GREMLIN Database
DEGA - HTH-type transcriptional regulator DegA
UniProt: P37947 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 337 (323)
Sequences: 37040 (26721)
Seq/√Len: 1486.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_V204_Q3.2761.00
180_H242_T3.0451.00
11_A43_E3.0421.00
265_K268_D2.9771.00
199_I203_R2.5971.00
119_G306_A2.5971.00
171_A273_I2.5571.00
180_H271_S2.4191.00
277_N292_A2.3501.00
158_D309_S2.3301.00
169_Y208_E2.2451.00
31_D35_Q2.2381.00
39_N43_E2.2031.00
233_G262_R2.1521.00
229_K261_I2.1501.00
35_Q39_N2.1341.00
85_R88_E2.1211.00
173_K205_A2.1051.00
233_G258_A2.0881.00
85_R304_R2.0841.00
169_Y205_A2.0651.00
176_L209_A2.0551.00
166_R170_E2.0501.00
169_Y204_Q2.0271.00
22_V37_V2.0081.00
301_E304_R1.9921.00
86_A303_H1.9361.00
85_R300_A1.9131.00
178_L332_T1.8951.00
165_V200_K1.8821.00
6_Y16_I1.8791.00
34_R38_M1.8711.00
23_I41_M1.8661.00
175_L243_A1.8491.00
167_G275_F1.8411.00
168_G172_A1.8121.00
11_A40_V1.7981.00
172_A202_F1.7731.00
292_A325_E1.7641.00
81_S299_G1.7611.00
237_D262_R1.7611.00
173_K177_S1.7581.00
12_A40_V1.7471.00
168_G245_F1.7471.00
173_K209_A1.7391.00
301_E320_I1.7341.00
184_A241_P1.7331.00
259_A270_L1.7171.00
169_Y173_K1.6891.00
308_R313_K1.6871.00
84_E296_K1.6791.00
228_G254_A1.6751.00
232_A255_A1.6711.00
229_K258_A1.6551.00
64_A117_V1.6531.00
246_A255_A1.6501.00
85_R89_L1.6291.00
258_A262_R1.6231.00
185_C247_F1.6211.00
81_S296_K1.6181.00
264_I269_D1.6101.00
294_P297_E1.6091.00
182_N214_D1.6021.00
170_E324_P1.5861.00
174_H178_L1.5831.00
148_I302_R1.5701.00
265_K269_D1.5501.00
174_H177_S1.5451.00
166_R169_Y1.5411.00
287_P330_H1.5361.00
260_R285_A1.5171.00
38_M42_N1.5161.00
258_A261_I1.5061.00
297_E301_E1.4971.00
219_I234_K1.4901.00
89_L307_G1.4801.00
174_H328_V1.4701.00
176_L205_A1.4681.00
200_K204_Q1.4491.00
307_G311_R1.4381.00
163_D166_R1.4211.00
273_I289_T1.4181.00
38_M41_M1.4141.00
22_V41_M1.4101.00
8_V40_V1.4031.00
205_A208_E1.4031.00
203_R207_E1.4001.00
61_N118_D1.3891.00
167_G324_P1.3631.00
197_N200_K1.3611.00
297_E300_A1.3541.00
214_D217_L1.3501.00
182_N242_T1.3481.00
11_A44_M1.3441.00
277_N329_R1.3411.00
259_A264_I1.3401.00
229_K257_Q1.3371.00
229_K233_G1.3361.00
85_R303_H1.3151.00
222_R227_S1.3051.00
233_G261_I1.2831.00
40_V43_E1.2791.00
6_Y10_K1.2761.00
31_D34_R1.2751.00
36_K40_V1.2731.00
172_A205_A1.2691.00
172_A176_L1.2651.00
121_I302_R1.2641.00
233_G237_D1.2631.00
165_V169_Y1.2601.00
172_A201_G1.2541.00
61_N91_F1.2511.00
7_D10_K1.2481.00
21_R26_T1.2381.00
184_A235_L1.2351.00
170_E173_K1.2341.00
174_H332_T1.2311.00
30_S33_T1.2261.00
168_G201_G1.2181.00
63_I86_A1.2121.00
232_A244_I1.2071.00
96_C108_Y1.2011.00
304_R308_R1.2001.00
86_A93_M1.1931.00
33_T36_K1.1891.00
232_A259_A1.1871.00
64_A112_L1.1841.00
205_A209_A1.1841.00
40_V44_M1.1831.00
201_G205_A1.1811.00
256_I272_I1.1771.00
173_K208_E1.1741.00
5_I16_I1.1711.00
82_I303_H1.1691.00
180_H243_A1.1591.00
234_K238_R1.1591.00
181_T242_T1.1511.00
296_K300_A1.1481.00
8_V12_A1.1481.00
8_V44_M1.1471.00
136_E140_S1.1441.00
96_C112_L1.1421.00
231_E234_K1.1411.00
62_M92_Q1.1401.00
202_F206_M1.1381.00
65_L82_I1.1371.00
22_V29_I1.1251.00
35_Q38_M1.1161.00
305_T320_I1.1111.00
165_V197_N1.1021.00
89_L304_R1.0921.00
62_M94_L1.0921.00
301_E305_T1.0871.00
185_C199_I1.0861.00
165_V201_G1.0801.00
110_S137_E1.0801.00
83_E87_D1.0801.00
271_S332_T1.0791.00
39_N42_N1.0781.00
171_A245_F1.0691.00
82_I121_I1.0651.00
224_S227_S1.0641.00
25_N34_R1.0571.00
204_Q208_E1.0521.00
226_E230_E1.0501.00
183_I206_M1.0471.00
254_A258_A1.0451.00
299_G303_H1.0401.00
244_I255_A1.0371.00
182_N240_A1.0341.00
186_I255_A1.0331.00
200_K203_R1.0311.00
65_L93_M1.0301.00
106_T110_S1.0291.00
292_A327_V1.0281.00
176_L211_V1.0241.00
249_D290_T1.0211.00
91_F307_G1.0211.00
219_I231_E1.0161.00
300_A304_R1.0161.00
5_I19_V1.0141.00
87_D104_K1.0121.00
246_A251_L1.0091.00
166_R323_P1.0011.00
196_K200_K0.9991.00
104_K107_K0.9971.00
158_D305_T0.9941.00
178_L328_V0.9831.00
260_R287_P0.9811.00
41_M44_M0.9801.00
202_F245_F0.9741.00
301_E322_L0.9731.00
178_L271_S0.9701.00
193_T197_N0.9691.00
51_H54_A0.9681.00
246_A252_A0.9681.00
177_S209_A0.9651.00
190_G220_Q0.9641.00
306_A310_N0.9621.00
213_I216_S0.9621.00
183_I243_A0.9611.00
206_M211_V0.9601.00
12_A19_V0.9581.00
132_M136_E0.9571.00
49_N55_L0.9561.00
89_L311_R0.9541.00
230_E234_K0.9521.00
294_P325_E0.9491.00
79_A83_E0.9481.00
174_H289_T0.9471.00
227_S230_E0.9461.00
249_D274_G0.9441.00
232_A236_L0.9401.00
225_L257_Q0.9381.00
25_N38_M0.9231.00
110_S114_Q0.9181.00
256_I266_V0.9121.00
256_I284_A0.9111.00
121_I306_A0.9111.00
228_G232_A0.9101.00
80_K84_E0.9101.00
325_E328_V0.9091.00
172_A206_M0.9061.00
88_E300_A0.9061.00
159_I319_K0.9061.00
171_A291_V0.8951.00
280_L283_M0.8901.00
244_I270_L0.8771.00
305_T308_R0.8721.00
203_R213_I0.8711.00
182_N217_L0.8701.00
176_L181_T0.8691.00
74_F295_I0.8581.00
82_I299_G0.8581.00
22_V38_M0.8561.00
48_P53_A0.8561.00
161_V319_K0.8521.00
163_D321_V0.8501.00
264_I270_L0.8481.00
49_N52_A0.8461.00
181_T211_V0.8451.00
78_L148_I0.8371.00
52_A55_L0.8321.00
230_E233_G0.8291.00
166_R324_P0.8281.00
238_R241_P0.8281.00
164_D198_R0.8281.00
84_E300_A0.8261.00
158_D318_Q0.8251.00
236_L258_A0.8251.00
162_I294_P0.8221.00
161_V321_V0.8201.00
160_V305_T0.8171.00
249_D277_N0.8141.00
217_L238_R0.8141.00
232_A258_A0.8111.00
277_N327_V0.8101.00
191_S196_K0.8071.00
63_I121_I0.8071.00
62_M115_K0.8021.00
162_I324_P0.8021.00
328_V332_T0.8021.00
227_S231_E0.8021.00
187_I199_I0.8011.00
204_Q207_E0.8001.00
199_I218_I0.7981.00
184_A244_I0.7971.00
14_V37_V0.7971.00
79_A95_I0.7961.00
84_E88_E0.7951.00
294_P322_L0.7941.00
188_G223_F0.7931.00
303_H307_G0.7921.00
232_A235_L0.7921.00
119_G310_N0.7911.00
259_A272_I0.7911.00
65_L79_A0.7891.00
17_T21_R0.7881.00
81_S85_R0.7881.00
162_I293_Q0.7801.00
32_K35_Q0.7801.00
151_D319_K0.7791.00
50_V53_A0.7701.00
182_N239_N0.7691.00
82_I93_M0.7611.00
113_K141_E0.7601.00
186_I246_A0.7591.00
81_S300_A0.7561.00
137_E140_S0.7561.00
175_L273_I0.7561.00
174_H326_L0.7501.00
219_I238_R0.7501.00
274_G290_T0.7501.00
101_D104_K0.7481.00
289_T332_T0.7461.00
163_D323_P0.7421.00
59_R118_D0.7421.00
257_Q260_R0.7421.00
18_T21_R0.7401.00
32_K36_K0.7391.00
252_A274_G0.7391.00
94_L117_V0.7331.00
107_K110_S0.7311.00
77_E296_K0.7301.00
104_K108_Y0.7291.00
139_A157_M0.7291.00
289_T326_L0.7291.00
197_N201_G0.7281.00
185_C245_F0.7281.00
206_M213_I0.7271.00
170_E291_V0.7241.00
280_L284_A0.7211.00
236_L262_R0.7191.00
80_K83_E0.7171.00
21_R27_G0.7171.00
139_A156_P0.7131.00
60_T118_D0.7081.00
259_A266_V0.7071.00
21_R28_R0.7071.00
99_D104_K0.7061.00
121_I148_I0.7031.00
221_T251_L0.6991.00
94_L115_K0.6961.00
68_P75_Y0.6951.00
47_T114_Q0.6941.00
22_V34_R0.6941.00
169_Y201_G0.6921.00
83_E97_S0.6901.00
281_A284_A0.6881.00
136_E139_A0.6851.00
219_I235_L0.6831.00
308_R312_G0.6821.00
234_K237_D0.6811.00
257_Q287_P0.6811.00
64_A120_I0.6801.00
66_V108_Y0.6801.00
145_I157_M0.6781.00
253_C284_A0.6781.00
139_A145_I0.6751.00
83_E93_M0.6691.00
257_Q261_I0.6691.00
14_V33_T0.6671.00
35_Q42_N0.6661.00
147_M152_K0.6651.00
63_I303_H0.6621.00
277_N281_A0.6581.00
185_C202_F0.6551.00
138_I145_I0.6551.00
221_T227_S0.6511.00
195_E223_F0.6501.00
119_G146_A0.6491.00
203_R218_I0.6481.00
176_L206_M0.6481.00
170_E174_H0.6481.00
240_A264_I0.6471.00
245_F273_I0.6461.00
276_D293_Q0.6421.00
183_I242_T0.6371.00
228_G231_E0.6371.00
256_I260_R0.6361.00
47_T110_S0.6341.00
120_I143_I0.6341.00
134_A137_E0.6331.00
199_I220_Q0.6321.00
146_A309_S0.6321.00
103_K107_K0.6301.00
60_T92_Q0.6281.00
241_P264_I0.6271.00
249_D252_A0.6261.00
312_G315_K0.6221.00
59_R311_R0.6191.00
106_T134_A0.6181.00
175_L245_F0.6171.00
77_E295_I0.6161.00
202_F213_I0.6161.00
223_F247_F0.6161.00
242_T271_S0.6111.00
80_K296_K0.6101.00
36_K39_N0.6071.00
146_A306_A0.6071.00
147_M157_M0.6021.00
146_A160_V0.6001.00
119_G302_R0.6001.00
28_R33_T0.5991.00
81_S295_I0.5981.00
248_N251_L0.5981.00
109_F120_I0.5981.00
149_S164_D0.5981.00
158_D317_K0.5951.00
19_V41_M0.5941.00
169_Y172_A0.5921.00
149_S194_G0.5921.00
113_K143_I0.5921.00
72_N250_V0.5911.00
86_A91_F0.5871.00
63_I310_N0.5861.00
257_Q285_A0.5841.00
8_V19_V0.5831.00
225_L254_A0.5821.00
6_Y56_T0.5821.00
96_C111_V0.5811.00
63_I119_G0.5801.00
309_S312_G0.5781.00
248_N276_D0.5751.00
19_V22_V0.5751.00
184_A217_L0.5741.00
91_F310_N0.5741.00
151_D159_I0.5741.00
21_R29_I0.5731.00
291_V324_P0.5721.00
133_S136_E0.5711.00
147_M159_I0.5711.00
42_N45_A0.5701.00
182_N241_P0.5691.00
226_E229_K0.5691.00
188_G195_E0.5681.00
187_I220_Q0.5681.00
213_I217_L0.5681.00
241_P244_I0.5681.00
305_T309_S0.5661.00
253_C278_T0.5661.00
102_P106_T0.5641.00
74_F78_L0.5641.00
164_D197_N0.5611.00
91_F118_D0.5591.00
110_S113_K0.5571.00
287_P329_R0.5551.00
245_F275_F0.5541.00
47_T51_H0.5521.00
259_A262_R0.5511.00
174_H273_I0.5501.00
260_R265_K0.5491.00
171_A243_A0.5491.00
146_A302_R0.5491.00
63_I91_F0.5491.00
182_N212_P0.5481.00
78_L295_I0.5471.00
75_Y123_A0.5461.00
223_F251_L0.5461.00
195_E247_F0.5431.00
260_R286_P0.5401.00
133_S137_E0.5391.00
255_A259_A0.5371.00
229_K232_A0.5361.00
308_R318_Q0.5351.00
232_A254_A0.5351.00
146_A305_T0.5331.00
137_E141_E0.5311.00
86_A307_G0.5301.00
281_A288_L0.5301.00
199_I213_I0.5301.00
81_S84_E0.5291.00
29_I34_R0.5281.00
183_I202_F0.5241.00
231_E235_L0.5231.00
225_L250_V0.5231.00
160_V301_E0.5211.00
80_K99_D0.5201.00
257_Q282_E0.5201.00
62_M118_D0.5181.00
26_T29_I0.5171.00
282_E287_P0.5161.00
249_D278_T0.5151.00
246_A274_G0.5141.00
229_K254_A0.5131.00
301_E308_R0.5121.00
14_V19_V0.5121.00
321_V324_P0.5111.00
298_M322_L0.5111.00
7_D11_A0.5101.00
111_V114_Q0.5081.00
73_P250_V0.5081.00
164_D194_G0.5071.00
25_N28_R0.5061.00
273_I332_T0.5061.00
112_L117_V0.5051.00
53_A57_G0.5051.00
82_I86_A0.5051.00
187_I218_I0.5041.00
106_T137_E0.5041.00
186_I231_E0.5021.00
266_V269_D0.5021.00
144_P309_S0.5011.00
296_K299_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hsgA 1 0.9674 100 0.063 Contact Map
2o20A 2 0.816 100 0.072 Contact Map
3bilA 2 0.7596 100 0.076 Contact Map
3dbiA 2 0.819 100 0.08 Contact Map
1qpzA 2 0.9852 100 0.082 Contact Map
3e3mA 2 0.7923 100 0.092 Contact Map
4o5aA 2 0.7953 100 0.092 Contact Map
3kjxA 2 0.9822 100 0.094 Contact Map
3jvdA 2 0.7745 100 0.094 Contact Map
3ctpA 2 0.7893 100 0.096 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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