MECA1 - BACSU - GREMLIN Contacts

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MECA1 - Adapter protein MecA 1

UniProt:	P37958	Sequences: MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEVMDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASEDLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENRYYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	218 (204)
Sequences:	797 (636)
Seq/√Len:	44.5

BACSU - MECA1 MECA2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
139_V	212_I	4.509	1.00
204_I	211_T	4.056	1.00
157_F	195_R	3.956	1.00
207_H	210_E	3.818	1.00
136_F	212_I	3.192	1.00
139_V	154_L	3.081	1.00
204_I	212_I	2.900	1.00
171_T	174_E	2.862	1.00
202_L	205_S	2.582	1.00
196_L	200_G	2.434	1.00
132_R	160_R	2.417	1.00
152_T	208_A	2.393	1.00
135_D	138_D	2.295	1.00
54_F	77_K	2.247	1.00
152_T	165_V	2.242	1.00
10_T	38_E	2.230	1.00
104_L	107_L	2.211	1.00
73_I	143_S	2.054	0.99
100_A	103_D	2.009	0.99
136_F	140_I	1.997	0.99
100_A	104_L	1.973	0.99
23_R	41_F	1.972	0.99
45_M	59_P	1.890	0.99
63_Q	72_E	1.872	0.99
54_F	59_P	1.871	0.99
38_E	62_I	1.833	0.99
40_L	43_E	1.824	0.99
172_D	176_E	1.822	0.99
131_L	186_A	1.803	0.98
140_I	144_K	1.796	0.98
10_T	63_Q	1.743	0.98
32_Y	40_L	1.734	0.98
5_R	64_V	1.734	0.98
161_Y	203_I	1.701	0.98
156_S	203_I	1.682	0.98
101_S	105_D	1.669	0.97
4_E	19_D	1.612	0.97
13_F	75_V	1.583	0.96
153_T	202_L	1.574	0.96
60_L	76_T	1.532	0.96
131_L	182_L	1.525	0.96
49_H	55_A	1.517	0.95
7_N	10_T	1.440	0.94
59_P	78_A	1.429	0.94
105_D	109_D	1.422	0.94
32_Y	44_V	1.381	0.93
19_D	75_V	1.367	0.92
134_G	158_E	1.332	0.91
130_V	196_L	1.321	0.91
155_Y	197_E	1.301	0.90
137_E	141_S	1.297	0.90
6_I	9_H	1.296	0.90
129_F	179_L	1.294	0.90
29_E	64_V	1.284	0.90
100_A	114_E	1.274	0.89
25_F	65_Q	1.267	0.89
140_I	143_S	1.267	0.89
45_M	60_L	1.267	0.89
207_H	211_T	1.252	0.88
142_L	182_L	1.244	0.88
20_I	66_A	1.234	0.88
10_T	40_L	1.225	0.87
137_E	200_G	1.215	0.87
14_Y	37_S	1.213	0.87
34_R	64_V	1.206	0.86
36_R	61_W	1.203	0.86
88_E	91_I	1.189	0.86
181_I	185_Y	1.184	0.85
5_R	52_E	1.183	0.85
40_L	44_V	1.181	0.85
24_G	47_E	1.171	0.85
103_D	107_L	1.165	0.84
20_I	25_F	1.152	0.84
136_F	204_I	1.152	0.84
118_V	159_N	1.150	0.84
108_L	114_E	1.127	0.82
85_Q	91_I	1.109	0.81
158_E	195_R	1.099	0.81
3_I	23_R	1.090	0.80
41_F	54_F	1.086	0.80
34_R	38_E	1.075	0.79
11_V	56_V	1.074	0.79
138_D	141_S	1.073	0.79
3_I	60_L	1.061	0.78
132_R	187_T	1.046	0.77
136_F	201_K	1.040	0.77
19_D	58_G	1.038	0.77
19_D	23_R	1.022	0.76
102_E	115_E	1.018	0.75
3_I	61_W	1.010	0.75
24_G	28_E	1.007	0.74
211_T	214_K	1.004	0.74
142_L	145_L	0.999	0.74
46_D	57_E	0.982	0.73
105_D	114_E	0.979	0.72
25_F	63_Q	0.977	0.72
59_P	62_I	0.975	0.72
10_T	61_W	0.973	0.72
54_F	62_I	0.969	0.72
63_Q	66_A	0.965	0.71
19_D	44_V	0.965	0.71
101_S	106_A	0.964	0.71
33_N	60_L	0.963	0.71
156_S	201_K	0.957	0.71
192_S	196_L	0.955	0.70
20_I	73_I	0.954	0.70
65_Q	73_I	0.950	0.70
134_G	160_R	0.943	0.70
131_L	183_L	0.939	0.69
41_F	77_K	0.939	0.69
95_K	120_Q	0.938	0.69
187_T	197_E	0.935	0.69
157_F	200_G	0.935	0.69
54_F	75_V	0.930	0.68
31_W	44_V	0.929	0.68
64_V	78_A	0.928	0.68
195_R	199_Y	0.921	0.68
118_V	121_E	0.920	0.68
103_D	115_E	0.916	0.67
138_D	172_D	0.912	0.67
104_L	115_E	0.906	0.66
10_T	72_E	0.899	0.66
33_N	38_E	0.899	0.66
37_S	61_W	0.897	0.66
41_F	192_S	0.892	0.65
159_N	206_E	0.888	0.65
45_M	62_I	0.888	0.65
32_Y	60_L	0.887	0.65
10_T	65_Q	0.887	0.65
3_I	52_E	0.883	0.64
101_S	151_K	0.879	0.64
133_F	142_L	0.874	0.64
19_D	66_A	0.873	0.63
152_T	209_L	0.873	0.63
209_L	214_K	0.868	0.63
102_E	121_E	0.868	0.63
104_L	108_L	0.867	0.63
122_E	134_G	0.866	0.63
140_I	212_I	0.863	0.63
123_K	126_K	0.859	0.62
128_Q	185_Y	0.856	0.62
47_E	64_V	0.851	0.61
7_N	76_T	0.849	0.61
3_I	41_F	0.846	0.61
23_R	30_I	0.843	0.61
20_I	23_R	0.843	0.61
20_I	208_A	0.841	0.61
131_L	141_S	0.841	0.61
124_E	134_G	0.836	0.60
23_R	54_F	0.835	0.60
115_E	118_V	0.828	0.59
54_F	66_A	0.827	0.59
13_F	17_Y	0.823	0.59
8_E	164_Y	0.819	0.59
19_D	60_L	0.814	0.58
25_F	35_E	0.810	0.58
38_E	54_F	0.810	0.58
29_E	76_T	0.803	0.57
57_E	161_Y	0.799	0.57
151_K	206_E	0.794	0.56
102_E	123_K	0.792	0.56
106_A	109_D	0.791	0.56
59_P	64_V	0.791	0.56
16_S	44_V	0.789	0.56
85_Q	88_E	0.788	0.56
202_L	206_E	0.788	0.56
25_F	57_E	0.787	0.55
134_G	170_M	0.787	0.55
165_V	182_L	0.786	0.55
187_T	201_K	0.784	0.55
2_E	48_V	0.782	0.55
60_L	65_Q	0.777	0.55
38_E	78_A	0.776	0.54
47_E	72_E	0.775	0.54
162_Y	177_N	0.769	0.54
2_E	71_L	0.764	0.53
36_R	185_Y	0.761	0.53
23_R	77_K	0.760	0.53
95_K	101_S	0.757	0.53
27_R	31_W	0.750	0.52
12_K	78_A	0.749	0.52
3_I	66_A	0.748	0.52
13_F	70_G	0.747	0.52
23_R	59_P	0.746	0.52
5_R	53_E	0.744	0.51
100_A	108_L	0.744	0.51
61_W	66_A	0.737	0.51
101_S	114_E	0.737	0.51
105_D	108_L	0.731	0.50
37_S	70_G	0.725	0.50
45_M	58_G	0.720	0.49
119_N	125_Q	0.717	0.49
102_E	108_L	0.714	0.48
36_R	59_P	0.714	0.48
10_T	62_I	0.712	0.48
159_N	191_I	0.708	0.48
61_W	72_E	0.706	0.48
191_I	207_H	0.700	0.47
23_R	43_E	0.695	0.47
19_D	41_F	0.694	0.47
37_S	66_A	0.692	0.46
8_E	179_L	0.692	0.46
5_R	24_G	0.691	0.46
34_R	63_Q	0.691	0.46
119_N	126_K	0.687	0.46
38_E	63_Q	0.681	0.45
13_F	30_I	0.679	0.45
62_I	67_L	0.678	0.45
154_L	204_I	0.673	0.44
168_C	211_T	0.669	0.44
9_H	137_E	0.661	0.43
62_I	72_E	0.659	0.43
82_K	89_L	0.657	0.43
106_A	114_E	0.653	0.43
23_R	72_E	0.650	0.42
51_E	182_L	0.647	0.42
101_S	107_L	0.645	0.42
160_R	191_I	0.642	0.42
119_N	124_E	0.640	0.41
59_P	77_K	0.639	0.41
13_F	62_I	0.638	0.41
38_E	61_W	0.636	0.41
64_V	69_K	0.635	0.41
2_E	14_Y	0.634	0.41
2_E	6_I	0.632	0.41
47_E	52_E	0.631	0.41
55_A	178_Q	0.631	0.41
7_N	19_D	0.626	0.40
29_E	68_D	0.626	0.40
74_I	208_A	0.625	0.40
145_L	150_S	0.620	0.40
58_G	75_V	0.615	0.39
37_S	42_W	0.612	0.39
5_R	28_E	0.610	0.39
193_I	197_E	0.602	0.38
68_D	137_E	0.602	0.38
3_I	77_K	0.598	0.37
147_V	202_L	0.597	0.37
57_E	62_I	0.597	0.37
51_E	166_D	0.593	0.37
103_D	203_I	0.592	0.37
56_V	185_Y	0.592	0.37
103_D	106_A	0.592	0.37
7_N	75_V	0.591	0.37
139_V	146_N	0.589	0.37
27_R	199_Y	0.588	0.37
13_F	48_V	0.586	0.36
165_V	213_K	0.585	0.36
14_Y	17_Y	0.584	0.36
34_R	61_W	0.582	0.36
30_I	54_F	0.580	0.36
114_E	132_R	0.579	0.36
115_E	157_F	0.579	0.36
197_E	202_L	0.577	0.36
28_E	31_W	0.574	0.35
20_I	54_F	0.574	0.35
145_L	181_I	0.574	0.35
4_E	60_L	0.572	0.35
73_I	76_T	0.571	0.35
75_V	166_D	0.569	0.35
19_D	76_T	0.569	0.35
59_P	75_V	0.567	0.35
196_L	209_L	0.565	0.35
209_L	213_K	0.564	0.34
25_F	34_R	0.561	0.34
54_F	60_L	0.560	0.34
25_F	68_D	0.556	0.34
177_N	181_I	0.552	0.33
102_E	213_K	0.551	0.33
95_K	119_N	0.551	0.33
156_S	199_Y	0.550	0.33
115_E	185_Y	0.550	0.33
106_A	160_R	0.547	0.33
17_Y	69_K	0.546	0.33
62_I	66_A	0.546	0.33
22_D	56_V	0.544	0.33
31_W	45_M	0.543	0.33
3_I	42_W	0.541	0.32
153_T	197_E	0.540	0.32
142_L	209_L	0.540	0.32
46_D	60_L	0.539	0.32
11_V	15_M	0.538	0.32
126_K	197_E	0.536	0.32
52_E	57_E	0.535	0.32
31_W	61_W	0.534	0.32
136_F	156_S	0.532	0.32
9_H	78_A	0.531	0.32
3_I	65_Q	0.529	0.31
13_F	66_A	0.523	0.31
4_E	41_F	0.523	0.31
36_R	79_Q	0.522	0.31
115_E	120_Q	0.522	0.31
45_M	73_I	0.522	0.31
6_I	16_S	0.522	0.31
42_W	62_I	0.519	0.31
21_E	165_V	0.518	0.31
34_R	59_P	0.513	0.30
54_F	64_V	0.512	0.30
70_G	137_E	0.512	0.30
102_E	171_T	0.511	0.30
34_R	62_I	0.510	0.30
32_Y	61_W	0.507	0.30
2_E	7_N	0.504	0.29
133_F	186_A	0.503	0.29
10_T	15_M	0.502	0.29
168_C	207_H	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3j3t1	1	0.4312	100	0.088	Contact Map
3pxia	1	0.4312	99.9	0.587	Contact Map
3jtpA	3	0.4266	99.9	0.588	Contact Map
3jtnA	1	0.4037	99.9	0.614	Contact Map
2d1pC	2	0.2431	13.1	0.953	Contact Map
2d1pB	1	0.2477	12.7	0.953	Contact Map
2lnaA	1	0.3028	12.4	0.953	Contact Map
1jx7A	5	0.2477	6.6	0.959	Contact Map
1pehA	1	0.1514	6.2	0.959	Contact Map
2hy5B	1	0.2477	5.6	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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