SPL - BACSU - GREMLIN Contacts

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SPL - Spore photoproduct lyase

UniProt:	P37956	Sequences: MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQVRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQTTMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIEHFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIEAAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFTKPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFPNAKIEYFT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	342 (271)
Sequences:	1233 (780)
Seq/√Len:	47.4

BACSU - SPL

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
124_D	164_Q	5.197	1.00
299_R	310_K	3.725	1.00
167_L	188_N	3.523	1.00
75_D	78_K	3.227	1.00
194_R	231_G	3.060	1.00
74_F	78_K	3.012	1.00
197_I	220_A	2.879	1.00
221_V	225_K	2.864	1.00
234_V	251_F	2.777	1.00
159_I	170_L	2.751	1.00
273_H	302_K	2.743	1.00
237_I	251_F	2.739	1.00
183_L	228_Y	2.639	1.00
301_Y	304_G	2.626	1.00
234_V	254_L	2.614	1.00
74_F	77_S	2.485	1.00
110_I	148_I	2.446	1.00
120_L	123_A	2.438	1.00
234_V	237_I	2.419	1.00
244_E	320_A	2.243	1.00
141_C	145_I	2.183	1.00
115_N	118_E	2.144	1.00
203_I	210_T	2.118	1.00
309_G	313_Y	2.061	1.00
124_D	165_S	2.043	1.00
300_R	304_G	2.037	1.00
62_S	69_R	1.999	0.99
314_Q	317_E	1.983	0.99
107_K	113_Y	1.967	0.99
284_E	310_K	1.957	0.99
128_K	165_S	1.951	0.99
252_E	332_F	1.905	0.99
218_E	222_K	1.853	0.99
163_G	188_N	1.842	0.99
215_K	218_E	1.839	0.99
112_T	115_N	1.804	0.99
106_S	113_Y	1.783	0.99
183_L	226_A	1.753	0.98
139_A	158_A	1.749	0.98
109_Y	113_Y	1.743	0.98
108_P	113_Y	1.729	0.98
255_D	268_F	1.723	0.98
231_G	267_T	1.719	0.98
232_F	258_L	1.694	0.98
108_P	112_T	1.685	0.98
235_A	271_I	1.681	0.98
220_A	232_F	1.662	0.98
107_K	111_R	1.661	0.98
113_Y	116_V	1.653	0.98
96_H	282_V	1.647	0.98
106_S	109_Y	1.637	0.98
157_R	160_E	1.625	0.98
99_Y	141_C	1.610	0.97
197_I	254_L	1.593	0.97
136_R	171_R	1.581	0.97
288_P	296_E	1.579	0.97
300_R	303_W	1.571	0.97
195_F	220_A	1.553	0.97
108_P	111_R	1.530	0.96
284_E	299_R	1.528	0.96
163_G	167_L	1.495	0.96
99_Y	138_E	1.485	0.96
116_V	120_L	1.484	0.96
203_I	213_L	1.480	0.96
201_Y	205_N	1.476	0.96
65_V	69_R	1.470	0.95
180_D	219_A	1.461	0.95
87_F	139_A	1.456	0.95
139_A	155_L	1.431	0.95
116_V	119_I	1.420	0.95
117_E	157_R	1.403	0.94
156_K	184_D	1.403	0.94
83_Y	135_T	1.382	0.94
268_F	333_F	1.378	0.94
257_A	260_Q	1.370	0.93
111_R	115_N	1.349	0.93
106_S	111_R	1.343	0.93
109_Y	112_T	1.329	0.92
82_E	135_T	1.328	0.92
111_R	116_V	1.326	0.92
96_H	208_P	1.320	0.92
324_A	328_Y	1.320	0.92
107_K	112_T	1.316	0.92
177_H	211_S	1.314	0.92
251_F	329_I	1.314	0.92
173_V	233_I	1.306	0.92
180_D	222_K	1.280	0.91
284_E	303_W	1.275	0.91
195_F	219_A	1.271	0.90
214_D	257_A	1.262	0.90
280_K	284_E	1.245	0.90
217_I	257_A	1.245	0.90
106_S	115_N	1.239	0.89
65_V	68_V	1.235	0.89
70_K	76_S	1.219	0.89
62_S	72_L	1.213	0.88
220_A	230_L	1.200	0.88
107_K	116_V	1.197	0.88
235_A	269_E	1.187	0.87
253_K	256_A	1.181	0.87
62_S	70_K	1.172	0.87
327_S	331_T	1.169	0.86
240_H	297_E	1.164	0.86
69_R	115_N	1.162	0.86
239_I	321_L	1.150	0.85
214_D	253_K	1.144	0.85
118_E	121_D	1.140	0.85
193_F	223_V	1.122	0.84
211_S	219_A	1.117	0.84
288_P	299_R	1.107	0.83
205_N	291_K	1.096	0.83
103_T	142_T	1.078	0.81
237_I	329_I	1.077	0.81
200_D	212_P	1.075	0.81
138_E	141_C	1.072	0.81
284_E	288_P	1.060	0.80
124_D	128_K	1.060	0.80
106_S	112_T	1.055	0.80
66_I	69_R	1.045	0.79
285_K	289_K	1.044	0.79
115_N	120_L	1.043	0.79
111_R	114_V	1.042	0.79
206_F	290_T	1.025	0.78
233_I	269_E	1.021	0.78
156_K	185_A	1.014	0.77
71_T	75_D	1.010	0.77
163_G	185_A	1.004	0.77
70_K	75_D	1.002	0.76
194_R	269_E	0.998	0.76
316_D	320_A	0.996	0.76
118_E	157_R	0.991	0.76
199_A	240_H	0.991	0.76
71_T	74_F	0.984	0.75
93_G	176_F	0.984	0.75
197_I	234_V	0.980	0.75
202_V	242_G	0.970	0.74
108_P	115_N	0.967	0.74
315_K	319_H	0.966	0.74
107_K	115_N	0.966	0.74
106_S	116_V	0.962	0.73
200_D	204_K	0.957	0.73
117_E	161_H	0.948	0.72
162_F	168_G	0.944	0.72
70_K	74_F	0.941	0.72
62_S	65_V	0.938	0.72
331_T	334_P	0.935	0.71
170_L	191_T	0.933	0.71
105_G	109_Y	0.930	0.71
327_S	330_D	0.924	0.70
194_R	233_I	0.923	0.70
240_H	301_Y	0.923	0.70
159_I	185_A	0.923	0.70
68_V	72_L	0.922	0.70
299_R	302_K	0.920	0.70
72_L	78_K	0.919	0.70
124_D	161_H	0.919	0.70
153_H	157_R	0.919	0.70
177_H	219_A	0.917	0.70
108_P	116_V	0.917	0.70
112_T	118_E	0.916	0.70
199_A	203_I	0.913	0.70
71_T	78_K	0.909	0.69
156_K	160_E	0.907	0.69
148_I	152_T	0.905	0.69
206_F	238_Y	0.902	0.69
145_I	173_V	0.901	0.68
200_D	203_I	0.899	0.68
69_R	72_L	0.899	0.68
304_G	325_L	0.890	0.68
84_A	141_C	0.889	0.67
68_V	71_T	0.888	0.67
192_R	267_T	0.888	0.67
88_A	143_S	0.879	0.67
70_K	78_K	0.878	0.66
139_A	170_L	0.876	0.66
163_G	191_T	0.870	0.66
67_G	72_L	0.868	0.66
302_K	305_R	0.865	0.65
119_I	123_A	0.865	0.65
295_D	298_K	0.864	0.65
71_T	76_S	0.863	0.65
221_V	260_Q	0.854	0.64
197_I	258_L	0.854	0.64
153_H	160_E	0.854	0.64
92_M	147_G	0.852	0.64
105_G	113_Y	0.852	0.64
272_Q	305_R	0.851	0.64
140_S	145_I	0.850	0.64
234_V	271_I	0.844	0.63
141_C	173_V	0.842	0.63
72_L	76_S	0.838	0.63
65_V	72_L	0.833	0.62
120_L	161_H	0.831	0.62
140_S	252_E	0.829	0.62
79_P	138_E	0.827	0.62
109_Y	116_V	0.819	0.61
99_Y	142_T	0.815	0.61
62_S	68_V	0.812	0.60
82_E	141_C	0.811	0.60
161_H	165_S	0.811	0.60
62_S	71_T	0.807	0.60
200_D	214_D	0.799	0.59
221_V	257_A	0.799	0.59
224_A	230_L	0.798	0.59
145_I	172_F	0.791	0.58
66_I	152_T	0.791	0.58
160_E	164_Q	0.790	0.58
151_L	201_Y	0.789	0.58
101_Q	286_N	0.788	0.58
188_N	191_T	0.779	0.57
86_P	143_S	0.775	0.57
187_H	228_Y	0.773	0.57
112_T	116_V	0.772	0.56
149_D	181_H	0.762	0.56
109_Y	115_N	0.758	0.55
291_K	294_L	0.756	0.55
116_V	123_A	0.753	0.55
301_Y	309_G	0.753	0.55
141_C	233_I	0.752	0.55
138_E	171_R	0.751	0.54
122_Q	125_K	0.749	0.54
187_H	191_T	0.747	0.54
138_E	173_V	0.745	0.54
64_L	70_K	0.739	0.53
180_D	183_L	0.739	0.53
328_Y	332_F	0.735	0.53
214_D	218_E	0.734	0.53
149_D	274_R	0.732	0.53
281_R	284_E	0.729	0.52
64_L	67_G	0.729	0.52
211_S	231_G	0.728	0.52
117_E	293_E	0.724	0.52
116_V	154_T	0.722	0.52
218_E	221_V	0.721	0.51
120_L	157_R	0.719	0.51
70_K	73_K	0.718	0.51
232_F	254_L	0.717	0.51
176_F	194_R	0.717	0.51
196_S	244_E	0.717	0.51
179_V	191_T	0.715	0.51
197_I	324_A	0.712	0.51
141_C	211_S	0.711	0.50
323_E	327_S	0.710	0.50
272_Q	313_Y	0.709	0.50
235_A	270_L	0.700	0.49
234_V	242_G	0.698	0.49
174_T	196_S	0.697	0.49
196_S	219_A	0.695	0.49
134_F	154_T	0.691	0.48
83_Y	141_C	0.690	0.48
303_W	310_K	0.690	0.48
107_K	114_V	0.687	0.48
311_Y	317_E	0.685	0.48
64_L	69_R	0.684	0.48
194_R	271_I	0.684	0.48
134_F	190_K	0.683	0.48
99_Y	155_L	0.682	0.48
205_N	289_K	0.676	0.47
253_K	327_S	0.676	0.47
205_N	241_E	0.675	0.47
297_E	300_R	0.673	0.47
76_S	83_Y	0.670	0.46
219_A	222_K	0.669	0.46
94_H	208_P	0.669	0.46
284_E	309_G	0.666	0.46
270_L	329_I	0.666	0.46
86_P	104_M	0.665	0.46
314_Q	322_R	0.665	0.46
237_I	270_L	0.664	0.46
59_N	62_S	0.660	0.45
65_V	70_K	0.658	0.45
74_F	83_Y	0.656	0.45
280_K	296_E	0.655	0.45
293_E	300_R	0.655	0.45
222_K	225_K	0.652	0.45
127_M	165_S	0.647	0.44
141_C	269_E	0.643	0.44
241_E	262_V	0.642	0.44
245_E	254_L	0.640	0.43
80_S	220_A	0.638	0.43
201_Y	204_K	0.635	0.43
125_K	331_T	0.631	0.43
99_Y	269_E	0.631	0.43
84_A	142_T	0.630	0.42
169_K	190_K	0.627	0.42
180_D	215_K	0.625	0.42
117_E	120_L	0.621	0.42
107_K	120_L	0.621	0.42
79_P	99_Y	0.619	0.41
252_E	328_Y	0.616	0.41
126_Y	162_F	0.616	0.41
94_H	106_S	0.615	0.41
241_E	291_K	0.614	0.41
307_G	311_Y	0.613	0.41
62_S	66_I	0.613	0.41
129_E	205_N	0.611	0.41
253_K	257_A	0.609	0.40
105_G	116_V	0.609	0.40
196_S	233_I	0.608	0.40
242_G	245_E	0.608	0.40
299_R	305_R	0.607	0.40
286_N	318_E	0.606	0.40
179_V	223_V	0.603	0.40
85_I	137_F	0.601	0.40
173_V	313_Y	0.600	0.40
217_I	245_E	0.598	0.39
125_K	157_R	0.597	0.39
62_S	209_G	0.597	0.39
178_H	181_H	0.594	0.39
114_V	117_E	0.591	0.39
302_K	306_Y	0.591	0.39
272_Q	325_L	0.590	0.39
312_I	318_E	0.590	0.39
85_I	162_F	0.590	0.39
102_T	276_T	0.588	0.38
231_G	269_E	0.587	0.38
131_A	167_L	0.586	0.38
138_E	194_R	0.582	0.38
72_L	75_D	0.581	0.38
171_R	235_A	0.581	0.38
195_F	223_V	0.578	0.37
233_I	299_R	0.578	0.37
79_P	171_R	0.578	0.37
164_Q	186_K	0.578	0.37
195_F	269_E	0.577	0.37
189_G	222_K	0.576	0.37
114_V	152_T	0.576	0.37
122_Q	242_G	0.573	0.37
66_I	72_L	0.573	0.37
64_L	68_V	0.573	0.37
203_I	215_K	0.573	0.37
189_G	194_R	0.572	0.37
171_R	194_R	0.571	0.37
65_V	110_I	0.571	0.37
301_Y	325_L	0.571	0.37
269_E	320_A	0.568	0.37
237_I	271_I	0.566	0.36
224_A	259_P	0.566	0.36
205_N	261_D	0.565	0.36
99_Y	211_S	0.564	0.36
119_I	122_Q	0.562	0.36
84_A	147_G	0.558	0.36
240_H	293_E	0.558	0.36
146_V	178_H	0.555	0.35
328_Y	331_T	0.555	0.35
187_H	304_G	0.554	0.35
184_D	252_E	0.554	0.35
132_P	168_G	0.552	0.35
85_I	172_F	0.551	0.35
164_Q	245_E	0.551	0.35
69_R	73_K	0.548	0.35
277_K	306_Y	0.547	0.35
209_G	286_N	0.547	0.35
172_F	193_F	0.546	0.34
123_A	127_M	0.545	0.34
106_S	114_V	0.545	0.34
253_K	331_T	0.544	0.34
194_R	267_T	0.543	0.34
105_G	111_R	0.543	0.34
273_H	311_Y	0.541	0.34
138_E	271_I	0.541	0.34
117_E	158_A	0.541	0.34
79_P	319_H	0.540	0.34
70_K	77_S	0.540	0.34
149_D	153_H	0.539	0.34
157_R	224_A	0.538	0.34
71_T	196_S	0.537	0.34
230_L	317_E	0.536	0.34
257_A	261_D	0.535	0.34
124_D	163_G	0.532	0.33
270_L	330_D	0.531	0.33
200_D	325_L	0.530	0.33
183_L	334_P	0.528	0.33
74_F	122_Q	0.528	0.33
61_K	68_V	0.527	0.33
317_E	330_D	0.525	0.33
96_H	291_K	0.524	0.33
138_E	233_I	0.524	0.33
174_T	329_I	0.523	0.32
318_E	321_L	0.523	0.32
99_Y	145_I	0.520	0.32
108_P	114_V	0.519	0.32
175_K	219_A	0.519	0.32
63_T	68_V	0.519	0.32
296_E	310_K	0.518	0.32
110_I	114_V	0.518	0.32
84_A	173_V	0.517	0.32
320_A	327_S	0.517	0.32
271_I	313_Y	0.517	0.32
129_E	217_I	0.516	0.32
109_Y	114_V	0.515	0.32
234_V	317_E	0.513	0.32
85_I	199_A	0.513	0.32
176_F	211_S	0.513	0.32
65_V	114_V	0.513	0.32
64_L	72_L	0.511	0.31
111_R	119_I	0.510	0.31
251_F	332_F	0.508	0.31
162_F	165_S	0.506	0.31
95_C	98_C	0.505	0.31
91_C	95_C	0.505	0.31
91_C	98_C	0.505	0.31
251_F	255_D	0.505	0.31
113_Y	120_L	0.503	0.31
256_A	260_Q	0.502	0.31
96_H	283_I	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4fhdA	1	0.9883	100	0.367	Contact Map
3t7vA	1	0.8392	99	0.882	Contact Map
3iixA	1	0.7749	99	0.884	Contact Map
3c8fA	1	0.6988	98.8	0.89	Contact Map
1oltA	1	0.8567	98.6	0.897	Contact Map
2z2uA	1	0.7339	98.6	0.898	Contact Map
2yx0A	1	0.8216	98.6	0.898	Contact Map
1r30A	2	0.8099	98.5	0.9	Contact Map
4u0oB	1	0.7544	98.5	0.9	Contact Map
2qgqA	1	0.655	98.5	0.901	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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