GREMLIN Database
MECA1 - Adapter protein MecA 1
UniProt: P37958 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (204)
Sequences: 797 (636)
Seq/√Len: 44.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_V212_I4.5091.00
204_I211_T4.0561.00
157_F195_R3.9561.00
207_H210_E3.8181.00
136_F212_I3.1921.00
139_V154_L3.0811.00
204_I212_I2.9001.00
171_T174_E2.8621.00
202_L205_S2.5821.00
196_L200_G2.4341.00
132_R160_R2.4171.00
152_T208_A2.3931.00
135_D138_D2.2951.00
54_F77_K2.2471.00
152_T165_V2.2421.00
10_T38_E2.2301.00
104_L107_L2.2111.00
73_I143_S2.0540.99
100_A103_D2.0090.99
136_F140_I1.9970.99
100_A104_L1.9730.99
23_R41_F1.9720.99
45_M59_P1.8900.99
63_Q72_E1.8720.99
54_F59_P1.8710.99
38_E62_I1.8330.99
40_L43_E1.8240.99
172_D176_E1.8220.99
131_L186_A1.8030.98
140_I144_K1.7960.98
10_T63_Q1.7430.98
32_Y40_L1.7340.98
5_R64_V1.7340.98
161_Y203_I1.7010.98
156_S203_I1.6820.98
101_S105_D1.6690.97
4_E19_D1.6120.97
13_F75_V1.5830.96
153_T202_L1.5740.96
60_L76_T1.5320.96
131_L182_L1.5250.96
49_H55_A1.5170.95
7_N10_T1.4400.94
59_P78_A1.4290.94
105_D109_D1.4220.94
32_Y44_V1.3810.93
19_D75_V1.3670.92
134_G158_E1.3320.91
130_V196_L1.3210.91
155_Y197_E1.3010.90
137_E141_S1.2970.90
6_I9_H1.2960.90
129_F179_L1.2940.90
29_E64_V1.2840.90
100_A114_E1.2740.89
25_F65_Q1.2670.89
140_I143_S1.2670.89
45_M60_L1.2670.89
207_H211_T1.2520.88
142_L182_L1.2440.88
20_I66_A1.2340.88
10_T40_L1.2250.87
137_E200_G1.2150.87
14_Y37_S1.2130.87
34_R64_V1.2060.86
36_R61_W1.2030.86
88_E91_I1.1890.86
181_I185_Y1.1840.85
5_R52_E1.1830.85
40_L44_V1.1810.85
24_G47_E1.1710.85
103_D107_L1.1650.84
20_I25_F1.1520.84
136_F204_I1.1520.84
118_V159_N1.1500.84
108_L114_E1.1270.82
85_Q91_I1.1090.81
158_E195_R1.0990.81
3_I23_R1.0900.80
41_F54_F1.0860.80
34_R38_E1.0750.79
11_V56_V1.0740.79
138_D141_S1.0730.79
3_I60_L1.0610.78
132_R187_T1.0460.77
136_F201_K1.0400.77
19_D58_G1.0380.77
19_D23_R1.0220.76
102_E115_E1.0180.75
3_I61_W1.0100.75
24_G28_E1.0070.74
211_T214_K1.0040.74
142_L145_L0.9990.74
46_D57_E0.9820.73
105_D114_E0.9790.72
25_F63_Q0.9770.72
59_P62_I0.9750.72
10_T61_W0.9730.72
54_F62_I0.9690.72
63_Q66_A0.9650.71
19_D44_V0.9650.71
101_S106_A0.9640.71
33_N60_L0.9630.71
156_S201_K0.9570.71
192_S196_L0.9550.70
20_I73_I0.9540.70
65_Q73_I0.9500.70
134_G160_R0.9430.70
131_L183_L0.9390.69
41_F77_K0.9390.69
95_K120_Q0.9380.69
187_T197_E0.9350.69
157_F200_G0.9350.69
54_F75_V0.9300.68
31_W44_V0.9290.68
64_V78_A0.9280.68
195_R199_Y0.9210.68
118_V121_E0.9200.68
103_D115_E0.9160.67
138_D172_D0.9120.67
104_L115_E0.9060.66
10_T72_E0.8990.66
33_N38_E0.8990.66
37_S61_W0.8970.66
41_F192_S0.8920.65
159_N206_E0.8880.65
45_M62_I0.8880.65
32_Y60_L0.8870.65
10_T65_Q0.8870.65
3_I52_E0.8830.64
101_S151_K0.8790.64
133_F142_L0.8740.64
19_D66_A0.8730.63
152_T209_L0.8730.63
209_L214_K0.8680.63
102_E121_E0.8680.63
104_L108_L0.8670.63
122_E134_G0.8660.63
140_I212_I0.8630.63
123_K126_K0.8590.62
128_Q185_Y0.8560.62
47_E64_V0.8510.61
7_N76_T0.8490.61
3_I41_F0.8460.61
23_R30_I0.8430.61
20_I23_R0.8430.61
20_I208_A0.8410.61
131_L141_S0.8410.61
124_E134_G0.8360.60
23_R54_F0.8350.60
115_E118_V0.8280.59
54_F66_A0.8270.59
13_F17_Y0.8230.59
8_E164_Y0.8190.59
19_D60_L0.8140.58
25_F35_E0.8100.58
38_E54_F0.8100.58
29_E76_T0.8030.57
57_E161_Y0.7990.57
151_K206_E0.7940.56
102_E123_K0.7920.56
106_A109_D0.7910.56
59_P64_V0.7910.56
16_S44_V0.7890.56
85_Q88_E0.7880.56
202_L206_E0.7880.56
25_F57_E0.7870.55
134_G170_M0.7870.55
165_V182_L0.7860.55
187_T201_K0.7840.55
2_E48_V0.7820.55
60_L65_Q0.7770.55
38_E78_A0.7760.54
47_E72_E0.7750.54
162_Y177_N0.7690.54
2_E71_L0.7640.53
36_R185_Y0.7610.53
23_R77_K0.7600.53
95_K101_S0.7570.53
27_R31_W0.7500.52
12_K78_A0.7490.52
3_I66_A0.7480.52
13_F70_G0.7470.52
23_R59_P0.7460.52
5_R53_E0.7440.51
100_A108_L0.7440.51
61_W66_A0.7370.51
101_S114_E0.7370.51
105_D108_L0.7310.50
37_S70_G0.7250.50
45_M58_G0.7200.49
119_N125_Q0.7170.49
102_E108_L0.7140.48
36_R59_P0.7140.48
10_T62_I0.7120.48
159_N191_I0.7080.48
61_W72_E0.7060.48
191_I207_H0.7000.47
23_R43_E0.6950.47
19_D41_F0.6940.47
37_S66_A0.6920.46
8_E179_L0.6920.46
5_R24_G0.6910.46
34_R63_Q0.6910.46
119_N126_K0.6870.46
38_E63_Q0.6810.45
13_F30_I0.6790.45
62_I67_L0.6780.45
154_L204_I0.6730.44
168_C211_T0.6690.44
9_H137_E0.6610.43
62_I72_E0.6590.43
82_K89_L0.6570.43
106_A114_E0.6530.43
23_R72_E0.6500.42
51_E182_L0.6470.42
101_S107_L0.6450.42
160_R191_I0.6420.42
119_N124_E0.6400.41
59_P77_K0.6390.41
13_F62_I0.6380.41
38_E61_W0.6360.41
64_V69_K0.6350.41
2_E14_Y0.6340.41
2_E6_I0.6320.41
47_E52_E0.6310.41
55_A178_Q0.6310.41
7_N19_D0.6260.40
29_E68_D0.6260.40
74_I208_A0.6250.40
145_L150_S0.6200.40
58_G75_V0.6150.39
37_S42_W0.6120.39
5_R28_E0.6100.39
193_I197_E0.6020.38
68_D137_E0.6020.38
3_I77_K0.5980.37
147_V202_L0.5970.37
57_E62_I0.5970.37
51_E166_D0.5930.37
103_D203_I0.5920.37
56_V185_Y0.5920.37
103_D106_A0.5920.37
7_N75_V0.5910.37
139_V146_N0.5890.37
27_R199_Y0.5880.37
13_F48_V0.5860.36
165_V213_K0.5850.36
14_Y17_Y0.5840.36
34_R61_W0.5820.36
30_I54_F0.5800.36
114_E132_R0.5790.36
115_E157_F0.5790.36
197_E202_L0.5770.36
28_E31_W0.5740.35
20_I54_F0.5740.35
145_L181_I0.5740.35
4_E60_L0.5720.35
73_I76_T0.5710.35
75_V166_D0.5690.35
19_D76_T0.5690.35
59_P75_V0.5670.35
196_L209_L0.5650.35
209_L213_K0.5640.34
25_F34_R0.5610.34
54_F60_L0.5600.34
25_F68_D0.5560.34
177_N181_I0.5520.33
102_E213_K0.5510.33
95_K119_N0.5510.33
156_S199_Y0.5500.33
115_E185_Y0.5500.33
106_A160_R0.5470.33
17_Y69_K0.5460.33
62_I66_A0.5460.33
22_D56_V0.5440.33
31_W45_M0.5430.33
3_I42_W0.5410.32
153_T197_E0.5400.32
142_L209_L0.5400.32
46_D60_L0.5390.32
11_V15_M0.5380.32
126_K197_E0.5360.32
52_E57_E0.5350.32
31_W61_W0.5340.32
136_F156_S0.5320.32
9_H78_A0.5310.32
3_I65_Q0.5290.31
13_F66_A0.5230.31
4_E41_F0.5230.31
36_R79_Q0.5220.31
115_E120_Q0.5220.31
45_M73_I0.5220.31
6_I16_S0.5220.31
42_W62_I0.5190.31
21_E165_V0.5180.31
34_R59_P0.5130.30
54_F64_V0.5120.30
70_G137_E0.5120.30
102_E171_T0.5110.30
34_R62_I0.5100.30
32_Y61_W0.5070.30
2_E7_N0.5040.29
133_F186_A0.5030.29
10_T15_M0.5020.29
168_C207_H0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j3t1 1 0.4312 100 0.088 Contact Map
3pxia 1 0.4312 99.9 0.587 Contact Map
3jtpA 3 0.4266 99.9 0.588 Contact Map
3jtnA 1 0.4037 99.9 0.614 Contact Map
2d1pC 2 0.2431 13.1 0.953 Contact Map
2d1pB 1 0.2477 12.7 0.953 Contact Map
2lnaA 1 0.3028 12.4 0.953 Contact Map
1jx7A 5 0.2477 6.6 0.959 Contact Map
1pehA 1 0.1514 6.2 0.959 Contact Map
2hy5B 1 0.2477 5.6 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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