GREMLIN Database
AROK - Shikimate kinase
UniProt: P37944 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 186 (160)
Sequences: 9799 (6819)
Seq/√Len: 539.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_W141_E3.0101.00
163_L171_Y2.9831.00
49_D76_D2.8841.00
34_K173_V2.7471.00
46_I70_E2.2941.00
30_L169_A2.2931.00
57_I66_F2.2501.00
112_D158_V2.2151.00
55_P59_E2.2081.00
133_H136_S2.1661.00
126_I129_R2.0231.00
117_N120_Q2.0001.00
163_L167_E1.9731.00
45_Q48_K1.9301.00
53_S56_E1.8751.00
28_G39_F1.8661.00
34_K169_A1.8471.00
141_E145_N1.8101.00
138_D142_Q1.8071.00
142_Q146_E1.6931.00
71_K101_C1.6841.00
103_L154_H1.6661.00
52_M61_K1.6581.00
96_E100_N1.6401.00
152_D158_V1.5631.00
110_H158_V1.5491.00
148_K152_D1.5441.00
164_S167_E1.5221.00
71_K95_Q1.5091.00
112_D159_A1.5031.00
132_L136_S1.4541.00
15_V106_C1.4411.00
71_K97_E1.4371.00
110_H148_K1.4201.00
71_K92_S1.3931.00
22_V113_L1.3911.00
27_I172_I1.3861.00
35_L173_V1.3851.00
45_Q73_Y1.3811.00
68_K72_E1.3491.00
117_N162_N1.3331.00
169_A173_V1.3281.00
42_I92_S1.3141.00
30_L33_K1.3131.00
65_F69_T1.3071.00
68_K95_Q1.3051.00
50_F58_F1.2861.00
77_I80_H1.2731.00
42_I74_I1.2651.00
61_K65_F1.2611.00
111_L161_D1.2371.00
139_E143_L1.2351.00
56_E59_E1.2321.00
19_F140_M1.2061.00
37_R83_F1.1941.00
109_L172_I1.1921.00
157_K175_T1.1901.00
119_K137_M1.1881.00
114_S162_N1.1741.00
137_M141_E1.1721.00
101_C104_E1.1651.00
16_L28_G1.1621.00
30_L166_E1.1531.00
40_I84_K1.1521.00
112_D148_K1.1471.00
128_S131_V1.1461.00
103_L155_N1.1431.00
49_D73_Y1.1421.00
65_F68_K1.1411.00
149_V153_K1.1221.00
140_M144_F1.1141.00
72_E75_L1.1071.00
71_K98_I1.1061.00
52_M56_E1.0931.00
119_K123_D1.0911.00
143_L147_R1.0871.00
135_R139_E1.0861.00
99_R153_K1.0721.00
27_I169_A1.0701.00
132_L135_R1.0631.00
69_T72_E1.0601.00
107_L157_K1.0601.00
170_D174_E1.0491.00
75_L79_H1.0451.00
128_S133_H1.0391.00
50_F65_F1.0391.00
114_S161_D1.0371.00
97_E100_N1.0351.00
27_I168_V1.0251.00
45_Q49_D1.0171.00
100_N104_E1.0161.00
94_K146_E1.0101.00
130_P133_H1.0091.00
56_E61_K1.0081.00
32_A39_F1.0071.00
113_L118_W1.0031.00
44_Q47_E0.9931.00
54_I58_F0.9891.00
163_L168_V0.9841.00
57_I63_E0.9821.00
50_F69_T0.9821.00
94_K150_I0.9811.00
114_S117_N0.9691.00
16_L31_V0.9561.00
170_D173_V0.9531.00
115_W137_M0.9471.00
171_Y174_E0.9461.00
116_E120_Q0.9411.00
75_L105_N0.9401.00
140_M147_R0.9331.00
13_N84_K0.9231.00
113_L121_R0.9161.00
144_F147_R0.9141.00
54_I57_I0.9141.00
112_D157_K0.9111.00
167_E171_Y0.9111.00
29_Q33_K0.9101.00
139_E142_Q0.9011.00
76_D80_H0.8991.00
144_F148_K0.8981.00
127_E130_P0.8891.00
13_N83_F0.8751.00
111_L172_I0.8671.00
127_E133_H0.8661.00
37_R84_K0.8621.00
150_I154_H0.8581.00
100_N103_L0.8551.00
171_Y175_T0.8431.00
15_V86_V0.8381.00
38_D77_I0.8361.00
93_F150_I0.8281.00
17_I108_V0.8161.00
102_C108_V0.8161.00
165_P169_A0.8151.00
30_L34_K0.8141.00
39_F87_S0.8071.00
127_E131_V0.7991.00
99_R150_I0.7931.00
160_T163_L0.7891.00
44_Q48_K0.7891.00
19_F118_W0.7811.00
47_E53_S0.7791.00
149_V152_D0.7741.00
113_L117_N0.7731.00
102_C106_C0.7661.00
13_N37_R0.7641.00
66_F69_T0.7601.00
135_R138_D0.7581.00
115_W119_K0.7551.00
71_K74_I0.7551.00
129_R132_L0.7451.00
140_M143_L0.7451.00
29_Q39_F0.7451.00
145_N149_V0.7411.00
64_D95_Q0.7391.00
21_G122_A0.7381.00
31_V172_I0.7381.00
26_T165_P0.7331.00
64_D68_K0.7311.00
53_S72_E0.7271.00
49_D72_E0.7261.00
57_I65_F0.7211.00
74_I92_S0.7211.00
130_P134_N0.7181.00
126_I130_P0.7181.00
17_I154_H0.7151.00
126_I131_V0.7081.00
145_N148_K0.7051.00
77_I81_K0.7041.00
42_I73_Y0.7041.00
75_L101_C0.6871.00
155_N159_A0.6841.00
156_S175_T0.6831.00
29_Q32_A0.6731.00
34_K170_D0.6731.00
134_N139_E0.6631.00
27_I165_P0.6621.00
136_S139_E0.6611.00
25_T29_Q0.6601.00
103_L150_I0.6591.00
15_V102_C0.6571.00
58_F63_E0.6531.00
40_I45_Q0.6501.00
126_I134_N0.6491.00
95_Q98_I0.6491.00
25_T87_S0.6431.00
74_I98_I0.6431.00
103_L151_Y0.6421.00
42_I77_I0.6371.00
43_D47_E0.6301.00
66_F70_E0.6291.00
22_V110_H0.6281.00
41_D87_S0.6271.00
113_L160_T0.6191.00
108_V156_S0.6161.00
143_L146_E0.6091.00
28_G32_A0.6061.00
32_A85_I0.5971.00
15_V78_C0.5961.00
71_K75_L0.5911.00
147_R151_Y0.5901.00
118_W140_M0.5860.99
57_I61_K0.5840.99
107_L176_L0.5810.99
31_V169_A0.5810.99
30_L165_P0.5780.99
50_F57_I0.5760.99
117_N161_D0.5720.99
40_I77_I0.5700.99
53_S68_K0.5650.99
131_V134_N0.5600.99
15_V105_N0.5580.99
45_Q76_D0.5580.99
110_H152_D0.5520.99
113_L161_D0.5510.99
128_S132_L0.5490.99
167_E170_D0.5480.99
16_L111_L0.5470.99
19_F115_W0.5460.99
23_G26_T0.5420.99
19_F143_L0.5400.99
20_M131_V0.5360.99
155_N158_V0.5350.99
109_L156_S0.5340.99
53_S57_I0.5310.99
69_T73_Y0.5310.99
38_D80_H0.5310.99
42_I45_Q0.5290.99
99_R154_H0.5270.99
31_V85_I0.5200.99
96_E99_R0.5160.99
48_K77_I0.5160.99
38_D81_K0.5140.99
103_L106_C0.5140.99
17_I148_K0.5120.99
67_R97_E0.5090.99
52_M57_I0.5090.99
107_L155_N0.5070.99
20_M58_F0.5020.98
54_I72_E0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gmtA 1 0.7849 99.9 0.443 Contact Map
4pzlA 2 0.9355 99.9 0.461 Contact Map
4qbgB 1 0.8925 99.9 0.463 Contact Map
4jzkA 1 0.871 99.9 0.463 Contact Map
3tlxA 1 0.9247 99.9 0.466 Contact Map
1akyA 1 0.8925 99.9 0.467 Contact Map
1ak2A 1 0.9086 99.9 0.468 Contact Map
1zd8A 1 0.8978 99.9 0.47 Contact Map
3be4A 1 0.8925 99.9 0.475 Contact Map
1zakA 2 0.9301 99.9 0.477 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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