GREMLIN Database
MRGA - Metalloregulation DNA-binding stress protein
UniProt: P37960 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 153 (143)
Sequences: 2906 (1679)
Seq/√Len: 140.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_S99_E3.2111.00
14_E73_G2.8411.00
132_D136_G2.6791.00
123_E131_A2.5341.00
30_K107_D2.4941.00
34_F103_A2.3941.00
80_K84_E2.3381.00
44_F48_E2.2301.00
132_D135_V2.1991.00
31_L57_A2.1831.00
23_N87_S2.1811.00
34_F91_G2.0191.00
76_V85_H1.9671.00
119_I135_V1.9491.00
51_E55_D1.8771.00
122_A131_A1.7691.00
131_A135_V1.7481.00
129_A138_I1.7011.00
25_F82_Y1.6871.00
29_S79_V1.6821.00
46_L50_F1.6631.00
109_K149_S1.6021.00
56_H144_Q1.5991.00
34_F100_M1.5651.00
105_V145_V1.5611.00
123_E128_N1.5611.00
16_S118_V1.5321.00
67_R127_D1.5141.00
109_K113_S1.4981.00
18_N76_V1.4871.00
128_N131_A1.4481.00
116_K142_E1.4301.00
49_K52_E1.4271.00
102_Q106_N1.4261.00
24_W64_I1.4181.00
112_S145_V1.4051.00
56_H140_E1.3921.00
91_G103_A1.3841.00
49_K53_L1.3821.00
120_G124_E1.3701.00
112_S142_E1.3601.00
56_H60_T1.3561.00
67_R130_T1.3471.00
145_V149_S1.3401.00
120_G126_Q1.3311.00
12_L15_N1.3281.00
23_N114_E1.3201.00
51_E54_Y1.3121.00
33_R77_A1.3001.00
109_K145_V1.2451.00
60_T137_L1.2431.00
113_S117_F1.2421.00
53_L108_Y1.2341.00
118_V134_F1.2251.00
26_L83_T1.2181.00
24_W57_A1.2051.00
80_K90_D1.1961.00
22_S85_H1.1881.00
63_T133_L1.1871.00
127_D130_T1.1731.00
31_L53_L1.1691.00
99_E102_Q1.1530.99
60_T140_E1.1450.99
98_S102_Q1.1260.99
26_L86_A1.0910.99
119_I131_A1.0890.99
112_S138_I1.0760.99
44_F52_E1.0740.99
116_K138_I1.0690.99
140_E143_K1.0540.99
67_R142_E1.0520.99
13_V125_N1.0440.99
16_S121_L1.0400.99
105_V149_S1.0370.99
32_H61_V1.0370.99
11_T15_N1.0240.99
20_Q118_V1.0190.99
25_F61_V1.0170.99
44_F49_K1.0030.98
91_G100_M1.0010.98
28_Y58_A0.9970.98
101_V148_L0.9970.98
108_Y144_Q0.9930.98
19_T114_E0.9920.98
50_F100_M0.9890.98
87_S114_E0.9740.98
72_G149_S0.9640.98
26_L90_D0.9620.98
122_A130_T0.9520.98
9_N124_E0.9350.98
129_A139_E0.9340.98
128_N135_V0.9310.98
18_N68_L0.9240.97
87_S110_Q0.9140.97
71_I130_T0.8950.97
119_I138_I0.8930.97
58_A61_V0.8920.97
20_Q115_S0.8910.97
13_V122_A0.8870.97
55_D59_E0.8780.96
19_T87_S0.8740.96
30_K90_D0.8720.96
47_H66_E0.8700.96
23_N86_A0.8640.96
105_V109_K0.8540.96
45_T151_Y0.8530.96
106_N109_K0.8490.96
21_L64_I0.8460.96
99_E103_A0.8450.96
26_L79_V0.8440.96
14_E68_L0.8430.96
108_Y141_V0.8220.95
120_G128_N0.8180.95
119_I128_N0.8070.94
44_F151_Y0.8010.94
81_E84_E0.7930.94
16_S117_F0.7750.93
42_H97_A0.7650.93
43_F66_E0.7630.93
59_E63_T0.7610.92
20_Q114_E0.7600.92
112_S116_K0.7550.92
48_E52_E0.7550.92
117_F121_L0.7450.92
140_E144_Q0.7370.91
41_P98_S0.7340.91
37_Y75_P0.7320.91
143_K146_W0.7320.91
112_S141_V0.7310.91
29_S77_A0.7270.91
18_N22_S0.7150.90
81_E85_H0.7120.90
83_T90_D0.7120.90
38_V100_M0.7110.90
115_S137_L0.7060.89
12_L121_L0.7030.89
68_L73_G0.7010.89
21_L24_W0.6980.89
104_L108_Y0.6970.89
23_N110_Q0.6950.89
49_K147_M0.6930.88
136_G139_E0.6910.88
35_H66_E0.6890.88
32_H51_E0.6860.88
101_V151_Y0.6830.88
70_A143_K0.6830.88
122_A126_Q0.6820.88
122_A134_F0.6810.88
98_S101_V0.6800.87
115_S134_F0.6750.87
42_H98_S0.6750.87
89_T106_N0.6740.87
63_T136_G0.6710.87
53_L148_L0.6700.87
117_F120_G0.6680.87
115_S141_V0.6630.86
24_W60_T0.6550.85
32_H54_Y0.6540.85
114_E117_F0.6510.85
12_L124_E0.6500.85
52_E55_D0.6490.85
35_H47_H0.6460.85
50_F101_V0.6430.84
45_T48_E0.6410.84
67_R71_I0.6360.84
29_S82_Y0.6360.84
10_Q13_V0.6290.83
32_H147_M0.6260.83
16_S19_T0.6240.83
51_E58_A0.6210.82
129_A142_E0.6190.82
13_V121_L0.6170.82
16_S122_A0.6110.81
88_I107_D0.6070.81
21_L61_V0.6060.81
76_V81_E0.6050.81
64_I137_L0.5960.80
37_Y77_A0.5960.80
28_Y64_I0.5950.80
15_N19_T0.5870.79
39_K69_L0.5830.78
18_N75_P0.5810.78
42_H151_Y0.5720.77
39_K150_S0.5710.77
127_D142_E0.5670.76
63_T139_E0.5620.76
88_I114_E0.5590.75
30_K88_I0.5590.75
43_F47_H0.5580.75
54_Y147_M0.5550.75
108_Y148_L0.5510.74
79_V83_T0.5510.74
78_T81_E0.5450.73
112_S129_A0.5450.73
138_I142_E0.5440.73
130_T142_E0.5420.73
132_D139_E0.5410.73
28_Y61_V0.5360.72
69_L150_S0.5350.72
20_Q134_F0.5320.72
46_L101_V0.5320.72
89_T110_Q0.5290.71
16_S114_E0.5290.71
20_Q23_N0.5280.71
54_Y65_A0.5210.70
35_H43_F0.5200.70
91_G95_T0.5200.70
80_K92_G0.5190.70
119_I122_A0.5180.70
81_E93_N0.5170.69
129_A135_V0.5130.69
27_L31_L0.5090.68
105_V148_L0.5040.68
103_A107_D0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zs3A 6 0.9804 100 0.221 Contact Map
1zujA 6 0.9804 100 0.224 Contact Map
2c2jA 6 0.9542 100 0.295 Contact Map
2c2uA 6 1 100 0.305 Contact Map
2cf7A 6 0.9935 100 0.305 Contact Map
3ak8A 6 0.9804 100 0.305 Contact Map
2xgwA 6 0.9608 100 0.309 Contact Map
4m32A 6 0.9869 100 0.313 Contact Map
2pybA 6 0.9542 100 0.314 Contact Map
2yw6A 6 0.9542 100 0.317 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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