GLPQ - BACSU - GREMLIN Contacts

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GLPQ - Glycerophosphoryl diester phosphodiesterase

UniProt:	P37965	Sequences: MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHRGASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDHTLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYPGMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMASMTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVTGVFTNYPDLFHKVKKGY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	293 (238)
Sequences:	8614 (6243)
Seq/√Len:	404.7

ECOLI - GLPQ UGPQ
BACSU - GLPQ YHDW YQIK
HALSA - Q9HP18

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
56_L	131_L	3.287	1.00
250_R	276_T	3.026	1.00
141_D	173_H	2.798	1.00
48_G	282_Y	2.692	1.00
137_E	169_S	2.668	1.00
60_T	63_K	2.621	1.00
103_T	106_D	2.462	1.00
104_L	108_K	2.414	1.00
262_N	281_N	2.317	1.00
108_K	138_E	2.299	1.00
59_E	142_R	2.284	1.00
267_M	286_F	2.252	1.00
104_L	135_T	2.223	1.00
58_Y	71_L	2.210	1.00
49_Y	284_D	2.165	1.00
84_M	99_V	2.159	1.00
150_Y	188_Q	2.151	1.00
137_E	172_K	2.130	1.00
89_L	110_L	2.048	1.00
55_I	134_P	2.025	1.00
75_M	165_K	2.012	1.00
98_W	101_D	1.984	1.00
80_K	104_L	1.956	1.00
137_E	173_H	1.939	1.00
93_T	112_A	1.859	1.00
282_Y	285_L	1.850	1.00
59_E	63_K	1.837	1.00
77_K	103_T	1.823	1.00
71_L	139_V	1.821	1.00
54_T	112_A	1.808	1.00
95_G	110_L	1.801	1.00
71_L	83_V	1.752	1.00
50_V	60_T	1.750	1.00
208_V	233_G	1.749	1.00
76_T	82_I	1.747	1.00
165_K	168_A	1.743	1.00
82_I	104_L	1.707	1.00
89_L	102_H	1.704	1.00
62_Q	147_A	1.701	1.00
257_H	277_G	1.687	1.00
83_V	139_V	1.685	1.00
84_M	92_T	1.679	1.00
41_V	68_F	1.676	1.00
68_F	148_N	1.644	1.00
97_G	102_H	1.639	1.00
238_Y	266_D	1.627	1.00
135_T	138_E	1.581	1.00
169_S	173_H	1.577	1.00
42_A	57_S	1.570	1.00
263_N	266_D	1.558	1.00
80_K	135_T	1.556	1.00
164_E	201_L	1.556	1.00
60_T	64_M	1.541	1.00
47_S	57_S	1.530	1.00
44_R	52_E	1.519	1.00
111_D	130_G	1.507	1.00
52_E	91_R	1.487	1.00
168_A	172_K	1.480	1.00
75_M	81_L	1.466	1.00
167_I	202_Q	1.463	1.00
266_D	269_R	1.456	1.00
171_Q	202_Q	1.453	1.00
258_P	275_V	1.448	1.00
90_D	96_M	1.440	1.00
136_L	151_I	1.436	1.00
236_P	258_P	1.424	1.00
82_I	99_V	1.410	1.00
269_R	273_W	1.400	1.00
137_E	141_D	1.396	1.00
164_E	168_A	1.385	1.00
76_T	107_I	1.381	1.00
107_I	133_V	1.366	1.00
58_Y	139_V	1.336	1.00
55_I	142_R	1.336	1.00
188_Q	279_F	1.326	1.00
90_D	97_G	1.321	1.00
80_K	137_E	1.311	1.00
187_I	198_V	1.304	1.00
243_Q	247_R	1.300	1.00
46_A	49_Y	1.299	1.00
76_T	80_K	1.296	1.00
167_I	198_V	1.280	1.00
102_H	107_I	1.276	1.00
187_I	205_L	1.271	1.00
46_A	60_T	1.266	1.00
79_G	161_G	1.265	1.00
199_H	207_T	1.262	1.00
79_G	165_K	1.255	1.00
246_V	256_L	1.229	1.00
102_H	106_D	1.214	1.00
249_I	256_L	1.209	1.00
73_L	81_L	1.207	1.00
170_L	187_I	1.203	1.00
153_T	166_L	1.194	1.00
41_V	277_G	1.190	1.00
163_E	194_S	1.186	1.00
62_Q	142_R	1.185	1.00
84_M	133_V	1.171	1.00
197_K	200_Q	1.168	1.00
255_L	276_T	1.164	1.00
40_T	286_F	1.156	1.00
267_M	289_V	1.151	1.00
46_A	64_M	1.148	1.00
199_H	232_V	1.146	1.00
106_D	109_K	1.136	1.00
86_D	91_R	1.134	1.00
169_S	172_K	1.130	1.00
88_K	98_W	1.129	1.00
163_E	197_K	1.126	1.00
140_L	149_Y	1.119	1.00
197_K	201_L	1.115	1.00
55_I	59_E	1.103	1.00
140_L	170_L	1.091	1.00
76_T	104_L	1.090	1.00
140_L	173_H	1.087	1.00
58_Y	69_I	1.078	1.00
41_V	150_Y	1.072	1.00
108_K	132_K	1.065	1.00
247_R	251_S	1.051	1.00
268_H	272_D	1.047	1.00
267_M	278_V	1.045	1.00
182_P	202_Q	1.033	1.00
246_V	250_R	1.025	1.00
81_L	166_L	1.024	1.00
70_E	85_H	1.021	1.00
73_L	136_L	1.020	1.00
259_Y	279_F	1.016	1.00
73_L	166_L	1.013	1.00
195_L	207_T	1.011	1.00
58_Y	83_V	1.010	1.00
56_L	60_T	0.999	1.00
268_H	289_V	0.996	1.00
188_Q	235_G	0.994	1.00
42_A	47_S	0.994	1.00
47_S	281_N	0.989	1.00
46_A	284_D	0.976	1.00
261_V	270_L	0.975	1.00
161_G	165_K	0.967	1.00
261_V	267_M	0.967	1.00
74_Q	87_E	0.964	1.00
150_Y	257_H	0.955	1.00
117_N	127_Q	0.955	1.00
53_H	58_Y	0.950	1.00
40_T	287_H	0.943	1.00
108_K	135_T	0.928	1.00
150_Y	279_F	0.926	1.00
143_F	149_Y	0.923	1.00
93_T	97_G	0.918	1.00
90_D	94_N	0.914	1.00
111_D	132_K	0.914	1.00
167_I	171_Q	0.911	1.00
42_A	66_A	0.909	1.00
171_Q	182_P	0.906	1.00
49_Y	64_M	0.905	1.00
50_V	56_L	0.897	1.00
249_I	254_L	0.895	1.00
73_L	151_I	0.892	1.00
81_L	165_K	0.887	1.00
153_T	194_S	0.882	1.00
77_K	101_D	0.882	1.00
82_I	107_I	0.877	1.00
245_N	249_I	0.876	1.00
136_L	140_L	0.856	1.00
264_E	268_H	0.853	1.00
202_Q	205_L	0.852	1.00
190_F	210_L	0.847	1.00
81_L	162_M	0.844	1.00
280_T	286_F	0.839	1.00
250_R	256_L	0.838	1.00
188_Q	208_V	0.837	1.00
164_E	197_K	0.832	1.00
102_H	110_L	0.829	1.00
42_A	46_A	0.826	1.00
53_H	134_P	0.825	1.00
233_G	257_H	0.822	1.00
150_Y	235_G	0.816	1.00
152_E	190_F	0.812	1.00
206_P	232_V	0.811	1.00
166_L	170_L	0.810	1.00
244_E	248_M	0.808	1.00
163_E	167_I	0.805	1.00
134_P	139_V	0.804	1.00
46_A	283_P	0.800	1.00
248_M	251_S	0.799	1.00
258_P	270_L	0.798	1.00
170_L	182_P	0.796	1.00
81_L	169_S	0.796	1.00
181_K	184_Q	0.791	1.00
59_E	143_F	0.789	1.00
246_V	273_W	0.789	1.00
89_L	95_G	0.787	1.00
88_K	91_R	0.786	1.00
235_G	257_H	0.781	1.00
248_M	252_H	0.778	1.00
264_E	288_K	0.777	1.00
192_K	196_V	0.776	1.00
66_A	283_P	0.773	1.00
150_Y	186_I	0.771	1.00
93_T	110_L	0.771	1.00
221_D	248_M	0.767	1.00
152_E	189_S	0.765	1.00
71_L	149_Y	0.764	1.00
153_T	162_M	0.761	1.00
43_H	85_H	0.756	1.00
267_M	285_L	0.755	1.00
90_D	95_G	0.749	1.00
105_A	109_K	0.745	1.00
89_L	97_G	0.740	1.00
220_T	223_A	0.739	1.00
174_K	182_P	0.738	1.00
206_P	255_L	0.735	1.00
167_I	201_L	0.732	1.00
278_V	286_F	0.730	1.00
182_P	185_V	0.728	1.00
40_T	66_A	0.720	1.00
61_A	66_A	0.720	1.00
75_M	79_G	0.719	1.00
219_M	222_A	0.716	1.00
165_K	169_S	0.713	1.00
266_D	270_L	0.709	1.00
271_L	286_F	0.708	1.00
243_Q	273_W	0.708	1.00
74_Q	100_K	0.705	1.00
41_V	279_F	0.704	1.00
264_E	285_L	0.704	1.00
208_V	257_H	0.702	1.00
72_D	85_H	0.702	1.00
247_R	250_R	0.701	1.00
88_K	96_M	0.701	1.00
140_L	169_S	0.699	1.00
49_Y	60_T	0.698	1.00
171_Q	204_N	0.695	1.00
166_L	187_I	0.694	1.00
136_L	166_L	0.690	1.00
233_G	255_L	0.689	1.00
192_K	209_Q	0.688	1.00
117_N	128_Y	0.686	1.00
198_V	207_T	0.685	1.00
64_M	284_D	0.683	1.00
59_E	131_L	0.678	0.99
69_I	147_A	0.673	0.99
111_D	114_S	0.669	0.99
111_D	115_W	0.661	0.99
113_G	116_F	0.660	0.99
188_Q	210_L	0.660	0.99
71_L	151_I	0.660	0.99
223_A	226_E	0.654	0.99
49_Y	282_Y	0.652	0.99
139_V	143_F	0.652	0.99
270_L	273_W	0.648	0.99
80_K	165_K	0.648	0.99
139_V	149_Y	0.645	0.99
191_S	194_S	0.645	0.99
265_A	268_H	0.644	0.99
260_T	280_T	0.640	0.99
136_L	169_S	0.639	0.99
225_E	252_H	0.639	0.99
161_G	164_E	0.639	0.99
41_V	257_H	0.633	0.99
196_V	200_Q	0.632	0.99
46_A	50_V	0.629	0.99
43_H	70_E	0.627	0.99
221_D	224_L	0.625	0.99
107_I	110_L	0.625	0.99
75_M	162_M	0.623	0.99
84_M	93_T	0.622	0.99
263_N	285_L	0.622	0.99
112_A	134_P	0.620	0.99
64_M	287_H	0.617	0.99
262_N	280_T	0.616	0.99
38_I	271_L	0.615	0.99
193_E	196_V	0.613	0.99
170_L	185_V	0.610	0.99
222_A	225_E	0.609	0.99
39_L	67_D	0.607	0.99
89_L	107_I	0.604	0.99
271_L	289_V	0.604	0.99
40_T	283_P	0.602	0.99
144_G	184_Q	0.601	0.99
208_V	235_G	0.601	0.99
186_I	233_G	0.601	0.99
237_D	240_A	0.601	0.99
45_G	58_Y	0.601	0.99
138_E	141_D	0.598	0.99
40_T	280_T	0.596	0.99
39_L	277_G	0.596	0.99
82_I	135_T	0.592	0.99
219_M	223_A	0.590	0.99
74_Q	99_V	0.590	0.99
241_L	258_P	0.590	0.99
146_H	184_Q	0.587	0.99
220_T	224_L	0.585	0.98
258_P	261_V	0.585	0.98
69_I	143_F	0.584	0.98
234_A	249_I	0.584	0.98
198_V	205_L	0.582	0.98
105_A	108_K	0.581	0.98
62_Q	146_H	0.576	0.98
92_T	112_A	0.576	0.98
58_Y	142_R	0.574	0.98
56_L	59_E	0.574	0.98
54_T	57_S	0.572	0.98
90_D	93_T	0.571	0.98
189_S	195_L	0.571	0.98
74_Q	155_S	0.569	0.98
68_F	150_Y	0.568	0.98
77_K	106_D	0.567	0.98
211_L	234_A	0.566	0.98
152_E	210_L	0.566	0.98
76_T	99_V	0.564	0.98
85_H	154_K	0.564	0.98
209_Q	230_Y	0.564	0.98
243_Q	246_V	0.560	0.98
39_L	148_N	0.558	0.98
127_Q	130_G	0.558	0.98
114_S	117_N	0.554	0.98
46_A	66_A	0.550	0.98
257_H	279_F	0.546	0.98
152_E	188_Q	0.545	0.98
111_D	116_F	0.543	0.98
102_H	133_V	0.543	0.98
241_L	273_W	0.542	0.98
206_P	209_Q	0.540	0.97
94_N	112_A	0.540	0.97
145_K	184_Q	0.538	0.97
97_G	110_L	0.537	0.97
190_F	259_Y	0.534	0.97
87_E	98_W	0.531	0.97
256_L	275_V	0.531	0.97
66_A	287_H	0.529	0.97
210_L	235_G	0.528	0.97
65_K	287_H	0.527	0.97
64_M	283_P	0.527	0.97
77_K	102_H	0.527	0.97
286_F	289_V	0.524	0.97
61_A	69_I	0.524	0.97
89_L	93_T	0.523	0.97
39_L	68_F	0.523	0.97
81_L	135_T	0.522	0.97
267_M	280_T	0.521	0.97
223_A	227_I	0.521	0.97
220_T	225_E	0.520	0.97
285_L	289_V	0.518	0.97
181_K	185_V	0.517	0.97
67_D	148_N	0.517	0.97
195_L	199_H	0.515	0.97
112_A	133_V	0.514	0.97
213_A	240_A	0.514	0.97
173_H	181_K	0.512	0.97
114_S	128_Y	0.510	0.96
230_Y	233_G	0.509	0.96
95_G	102_H	0.505	0.96
221_D	226_E	0.505	0.96
48_G	284_D	0.504	0.96
84_M	134_P	0.503	0.96
70_E	86_D	0.502	0.96
267_M	271_L	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4r7oA	4	0.884	100	0.173	Contact Map
2oogA	4	0.9044	100	0.181	Contact Map
2pz0A	2	0.8191	100	0.197	Contact Map
1zccA	5	0.7952	100	0.203	Contact Map
1ydyA	2	0.8635	100	0.206	Contact Map
3qvqA	4	0.8464	100	0.206	Contact Map
3ks6A	1	0.8089	100	0.207	Contact Map
2o55A	1	0.8089	100	0.214	Contact Map
4oecA	1	0.7952	100	0.215	Contact Map
2otdA	1	0.8225	100	0.216	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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