GREMLIN Database
ESTA - Lipase EstA
UniProt: P37957 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (176)
Sequences: 3613 (2585)
Seq/√Len: 194.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_G190_L3.7551.00
132_T137_N3.4031.00
114_T130_V3.1371.00
111_G135_G3.1311.00
43_I109_M2.9571.00
115_L137_N2.7791.00
132_T135_G2.5191.00
35_N101_K2.4341.00
35_N103_D2.3581.00
40_V114_T2.3531.00
116_Y121_L2.3471.00
104_I114_T2.3431.00
47_S71_D2.3011.00
103_D128_A2.2971.00
40_V86_L2.2361.00
106_A114_T2.1271.00
91_Q126_K2.0841.00
112_A135_G2.0571.00
60_Q201_K2.0151.00
56_Y197_N1.9841.00
101_K128_A1.9711.00
94_L126_K1.8791.00
118_I130_V1.8791.00
56_Y60_Q1.8021.00
141_T168_M1.7821.00
53_I200_I1.7751.00
83_G116_Y1.7721.00
112_A136_A1.7471.00
116_Y120_N1.7331.00
45_G49_N1.6621.00
38_V104_I1.6411.00
37_V105_V1.6301.00
90_V117_Y1.6021.00
92_K96_E1.5991.00
157_T203_G1.5981.00
35_N128_A1.5941.00
167_V172_S1.5591.00
70_V86_L1.5581.00
87_S117_Y1.5191.00
43_I140_T1.5041.00
83_G117_Y1.4981.00
38_V93_V1.4681.00
186_G189_G1.4301.00
93_V97_T1.4231.00
87_S91_Q1.4101.00
118_I127_V1.3971.00
90_V102_V1.3951.00
38_V89_F1.3901.00
39_M57_L1.3801.00
129_N157_T1.3531.00
39_M50_F1.3431.00
54_K58_V1.3401.00
117_Y123_G1.3331.00
43_I166_I1.3241.00
80_Y116_Y1.3041.00
111_G132_T1.2931.00
94_L99_A1.2901.00
39_M54_K1.2851.00
103_D129_N1.2831.00
38_V102_V1.2801.00
129_N155_L1.2741.00
105_V200_I1.2601.00
185_V193_S1.2581.00
140_T143_K1.2521.00
49_N191_L1.2471.00
70_V89_F1.2271.00
53_I197_N1.1911.00
199_L202_E1.1731.00
89_F92_K1.1501.00
78_T81_N1.1421.00
185_V189_G1.1321.00
37_V57_L1.1291.00
41_H71_D1.1261.00
139_L143_K1.1111.00
106_A135_G1.1001.00
169_N172_S1.0851.00
148_T152_Q1.0791.00
72_F75_K1.0751.00
136_A167_V1.0751.00
104_I127_V1.0651.00
137_N158_S1.0631.00
68_Y93_V1.0601.00
201_K205_N1.0451.00
133_L196_V1.0361.00
89_F93_V1.0241.00
131_V200_I1.0231.00
68_Y97_T1.0171.00
79_N109_M1.0161.00
74_D109_M1.0101.00
168_M172_S0.9941.00
56_Y59_S0.9941.00
188_I191_L0.9881.00
82_N113_N0.9870.99
42_G108_S0.9840.99
56_Y201_K0.9830.99
111_G136_A0.9610.99
115_L136_A0.9600.99
168_M171_L0.9550.99
176_G182_I0.9510.99
119_K147_G0.9460.99
103_D204_L0.9280.99
131_V203_G0.9240.99
39_M105_V0.9170.99
41_H69_A0.9160.99
45_G191_L0.9130.99
51_A55_S0.9070.99
54_K69_A0.8990.99
88_R92_K0.8970.99
149_D152_Q0.8860.99
185_V190_L0.8840.99
74_D77_G0.8790.99
30_K34_H0.8790.99
30_K33_E0.8720.99
83_G87_S0.8680.99
148_T156_Y0.8520.99
77_G81_N0.8510.99
37_V103_D0.8490.98
84_P88_R0.8430.98
115_L145_L0.8350.98
27_P63_S0.8230.98
72_F82_N0.8120.98
160_Y181_Q0.8040.98
198_S201_K0.8020.98
91_Q94_L0.8000.98
52_G55_S0.8000.98
26_Q29_A0.7970.98
151_N156_Y0.7910.98
147_G150_P0.7880.98
44_G76_T0.7880.98
60_Q197_N0.7880.98
133_L190_L0.7850.97
41_H166_I0.7850.97
48_F51_A0.7840.97
92_K95_D0.7750.97
167_V171_L0.7740.97
165_M169_N0.7710.97
41_H50_F0.7700.97
111_G130_V0.7690.97
83_G121_L0.7600.97
151_N154_I0.7550.97
85_V89_F0.7530.97
105_V133_L0.7480.97
62_W67_L0.7440.97
146_P153_K0.7440.97
112_A143_K0.7420.96
79_N113_N0.7400.96
107_H191_L0.7390.96
68_Y89_F0.7380.96
31_A34_H0.7370.96
123_G126_K0.7360.96
45_G166_I0.7300.96
36_P68_Y0.7280.96
58_V67_L0.7250.96
94_L100_K0.7240.96
53_I57_L0.7190.96
72_F109_M0.7170.96
166_I191_L0.7160.96
91_Q123_G0.7110.95
39_M67_L0.7080.95
149_D155_L0.7040.95
145_L150_P0.7020.95
195_Q198_S0.6970.95
106_A118_I0.6920.95
116_Y119_K0.6890.95
179_N182_I0.6850.94
138_R145_L0.6830.94
41_H142_G0.6810.94
84_P87_S0.6800.94
118_I151_N0.6780.94
39_M53_I0.6750.94
79_N112_A0.6740.94
181_Q184_G0.6700.94
52_G56_Y0.6700.94
142_G166_I0.6700.94
72_F113_N0.6690.94
78_T82_N0.6670.94
47_S69_A0.6670.94
47_S70_V0.6660.94
80_Y84_P0.6610.93
85_V88_R0.6590.93
150_P156_Y0.6590.93
93_V99_A0.6580.93
27_P30_K0.6550.93
72_F76_T0.6510.93
135_G158_S0.6440.92
185_V196_V0.6430.92
177_A180_V0.6420.92
199_L203_G0.6400.92
133_L200_I0.6370.92
145_L151_N0.6360.92
86_L113_N0.6340.92
138_R174_L0.6310.92
106_A132_T0.6240.91
79_N83_G0.6220.91
105_V131_V0.6210.91
113_N135_G0.6160.91
197_N201_K0.6140.91
26_Q31_A0.6120.90
29_A34_H0.6120.90
132_T136_A0.6110.90
90_V104_I0.6100.90
153_K156_Y0.6100.90
97_T101_K0.6080.90
48_F192_Y0.6040.90
145_L156_Y0.6020.90
162_S183_H0.5980.89
81_N85_V0.5950.89
57_L204_L0.5910.89
35_N100_K0.5870.89
159_I163_A0.5860.89
161_S169_N0.5850.88
160_Y173_R0.5840.88
43_I167_V0.5820.88
26_Q30_K0.5800.88
145_L148_T0.5760.88
159_I180_V0.5740.87
115_L139_L0.5730.87
87_S123_G0.5710.87
157_T180_V0.5700.87
159_I169_N0.5650.87
117_Y126_K0.5620.86
107_H133_L0.5620.86
57_L62_W0.5610.86
91_Q117_Y0.5590.86
46_A75_K0.5580.86
45_G109_M0.5570.86
79_N82_N0.5570.86
87_S122_D0.5560.86
150_P153_K0.5540.86
165_M186_G0.5490.85
199_L205_N0.5470.85
55_S58_V0.5450.85
146_P151_N0.5420.84
111_G137_N0.5410.84
54_K67_L0.5380.84
107_H166_I0.5380.84
103_D131_V0.5380.84
46_A49_N0.5350.84
36_P99_A0.5340.83
140_T166_I0.5340.83
31_A95_D0.5300.83
136_A171_L0.5290.83
104_I117_Y0.5280.83
38_V90_V0.5280.83
49_N107_H0.5270.83
81_N84_P0.5260.83
146_P149_D0.5220.82
36_P127_V0.5200.82
107_H110_G0.5200.82
112_A139_L0.5180.82
159_I190_L0.5180.82
158_S173_R0.5180.82
179_N183_H0.5170.81
50_F107_H0.5160.81
119_K148_T0.5140.81
140_T169_N0.5130.81
45_G107_H0.5100.81
80_Y120_N0.5080.80
51_A54_K0.5060.80
170_Y173_R0.5050.80
170_Y181_Q0.5030.80
145_L152_Q0.5010.79
93_V102_V0.5000.79
140_T167_V0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ispA 1 0.8443 100 0.448 Contact Map
3ds8A 1 0.8491 99.9 0.506 Contact Map
2x5xA 2 1 99.9 0.525 Contact Map
3lp5A 1 0.8443 99.9 0.534 Contact Map
4k5qA 1 0.9717 99.9 0.539 Contact Map
3icvA 2 0.9623 99.9 0.543 Contact Map
4hs9A 1 0.8113 99.9 0.545 Contact Map
4fkbA 2 0.8255 99.9 0.554 Contact Map
3fleA 1 0.8066 99.9 0.558 Contact Map
2hihA 2 0.8632 99.9 0.559 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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