GREMLIN Database
LON1 - Lon protease 1
UniProt: P37945 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 774 (763)
Sequences: 3203 (1837)
Seq/√Len: 66.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
714_I717_L5.2791.00
736_K739_E4.8391.00
315_G319_D4.6921.00
502_K524_D4.6701.00
736_K759_S4.5501.00
305_T413_K4.4341.00
320_E369_K4.1591.00
49_F96_A3.7471.00
731_T756_I3.6011.00
341_L555_A3.5911.00
499_E503_D3.5471.00
407_G418_F3.4401.00
99_V113_Q3.3851.00
506_L522_L3.3731.00
100_K111_D3.1841.00
613_V685_A3.1231.00
254_E258_E3.0681.00
321_E369_K3.0521.00
184_T189_D3.0521.00
405_I459_F3.0431.00
747_E750_R3.0351.00
734_A757_L3.0061.00
97_H113_Q2.9941.00
557_A575_D2.9831.00
756_I767_H2.9631.00
630_D633_R2.9591.00
550_I568_V2.9191.00
721_A755_F2.8221.00
731_T754_T2.8131.00
523_R526_A2.8081.00
700_G729_L2.7801.00
269_A296_L2.7681.00
529_D533_Y2.7621.00
758_A763_E2.7111.00
304_E463_K2.7101.00
725_H752_G2.7001.00
698_E730_T2.6961.00
506_L547_L2.6921.00
569_T572_N2.6631.00
253_T277_E2.6571.00
426_M438_M2.6111.00
655_D659_K2.5961.00
304_E414_L2.5891.00
263_D267_E2.5761.00
256_I269_A2.5571.00
165_D190_R2.5181.00
256_I273_L2.4891.00
414_L459_F2.4661.00
717_L734_A2.4601.00
9_I72_Y2.4101.00
680_I764_V2.4021.00
624_L636_A2.3761.00
315_G560_A2.3651.00
180_D193_K2.3631.00
266_K270_L2.3501.00
72_Y96_A2.3421.00
522_L550_I2.3381.00
733_I767_H2.3271.00
530_I550_I2.3091.00
513_H548_A2.3031.00
262_P265_V2.3011.00
742_I757_L2.2981.00
763_E766_E2.2891.00
646_K649_E2.2851.00
556_K560_A2.2771.00
520_L551_C2.2351.00
51_A98_I2.2251.00
313_E316_R2.1811.00
305_T374_K2.1661.00
619_K658_E2.1651.00
299_L459_F2.1401.00
731_T767_H2.1391.00
733_I758_A2.1081.00
646_K762_D2.1071.00
296_L457_E2.1061.00
11_L110_V2.1001.00
259_A303_D2.1001.00
530_I577_I2.0731.00
495_I748_S2.0691.00
31_R53_Q2.0681.00
408_M459_F2.0581.00
533_Y580_R2.0561.00
683_A705_I2.0471.00
481_R486_I2.0361.00
498_L528_L2.0291.00
51_A66_I1.9991.00
494_E532_R1.9891.00
509_Q548_A1.9681.00
316_R320_E1.9641.00
739_E757_L1.9141.00
312_K560_A1.8941.00
352_L367_I1.8901.00
633_R637_Q1.8901.00
620_G661_D1.8891.00
228_L235_I1.8821.00
308_K313_E1.8771.00
179_Q183_E1.8721.00
261_M297_V1.8711.00
473_L486_I1.8701.00
684_T768_A1.8661.00
693_R769_L1.8581.00
758_A764_V1.8531.00
103_E106_D1.8521.00
376_V411_A1.8511.00
506_L527_I1.8511.00
529_D570_E1.8311.00
186_D189_D1.8171.00
747_E751_E1.8161.00
177_D180_D1.8121.00
414_L463_K1.8101.00
313_E317_L1.8091.00
529_D580_R1.8081.00
572_N576_F1.8071.00
253_T270_L1.8041.00
384_R453_H1.8001.00
333_L556_K1.7981.00
257_E266_K1.7931.00
374_K413_K1.7931.00
699_V731_T1.7911.00
11_L49_F1.7881.00
389_I441_V1.7881.00
71_T92_G1.7811.00
529_D573_L1.7791.00
613_V689_A1.7791.00
591_D770_V1.7751.00
74_K93_L1.7671.00
376_V418_F1.7651.00
124_E188_K1.7591.00
499_E502_K1.7591.00
705_I761_L1.7561.00
261_M269_A1.7521.00
687_V765_L1.7501.00
256_I270_L1.7391.00
608_T727_A1.7211.00
714_I734_A1.6950.99
177_D200_N1.6920.99
30_G34_S1.6750.99
478_G481_R1.6740.99
684_T764_V1.6580.99
557_A576_F1.6540.99
232_M235_I1.6490.99
516_K519_N1.6430.99
554_A566_I1.6420.99
498_L524_D1.6390.99
509_Q544_E1.6360.99
615_L689_A1.6340.99
666_V682_M1.6320.99
164_A191_L1.6250.99
759_S763_E1.6200.99
526_A573_L1.6150.99
508_K544_E1.6150.99
380_L420_L1.6140.99
58_I65_E1.6050.99
374_K412_G1.6020.99
721_A732_I1.5990.99
367_I467_I1.5940.99
33_K60_E1.5940.99
734_A742_I1.5940.99
260_G302_T1.5910.99
593_V692_G1.5840.99
98_I110_V1.5810.99
267_E412_G1.5780.99
523_R567_T1.5680.99
138_Q206_E1.5680.99
117_E161_G1.5660.99
733_I764_V1.5660.99
31_R34_S1.5610.99
714_I721_A1.5580.99
118_D186_D1.5520.99
451_S458_T1.5520.99
520_L550_I1.5500.99
683_A761_L1.5500.99
616_S641_S1.5430.99
680_I758_A1.5380.99
472_N475_T1.5270.99
521_Q567_T1.5240.99
95_R190_R1.5230.99
502_K527_I1.5200.99
94_K114_L1.5180.99
521_Q565_R1.5160.99
750_R755_F1.5140.99
165_D185_A1.5060.99
256_I261_M1.4950.99
15_R31_R1.4700.98
68_T97_H1.4680.98
717_L757_L1.4670.98
623_I637_Q1.4650.98
721_A734_A1.4580.98
31_R61_P1.4560.98
263_D266_K1.4540.98
48_I73_T1.4470.98
557_A562_E1.4430.98
132_L191_L1.4340.98
8_S111_D1.4340.98
546_Q581_I1.4320.98
642_Y761_L1.4320.98
72_Y94_K1.4300.98
327_K549_A1.4290.98
63_E101_Y1.4250.98
394_R456_E1.4190.98
530_I547_L1.4180.98
69_V185_A1.4140.98
696_S731_T1.4130.98
302_T414_L1.4080.98
261_M296_L1.4080.98
649_E762_D1.4040.98
384_R387_S1.3980.98
269_A293_I1.3970.98
161_G164_A1.3960.98
554_A558_I1.3910.98
680_I711_V1.3870.98
509_Q547_L1.3850.98
275_R291_N1.3830.98
295_W406_Q1.3800.98
15_R53_Q1.3770.98
216_K220_E1.3740.98
615_L660_Y1.3700.98
717_L721_A1.3610.97
624_L633_R1.3600.97
317_L369_K1.3570.97
640_F662_I1.3500.97
330_E553_K1.3480.97
591_D697_R1.3450.97
526_A570_E1.3430.97
214_R237_K1.3430.97
181_I194_V1.3390.97
328_V352_L1.3320.97
684_T695_V1.3320.97
627_K630_D1.3310.97
643_V687_V1.3270.97
584_Y607_D1.3230.97
618_G661_D1.3190.97
734_A755_F1.3140.97
184_T193_K1.3120.97
611_I681_T1.3100.97
583_R737_D1.3070.97
66_I98_I1.3020.97
260_G306_D1.3010.97
161_G165_D1.2990.97
142_I205_L1.2980.97
662_I690_L1.2950.97
739_E743_E1.2920.97
252_L294_D1.2900.96
55_D58_I1.2870.96
69_V115_I1.2870.96
49_F112_I1.2840.96
662_I686_L1.2820.96
95_R165_D1.2820.96
553_K576_F1.2800.96
599_L732_I1.2790.96
546_Q549_A1.2780.96
256_I297_V1.2770.96
341_L558_I1.2650.96
375_F419_L1.2630.96
221_R225_E1.2630.96
130_R201_E1.2580.96
498_L531_I1.2530.96
572_N575_D1.2510.96
524_D528_L1.2510.96
269_A273_L1.2450.96
423_I438_M1.2450.96
132_L198_I1.2410.96
378_I407_G1.2360.95
15_R30_G1.2320.95
522_L573_L1.2310.95
522_L547_L1.2310.95
364_A419_L1.2290.95
525_Q570_E1.2280.95
8_S109_S1.2280.95
596_V681_T1.2250.95
628_L666_V1.2240.95
315_G333_L1.2210.95
315_G556_K1.2190.95
636_A664_I1.2170.95
721_A753_L1.2130.95
656_F690_L1.2100.95
284_A397_V1.2020.95
574_Q743_E1.2010.95
657_H690_L1.2000.95
259_A262_P1.1950.95
259_A269_A1.1920.95
647_T652_I1.1900.94
579_K743_E1.1880.94
371_L465_L1.1860.94
50_L73_T1.1850.94
346_K512_E1.1850.94
98_I101_Y1.1820.94
34_S53_Q1.1770.94
341_L559_V1.1770.94
260_G263_D1.1660.94
37_A41_A1.1650.94
299_L405_I1.1650.94
210_K214_R1.1610.94
160_P164_A1.1590.94
542_S545_R1.1580.94
758_A767_H1.1480.93
765_L769_L1.1480.93
328_V489_I1.1480.93
520_L554_A1.1450.93
47_M93_L1.1410.93
135_H195_I1.1400.93
307_D371_L1.1380.93
258_E263_D1.1360.93
40_Q44_H1.1350.93
473_L481_R1.1340.93
68_T183_E1.1330.93
174_K177_D1.1320.93
408_M464_V1.1320.93
363_L489_I1.1240.93
53_Q61_P1.1230.93
760_H763_E1.1230.93
30_G53_Q1.1220.93
764_V768_A1.1220.93
49_F98_I1.1200.92
376_V407_G1.1170.92
493_T718_K1.1150.92
408_M414_L1.1110.92
687_V769_L1.1090.92
295_W409_K1.1080.92
12_L48_I1.1060.92
255_K298_A1.1030.92
291_N454_Y1.1020.92
568_V573_L1.1000.92
160_P191_L1.1000.92
742_I755_F1.0980.92
509_Q551_C1.0860.91
173_L197_F1.0810.91
15_R34_S1.0750.91
40_Q107_Y1.0740.91
340_K559_V1.0740.91
375_F379_S1.0720.91
668_E706_T1.0710.91
258_E306_D1.0690.91
279_I287_S1.0670.91
595_V610_S1.0670.91
522_L526_A1.0630.90
51_A110_V1.0580.90
375_F417_V1.0580.90
345_L348_P1.0580.90
279_I289_I1.0560.90
193_K196_D1.0540.90
600_A609_L1.0540.90
47_M74_K1.0540.90
299_L455_I1.0520.90
314_A317_L1.0510.90
353_A472_N1.0510.90
706_T712_L1.0500.90
510_I520_L1.0470.90
341_L519_N1.0440.90
250_Q253_T1.0430.89
52_T175_L1.0420.89
523_R569_T1.0400.89
203_E206_E1.0380.89
353_A473_L1.0350.89
19_V73_T1.0350.89
250_Q254_E1.0310.89
28_D87_R1.0290.89
596_V695_V1.0290.89
321_E366_S1.0280.89
312_K562_E1.0270.89
542_S546_Q1.0260.89
314_A336_L1.0250.89
323_H499_E1.0210.88
96_A112_I1.0210.88
270_L273_L1.0200.88
311_L337_A1.0110.88
554_A576_F1.0100.88
544_E548_A1.0090.88
377_R484_M1.0090.88
39_E80_K1.0070.88
307_D415_N1.0040.88
475_T481_R1.0040.88
61_P65_E1.0040.88
303_D306_D1.0020.88
699_V767_H1.0000.87
646_K650_L0.9980.87
129_M133_L0.9970.87
683_A687_V0.9950.87
263_D306_D0.9930.87
132_L195_I0.9920.87
445_E508_K0.9910.87
652_I691_T0.9910.87
279_I286_S0.9890.87
273_L297_V0.9840.87
131_T195_I0.9810.86
334_E556_K0.9780.86
353_A481_R0.9770.86
730_T752_G0.9770.86
383_V453_H0.9730.86
11_L96_A0.9720.86
599_L700_G0.9710.86
225_E239_L0.9660.86
296_L455_I0.9660.86
523_R571_K0.9650.85
38_L86_I0.9640.85
63_E68_T0.9610.85
510_I517_K0.9580.85
122_D188_K0.9580.85
253_T257_E0.9560.85
650_L687_V0.9550.85
622_L640_F0.9550.85
249_V273_L0.9550.85
243_E246_T0.9540.85
223_Q226_Y0.9520.85
742_I745_I0.9520.85
617_P660_Y0.9500.85
168_A181_I0.9490.85
680_I683_A0.9470.84
575_D747_E0.9470.84
451_S456_E0.9460.84
501_V527_I0.9450.84
435_S477_P0.9440.84
261_M265_V0.9430.84
721_A750_R0.9420.84
732_I753_L0.9400.84
472_N481_R0.9400.84
157_I166_I0.9360.84
99_V111_D0.9340.84
215_V234_A0.9330.83
510_I515_L0.9320.83
295_W455_I0.9320.83
51_A96_A0.9310.83
15_R61_P0.9290.83
647_T651_G0.9290.83
621_K661_D0.9270.83
256_I259_A0.9240.83
49_F72_Y0.9230.83
642_Y646_K0.9210.83
255_K297_V0.9200.83
16_G28_D0.9180.82
214_R234_A0.9150.82
601_Y723_G0.9140.82
600_A723_G0.9140.82
127_A130_R0.9130.82
732_I755_F0.9130.82
26_H76_K0.9110.82
365_K445_E0.9090.82
11_L51_A0.9090.82
115_I185_A0.9060.82
761_L765_L0.9050.82
644_R656_F0.9030.81
235_I239_L0.9030.81
607_D611_I0.9010.81
219_M226_Y0.9010.81
596_V685_A0.9010.81
721_A757_L0.9000.81
383_V426_M0.8970.81
58_I61_P0.8950.81
519_N558_I0.8950.81
228_L239_L0.8940.81
616_S644_R0.8940.81
423_I426_M0.8930.81
627_K668_E0.8880.80
130_R204_V0.8880.80
256_I293_I0.8870.80
405_I408_M0.8860.80
218_S237_K0.8850.80
257_E270_L0.8830.80
734_A739_E0.8810.80
555_A559_V0.8800.80
50_L90_V0.8790.80
265_V457_E0.8790.80
736_K763_E0.8750.79
312_K316_R0.8750.79
652_I687_V0.8720.79
14_L50_L0.8670.79
644_R657_H0.8640.78
259_A302_T0.8640.78
330_E556_K0.8630.78
230_E233_K0.8600.78
510_I551_C0.8560.78
259_A266_K0.8560.78
590_E593_V0.8530.78
507_P511_K0.8520.78
725_H749_V0.8520.78
525_Q571_K0.8490.77
687_V761_L0.8490.77
140_I146_I0.8480.77
231_Q238_E0.8450.77
426_M477_P0.8420.77
79_L82_P0.8410.77
523_R570_E0.8410.77
63_E108_T0.8410.77
275_R295_W0.8400.77
94_K116_H0.8390.76
308_K372_G0.8390.76
617_P654_P0.8360.76
161_G190_R0.8360.76
326_E330_E0.8350.76
309_L340_K0.8340.76
102_N106_D0.8340.76
163_M167_V0.8340.76
52_T179_Q0.8340.76
509_Q512_E0.8330.76
636_A681_T0.8300.76
498_L502_K0.8290.76
315_G330_E0.8280.75
714_I757_L0.8280.75
62_G65_E0.8280.75
528_L532_R0.8270.75
597_T610_S0.8270.75
32_D36_Q0.8260.75
494_E528_L0.8250.75
323_H503_D0.8230.75
11_L108_T0.8230.75
317_L320_E0.8220.75
251_T271_K0.8190.75
696_S768_A0.8190.75
24_V76_K0.8180.75
363_L406_Q0.8180.75
379_S409_K0.8170.74
614_S641_S0.8150.74
259_A273_L0.8120.74
310_D313_E0.8110.74
713_P737_D0.8080.74
721_A742_I0.8070.74
643_V705_I0.8060.73
710_R759_S0.8060.73
127_A204_V0.8050.73
16_G87_R0.8050.73
353_A475_T0.8050.73
34_S61_P0.8040.73
307_D374_K0.8040.73
371_L417_V0.8040.73
271_K409_K0.8030.73
757_L763_E0.8030.73
761_L764_V0.8020.73
660_Y690_L0.7990.73
622_L636_A0.7960.73
302_T459_F0.7960.73
97_H115_I0.7950.72
557_A561_E0.7920.72
587_A727_A0.7920.72
369_K504_H0.7910.72
551_C555_A0.7900.72
738_N741_D0.7880.72
597_T608_T0.7880.72
408_M411_A0.7870.72
76_K91_E0.7850.72
532_R584_Y0.7850.72
526_A568_V0.7830.71
369_K372_G0.7830.71
680_I761_L0.7820.71
384_R429_D0.7810.71
681_T723_G0.7810.71
211_I228_L0.7780.71
696_S770_V0.7770.71
621_K637_Q0.7750.71
699_V768_A0.7730.70
714_I738_N0.7720.70
42_M78_M0.7720.70
575_D751_E0.7720.70
595_V710_R0.7690.70
72_Y112_I0.7650.70
380_L390_R0.7620.69
242_K245_K0.7600.69
19_V25_L0.7570.69
763_E767_H0.7560.69
253_T273_L0.7560.69
297_V457_E0.7560.69
26_H87_R0.7550.69
27_L363_L0.7530.68
117_E187_V0.7530.68
34_S37_A0.7530.68
408_M455_I0.7520.68
152_A156_D0.7510.68
643_V686_L0.7500.68
522_L554_A0.7490.68
725_H746_P0.7470.68
718_K722_L0.7460.68
506_L550_I0.7440.67
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291_N295_W0.5300.43
331_R334_E0.5300.43
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550_I554_A0.5290.43
230_E237_K0.5280.43
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320_E372_G0.5200.42
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332_I465_L0.5140.41
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110_V489_I0.5130.41
231_Q235_I0.5130.41
508_K548_A0.5130.41
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338_V514_G0.5120.41
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717_L725_H0.5110.41
28_D76_K0.5090.40
93_L550_I0.5090.40
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572_N577_I0.5080.40
37_A53_Q0.5080.40
682_M696_S0.5080.40
288_V453_H0.5070.40
547_L570_E0.5070.40
133_L143_S0.5070.40
15_R55_D0.5070.40
509_Q514_G0.5070.40
554_A568_V0.5070.40
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721_A733_I0.5060.40
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78_M192_N0.5060.40
695_V769_L0.5050.40
257_E263_D0.5050.40
743_E750_R0.5050.40
129_M132_L0.5050.40
189_D569_T0.5040.40
112_I258_E0.5040.40
233_K455_I0.5040.40
275_R294_D0.5030.40
312_K561_E0.5030.40
285_E289_I0.5030.40
366_S369_K0.5030.40
262_P408_M0.5030.40
664_I705_I0.5030.40
62_G100_K0.5020.40
517_K521_Q0.5020.40
305_T371_L0.5020.40
128_L195_I0.5020.40
640_F644_R0.5020.40
750_R757_L0.5020.40
379_S547_L0.5010.40
435_S616_S0.5010.40
601_Y674_D0.5010.40
33_K105_E0.5010.40
62_G68_T0.5010.40
227_Y234_A0.5010.40
417_V529_D0.5010.40
201_E553_K0.5010.40
320_E352_L0.5000.39
390_R420_L0.5000.39
330_E642_Y0.5000.39
211_I239_L0.5000.39
102_N105_E0.5000.39
614_S640_F0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m6aA 3 0.6408 100 0.552 Contact Map
3k1jA 4 0.5736 100 0.728 Contact Map
4fwgA 3 0.6395 100 0.783 Contact Map
3wu4A 3 0.2403 100 0.83 Contact Map
2x36A 3 0.2442 100 0.831 Contact Map
3ljcA 1 0.3088 100 0.845 Contact Map
1xhkA 2 0.23 100 0.846 Contact Map
1z0wA 3 0.239 100 0.849 Contact Map
4gitA 2 0.1189 100 0.856 Contact Map
1qvrA 3 0.6408 100 0.865 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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