GREMLIN Database
ILVA - L-threonine dehydratase biosynthetic IlvA
UniProt: P37946 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (342)
Sequences: 4633 (2447)
Seq/√Len: 132.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_S145_E4.3581.00
185_L202_L4.3481.00
45_N309_N3.8151.00
96_C103_G3.8121.00
72_S75_Q3.7081.00
174_I311_V3.4921.00
223_F227_K3.3551.00
29_H177_D3.0741.00
145_E149_A3.0681.00
195_L261_V3.0591.00
106_F146_C3.0441.00
206_S209_T2.9901.00
70_Q162_D2.9681.00
217_A268_P2.9351.00
199_G260_V2.8101.00
210_K263_D2.7801.00
29_H176_N2.6741.00
67_K160_D2.6621.00
34_R45_N2.6171.00
102_H128_D2.6111.00
233_T248_K2.4881.00
271_K300_L2.4691.00
104_K128_D2.3221.00
22_N66_H2.3211.00
220_A224_E2.2271.00
182_P311_V2.1781.00
32_L178_I2.1511.00
216_P244_A1.9371.00
159_D251_E1.9121.00
244_A293_L1.8861.00
224_E227_K1.8791.00
195_L257_L1.8741.00
113_R117_S1.8661.00
228_A232_V1.8531.00
26_V65_Y1.8521.00
203_K262_D1.8471.00
46_I298_L1.8201.00
146_C150_E1.8151.00
73_S76_T1.7791.00
183_H308_K1.7591.00
222_Y249_I1.7541.00
47_Y309_N1.7371.00
184_F212_I1.7291.00
171_A198_V1.7291.00
220_A266_L1.7181.00
73_S77_E1.7001.00
212_I263_D1.6961.00
97_K103_G1.6781.00
248_K251_E1.6741.00
189_V264_I1.6721.00
178_I182_P1.6551.00
223_F266_L1.6541.00
164_M256_T1.6541.00
294_S312_C1.6491.00
222_Y257_L1.6481.00
47_Y178_I1.6311.00
68_M99_L1.6141.00
34_R47_Y1.6141.00
104_K152_R1.6131.00
171_A202_L1.6051.00
226_N264_I1.5871.00
174_I182_P1.5811.00
102_H152_R1.5761.00
244_A290_A1.5761.00
276_I319_N1.5751.00
181_E309_N1.5551.00
241_V272_V1.5491.00
14_K17_L1.5451.00
172_V201_Y1.5291.00
252_E255_R1.5231.00
257_L261_V1.5201.00
268_P271_K1.5181.00
140_Y144_A1.5101.00
186_F301_Y1.4911.00
221_S225_S1.4851.00
13_V17_L1.4821.00
32_L311_V1.4551.00
222_Y264_I1.4461.00
161_P252_E1.4211.00
187_A198_V1.4181.00
186_F214_V1.4151.00
135_T138_D1.4071.00
183_H309_N1.3971.00
185_L198_V1.3961.00
76_T101_I1.3921.00
287_A314_V1.3921.00
142_S146_C1.3831.00
144_A147_C1.3801.00
218_G269_E1.3771.00
229_G258_E1.3761.00
32_L174_I1.3751.00
75_Q153_T1.3701.00
31_P53_L1.3531.00
43_E306_K1.3511.00
212_I265_L1.3481.00
189_V195_L1.3481.00
220_A223_F1.3441.00
198_V313_V1.3361.00
128_D150_E1.3301.00
156_H160_D1.3291.00
20_H176_N1.3251.00
184_F210_K1.3241.00
353_R357_D1.3201.00
107_M131_L1.3131.00
170_L198_V1.3011.00
189_V222_Y1.3001.00
224_E228_A1.2831.00
117_S120_E1.2781.00
82_C105_I1.2711.00
83_A136_F1.2581.00
184_F308_K1.2541.00
104_K130_I1.2521.00
134_D138_D1.2501.00
116_V120_E1.2401.00
170_L194_L1.2401.00
143_A154_F1.2311.00
202_L209_T1.2251.00
186_F298_L1.2241.00
348_R354_E1.2241.00
280_Y286_V1.2181.00
21_Q24_K1.2181.00
132_T142_S1.2091.00
146_C152_R1.2020.99
120_E128_D1.1940.99
255_R258_E1.1930.99
276_I292_A1.1870.99
72_S76_T1.1870.99
107_M119_V1.1860.99
214_V297_A1.1780.99
164_M252_E1.1770.99
34_R39_S1.1740.99
188_S315_S1.1730.99
178_I311_V1.1720.99
189_V213_A1.1670.99
164_M200_T1.1670.99
92_V105_I1.1660.99
38_L295_V1.1580.99
210_K308_K1.1540.99
255_R259_T1.1480.99
89_A119_V1.1450.99
272_V293_L1.1450.99
195_L211_V1.1390.99
44_C310_V1.1350.99
22_N69_K1.1270.99
68_M92_V1.1200.99
81_V152_R1.1170.99
136_F140_Y1.1160.99
175_L202_L1.1020.99
71_L75_Q1.0970.99
256_T260_V1.0910.99
351_A354_E1.0780.99
172_V176_N1.0740.99
225_S231_V1.0690.99
15_H18_K1.0620.99
224_E232_V1.0590.99
76_T153_T1.0580.99
217_A266_L1.0490.99
351_A355_F1.0410.99
111_T242_D1.0360.98
213_A222_Y1.0360.98
13_V172_V1.0350.98
23_V65_Y1.0300.98
116_V131_L1.0290.98
102_H150_E1.0280.98
223_F264_I1.0280.98
279_L287_A1.0260.98
199_G211_V1.0160.98
16_I201_Y1.0130.98
239_K245_A1.0130.98
44_C308_K1.0120.98
78_N151_S1.0120.98
221_S249_I1.0040.98
254_F258_E1.0040.98
141_K145_E0.9970.98
218_G238_D0.9930.98
94_F98_H0.9930.98
109_S134_D0.9850.98
267_V296_A0.9820.98
41_R278_E0.9820.98
175_L206_S0.9810.98
67_K70_Q0.9790.98
353_R356_L0.9730.98
74_E78_N0.9730.98
291_G314_V0.9690.98
75_Q78_N0.9600.98
203_K211_V0.9560.97
106_F132_T0.9540.97
278_E299_D0.9460.97
251_E255_R0.9430.97
144_A148_E0.9420.97
145_E148_E0.9390.97
276_I290_A0.9390.97
66_H70_Q0.9330.97
213_A264_I0.9310.97
187_A195_L0.9310.97
103_G124_K0.9220.97
186_F297_A0.9190.97
67_K75_Q0.9170.97
165_A168_G0.9130.97
68_M101_I0.9110.97
68_M80_V0.9100.97
276_I327_M0.9100.97
106_F142_S0.9090.97
33_Q50_R0.9090.97
231_V251_E0.9050.96
81_V147_C0.9000.96
130_I142_S0.9000.96
17_L205_V0.8990.96
263_D304_Q0.8980.96
104_K146_C0.8970.96
13_V204_N0.8960.96
37_R282_E0.8930.96
40_E121_L0.8880.96
215_E221_S0.8880.96
279_L314_V0.8880.96
225_S249_I0.8870.96
67_K155_I0.8860.96
171_A174_I0.8790.96
182_P209_T0.8770.96
136_F157_P0.8770.96
17_L20_H0.8760.96
92_V103_G0.8740.96
195_L213_A0.8710.96
345_F351_A0.8690.96
231_V248_K0.8690.96
200_T256_T0.8640.95
215_E249_I0.8640.95
230_H254_F0.8630.95
171_A201_Y0.8620.95
97_K124_K0.8590.95
216_P219_A0.8590.95
170_L313_V0.8580.95
97_K122_F0.8490.95
36_D40_E0.8470.95
81_V146_C0.8450.95
291_G315_S0.8410.95
240_F269_E0.8370.95
183_H307_G0.8350.94
275_S295_V0.8350.94
274_T331_S0.8310.94
275_S296_A0.8290.94
215_E223_F0.8250.94
118_Q122_F0.8230.94
218_G237_I0.8220.94
13_V205_V0.8190.94
107_M129_I0.8190.94
42_Y46_I0.8170.94
65_Y69_K0.8100.94
55_V94_F0.8090.93
279_L295_V0.8090.93
67_K162_D0.8060.93
343_V355_F0.8040.93
67_K156_H0.8040.93
298_L302_K0.7970.93
50_R314_V0.7950.93
22_N70_Q0.7930.93
188_S294_S0.7850.92
74_E77_E0.7820.92
72_S153_T0.7770.92
240_F273_C0.7760.92
118_Q282_E0.7740.92
23_V26_V0.7720.92
272_V292_A0.7700.92
130_I146_C0.7700.92
71_L79_G0.7690.92
140_Y156_H0.7670.92
163_V167_Q0.7660.91
354_E358_E0.7630.91
45_N307_G0.7620.91
80_V101_I0.7600.91
31_P50_R0.7600.91
273_C330_R0.7580.91
76_T99_L0.7580.91
48_L314_V0.7570.91
354_E357_D0.7550.91
106_F130_I0.7540.91
233_T247_K0.7480.91
296_A300_L0.7440.90
71_L153_T0.7430.90
273_C289_P0.7430.90
185_L311_V0.7400.90
85_A243_G0.7390.90
67_K163_V0.7390.90
20_H172_V0.7380.90
92_V101_I0.7350.90
184_F310_V0.7350.90
137_D247_K0.7350.90
268_P300_L0.7340.90
351_A356_L0.7310.89
38_L48_L0.7290.89
104_K150_E0.7290.89
15_H165_A0.7280.89
219_A237_I0.7260.89
48_L287_A0.7250.89
301_Y304_Q0.7240.89
210_K262_D0.7230.89
56_V94_F0.7210.89
82_C154_F0.7190.89
28_I55_V0.7170.89
27_V61_L0.7130.88
322_G326_E0.7120.88
61_L95_S0.7110.88
35_N283_C0.7060.88
216_P272_V0.7050.88
119_V124_K0.7010.87
76_T79_G0.6990.87
48_L279_L0.6970.87
14_K18_K0.6970.87
227_K263_D0.6960.87
183_H310_V0.6960.87
18_K21_Q0.6940.87
281_N337_L0.6930.87
267_V297_A0.6920.87
298_L312_C0.6890.87
305_I308_K0.6860.86
273_C327_M0.6860.86
200_T204_N0.6850.86
28_I54_Q0.6840.86
187_A211_V0.6840.86
219_A234_L0.6810.86
81_V106_F0.6800.86
196_S256_T0.6790.86
140_Y154_F0.6780.86
109_S133_G0.6760.86
175_L201_Y0.6750.85
42_Y299_D0.6750.85
83_A143_A0.6740.85
265_L297_A0.6730.85
81_V143_A0.6720.85
234_L237_I0.6670.85
202_L206_S0.6670.85
147_C154_F0.6660.85
50_R285_V0.6650.85
225_S254_F0.6650.85
178_I181_E0.6630.84
109_S132_T0.6630.84
19_A66_H0.6620.84
201_Y205_V0.6620.84
226_N258_E0.6620.84
90_Q119_V0.6610.84
326_E331_S0.6590.84
118_Q121_L0.6560.84
276_I324_M0.6520.83
198_V202_L0.6520.83
225_S229_G0.6510.83
72_S79_G0.6500.83
66_H165_A0.6490.83
24_K29_H0.6490.83
158_F193_G0.6490.83
270_G274_T0.6460.83
156_H163_V0.6450.83
84_S89_A0.6450.83
200_T260_V0.6440.83
38_L46_I0.6440.83
226_N231_V0.6430.83
37_R40_E0.6420.82
271_K296_A0.6390.82
215_E219_A0.6390.82
181_E209_T0.6380.82
301_Y305_I0.6360.82
143_A147_C0.6360.82
75_Q79_G0.6350.82
274_T300_L0.6350.82
41_R282_E0.6330.82
323_R326_E0.6330.82
243_G290_A0.6330.82
277_L321_I0.6320.81
65_Y98_H0.6320.81
115_K242_D0.6310.81
185_L209_T0.6300.81
59_F188_S0.6290.81
66_H69_K0.6270.81
265_L304_Q0.6250.81
170_L174_I0.6250.81
341_F353_R0.6250.81
44_C307_G0.6220.80
82_C156_H0.6220.80
116_V129_I0.6210.80
61_L94_F0.6200.80
241_V244_A0.6170.80
40_E43_E0.6160.80
18_K70_Q0.6160.80
189_V215_E0.6140.80
274_T278_E0.6130.79
164_M253_T0.6130.79
215_E250_G0.6120.79
117_S121_L0.6110.79
175_L179_D0.6100.79
83_A157_P0.6080.79
278_E282_E0.6080.79
175_L205_V0.6080.79
93_A124_K0.6080.79
242_D289_P0.6060.79
324_M341_F0.6060.79
78_N153_T0.6060.79
348_R351_A0.6060.79
322_G325_Q0.6060.79
227_K230_H0.6050.79
189_V291_G0.6050.79
174_I185_L0.6050.79
72_S101_I0.6040.78
213_A261_V0.6040.78
181_E206_S0.6040.78
110_T134_D0.6030.78
179_D182_P0.6020.78
16_I200_T0.6020.78
178_I309_N0.6020.78
241_V290_A0.6000.78
214_V293_L0.5990.78
138_D141_K0.5960.78
182_P206_S0.5930.77
167_Q191_G0.5910.77
295_V298_L0.5910.77
72_S77_E0.5900.77
42_Y298_L0.5880.77
158_F248_K0.5870.77
72_S102_H0.5860.76
271_K302_K0.5860.76
221_S224_E0.5850.76
29_H54_Q0.5830.76
252_E256_T0.5830.76
159_D250_G0.5820.76
312_C315_S0.5810.76
100_G151_S0.5810.76
269_E272_V0.5800.76
345_F355_F0.5800.76
13_V200_T0.5790.76
303_D306_K0.5790.76
215_E244_A0.5750.75
17_L172_V0.5740.75
16_I171_A0.5740.75
302_K305_I0.5730.75
263_D301_Y0.5720.75
88_H167_Q0.5710.75
48_L312_C0.5710.75
186_F212_I0.5700.74
271_K299_D0.5690.74
225_S232_V0.5640.74
257_L264_I0.5600.73
111_T116_V0.5600.73
119_V129_I0.5600.73
20_H29_H0.5600.73
18_K22_N0.5590.73
79_G152_R0.5590.73
349_A352_L0.5580.73
137_D141_K0.5560.73
110_T216_P0.5560.73
91_G136_F0.5550.72
199_G262_D0.5540.72
325_Q328_K0.5540.72
280_Y324_M0.5530.72
48_L295_V0.5520.72
83_A154_F0.5480.72
90_Q115_K0.5480.72
146_C149_A0.5470.71
23_V66_H0.5460.71
84_S288_E0.5450.71
249_I253_T0.5440.71
90_Q118_Q0.5440.71
288_E316_G0.5410.71
85_A191_G0.5410.71
234_L238_D0.5400.70
20_H24_K0.5390.70
321_I331_S0.5380.70
17_L176_N0.5370.70
290_A293_L0.5360.70
90_Q167_Q0.5350.70
36_D45_N0.5350.70
74_E153_T0.5320.69
274_T335_E0.5310.69
257_L260_V0.5300.69
147_C156_H0.5290.69
286_V319_N0.5290.69
228_A231_V0.5290.69
295_V312_C0.5290.69
140_Y147_C0.5280.69
184_F309_N0.5270.69
45_N183_H0.5260.68
345_F352_L0.5250.68
32_L47_Y0.5250.68
205_V209_T0.5250.68
52_D285_V0.5250.68
32_L177_D0.5250.68
176_N205_V0.5230.68
295_V314_V0.5220.68
17_L21_Q0.5210.68
133_G138_D0.5210.68
241_V273_C0.5190.67
230_H233_T0.5170.67
37_R278_E0.5170.67
341_F357_D0.5160.67
95_S99_L0.5160.67
220_A234_L0.5160.67
115_K243_G0.5150.67
15_H161_P0.5140.67
203_K261_V0.5140.67
336_G356_L0.5110.66
190_G246_V0.5110.66
33_Q52_D0.5080.66
344_N354_E0.5080.66
57_R269_E0.5070.66
203_K260_V0.5060.65
157_P191_G0.5050.65
37_R283_C0.5050.65
233_T236_K0.5050.65
160_D163_V0.5050.65
186_F265_L0.5050.65
222_Y226_N0.5040.65
286_V324_M0.5030.65
145_E354_E0.5010.65
199_G261_V0.5010.65
27_V65_Y0.5010.65
325_Q329_E0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tdjA 2 0.9692 100 0.21 Contact Map
2gn0A 2 0.7701 100 0.388 Contact Map
1v71A 2 0.7536 100 0.399 Contact Map
3ss7X 1 0.7796 100 0.417 Contact Map
1ve5A 3 0.718 100 0.421 Contact Map
3l6bA 2 0.7536 100 0.425 Contact Map
3iauA 1 0.7749 100 0.426 Contact Map
4h27A 1 0.7251 100 0.437 Contact Map
2rkbA 2 0.7275 100 0.438 Contact Map
4d9iA 2 0.7749 100 0.444 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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