GREMLIN Database
YSXE - Uncharacterized protein YsxE
UniProt: P37964 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 341 (276)
Sequences: 1976 (1636)
Seq/√Len: 98.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_T76_S5.8411.00
111_A264_S4.9531.00
262_T272_V3.7971.00
37_L87_L3.3531.00
107_F260_G3.2701.00
108_R263_K3.2531.00
12_G70_N3.1071.00
36_A90_W3.0511.00
27_K90_W3.0271.00
236_L257_W2.9081.00
110_T206_L2.8821.00
54_A120_E2.8331.00
68_R74_F2.6561.00
104_A260_G2.6131.00
180_A184_L2.4331.00
30_T33_G2.4121.00
65_P89_P2.4071.00
23_P26_W2.3611.00
29_Y34_I2.2971.00
212_L222_T2.2291.00
205_S223_N2.2091.00
109_E221_F2.1591.00
210_H223_N2.1501.00
175_S178_N2.1431.00
202_N230_G2.0511.00
28_V87_L2.0181.00
113_L224_F2.0181.00
56_E65_P2.0021.00
173_T176_A1.9731.00
179_F182_E1.9591.00
17_F29_Y1.9341.00
200_V232_P1.9191.00
42_E77_A1.9151.00
16_Q31_D1.8251.00
182_E186_D1.8131.00
115_E265_F1.8071.00
206_L221_F1.8051.00
54_A119_Q1.7641.00
104_A259_Y1.7351.00
114_H261_Y1.7261.00
115_E264_S1.7241.00
107_F257_W1.6911.00
110_T114_H1.6791.00
260_G263_K1.6731.00
146_Y149_F1.6721.00
177_V180_A1.6711.00
35_F89_P1.6331.00
91_L220_Y1.6261.00
205_S210_H1.6221.00
237_L279_M1.6091.00
51_H117_T1.6031.00
96_E211_F1.5861.00
14_T31_D1.5831.00
134_Q137_K1.5771.00
176_A180_A1.5751.00
53_V68_R1.5671.00
39_K85_Y1.5471.00
180_A183_R1.5441.00
114_H235_D1.5351.00
169_Y285_M1.5331.00
22_S209_H1.5221.00
49_T86_Y1.5181.00
178_N182_E1.5181.00
176_A179_F1.5111.00
27_K34_I1.5111.00
69_T73_E1.5031.00
256_E260_G1.4841.00
51_H201_M1.4781.00
149_F152_R1.4661.00
38_K48_F1.4641.00
35_F87_L1.4601.00
106_L239_F1.4531.00
49_T74_F1.4211.00
104_A263_K1.3980.99
236_L267_L1.3950.99
8_L11_Y1.3940.99
131_Y135_T1.3810.99
181_L184_L1.3780.99
51_H227_A1.3630.99
19_E27_K1.3620.99
140_E185_E1.3460.99
93_F205_S1.3410.99
262_T266_P1.3400.99
224_F278_Y1.3380.99
106_L221_F1.3380.99
179_F183_R1.3020.99
240_Y275_F1.2680.99
27_K36_A1.2650.99
182_E185_E1.2500.99
203_H210_H1.2470.99
38_K225_E1.2450.99
118_A265_F1.2370.99
13_L87_L1.2350.99
148_Q151_D1.2350.99
137_K140_E1.2220.99
39_K83_D1.2200.99
209_H242_K1.2180.99
58_K119_Q1.2060.98
130_R134_Q1.1950.98
10_E69_T1.1690.98
255_V259_Y1.1580.98
104_A256_E1.1480.98
22_S38_K1.1460.98
302_E306_Q1.1450.98
55_I113_L1.1440.98
50_D122_K1.1310.98
184_L187_W1.1230.98
198_R271_E1.1200.98
173_T180_A1.1140.97
233_Q271_E1.1020.97
208_I242_K1.0970.97
133_G137_K1.0900.97
6_S9_Q1.0830.97
60_F109_E1.0760.97
239_F257_W1.0720.97
224_F227_A1.0660.97
48_F52_M1.0660.97
8_L15_A1.0610.97
230_G234_N1.0600.97
146_Y153_A1.0580.97
6_S10_E1.0440.96
106_L206_L1.0420.96
210_H225_E1.0370.96
118_A198_R1.0370.96
111_A265_F1.0330.96
175_S179_F1.0210.96
267_L272_V1.0160.96
107_F111_A1.0100.95
298_Q306_Q1.0100.95
60_F113_L1.0100.95
38_K223_N1.0080.95
207_S241_T1.0060.95
13_L35_F1.0050.95
53_V65_P1.0000.95
25_V225_E0.9950.95
183_R277_S0.9940.95
233_Q267_L0.9900.95
233_Q275_F0.9880.95
198_R232_P0.9880.95
297_R301_K0.9790.95
282_P285_M0.9730.94
136_K139_W0.9690.94
174_I178_N0.9680.94
53_V74_F0.9570.94
299_H302_E0.9560.94
9_Q70_N0.9540.94
25_V36_A0.9510.94
110_T235_D0.9510.94
113_L227_A0.9480.94
8_L14_T0.9440.94
238_G241_T0.9380.93
25_V223_N0.9370.93
214_N218_T0.9360.93
94_D102_K0.9300.93
11_Y76_S0.9300.93
78_G85_Y0.9290.93
111_A262_T0.9200.93
228_S234_N0.9200.93
106_L211_F0.9170.93
50_D120_E0.9170.93
7_V78_G0.9160.92
183_R273_S0.9140.92
236_L275_F0.9100.92
146_Y150_V0.9060.92
69_T75_F0.9000.92
232_P271_E0.8960.92
108_R264_S0.8910.91
241_T286_Y0.8900.91
198_R265_F0.8830.91
48_F224_F0.8770.91
92_Q214_N0.8720.91
150_V153_A0.8680.90
112_R264_S0.8610.90
10_E76_S0.8590.90
49_T200_V0.8580.90
240_Y254_C0.8480.89
37_L85_Y0.8390.89
213_Y219_G0.8350.89
25_V38_K0.8320.88
178_N181_L0.8300.88
207_S242_K0.8290.88
52_M224_F0.8280.88
93_F210_H0.8170.87
60_F63_F0.8090.87
73_E108_R0.8060.87
226_R282_P0.8020.86
177_V181_L0.8010.86
74_F275_F0.8010.86
179_F184_L0.7970.86
34_I87_L0.7970.86
40_L48_F0.7960.86
54_A116_R0.7940.86
142_D145_F0.7910.86
7_V76_S0.7900.86
40_L86_Y0.7870.85
134_Q138_K0.7860.85
131_Y134_Q0.7860.85
40_L45_G0.7850.85
267_L276_L0.7820.85
130_R137_K0.7810.85
260_G264_S0.7790.85
204_G234_N0.7720.84
104_A108_R0.7670.84
52_M88_M0.7670.84
48_F226_R0.7640.84
238_G282_P0.7640.84
41_K83_D0.7620.84
93_F223_N0.7610.83
230_G233_Q0.7590.83
105_Y108_R0.7560.83
117_T200_V0.7530.83
299_H306_Q0.7530.83
244_F249_K0.7530.83
207_S225_E0.7520.83
151_D154_E0.7510.83
177_V184_L0.7500.83
18_I28_V0.7460.82
48_F51_H0.7450.82
237_L278_Y0.7430.82
268_R271_E0.7430.82
8_L37_L0.7420.82
52_M66_V0.7380.82
132_Y135_T0.7380.82
26_W225_E0.7360.81
81_Y85_Y0.7340.81
301_K305_T0.7310.81
108_R112_R0.7300.81
287_K290_N0.7300.81
64_V91_L0.7300.81
38_K207_S0.7290.81
301_K304_C0.7250.80
91_L212_L0.7240.80
144_I147_E0.7240.80
45_G227_A0.7220.80
111_A228_S0.7210.80
93_F212_L0.7210.80
64_V222_T0.7200.80
207_S238_G0.7190.80
297_R302_E0.7170.80
136_K185_E0.7170.80
151_D175_S0.7160.80
101_Q216_A0.7140.79
139_W142_D0.7120.79
105_Y218_T0.7120.79
139_W234_N0.7070.79
180_A187_W0.7050.79
75_F84_I0.7040.78
41_K207_S0.7040.78
180_A185_E0.7040.78
15_A33_G0.6990.78
108_R260_G0.6950.78
300_E303_E0.6930.77
58_K67_Y0.6920.77
242_K245_R0.6870.77
38_K241_T0.6850.77
8_L28_V0.6850.77
96_E106_L0.6830.76
115_E119_Q0.6820.76
225_E238_G0.6820.76
299_H303_E0.6800.76
9_Q72_G0.6790.76
55_I59_G0.6790.76
211_F222_T0.6720.75
7_V275_F0.6700.75
234_N238_G0.6680.75
64_V223_N0.6660.75
203_H223_N0.6640.74
207_S213_Y0.6610.74
284_A287_K0.6590.74
91_L223_N0.6580.74
38_K86_Y0.6560.73
296_K305_T0.6550.73
36_A88_M0.6520.73
236_L240_Y0.6510.73
196_V270_A0.6490.73
232_P265_F0.6480.73
297_R300_E0.6470.72
199_V229_V0.6440.72
300_E305_T0.6430.72
66_V88_M0.6430.72
50_D123_V0.6400.72
90_W279_M0.6310.71
204_G225_E0.6300.70
64_V89_P0.6300.70
11_Y35_F0.6300.70
92_Q121_L0.6290.70
108_R269_E0.6290.70
110_T204_G0.6270.70
301_K306_Q0.6260.70
236_L258_F0.6250.70
252_P256_E0.6230.70
294_T297_R0.6220.69
204_G228_S0.6210.69
269_E273_S0.6210.69
118_A232_P0.6200.69
106_L110_T0.6200.69
282_P287_K0.6190.69
11_Y66_V0.6190.69
241_T283_A0.6180.69
233_Q278_Y0.6160.69
14_T101_Q0.6160.69
68_R72_G0.6150.69
70_N182_E0.6140.68
77_A84_I0.6120.68
6_S14_T0.6120.68
170_F174_I0.6090.68
242_K282_P0.6080.68
238_G278_Y0.6080.68
58_K125_R0.6070.68
48_F225_E0.6050.67
267_L275_F0.6030.67
135_T238_G0.6010.67
213_Y244_F0.5990.67
77_A82_G0.5980.66
234_N282_P0.5970.66
104_A107_F0.5930.66
288_V303_E0.5930.66
118_A273_S0.5910.66
146_Y152_R0.5890.65
138_K201_M0.5870.65
66_V230_G0.5850.65
274_L277_S0.5840.65
45_G86_Y0.5840.65
38_K242_K0.5840.65
105_Y116_R0.5790.64
209_H213_Y0.5780.64
38_K224_F0.5780.64
47_H51_H0.5770.64
55_I60_F0.5770.64
252_P262_T0.5770.64
13_L19_E0.5760.64
205_S222_T0.5750.63
11_Y69_T0.5740.63
15_A20_P0.5740.63
133_G136_K0.5740.63
89_P120_E0.5740.63
141_Q145_F0.5720.63
110_T287_K0.5720.63
50_D121_L0.5710.63
116_R120_E0.5700.63
103_H257_W0.5690.63
240_Y258_F0.5660.62
212_L219_G0.5660.62
38_K41_K0.5660.62
111_A266_P0.5660.62
22_S25_V0.5650.62
202_N240_Y0.5630.62
35_F119_Q0.5630.62
59_G113_L0.5630.62
91_L145_F0.5610.62
202_N211_F0.5590.61
103_H236_L0.5590.61
55_I200_V0.5580.61
21_V27_K0.5580.61
139_W181_L0.5570.61
63_F224_F0.5570.61
139_W173_T0.5570.61
241_T282_P0.5570.61
206_L238_G0.5560.61
300_E304_C0.5540.61
11_Y176_A0.5530.60
186_D252_P0.5530.60
142_D146_Y0.5520.60
132_Y138_K0.5450.59
101_Q104_A0.5440.59
112_R115_E0.5440.59
11_Y218_T0.5440.59
200_V237_L0.5420.59
249_K281_Y0.5400.59
238_G281_Y0.5390.58
96_E209_H0.5370.58
226_R238_G0.5370.58
9_Q57_E0.5360.58
26_W220_Y0.5360.58
23_P41_K0.5360.58
298_Q303_E0.5350.58
25_V207_S0.5350.58
36_A64_V0.5340.58
38_K209_H0.5320.57
204_G230_G0.5290.57
116_R264_S0.5290.57
153_A156_E0.5280.57
9_Q16_Q0.5280.57
51_H230_G0.5270.57
114_H117_T0.5270.57
207_S222_T0.5250.57
42_E84_I0.5250.57
39_K110_T0.5220.56
107_F223_N0.5220.56
23_P207_S0.5210.56
22_S205_S0.5210.56
16_Q71_S0.5200.56
204_G257_W0.5200.56
37_L45_G0.5190.56
210_H224_F0.5160.55
224_F238_G0.5150.55
236_L239_F0.5140.55
234_N278_Y0.5140.55
303_E306_Q0.5120.55
130_R133_G0.5120.55
204_G226_R0.5110.55
138_K143_K0.5070.54
298_Q301_K0.5060.54
149_F221_F0.5050.54
81_Y212_L0.5050.54
100_D279_M0.5050.54
236_L261_Y0.5040.54
134_Q139_W0.5040.54
199_V231_P0.5030.53
9_Q183_R0.5010.53
72_G260_G0.5010.53
11_Y236_L0.5010.53
183_R268_R0.5000.53
219_G225_E0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pdyA 1 0.9355 100 0.29 Contact Map
2q83A 1 0.9296 100 0.337 Contact Map
2ppqA 2 0.8534 100 0.482 Contact Map
4ocvA 1 0.9091 100 0.496 Contact Map
3i1aA 1 0.915 100 0.537 Contact Map
1zylA 1 0.8768 100 0.555 Contact Map
3jr1A 1 0.7947 99.9 0.621 Contact Map
3atsA 1 0.8475 99.9 0.626 Contact Map
3csvA 2 0.8651 99.9 0.635 Contact Map
4dcaA 1 0.7977 99.9 0.637 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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