YSXE - BACSU - GREMLIN Contacts

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YSXE - Uncharacterized protein YsxE

UniProt:	P37964	Sequences: MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGRGKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQKHAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLSPFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGTGYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFLSYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQAENESTS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	341 (276)
Sequences:	1976 (1636)
Seq/√Len:	98.4

ECOLI - RDOA
BACSU - YSXE COTS COTI YUTH YERI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
69_T	76_S	5.841	1.00
111_A	264_S	4.953	1.00
262_T	272_V	3.797	1.00
37_L	87_L	3.353	1.00
107_F	260_G	3.270	1.00
108_R	263_K	3.253	1.00
12_G	70_N	3.107	1.00
36_A	90_W	3.051	1.00
27_K	90_W	3.027	1.00
236_L	257_W	2.908	1.00
110_T	206_L	2.882	1.00
54_A	120_E	2.833	1.00
68_R	74_F	2.656	1.00
104_A	260_G	2.613	1.00
180_A	184_L	2.433	1.00
30_T	33_G	2.412	1.00
65_P	89_P	2.407	1.00
23_P	26_W	2.361	1.00
29_Y	34_I	2.297	1.00
212_L	222_T	2.229	1.00
205_S	223_N	2.209	1.00
109_E	221_F	2.159	1.00
210_H	223_N	2.150	1.00
175_S	178_N	2.143	1.00
202_N	230_G	2.051	1.00
28_V	87_L	2.018	1.00
113_L	224_F	2.018	1.00
56_E	65_P	2.002	1.00
173_T	176_A	1.973	1.00
179_F	182_E	1.959	1.00
17_F	29_Y	1.934	1.00
200_V	232_P	1.919	1.00
42_E	77_A	1.915	1.00
16_Q	31_D	1.825	1.00
182_E	186_D	1.813	1.00
115_E	265_F	1.807	1.00
206_L	221_F	1.805	1.00
54_A	119_Q	1.764	1.00
104_A	259_Y	1.735	1.00
114_H	261_Y	1.726	1.00
115_E	264_S	1.724	1.00
107_F	257_W	1.691	1.00
110_T	114_H	1.679	1.00
260_G	263_K	1.673	1.00
146_Y	149_F	1.672	1.00
177_V	180_A	1.671	1.00
35_F	89_P	1.633	1.00
91_L	220_Y	1.626	1.00
205_S	210_H	1.622	1.00
237_L	279_M	1.609	1.00
51_H	117_T	1.603	1.00
96_E	211_F	1.586	1.00
14_T	31_D	1.583	1.00
134_Q	137_K	1.577	1.00
176_A	180_A	1.575	1.00
53_V	68_R	1.567	1.00
39_K	85_Y	1.547	1.00
180_A	183_R	1.544	1.00
114_H	235_D	1.535	1.00
169_Y	285_M	1.533	1.00
22_S	209_H	1.522	1.00
49_T	86_Y	1.518	1.00
178_N	182_E	1.518	1.00
176_A	179_F	1.511	1.00
27_K	34_I	1.511	1.00
69_T	73_E	1.503	1.00
256_E	260_G	1.484	1.00
51_H	201_M	1.478	1.00
149_F	152_R	1.466	1.00
38_K	48_F	1.464	1.00
35_F	87_L	1.460	1.00
106_L	239_F	1.453	1.00
49_T	74_F	1.421	1.00
104_A	263_K	1.398	0.99
236_L	267_L	1.395	0.99
8_L	11_Y	1.394	0.99
131_Y	135_T	1.381	0.99
181_L	184_L	1.378	0.99
51_H	227_A	1.363	0.99
19_E	27_K	1.362	0.99
140_E	185_E	1.346	0.99
93_F	205_S	1.341	0.99
262_T	266_P	1.340	0.99
224_F	278_Y	1.338	0.99
106_L	221_F	1.338	0.99
179_F	183_R	1.302	0.99
240_Y	275_F	1.268	0.99
27_K	36_A	1.265	0.99
182_E	185_E	1.250	0.99
203_H	210_H	1.247	0.99
38_K	225_E	1.245	0.99
118_A	265_F	1.237	0.99
13_L	87_L	1.235	0.99
148_Q	151_D	1.235	0.99
137_K	140_E	1.222	0.99
39_K	83_D	1.220	0.99
209_H	242_K	1.218	0.99
58_K	119_Q	1.206	0.98
130_R	134_Q	1.195	0.98
10_E	69_T	1.169	0.98
255_V	259_Y	1.158	0.98
104_A	256_E	1.148	0.98
22_S	38_K	1.146	0.98
302_E	306_Q	1.145	0.98
55_I	113_L	1.144	0.98
50_D	122_K	1.131	0.98
184_L	187_W	1.123	0.98
198_R	271_E	1.120	0.98
173_T	180_A	1.114	0.97
233_Q	271_E	1.102	0.97
208_I	242_K	1.097	0.97
133_G	137_K	1.090	0.97
6_S	9_Q	1.083	0.97
60_F	109_E	1.076	0.97
239_F	257_W	1.072	0.97
224_F	227_A	1.066	0.97
48_F	52_M	1.066	0.97
8_L	15_A	1.061	0.97
230_G	234_N	1.060	0.97
146_Y	153_A	1.058	0.97
6_S	10_E	1.044	0.96
106_L	206_L	1.042	0.96
210_H	225_E	1.037	0.96
118_A	198_R	1.037	0.96
111_A	265_F	1.033	0.96
175_S	179_F	1.021	0.96
267_L	272_V	1.016	0.96
107_F	111_A	1.010	0.95
298_Q	306_Q	1.010	0.95
60_F	113_L	1.010	0.95
38_K	223_N	1.008	0.95
207_S	241_T	1.006	0.95
13_L	35_F	1.005	0.95
53_V	65_P	1.000	0.95
25_V	225_E	0.995	0.95
183_R	277_S	0.994	0.95
233_Q	267_L	0.990	0.95
233_Q	275_F	0.988	0.95
198_R	232_P	0.988	0.95
297_R	301_K	0.979	0.95
282_P	285_M	0.973	0.94
136_K	139_W	0.969	0.94
174_I	178_N	0.968	0.94
53_V	74_F	0.957	0.94
299_H	302_E	0.956	0.94
9_Q	70_N	0.954	0.94
25_V	36_A	0.951	0.94
110_T	235_D	0.951	0.94
113_L	227_A	0.948	0.94
8_L	14_T	0.944	0.94
238_G	241_T	0.938	0.93
25_V	223_N	0.937	0.93
214_N	218_T	0.936	0.93
94_D	102_K	0.930	0.93
11_Y	76_S	0.930	0.93
78_G	85_Y	0.929	0.93
111_A	262_T	0.920	0.93
228_S	234_N	0.920	0.93
106_L	211_F	0.917	0.93
50_D	120_E	0.917	0.93
7_V	78_G	0.916	0.92
183_R	273_S	0.914	0.92
236_L	275_F	0.910	0.92
146_Y	150_V	0.906	0.92
69_T	75_F	0.900	0.92
232_P	271_E	0.896	0.92
108_R	264_S	0.891	0.91
241_T	286_Y	0.890	0.91
198_R	265_F	0.883	0.91
48_F	224_F	0.877	0.91
92_Q	214_N	0.872	0.91
150_V	153_A	0.868	0.90
112_R	264_S	0.861	0.90
10_E	76_S	0.859	0.90
49_T	200_V	0.858	0.90
240_Y	254_C	0.848	0.89
37_L	85_Y	0.839	0.89
213_Y	219_G	0.835	0.89
25_V	38_K	0.832	0.88
178_N	181_L	0.830	0.88
207_S	242_K	0.829	0.88
52_M	224_F	0.828	0.88
93_F	210_H	0.817	0.87
60_F	63_F	0.809	0.87
73_E	108_R	0.806	0.87
226_R	282_P	0.802	0.86
177_V	181_L	0.801	0.86
74_F	275_F	0.801	0.86
179_F	184_L	0.797	0.86
34_I	87_L	0.797	0.86
40_L	48_F	0.796	0.86
54_A	116_R	0.794	0.86
142_D	145_F	0.791	0.86
7_V	76_S	0.790	0.86
40_L	86_Y	0.787	0.85
134_Q	138_K	0.786	0.85
131_Y	134_Q	0.786	0.85
40_L	45_G	0.785	0.85
267_L	276_L	0.782	0.85
130_R	137_K	0.781	0.85
260_G	264_S	0.779	0.85
204_G	234_N	0.772	0.84
104_A	108_R	0.767	0.84
52_M	88_M	0.767	0.84
48_F	226_R	0.764	0.84
238_G	282_P	0.764	0.84
41_K	83_D	0.762	0.84
93_F	223_N	0.761	0.83
230_G	233_Q	0.759	0.83
105_Y	108_R	0.756	0.83
117_T	200_V	0.753	0.83
299_H	306_Q	0.753	0.83
244_F	249_K	0.753	0.83
207_S	225_E	0.752	0.83
151_D	154_E	0.751	0.83
177_V	184_L	0.750	0.83
18_I	28_V	0.746	0.82
48_F	51_H	0.745	0.82
237_L	278_Y	0.743	0.82
268_R	271_E	0.743	0.82
8_L	37_L	0.742	0.82
52_M	66_V	0.738	0.82
132_Y	135_T	0.738	0.82
26_W	225_E	0.736	0.81
81_Y	85_Y	0.734	0.81
301_K	305_T	0.731	0.81
108_R	112_R	0.730	0.81
287_K	290_N	0.730	0.81
64_V	91_L	0.730	0.81
38_K	207_S	0.729	0.81
301_K	304_C	0.725	0.80
91_L	212_L	0.724	0.80
144_I	147_E	0.724	0.80
45_G	227_A	0.722	0.80
111_A	228_S	0.721	0.80
93_F	212_L	0.721	0.80
64_V	222_T	0.720	0.80
207_S	238_G	0.719	0.80
297_R	302_E	0.717	0.80
136_K	185_E	0.717	0.80
151_D	175_S	0.716	0.80
101_Q	216_A	0.714	0.79
139_W	142_D	0.712	0.79
105_Y	218_T	0.712	0.79
139_W	234_N	0.707	0.79
180_A	187_W	0.705	0.79
75_F	84_I	0.704	0.78
41_K	207_S	0.704	0.78
180_A	185_E	0.704	0.78
15_A	33_G	0.699	0.78
108_R	260_G	0.695	0.78
300_E	303_E	0.693	0.77
58_K	67_Y	0.692	0.77
242_K	245_R	0.687	0.77
38_K	241_T	0.685	0.77
8_L	28_V	0.685	0.77
96_E	106_L	0.683	0.76
115_E	119_Q	0.682	0.76
225_E	238_G	0.682	0.76
299_H	303_E	0.680	0.76
9_Q	72_G	0.679	0.76
55_I	59_G	0.679	0.76
211_F	222_T	0.672	0.75
7_V	275_F	0.670	0.75
234_N	238_G	0.668	0.75
64_V	223_N	0.666	0.75
203_H	223_N	0.664	0.74
207_S	213_Y	0.661	0.74
284_A	287_K	0.659	0.74
91_L	223_N	0.658	0.74
38_K	86_Y	0.656	0.73
296_K	305_T	0.655	0.73
36_A	88_M	0.652	0.73
236_L	240_Y	0.651	0.73
196_V	270_A	0.649	0.73
232_P	265_F	0.648	0.73
297_R	300_E	0.647	0.72
199_V	229_V	0.644	0.72
300_E	305_T	0.643	0.72
66_V	88_M	0.643	0.72
50_D	123_V	0.640	0.72
90_W	279_M	0.631	0.71
204_G	225_E	0.630	0.70
64_V	89_P	0.630	0.70
11_Y	35_F	0.630	0.70
92_Q	121_L	0.629	0.70
108_R	269_E	0.629	0.70
110_T	204_G	0.627	0.70
301_K	306_Q	0.626	0.70
236_L	258_F	0.625	0.70
252_P	256_E	0.623	0.70
294_T	297_R	0.622	0.69
204_G	228_S	0.621	0.69
269_E	273_S	0.621	0.69
118_A	232_P	0.620	0.69
106_L	110_T	0.620	0.69
282_P	287_K	0.619	0.69
11_Y	66_V	0.619	0.69
241_T	283_A	0.618	0.69
233_Q	278_Y	0.616	0.69
14_T	101_Q	0.616	0.69
68_R	72_G	0.615	0.69
70_N	182_E	0.614	0.68
77_A	84_I	0.612	0.68
6_S	14_T	0.612	0.68
170_F	174_I	0.609	0.68
242_K	282_P	0.608	0.68
238_G	278_Y	0.608	0.68
58_K	125_R	0.607	0.68
48_F	225_E	0.605	0.67
267_L	275_F	0.603	0.67
135_T	238_G	0.601	0.67
213_Y	244_F	0.599	0.67
77_A	82_G	0.598	0.66
234_N	282_P	0.597	0.66
104_A	107_F	0.593	0.66
288_V	303_E	0.593	0.66
118_A	273_S	0.591	0.66
146_Y	152_R	0.589	0.65
138_K	201_M	0.587	0.65
66_V	230_G	0.585	0.65
274_L	277_S	0.584	0.65
45_G	86_Y	0.584	0.65
38_K	242_K	0.584	0.65
105_Y	116_R	0.579	0.64
209_H	213_Y	0.578	0.64
38_K	224_F	0.578	0.64
47_H	51_H	0.577	0.64
55_I	60_F	0.577	0.64
252_P	262_T	0.577	0.64
13_L	19_E	0.576	0.64
205_S	222_T	0.575	0.63
11_Y	69_T	0.574	0.63
15_A	20_P	0.574	0.63
133_G	136_K	0.574	0.63
89_P	120_E	0.574	0.63
141_Q	145_F	0.572	0.63
110_T	287_K	0.572	0.63
50_D	121_L	0.571	0.63
116_R	120_E	0.570	0.63
103_H	257_W	0.569	0.63
240_Y	258_F	0.566	0.62
212_L	219_G	0.566	0.62
38_K	41_K	0.566	0.62
111_A	266_P	0.566	0.62
22_S	25_V	0.565	0.62
202_N	240_Y	0.563	0.62
35_F	119_Q	0.563	0.62
59_G	113_L	0.563	0.62
91_L	145_F	0.561	0.62
202_N	211_F	0.559	0.61
103_H	236_L	0.559	0.61
55_I	200_V	0.558	0.61
21_V	27_K	0.558	0.61
139_W	181_L	0.557	0.61
63_F	224_F	0.557	0.61
139_W	173_T	0.557	0.61
241_T	282_P	0.557	0.61
206_L	238_G	0.556	0.61
300_E	304_C	0.554	0.61
11_Y	176_A	0.553	0.60
186_D	252_P	0.553	0.60
142_D	146_Y	0.552	0.60
132_Y	138_K	0.545	0.59
101_Q	104_A	0.544	0.59
112_R	115_E	0.544	0.59
11_Y	218_T	0.544	0.59
200_V	237_L	0.542	0.59
249_K	281_Y	0.540	0.59
238_G	281_Y	0.539	0.58
96_E	209_H	0.537	0.58
226_R	238_G	0.537	0.58
9_Q	57_E	0.536	0.58
26_W	220_Y	0.536	0.58
23_P	41_K	0.536	0.58
298_Q	303_E	0.535	0.58
25_V	207_S	0.535	0.58
36_A	64_V	0.534	0.58
38_K	209_H	0.532	0.57
204_G	230_G	0.529	0.57
116_R	264_S	0.529	0.57
153_A	156_E	0.528	0.57
9_Q	16_Q	0.528	0.57
51_H	230_G	0.527	0.57
114_H	117_T	0.527	0.57
207_S	222_T	0.525	0.57
42_E	84_I	0.525	0.57
39_K	110_T	0.522	0.56
107_F	223_N	0.522	0.56
23_P	207_S	0.521	0.56
22_S	205_S	0.521	0.56
16_Q	71_S	0.520	0.56
204_G	257_W	0.520	0.56
37_L	45_G	0.519	0.56
210_H	224_F	0.516	0.55
224_F	238_G	0.515	0.55
236_L	239_F	0.514	0.55
234_N	278_Y	0.514	0.55
303_E	306_Q	0.512	0.55
130_R	133_G	0.512	0.55
204_G	226_R	0.511	0.55
138_K	143_K	0.507	0.54
298_Q	301_K	0.506	0.54
149_F	221_F	0.505	0.54
81_Y	212_L	0.505	0.54
100_D	279_M	0.505	0.54
236_L	261_Y	0.504	0.54
134_Q	139_W	0.504	0.54
199_V	231_P	0.503	0.53
9_Q	183_R	0.501	0.53
72_G	260_G	0.501	0.53
11_Y	236_L	0.501	0.53
183_R	268_R	0.500	0.53
219_G	225_E	0.500	0.53

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pdyA	1	0.9355	100	0.29	Contact Map
2q83A	1	0.9296	100	0.337	Contact Map
2ppqA	2	0.8534	100	0.482	Contact Map
4ocvA	1	0.9091	100	0.496	Contact Map
3i1aA	1	0.915	100	0.537	Contact Map
1zylA	1	0.8768	100	0.555	Contact Map
3jr1A	1	0.7947	99.9	0.621	Contact Map
3atsA	1	0.8475	99.9	0.626	Contact Map
3csvA	2	0.8651	99.9	0.635	Contact Map
4dcaA	1	0.7977	99.9	0.637	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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