GREMLIN Database
GLPQ - Glycerophosphoryl diester phosphodiesterase
UniProt: P37965 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (238)
Sequences: 8614 (6243)
Seq/√Len: 404.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_L131_L3.2871.00
250_R276_T3.0261.00
141_D173_H2.7981.00
48_G282_Y2.6921.00
137_E169_S2.6681.00
60_T63_K2.6211.00
103_T106_D2.4621.00
104_L108_K2.4141.00
262_N281_N2.3171.00
108_K138_E2.2991.00
59_E142_R2.2841.00
267_M286_F2.2521.00
104_L135_T2.2231.00
58_Y71_L2.2101.00
49_Y284_D2.1651.00
84_M99_V2.1591.00
150_Y188_Q2.1511.00
137_E172_K2.1301.00
89_L110_L2.0481.00
55_I134_P2.0251.00
75_M165_K2.0121.00
98_W101_D1.9841.00
80_K104_L1.9561.00
137_E173_H1.9391.00
93_T112_A1.8591.00
282_Y285_L1.8501.00
59_E63_K1.8371.00
77_K103_T1.8231.00
71_L139_V1.8211.00
54_T112_A1.8081.00
95_G110_L1.8011.00
71_L83_V1.7521.00
50_V60_T1.7501.00
208_V233_G1.7491.00
76_T82_I1.7471.00
165_K168_A1.7431.00
82_I104_L1.7071.00
89_L102_H1.7041.00
62_Q147_A1.7011.00
257_H277_G1.6871.00
83_V139_V1.6851.00
84_M92_T1.6791.00
41_V68_F1.6761.00
68_F148_N1.6441.00
97_G102_H1.6391.00
238_Y266_D1.6271.00
135_T138_E1.5811.00
169_S173_H1.5771.00
42_A57_S1.5701.00
263_N266_D1.5581.00
80_K135_T1.5561.00
164_E201_L1.5561.00
60_T64_M1.5411.00
47_S57_S1.5301.00
44_R52_E1.5191.00
111_D130_G1.5071.00
52_E91_R1.4871.00
168_A172_K1.4801.00
75_M81_L1.4661.00
167_I202_Q1.4631.00
266_D269_R1.4561.00
171_Q202_Q1.4531.00
258_P275_V1.4481.00
90_D96_M1.4401.00
136_L151_I1.4361.00
236_P258_P1.4241.00
82_I99_V1.4101.00
269_R273_W1.4001.00
137_E141_D1.3961.00
164_E168_A1.3851.00
76_T107_I1.3811.00
107_I133_V1.3661.00
58_Y139_V1.3361.00
55_I142_R1.3361.00
188_Q279_F1.3261.00
90_D97_G1.3211.00
80_K137_E1.3111.00
187_I198_V1.3041.00
243_Q247_R1.3001.00
46_A49_Y1.2991.00
76_T80_K1.2961.00
167_I198_V1.2801.00
102_H107_I1.2761.00
187_I205_L1.2711.00
46_A60_T1.2661.00
79_G161_G1.2651.00
199_H207_T1.2621.00
79_G165_K1.2551.00
246_V256_L1.2291.00
102_H106_D1.2141.00
249_I256_L1.2091.00
73_L81_L1.2071.00
170_L187_I1.2031.00
153_T166_L1.1941.00
41_V277_G1.1901.00
163_E194_S1.1861.00
62_Q142_R1.1851.00
84_M133_V1.1711.00
197_K200_Q1.1681.00
255_L276_T1.1641.00
40_T286_F1.1561.00
267_M289_V1.1511.00
46_A64_M1.1481.00
199_H232_V1.1461.00
106_D109_K1.1361.00
86_D91_R1.1341.00
169_S172_K1.1301.00
88_K98_W1.1291.00
163_E197_K1.1261.00
140_L149_Y1.1191.00
197_K201_L1.1151.00
55_I59_E1.1031.00
140_L170_L1.0911.00
76_T104_L1.0901.00
140_L173_H1.0871.00
58_Y69_I1.0781.00
41_V150_Y1.0721.00
108_K132_K1.0651.00
247_R251_S1.0511.00
268_H272_D1.0471.00
267_M278_V1.0451.00
182_P202_Q1.0331.00
246_V250_R1.0251.00
81_L166_L1.0241.00
70_E85_H1.0211.00
73_L136_L1.0201.00
259_Y279_F1.0161.00
73_L166_L1.0131.00
195_L207_T1.0111.00
58_Y83_V1.0101.00
56_L60_T0.9991.00
268_H289_V0.9961.00
188_Q235_G0.9941.00
42_A47_S0.9941.00
47_S281_N0.9891.00
46_A284_D0.9761.00
261_V270_L0.9751.00
161_G165_K0.9671.00
261_V267_M0.9671.00
74_Q87_E0.9641.00
150_Y257_H0.9551.00
117_N127_Q0.9551.00
53_H58_Y0.9501.00
40_T287_H0.9431.00
108_K135_T0.9281.00
150_Y279_F0.9261.00
143_F149_Y0.9231.00
93_T97_G0.9181.00
90_D94_N0.9141.00
111_D132_K0.9141.00
167_I171_Q0.9111.00
42_A66_A0.9091.00
171_Q182_P0.9061.00
49_Y64_M0.9051.00
50_V56_L0.8971.00
249_I254_L0.8951.00
73_L151_I0.8921.00
81_L165_K0.8871.00
153_T194_S0.8821.00
77_K101_D0.8821.00
82_I107_I0.8771.00
245_N249_I0.8761.00
136_L140_L0.8561.00
264_E268_H0.8531.00
202_Q205_L0.8521.00
190_F210_L0.8471.00
81_L162_M0.8441.00
280_T286_F0.8391.00
250_R256_L0.8381.00
188_Q208_V0.8371.00
164_E197_K0.8321.00
102_H110_L0.8291.00
42_A46_A0.8261.00
53_H134_P0.8251.00
233_G257_H0.8221.00
150_Y235_G0.8161.00
152_E190_F0.8121.00
206_P232_V0.8111.00
166_L170_L0.8101.00
244_E248_M0.8081.00
163_E167_I0.8051.00
134_P139_V0.8041.00
46_A283_P0.8001.00
248_M251_S0.7991.00
258_P270_L0.7981.00
170_L182_P0.7961.00
81_L169_S0.7961.00
181_K184_Q0.7911.00
59_E143_F0.7891.00
246_V273_W0.7891.00
89_L95_G0.7871.00
88_K91_R0.7861.00
235_G257_H0.7811.00
248_M252_H0.7781.00
264_E288_K0.7771.00
192_K196_V0.7761.00
66_A283_P0.7731.00
150_Y186_I0.7711.00
93_T110_L0.7711.00
221_D248_M0.7671.00
152_E189_S0.7651.00
71_L149_Y0.7641.00
153_T162_M0.7611.00
43_H85_H0.7561.00
267_M285_L0.7551.00
90_D95_G0.7491.00
105_A109_K0.7451.00
89_L97_G0.7401.00
220_T223_A0.7391.00
174_K182_P0.7381.00
206_P255_L0.7351.00
167_I201_L0.7321.00
278_V286_F0.7301.00
182_P185_V0.7281.00
40_T66_A0.7201.00
61_A66_A0.7201.00
75_M79_G0.7191.00
219_M222_A0.7161.00
165_K169_S0.7131.00
266_D270_L0.7091.00
271_L286_F0.7081.00
243_Q273_W0.7081.00
74_Q100_K0.7051.00
41_V279_F0.7041.00
264_E285_L0.7041.00
208_V257_H0.7021.00
72_D85_H0.7021.00
247_R250_R0.7011.00
88_K96_M0.7011.00
140_L169_S0.6991.00
49_Y60_T0.6981.00
171_Q204_N0.6951.00
166_L187_I0.6941.00
136_L166_L0.6901.00
233_G255_L0.6891.00
192_K209_Q0.6881.00
117_N128_Y0.6861.00
198_V207_T0.6851.00
64_M284_D0.6831.00
59_E131_L0.6780.99
69_I147_A0.6730.99
111_D114_S0.6690.99
111_D115_W0.6610.99
113_G116_F0.6600.99
188_Q210_L0.6600.99
71_L151_I0.6600.99
223_A226_E0.6540.99
49_Y282_Y0.6520.99
139_V143_F0.6520.99
270_L273_W0.6480.99
80_K165_K0.6480.99
139_V149_Y0.6450.99
191_S194_S0.6450.99
265_A268_H0.6440.99
260_T280_T0.6400.99
136_L169_S0.6390.99
225_E252_H0.6390.99
161_G164_E0.6390.99
41_V257_H0.6330.99
196_V200_Q0.6320.99
46_A50_V0.6290.99
43_H70_E0.6270.99
221_D224_L0.6250.99
107_I110_L0.6250.99
75_M162_M0.6230.99
84_M93_T0.6220.99
263_N285_L0.6220.99
112_A134_P0.6200.99
64_M287_H0.6170.99
262_N280_T0.6160.99
38_I271_L0.6150.99
193_E196_V0.6130.99
170_L185_V0.6100.99
222_A225_E0.6090.99
39_L67_D0.6070.99
89_L107_I0.6040.99
271_L289_V0.6040.99
40_T283_P0.6020.99
144_G184_Q0.6010.99
208_V235_G0.6010.99
186_I233_G0.6010.99
237_D240_A0.6010.99
45_G58_Y0.6010.99
138_E141_D0.5980.99
40_T280_T0.5960.99
39_L277_G0.5960.99
82_I135_T0.5920.99
219_M223_A0.5900.99
74_Q99_V0.5900.99
241_L258_P0.5900.99
146_H184_Q0.5870.99
220_T224_L0.5850.98
258_P261_V0.5850.98
69_I143_F0.5840.98
234_A249_I0.5840.98
198_V205_L0.5820.98
105_A108_K0.5810.98
62_Q146_H0.5760.98
92_T112_A0.5760.98
58_Y142_R0.5740.98
56_L59_E0.5740.98
54_T57_S0.5720.98
90_D93_T0.5710.98
189_S195_L0.5710.98
74_Q155_S0.5690.98
68_F150_Y0.5680.98
77_K106_D0.5670.98
211_L234_A0.5660.98
152_E210_L0.5660.98
76_T99_V0.5640.98
85_H154_K0.5640.98
209_Q230_Y0.5640.98
243_Q246_V0.5600.98
39_L148_N0.5580.98
127_Q130_G0.5580.98
114_S117_N0.5540.98
46_A66_A0.5500.98
257_H279_F0.5460.98
152_E188_Q0.5450.98
111_D116_F0.5430.98
102_H133_V0.5430.98
241_L273_W0.5420.98
206_P209_Q0.5400.97
94_N112_A0.5400.97
145_K184_Q0.5380.97
97_G110_L0.5370.97
190_F259_Y0.5340.97
87_E98_W0.5310.97
256_L275_V0.5310.97
66_A287_H0.5290.97
210_L235_G0.5280.97
65_K287_H0.5270.97
64_M283_P0.5270.97
77_K102_H0.5270.97
286_F289_V0.5240.97
61_A69_I0.5240.97
89_L93_T0.5230.97
39_L68_F0.5230.97
81_L135_T0.5220.97
267_M280_T0.5210.97
223_A227_I0.5210.97
220_T225_E0.5200.97
285_L289_V0.5180.97
181_K185_V0.5170.97
67_D148_N0.5170.97
195_L199_H0.5150.97
112_A133_V0.5140.97
213_A240_A0.5140.97
173_H181_K0.5120.97
114_S128_Y0.5100.96
230_Y233_G0.5090.96
95_G102_H0.5050.96
221_D226_E0.5050.96
48_G284_D0.5040.96
84_M134_P0.5030.96
70_E86_D0.5020.96
267_M271_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r7oA 4 0.884 100 0.173 Contact Map
2oogA 4 0.9044 100 0.181 Contact Map
2pz0A 2 0.8191 100 0.197 Contact Map
1zccA 5 0.7952 100 0.203 Contact Map
1ydyA 2 0.8635 100 0.206 Contact Map
3qvqA 4 0.8464 100 0.206 Contact Map
3ks6A 1 0.8089 100 0.207 Contact Map
2o55A 1 0.8089 100 0.214 Contact Map
4oecA 1 0.7952 100 0.215 Contact Map
2otdA 1 0.8225 100 0.216 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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