GREMLIN Database
SPL - Spore photoproduct lyase
UniProt: P37956 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 342 (271)
Sequences: 1233 (780)
Seq/√Len: 47.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_D164_Q5.1971.00
299_R310_K3.7251.00
167_L188_N3.5231.00
75_D78_K3.2271.00
194_R231_G3.0601.00
74_F78_K3.0121.00
197_I220_A2.8791.00
221_V225_K2.8641.00
234_V251_F2.7771.00
159_I170_L2.7511.00
273_H302_K2.7431.00
237_I251_F2.7391.00
183_L228_Y2.6391.00
301_Y304_G2.6261.00
234_V254_L2.6141.00
74_F77_S2.4851.00
110_I148_I2.4461.00
120_L123_A2.4381.00
234_V237_I2.4191.00
244_E320_A2.2431.00
141_C145_I2.1831.00
115_N118_E2.1441.00
203_I210_T2.1181.00
309_G313_Y2.0611.00
124_D165_S2.0431.00
300_R304_G2.0371.00
62_S69_R1.9990.99
314_Q317_E1.9830.99
107_K113_Y1.9670.99
284_E310_K1.9570.99
128_K165_S1.9510.99
252_E332_F1.9050.99
218_E222_K1.8530.99
163_G188_N1.8420.99
215_K218_E1.8390.99
112_T115_N1.8040.99
106_S113_Y1.7830.99
183_L226_A1.7530.98
139_A158_A1.7490.98
109_Y113_Y1.7430.98
108_P113_Y1.7290.98
255_D268_F1.7230.98
231_G267_T1.7190.98
232_F258_L1.6940.98
108_P112_T1.6850.98
235_A271_I1.6810.98
220_A232_F1.6620.98
107_K111_R1.6610.98
113_Y116_V1.6530.98
96_H282_V1.6470.98
106_S109_Y1.6370.98
157_R160_E1.6250.98
99_Y141_C1.6100.97
197_I254_L1.5930.97
136_R171_R1.5810.97
288_P296_E1.5790.97
300_R303_W1.5710.97
195_F220_A1.5530.97
108_P111_R1.5300.96
284_E299_R1.5280.96
163_G167_L1.4950.96
99_Y138_E1.4850.96
116_V120_L1.4840.96
203_I213_L1.4800.96
201_Y205_N1.4760.96
65_V69_R1.4700.95
180_D219_A1.4610.95
87_F139_A1.4560.95
139_A155_L1.4310.95
116_V119_I1.4200.95
117_E157_R1.4030.94
156_K184_D1.4030.94
83_Y135_T1.3820.94
268_F333_F1.3780.94
257_A260_Q1.3700.93
111_R115_N1.3490.93
106_S111_R1.3430.93
109_Y112_T1.3290.92
82_E135_T1.3280.92
111_R116_V1.3260.92
96_H208_P1.3200.92
324_A328_Y1.3200.92
107_K112_T1.3160.92
177_H211_S1.3140.92
251_F329_I1.3140.92
173_V233_I1.3060.92
180_D222_K1.2800.91
284_E303_W1.2750.91
195_F219_A1.2710.90
214_D257_A1.2620.90
280_K284_E1.2450.90
217_I257_A1.2450.90
106_S115_N1.2390.89
65_V68_V1.2350.89
70_K76_S1.2190.89
62_S72_L1.2130.88
220_A230_L1.2000.88
107_K116_V1.1970.88
235_A269_E1.1870.87
253_K256_A1.1810.87
62_S70_K1.1720.87
327_S331_T1.1690.86
240_H297_E1.1640.86
69_R115_N1.1620.86
239_I321_L1.1500.85
214_D253_K1.1440.85
118_E121_D1.1400.85
193_F223_V1.1220.84
211_S219_A1.1170.84
288_P299_R1.1070.83
205_N291_K1.0960.83
103_T142_T1.0780.81
237_I329_I1.0770.81
200_D212_P1.0750.81
138_E141_C1.0720.81
284_E288_P1.0600.80
124_D128_K1.0600.80
106_S112_T1.0550.80
66_I69_R1.0450.79
285_K289_K1.0440.79
115_N120_L1.0430.79
111_R114_V1.0420.79
206_F290_T1.0250.78
233_I269_E1.0210.78
156_K185_A1.0140.77
71_T75_D1.0100.77
163_G185_A1.0040.77
70_K75_D1.0020.76
194_R269_E0.9980.76
316_D320_A0.9960.76
118_E157_R0.9910.76
199_A240_H0.9910.76
71_T74_F0.9840.75
93_G176_F0.9840.75
197_I234_V0.9800.75
202_V242_G0.9700.74
108_P115_N0.9670.74
315_K319_H0.9660.74
107_K115_N0.9660.74
106_S116_V0.9620.73
200_D204_K0.9570.73
117_E161_H0.9480.72
162_F168_G0.9440.72
70_K74_F0.9410.72
62_S65_V0.9380.72
331_T334_P0.9350.71
170_L191_T0.9330.71
105_G109_Y0.9300.71
327_S330_D0.9240.70
194_R233_I0.9230.70
240_H301_Y0.9230.70
159_I185_A0.9230.70
68_V72_L0.9220.70
299_R302_K0.9200.70
72_L78_K0.9190.70
124_D161_H0.9190.70
153_H157_R0.9190.70
177_H219_A0.9170.70
108_P116_V0.9170.70
112_T118_E0.9160.70
199_A203_I0.9130.70
71_T78_K0.9090.69
156_K160_E0.9070.69
148_I152_T0.9050.69
206_F238_Y0.9020.69
145_I173_V0.9010.68
200_D203_I0.8990.68
69_R72_L0.8990.68
304_G325_L0.8900.68
84_A141_C0.8890.67
68_V71_T0.8880.67
192_R267_T0.8880.67
88_A143_S0.8790.67
70_K78_K0.8780.66
139_A170_L0.8760.66
163_G191_T0.8700.66
67_G72_L0.8680.66
302_K305_R0.8650.65
119_I123_A0.8650.65
295_D298_K0.8640.65
71_T76_S0.8630.65
221_V260_Q0.8540.64
197_I258_L0.8540.64
153_H160_E0.8540.64
92_M147_G0.8520.64
105_G113_Y0.8520.64
272_Q305_R0.8510.64
140_S145_I0.8500.64
234_V271_I0.8440.63
141_C173_V0.8420.63
72_L76_S0.8380.63
65_V72_L0.8330.62
120_L161_H0.8310.62
140_S252_E0.8290.62
79_P138_E0.8270.62
109_Y116_V0.8190.61
99_Y142_T0.8150.61
62_S68_V0.8120.60
82_E141_C0.8110.60
161_H165_S0.8110.60
62_S71_T0.8070.60
200_D214_D0.7990.59
221_V257_A0.7990.59
224_A230_L0.7980.59
145_I172_F0.7910.58
66_I152_T0.7910.58
160_E164_Q0.7900.58
151_L201_Y0.7890.58
101_Q286_N0.7880.58
188_N191_T0.7790.57
86_P143_S0.7750.57
187_H228_Y0.7730.57
112_T116_V0.7720.56
149_D181_H0.7620.56
109_Y115_N0.7580.55
291_K294_L0.7560.55
116_V123_A0.7530.55
301_Y309_G0.7530.55
141_C233_I0.7520.55
138_E171_R0.7510.54
122_Q125_K0.7490.54
187_H191_T0.7470.54
138_E173_V0.7450.54
64_L70_K0.7390.53
180_D183_L0.7390.53
328_Y332_F0.7350.53
214_D218_E0.7340.53
149_D274_R0.7320.53
281_R284_E0.7290.52
64_L67_G0.7290.52
211_S231_G0.7280.52
117_E293_E0.7240.52
116_V154_T0.7220.52
218_E221_V0.7210.51
120_L157_R0.7190.51
70_K73_K0.7180.51
232_F254_L0.7170.51
176_F194_R0.7170.51
196_S244_E0.7170.51
179_V191_T0.7150.51
197_I324_A0.7120.51
141_C211_S0.7110.50
323_E327_S0.7100.50
272_Q313_Y0.7090.50
235_A270_L0.7000.49
234_V242_G0.6980.49
174_T196_S0.6970.49
196_S219_A0.6950.49
134_F154_T0.6910.48
83_Y141_C0.6900.48
303_W310_K0.6900.48
107_K114_V0.6870.48
311_Y317_E0.6850.48
64_L69_R0.6840.48
194_R271_I0.6840.48
134_F190_K0.6830.48
99_Y155_L0.6820.48
205_N289_K0.6760.47
253_K327_S0.6760.47
205_N241_E0.6750.47
297_E300_R0.6730.47
76_S83_Y0.6700.46
219_A222_K0.6690.46
94_H208_P0.6690.46
284_E309_G0.6660.46
270_L329_I0.6660.46
86_P104_M0.6650.46
314_Q322_R0.6650.46
237_I270_L0.6640.46
59_N62_S0.6600.45
65_V70_K0.6580.45
74_F83_Y0.6560.45
280_K296_E0.6550.45
293_E300_R0.6550.45
222_K225_K0.6520.45
127_M165_S0.6470.44
141_C269_E0.6430.44
241_E262_V0.6420.44
245_E254_L0.6400.43
80_S220_A0.6380.43
201_Y204_K0.6350.43
125_K331_T0.6310.43
99_Y269_E0.6310.43
84_A142_T0.6300.42
169_K190_K0.6270.42
180_D215_K0.6250.42
117_E120_L0.6210.42
107_K120_L0.6210.42
79_P99_Y0.6190.41
252_E328_Y0.6160.41
126_Y162_F0.6160.41
94_H106_S0.6150.41
241_E291_K0.6140.41
307_G311_Y0.6130.41
62_S66_I0.6130.41
129_E205_N0.6110.41
253_K257_A0.6090.40
105_G116_V0.6090.40
196_S233_I0.6080.40
242_G245_E0.6080.40
299_R305_R0.6070.40
286_N318_E0.6060.40
179_V223_V0.6030.40
85_I137_F0.6010.40
173_V313_Y0.6000.40
217_I245_E0.5980.39
125_K157_R0.5970.39
62_S209_G0.5970.39
178_H181_H0.5940.39
114_V117_E0.5910.39
302_K306_Y0.5910.39
272_Q325_L0.5900.39
312_I318_E0.5900.39
85_I162_F0.5900.39
102_T276_T0.5880.38
231_G269_E0.5870.38
131_A167_L0.5860.38
138_E194_R0.5820.38
72_L75_D0.5810.38
171_R235_A0.5810.38
195_F223_V0.5780.37
233_I299_R0.5780.37
79_P171_R0.5780.37
164_Q186_K0.5780.37
195_F269_E0.5770.37
189_G222_K0.5760.37
114_V152_T0.5760.37
122_Q242_G0.5730.37
66_I72_L0.5730.37
64_L68_V0.5730.37
203_I215_K0.5730.37
189_G194_R0.5720.37
171_R194_R0.5710.37
65_V110_I0.5710.37
301_Y325_L0.5710.37
269_E320_A0.5680.37
237_I271_I0.5660.36
224_A259_P0.5660.36
205_N261_D0.5650.36
99_Y211_S0.5640.36
119_I122_Q0.5620.36
84_A147_G0.5580.36
240_H293_E0.5580.36
146_V178_H0.5550.35
328_Y331_T0.5550.35
187_H304_G0.5540.35
184_D252_E0.5540.35
132_P168_G0.5520.35
85_I172_F0.5510.35
164_Q245_E0.5510.35
69_R73_K0.5480.35
277_K306_Y0.5470.35
209_G286_N0.5470.35
172_F193_F0.5460.34
123_A127_M0.5450.34
106_S114_V0.5450.34
253_K331_T0.5440.34
194_R267_T0.5430.34
105_G111_R0.5430.34
273_H311_Y0.5410.34
138_E271_I0.5410.34
117_E158_A0.5410.34
79_P319_H0.5400.34
70_K77_S0.5400.34
149_D153_H0.5390.34
157_R224_A0.5380.34
71_T196_S0.5370.34
230_L317_E0.5360.34
257_A261_D0.5350.34
124_D163_G0.5320.33
270_L330_D0.5310.33
200_D325_L0.5300.33
183_L334_P0.5280.33
74_F122_Q0.5280.33
61_K68_V0.5270.33
317_E330_D0.5250.33
96_H291_K0.5240.33
138_E233_I0.5240.33
174_T329_I0.5230.32
318_E321_L0.5230.32
99_Y145_I0.5200.32
108_P114_V0.5190.32
175_K219_A0.5190.32
63_T68_V0.5190.32
296_E310_K0.5180.32
110_I114_V0.5180.32
84_A173_V0.5170.32
320_A327_S0.5170.32
271_I313_Y0.5170.32
129_E217_I0.5160.32
109_Y114_V0.5150.32
234_V317_E0.5130.32
85_I199_A0.5130.32
176_F211_S0.5130.32
65_V114_V0.5130.32
64_L72_L0.5110.31
111_R119_I0.5100.31
251_F332_F0.5080.31
162_F165_S0.5060.31
95_C98_C0.5050.31
91_C95_C0.5050.31
91_C98_C0.5050.31
251_F255_D0.5050.31
113_Y120_L0.5030.31
256_A260_Q0.5020.31
96_H283_I0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fhdA 1 0.9883 100 0.367 Contact Map
3t7vA 1 0.8392 99 0.882 Contact Map
3iixA 1 0.7749 99 0.884 Contact Map
3c8fA 1 0.6988 98.8 0.89 Contact Map
1oltA 1 0.8567 98.6 0.897 Contact Map
2z2uA 1 0.7339 98.6 0.898 Contact Map
2yx0A 1 0.8216 98.6 0.898 Contact Map
1r30A 2 0.8099 98.5 0.9 Contact Map
4u0oB 1 0.7544 98.5 0.9 Contact Map
2qgqA 1 0.655 98.5 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.