417_T421_Q2.0881.00
358_D361_A2.0531.00
421_Q425_D2.0311.00
14_L17_M2.0281.00
93_H345_E2.0201.00
424_K428_T2.0041.00
169_L181_V1.9971.00
246_D249_T1.9691.00
41_M85_V1.9591.00
59_A63_Y1.9421.00
410_Y418_K1.9321.00
184_A188_K1.9061.00
39_K71_T1.8621.00
268_D271_K1.8611.00
180_E183_K1.8521.00
113_F334_T1.8371.00
135_K138_S1.8221.00
61_E64_T1.8171.00
240_T417_T1.8081.00
15_A18_M1.7811.00
363_I367_N1.7391.00
347_K351_S1.7111.00
339_S345_E1.7031.00
230_V234_K1.6991.00
59_A355_K1.6971.00
176_D179_Y1.6881.00
119_Y350_L1.6771.00
57_L61_E1.6711.00
179_Y183_K1.6691.00
58_K61_E1.6561.00
145_G332_M1.6541.00
95_I336_P1.6441.00
115_E118_P1.6251.00
179_Y254_L1.6191.00
157_M312_V1.6171.00
202_V281_A1.6001.00
245_M249_T1.5821.00
57_L352_F1.5791.00
179_Y257_E1.5741.00
183_K259_L1.5461.00
159_I312_V1.5461.00
186_K200_G1.5391.00
339_S346_L1.5281.00
60_L64_T1.5221.00
250_F254_L1.5171.00
185_F282_G1.5141.00
50_P54_S1.5031.00
114_W337_K1.4691.00
163_W282_G1.4611.00
335_I353_L1.4521.00
137_S332_M1.4521.00
414_D418_K1.4491.00
59_A364_L1.4481.00
359_K363_I1.4461.00
176_D180_E1.4411.00
81_K85_V1.4341.00
60_L66_K1.4251.00
418_K421_Q1.4231.00
249_T412_I1.4201.00
161_T308_I1.4181.00
86_M91_M1.4121.00
163_W185_F1.4101.00
172_P177_D1.4031.00
339_S349_V1.3941.00
179_Y250_F1.3811.00
361_A364_L1.3591.00
169_L184_A1.3491.00
414_D417_T1.3451.00
55_P59_A1.3431.00
97_I334_T1.3361.00
173_E177_D1.3351.00
182_L283_V1.3321.00
243_E246_D1.3311.00
167_V185_F1.3311.00
93_H339_S1.3281.00
421_Q424_K1.3251.00
418_K422_H1.3061.00
108_V144_Y1.3021.00
422_H425_D1.2861.00
60_L355_K1.2841.00
51_S54_S1.2841.00
66_K351_S1.2841.00
57_L70_V1.2811.00
250_F253_K1.2751.00
123_Y354_D1.2691.00
275_P280_K1.2661.00
276_V309_I1.2521.00
94_A353_L1.2511.00
12_L16_A1.2451.00
137_S143_V1.2321.00
11_A17_M1.2261.00
245_M412_I1.2211.00
157_M283_V1.2201.00
125_N128_Q1.2151.00
178_F182_L1.2081.00
163_W198_T1.2051.00
378_D381_F1.2021.00
181_V184_A1.1981.00
253_K256_D1.1951.00
111_G337_K1.1941.00
182_L259_L1.1861.00
348_E351_S1.1851.00
355_K361_A1.1811.00
42_A70_V1.1671.00
186_K259_L1.1651.00
118_P121_K1.1631.00
12_L18_M1.1591.00
163_W167_V1.1581.00
74_P77_S1.1461.00
60_L352_F1.1441.00
336_P339_S1.1431.00
199_Y262_K1.1421.00
121_K127_S1.1401.00
178_F201_M1.1381.00
352_F356_M1.1311.00
337_K346_L1.1301.00
61_E65_G1.1281.00
51_S55_P1.1271.00
271_K274_D1.1241.00
410_Y415_Q1.1211.00
382_T385_E1.1171.00
249_T413_E1.1161.00
94_A349_V1.1141.00
156_C311_I1.1081.00
165_K171_M1.1061.00
128_Q377_K1.1011.00
335_I350_L1.0971.00
386_K389_K1.0951.00
108_V139_V1.0901.00
198_T280_K1.0871.00
364_L367_N1.0771.00
386_K390_S1.0771.00
410_Y414_D1.0761.00
417_T420_F1.0761.00
164_L169_L1.0741.00
185_F189_D1.0721.00
114_W339_S1.0721.00
221_W226_N1.0691.00
165_K170_D1.0691.00
274_D278_K1.0671.00
352_F355_K1.0671.00
381_F385_E1.0661.00
178_F283_V1.0651.00
350_L354_D1.0631.00
11_A14_L1.0621.00
68_I352_F1.0621.00
164_L181_V1.0621.00
381_F384_L1.0611.00
134_L138_S1.0561.00
398_L401_F1.0561.00
163_W166_N1.0521.00
364_L368_G1.0481.00
22_C25_S1.0421.00
40_I333_I1.0341.00
38_I352_F1.0291.00
11_A15_A1.0291.00
189_D198_T1.0281.00
124_K127_S1.0241.00
167_V188_K1.0231.00
60_L348_E1.0191.00
91_M336_P1.0171.00
82_F95_I1.0171.00
176_D318_P1.0121.00
7_K14_L1.0081.00
160_R163_W1.0021.00
179_Y259_L0.9971.00
16_A19_I0.9941.00
63_Y360_E0.9941.00
335_I349_V0.9921.00
15_A19_I0.9911.00
94_A352_F0.9891.00
166_N198_T0.9781.00
125_N354_D0.9731.00
86_M112_A0.9731.00
360_E363_I0.9731.00
165_K308_I0.9671.00
89_G338_S0.9661.00
413_E416_K0.9651.00
403_M407_K0.9631.00
181_V283_V0.9621.00
117_S121_K0.9611.00
346_L350_L0.9601.00
7_K10_M0.9551.00
169_L185_F0.9541.00
182_L200_G0.9531.00
10_M14_L0.9521.00
79_N103_G0.9501.00
249_T252_K0.9461.00
385_E389_K0.9441.00
13_P16_A0.9411.00
246_D250_F0.9391.00
95_I334_T0.9391.00
184_A187_E0.9351.00
81_K84_I0.9321.00
286_D290_R0.9301.00
57_L68_I0.9301.00
240_T420_F0.9291.00
167_V184_A0.9271.00
145_G334_T0.9231.00
10_M16_A0.9181.00
293_Q296_S0.9181.00
7_K17_M0.9171.00
258_G262_K0.9161.00
134_L143_V0.9131.00
56_S59_A0.9121.00
19_I22_C0.9091.00
120_L143_V0.9071.00
162_D165_K0.9021.00
12_L15_A0.9021.00
11_A18_M0.9011.00
254_L259_L0.9001.00
238_D241_T0.8971.00
14_L18_M0.8941.00
186_K189_D0.8931.00
275_P281_A0.8901.00
119_Y347_K0.8861.00
242_K245_M0.8851.00
22_C26_E0.8831.00
84_I88_S0.8791.00
395_H398_L0.8791.00
224_A246_D0.8781.00
124_K128_Q0.8741.00
425_D428_T0.8731.00
114_W336_P0.8721.00
95_I113_F0.8681.00
5_M17_M0.8671.00
41_M73_V0.8571.00
13_P17_M0.8561.00
117_S138_S0.8561.00
59_A360_E0.8511.00
239_F244_Y0.8501.00
170_D173_E0.8471.00
117_S143_V0.8461.00
113_F144_Y0.8441.00
10_M17_M0.8371.00
65_G351_S0.8341.00
33_G36_D0.8331.00
359_K377_K0.8291.00
400_Q403_M0.8271.00
114_W119_Y0.8261.00
52_D55_P0.8251.00
159_I171_M0.8251.00
360_E364_L0.8161.00
171_M177_D0.8111.00
41_M92_P0.8101.00
114_W335_I0.8101.00
85_V90_E0.8101.00
170_D181_V0.8081.00
8_K15_A0.8081.00
164_L185_F0.8041.00
392_L395_H0.8011.00
412_I415_Q0.7991.00
379_G384_L0.7981.00
385_E388_N0.7981.00
398_L402_S0.7951.00
108_V113_F0.7921.00
415_Q419_L0.7911.00
7_K18_M0.7891.00
380_V383_S0.7881.00
186_K258_G0.7871.00
370_K374_Y0.7871.00
73_V81_K0.7871.00
182_L186_K0.7861.00
261_N275_P0.7861.00
138_S141_G0.7841.00
41_M71_T0.7821.00
346_L349_V0.7811.00
167_V189_D0.7811.00
21_G24_H0.7801.00
131_E376_L0.7791.00
38_I345_E0.7751.00
409_E415_Q0.7731.00
335_I339_S0.7721.00
349_V353_L0.7711.00
10_M13_P0.7701.00
227_R230_V0.7671.00
411_Y415_Q0.7661.00
7_K11_A0.7651.00
158_I286_D0.7651.00
55_P364_L0.7651.00
38_I349_V0.7651.00
55_P368_G0.7641.00
80_D84_I0.7631.00
221_W244_Y0.7631.00
171_M181_V0.7621.00
403_M406_P0.7621.00
35_K67_E0.7611.00
18_M21_G0.7611.00
392_L398_L0.7611.00
115_E144_Y0.7601.00
171_M312_V0.7591.00
38_I348_E0.7581.00
393_Y397_G0.7561.00
241_T244_Y0.7521.00
129_A357_N0.7511.00
9_W13_P0.7511.00
166_N188_K0.7511.00
402_S405_I0.7491.00
392_L396_E0.7491.00
114_W118_P0.7481.00
175_L179_Y0.7461.00
166_N189_D0.7461.00
378_D383_S0.7451.00
227_R231_E0.7431.00
252_K412_I0.7411.00
274_D277_V0.7411.00
397_G400_Q0.7321.00
245_M416_K0.7281.00
378_D382_T0.7271.00
169_L172_P0.7261.00
148_R333_I0.7261.00
181_V185_F0.7221.00
61_E68_I0.7191.00
399_A403_M0.7181.00
56_S361_A0.7171.00
63_Y355_K0.7121.00
94_A333_I0.7111.00
119_Y346_L0.7101.00
292_S296_S0.7101.00
22_C28_S0.7091.00
416_K419_L0.7091.00
402_S406_P0.7081.00
408_S411_Y0.7071.00
167_V181_V0.7061.00
131_E134_L0.7061.00
167_V198_T0.7061.00
123_Y350_L0.6991.00
347_K350_L0.6981.00
38_I41_M0.6971.00
179_Y182_L0.6971.00
226_N244_Y0.6961.00
132_K135_K0.6951.00
399_A402_S0.6941.00
217_V221_W0.6931.00
129_A134_L0.6921.00
13_P18_M0.6921.00
9_W16_A0.6901.00
270_A273_N0.6901.00
5_M18_M0.6861.00
86_M336_P0.6851.00
318_P321_K0.6851.00
175_L250_F0.6851.00
393_Y396_E0.6841.00
59_A361_A0.6831.00
270_A274_D0.6831.00
118_P350_L0.6821.00
8_K18_M0.6811.00
183_K186_K0.6791.00
392_L402_S0.6781.00
185_F283_V0.6771.00
395_H399_A0.6751.00
247_A251_F0.6741.00
248_L416_K0.6721.00
382_T386_K0.6691.00
396_E400_Q0.6681.00
5_M14_L0.6671.00
411_Y416_K0.6671.00
20_A24_H0.6651.00
40_I94_A0.6641.00
8_K12_L0.6641.00
56_S355_K0.6631.00
8_K11_A0.6631.00
16_A20_A0.6631.00
230_V238_D0.6601.00
199_Y261_N0.6591.00
387_N390_S0.6581.00
167_V282_G0.6571.00
98_K102_A0.6571.00
159_I164_L0.6531.00
83_N106_K0.6501.00
252_K255_Y0.6501.00
163_W189_D0.6501.00
218_L221_W0.6491.00
371_G375_E0.6431.00
420_F423_R0.6421.00
408_S416_K0.6411.00
408_S415_Q0.6401.00
198_T282_G0.6401.00
255_Y260_I0.6381.00
25_S28_S0.6371.00
393_Y398_L0.6361.00
151_D331_G0.6341.00
118_P122_D0.6321.00
237_P424_K0.6321.00
160_R279_G0.6301.00
186_K199_Y0.6301.00
105_I109_K0.6291.00
230_V233_G0.6291.00
396_E403_M0.6271.00
398_L405_I0.6261.00
200_G259_L0.6251.00
119_Y123_Y0.6231.00
339_S344_K0.6211.00
186_K198_T0.6201.00
22_C27_T0.6191.00
79_N106_K0.6191.00
371_G374_Y0.6191.00
397_G401_F0.6181.00
71_T81_K0.6181.00
56_S356_M0.6161.00
8_K14_L0.6151.00
12_L17_M0.6151.00
118_P142_E0.6151.00
104_F108_V0.6141.00
202_V272_W0.6131.00
64_T352_F0.6131.00
185_F198_T0.6121.00
19_I24_H0.6091.00
222_F227_R0.6091.00
267_M275_P0.6081.00
122_D347_K0.6081.00
165_K168_G0.6081.00
394_E401_F0.6061.00
130_D376_L0.6061.00
63_Y358_D0.6051.00
78_Y82_F0.6051.00
164_L171_M0.6051.00
248_L415_Q0.6051.00
220_I223_G0.6041.00
65_G348_E0.6021.00
56_S364_L0.6021.00
77_S81_K0.5991.00
104_F145_G0.5991.00
26_E29_N0.5951.00
379_G383_S0.5951.00
57_L64_T0.5921.00
424_K427_I0.5911.00
423_R427_I0.5911.00
158_I311_I0.5911.00
380_V384_L0.5911.00
160_R308_I0.5901.00
40_I352_F0.5891.00
296_S299_E0.5891.00
9_W15_A0.5891.00
398_L406_P0.5881.00
111_G114_W0.5861.00
103_G106_K0.5841.00
419_L423_R0.5841.00
275_P278_K0.5841.00
416_K420_F0.5821.00
241_T245_M0.5791.00
5_M15_A0.5791.00
6_R13_P0.5771.00
316_E320_G0.5771.00
75_D79_N0.5761.00
188_K198_T0.5761.00
272_W284_I0.5741.00
206_W268_D0.5741.00
119_Y122_D0.5741.00
409_E412_I0.5731.00
112_A115_E0.5731.00
423_R426_I0.5721.00
231_E234_K0.5721.00
54_S57_L0.5711.00
408_S412_I0.5711.00
64_T348_E0.5701.00
48_E51_S0.5691.00
379_G382_T0.5681.00
71_T85_V0.5671.00
21_G25_S0.5661.00
79_N98_K0.5651.00
298_M301_A0.5651.00
91_M338_S0.5641.00
157_M285_V0.5621.00
404_S407_K0.5611.00
80_D83_N0.5601.00
9_W12_L0.5581.00
5_M8_K0.5571.00
394_E397_G0.5571.00
137_S145_G0.5561.00
173_E316_E0.5561.00
158_I309_I0.5551.00
116_L353_L0.5541.00
60_L68_I0.5541.00
106_K110_A0.5521.00
98_K329_Y0.5521.00
107_S113_F0.5511.00
293_Q297_A0.5511.00
383_S387_N0.5511.00
187_E198_T0.5511.00
130_D133_I0.5501.00
164_L170_D0.5491.00
36_D345_E0.5491.00
296_S300_E0.5481.00
114_W350_L0.5471.00
40_I57_L0.5471.00
97_I113_F0.5471.00
295_Q309_I0.5471.00
85_V92_P0.5471.00
381_F386_K0.5461.00
52_D56_S0.5451.00
391_L394_E0.5451.00
20_A23_S0.5441.00
290_R293_Q0.5431.00
104_F113_F0.5431.00
392_L397_G0.5401.00
61_E66_K0.5391.00
291_A295_Q0.5371.00
391_L398_L0.5371.00
297_A300_E0.5371.00
158_I291_A0.5361.00
216_D219_Q0.5361.00
38_I93_H0.5351.00
30_S33_G0.5351.00
401_F406_P0.5341.00
345_E349_V0.5341.00
221_W224_A0.5331.00
127_S134_L0.5321.00
164_L282_G0.5321.00
378_D384_L0.5311.00
98_K331_G0.5311.00
243_E247_A0.5301.00
97_I107_S0.5291.00
114_W338_S0.5281.00
246_D318_P0.5271.00
384_L388_N0.5261.00
38_I94_A0.5251.00
183_K253_K0.5241.00
409_E416_K0.5231.00
128_Q376_L0.5211.00
244_Y248_L0.5201.00
185_F188_K0.5191.00
330_S333_I0.5181.00
79_N107_S0.5181.00
219_Q222_F0.5181.00
172_P283_V0.5151.00
35_K65_G0.5151.00
93_H349_V0.5151.00
383_S388_N0.5141.00
24_H27_T0.5131.00
202_V267_M0.5121.00
120_L350_L0.5111.00
218_L222_F0.5101.00
182_L254_L0.5101.00
393_Y401_F0.5101.00
93_H346_L0.5091.00
362_Q374_Y0.5091.00
335_I346_L0.5091.00
177_D181_V0.5081.00
401_F405_I0.5081.00
93_H344_K0.5071.00
61_E352_F0.5071.00
28_S31_A0.5061.00
219_Q223_G0.5061.00
29_N32_S0.5051.00
73_V78_Y0.5041.00
261_N264_F0.5031.00
27_T30_S0.5021.00
40_I53_K0.5021.00
5_M16_A0.5021.00
165_K310_D0.5021.00
396_E399_A0.5011.00
277_V297_A0.5011.00
162_D279_G0.5001.00
75_D78_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ombA 1 0.9084 100 0.247 Contact Map
3a09A 1 0.9143 100 0.33 Contact Map
4r2fA 1 0.7211 100 0.338 Contact Map
4mfiA 1 0.7849 100 0.355 Contact Map
3uorA 1 0.747 100 0.357 Contact Map
4r9fA 1 0.753 100 0.36 Contact Map
3vxbA 1 0.759 100 0.365 Contact Map
4r6kA 1 0.7271 100 0.371 Contact Map
4r6hA 1 0.747 100 0.388 Contact Map
4ovjA 1 0.7171 100 0.392 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0126 seconds.