GREMLIN Database
ODB2 - Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex
UniProt: P37942 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (398)
Sequences: 7701 (4728)
Seq/√Len: 237.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
319_G323_K3.6501.00
308_K316_D3.4831.00
27_P59_E3.4731.00
58_T78_E3.3591.00
266_E409_R3.3281.00
371_K379_G3.2841.00
322_K326_D3.2561.00
195_K283_K3.1201.00
25_V35_D3.0291.00
196_E278_K3.0281.00
63_E66_Q2.9411.00
323_K333_D2.7881.00
375_V381_I2.6791.00
316_D319_G2.6301.00
128_H153_I2.6121.00
273_M282_K2.5711.00
59_E76_K2.5491.00
225_E372_R2.5331.00
267_F409_R2.5111.00
257_V287_I2.4981.00
205_A208_S2.4951.00
131_D134_Q2.4921.00
25_V57_I2.4821.00
24_L36_P2.4711.00
260_V339_F2.4511.00
32_N54_T2.4361.00
375_V383_V2.3781.00
371_K385_D2.3531.00
5_Q76_K2.3191.00
284_D304_N2.2481.00
197_I281_Q2.2291.00
22_K64_E2.1961.00
61_V76_K2.1941.00
226_V389_L2.1471.00
62_G72_E2.1031.00
5_Q73_M2.0811.00
30_K56_T2.0641.00
308_K312_G2.0261.00
376_M382_A2.0041.00
227_D384_R2.0021.00
219_H392_S1.9871.00
124_L150_Q1.9701.00
337_G360_Q1.9651.00
376_M380_M1.9591.00
26_A29_D1.9571.00
57_I75_C1.9541.00
288_S299_V1.9391.00
265_K306_D1.9161.00
146_R150_Q1.9161.00
264_L339_F1.8991.00
261_A285_I1.8891.00
193_G283_K1.8781.00
199_V274_W1.8551.00
22_K39_E1.8391.00
260_V410_V1.8341.00
134_Q152_L1.8321.00
17_E67_T1.8311.00
123_R127_E1.8281.00
32_N35_D1.8191.00
61_V73_M1.8121.00
196_E280_I1.8051.00
295_D327_G1.7831.00
33_K54_T1.7741.00
261_A305_A1.7561.00
257_V289_I1.7511.00
57_I60_L1.7471.00
20_I38_A1.7441.00
286_N303_K1.7321.00
240_D244_K1.7241.00
269_Q281_Q1.7181.00
243_K249_N1.7021.00
69_Q72_E1.7001.00
257_V305_A1.6951.00
230_N233_A1.6791.00
212_R216_E1.6711.00
205_A209_N1.6501.00
256_F366_V1.6421.00
202_V206_I1.6341.00
409_R412_Q1.6201.00
289_I317_I1.6101.00
324_V329_L1.5991.00
272_S281_Q1.5931.00
38_A74_I1.5931.00
4_E53_F1.5811.00
209_N212_R1.5801.00
214_K219_H1.5721.00
125_A132_L1.5681.00
232_V252_F1.5651.00
257_V317_I1.5611.00
302_I316_D1.5501.00
24_L39_E1.5491.00
262_Q413_I1.5441.00
195_K281_Q1.5311.00
272_S397_V1.5021.00
124_L149_I1.5011.00
150_Q154_E1.4831.00
62_G68_L1.4731.00
309_T312_G1.4671.00
117_Y132_L1.4641.00
237_S418_D1.4611.00
217_I356_I1.4511.00
304_N307_E1.4491.00
373_P381_I1.4391.00
269_Q402_V1.4161.00
257_V341_V1.4111.00
203_R206_I1.4091.00
137_G144_I1.4071.00
263_A410_V1.4051.00
130_I135_V1.3841.00
267_F405_R1.3831.00
229_T384_R1.3791.00
223_M351_Q1.3761.00
194_D280_I1.3731.00
361_A397_V1.3731.00
408_G412_Q1.3391.00
211_K215_T1.3311.00
147_K151_R1.3301.00
354_G365_Q1.3161.00
317_I321_A1.2901.00
39_E48_E1.2891.00
339_F362_A1.2871.00
372_R386_M1.2861.00
208_S212_R1.2841.00
371_K383_V1.2831.00
6_M75_C1.2781.00
27_P63_E1.2781.00
275_A278_K1.2781.00
56_T78_E1.2731.00
389_L410_V1.2711.00
236_N240_D1.2511.00
194_D283_K1.2401.00
198_P278_K1.2271.00
7_T73_M1.2231.00
260_V406_F1.2231.00
222_T403_C1.2201.00
21_S46_N1.2171.00
26_A60_L1.2081.00
239_K249_N1.2031.00
364_L410_V1.2011.00
286_N304_N1.2001.00
284_D306_D1.1981.00
124_L128_H1.1981.00
137_G143_R1.1931.00
231_M255_F1.1931.00
227_D376_M1.1861.00
203_R399_D1.1841.00
373_P383_V1.1831.00
357_N360_Q1.1801.00
196_E275_A1.1691.00
288_S360_Q1.1661.00
217_I358_Y1.1641.00
279_I397_V1.1631.00
222_T393_L1.1601.00
233_A237_S1.1531.00
128_H150_Q1.1511.00
222_T349_S1.1461.00
225_E350_V1.1431.00
258_K262_Q1.1421.00
147_K150_Q1.1351.00
275_A280_I1.1331.00
260_V362_A1.1271.00
274_W397_V1.1261.00
233_A236_N1.1251.00
221_W392_S1.1141.00
132_L144_I1.1111.00
228_V231_M1.1101.00
409_R413_I1.1011.00
229_T233_A1.0951.00
321_A325_R1.0911.00
241_S419_E1.0881.00
56_T81_G1.0861.00
350_V370_V1.0771.00
221_W353_M1.0721.00
411_K415_E1.0671.00
292_A405_R1.0641.00
36_P48_E1.0591.00
257_V302_I1.0511.00
369_I385_D1.0511.00
204_K277_D1.0501.00
224_M411_K1.0481.00
115_K144_I1.0461.00
374_V386_M1.0431.00
366_V387_V1.0391.00
236_N239_K1.0381.00
151_R155_T1.0381.00
292_A347_F1.0331.00
228_V387_V1.0331.00
130_I153_I1.0271.00
270_M398_L1.0261.00
6_M77_I1.0231.00
136_T152_L1.0201.00
90_E93_A1.0171.00
194_D284_D1.0111.00
285_I306_D1.0101.00
211_K217_I1.0091.00
31_V51_S1.0061.00
238_I250_L1.0031.00
330_T333_D0.9961.00
401_L405_R0.9951.00
27_P58_T0.9931.00
374_V384_R0.9891.00
298_F334_M0.9851.00
6_M37_I0.9821.00
232_V385_D0.9821.00
214_K218_P0.9811.00
228_V369_I0.9801.00
376_M384_R0.9751.00
20_I74_I0.9681.00
270_M362_A0.9651.00
223_M353_M0.9641.00
229_T385_D0.9641.00
125_A144_I0.9631.00
257_V313_I0.9601.00
339_F406_F0.9581.00
23_W60_L0.9571.00
220_A393_L0.9551.00
319_G322_K0.9541.00
262_Q265_K0.9541.00
391_L407_L0.9531.00
311_K315_K0.9521.00
62_G66_Q0.9511.00
151_R154_E0.9501.00
286_N301_V0.9491.00
364_L391_L0.9491.00
26_A64_E0.9481.00
8_M18_G0.9481.00
15_V18_G0.9471.00
125_A130_I0.9461.00
27_P60_L0.9451.00
262_Q420_K0.9441.00
53_F77_I0.9431.00
246_E315_K0.9371.00
226_V411_K0.9361.00
20_I62_G0.9331.00
153_I156_G0.9301.00
120_A146_R0.9251.00
130_I149_I0.9231.00
17_E69_Q0.9221.00
266_E413_I0.9221.00
304_N308_K0.9171.00
292_A401_L0.9111.00
125_A135_V0.9071.00
194_D282_K0.9061.00
68_L72_E0.9051.00
323_K330_T0.9041.00
298_F329_L0.9011.00
121_V146_R0.8971.00
139_G148_D0.8961.00
222_T407_L0.8941.00
219_H356_I0.8941.00
339_F364_L0.8910.99
395_H400_G0.8870.99
265_K285_I0.8830.99
132_L135_V0.8820.99
260_V364_L0.8760.99
98_A102_V0.8760.99
31_V57_I0.8750.99
201_G204_K0.8730.99
138_T148_D0.8730.99
254_A310_I0.8720.99
379_G383_V0.8710.99
117_Y125_A0.8670.99
139_G142_G0.8620.99
204_K208_S0.8600.99
86_E89_Q0.8590.99
11_L18_G0.8570.99
302_I317_I0.8560.99
344_T352_S0.8550.99
302_I308_K0.8550.99
37_I51_S0.8550.99
40_V49_V0.8540.99
138_T142_G0.8520.99
24_L48_E0.8510.99
221_W390_C0.8440.99
138_T145_T0.8430.99
206_I210_M0.8420.99
376_M379_G0.8410.99
60_L63_E0.8390.99
312_G315_K0.8360.99
329_L334_M0.8350.99
214_K217_I0.8330.99
339_F391_L0.8310.99
214_K355_I0.8300.99
137_G142_G0.8290.99
121_V149_I0.8280.99
350_V388_N0.8150.99
8_M40_V0.8140.99
60_L66_Q0.8110.99
135_V152_L0.8080.99
393_L403_C0.8030.99
19_T67_T0.8000.99
58_T76_K0.7990.99
256_F387_V0.7960.99
25_V29_D0.7940.99
34_Y50_P0.7910.99
87_Q91_Q0.7910.99
199_V279_I0.7910.99
243_K246_E0.7880.99
371_K378_N0.7790.99
228_V414_L0.7790.99
222_T367_E0.7770.99
149_I152_L0.7740.99
234_Y255_F0.7710.99
241_S245_T0.7690.98
366_V389_L0.7680.98
362_A391_L0.7680.98
19_T65_G0.7640.98
157_G160_E0.7640.98
90_E94_A0.7620.98
30_K54_T0.7550.98
199_V276_G0.7530.98
248_F315_K0.7510.98
202_V295_D0.7500.98
115_K133_D0.7480.98
11_L40_V0.7480.98
193_G284_D0.7450.98
303_K332_D0.7440.98
33_K51_S0.7430.98
225_E386_M0.7410.98
117_Y121_V0.7390.98
51_S54_T0.7360.98
254_A313_I0.7340.98
99_E102_V0.7330.98
121_V125_A0.7320.98
225_E370_V0.7310.98
288_S337_G0.7310.98
240_D243_K0.7290.98
4_E79_T0.7280.98
270_M402_V0.7260.98
271_N338_T0.7250.98
262_Q266_E0.7230.98
202_V293_T0.7230.98
160_E163_P0.7220.98
241_S244_K0.7220.98
323_K328_K0.7210.98
319_G333_D0.7200.98
223_M390_C0.7160.98
154_E157_G0.7150.98
270_M361_A0.7150.98
350_V368_S0.7150.98
286_N333_D0.7130.98
286_N360_Q0.7120.98
124_L146_R0.7100.97
58_T80_E0.7090.97
152_L156_G0.7090.97
293_T298_F0.7080.97
291_V325_R0.7070.97
362_A398_L0.7060.97
308_K319_G0.7050.97
125_A131_D0.7050.97
332_D335_Q0.7040.97
351_Q388_N0.7040.97
239_K243_K0.7020.97
256_F414_L0.7010.97
331_A335_Q0.7000.97
213_S219_H0.7000.97
156_G159_Q0.7000.97
237_S416_S0.6990.97
260_V263_A0.6990.97
16_T69_Q0.6990.97
250_L254_A0.6980.97
209_N357_N0.6980.97
31_V77_I0.6960.97
344_T365_Q0.6960.97
226_V414_L0.6940.97
389_L407_L0.6940.97
214_K392_S0.6910.97
224_M349_S0.6890.97
228_V385_D0.6890.97
10_Q13_E0.6860.97
264_L406_F0.6850.97
286_N337_G0.6840.97
312_G316_D0.6830.97
252_F369_I0.6830.97
210_M299_V0.6830.97
125_A149_I0.6820.97
267_F402_V0.6810.97
263_A409_R0.6810.97
318_T322_K0.6800.97
238_I241_S0.6780.97
305_A313_I0.6740.97
250_L255_F0.6730.97
36_P39_E0.6690.96
416_S419_E0.6690.96
222_T344_T0.6680.96
337_G357_N0.6680.96
37_I75_C0.6670.96
214_K221_W0.6660.96
137_G148_D0.6650.96
197_I269_Q0.6630.96
391_L403_C0.6590.96
30_K80_E0.6590.96
406_F410_V0.6580.96
270_M406_F0.6580.96
213_S358_Y0.6570.96
230_N384_R0.6570.96
20_I60_L0.6570.96
371_K375_V0.6570.96
301_V336_G0.6570.96
51_S77_I0.6540.96
56_T80_E0.6520.96
124_L130_I0.6520.96
356_I362_A0.6510.96
410_V414_L0.6490.96
230_N418_D0.6490.96
323_K329_L0.6480.96
24_L27_P0.6460.96
211_K214_K0.6450.96
183_E186_S0.6450.96
192_A284_D0.6440.96
269_Q272_S0.6440.96
375_V378_N0.6440.96
115_K132_L0.6390.95
5_Q61_V0.6390.95
344_T349_S0.6360.95
253_F256_F0.6350.95
225_E388_N0.6350.95
117_Y144_I0.6340.95
121_V144_I0.6340.95
256_F341_V0.6340.95
199_V278_K0.6340.95
80_E83_N0.6330.95
8_M68_L0.6330.95
216_E358_Y0.6320.95
376_M383_V0.6320.95
11_L14_S0.6310.95
301_V360_Q0.6300.95
244_K247_G0.6280.95
91_Q94_A0.6280.95
303_K316_D0.6250.95
287_I339_F0.6240.95
264_L285_I0.6230.95
376_M381_I0.6230.95
188_P191_A0.6220.95
92_P95_S0.6220.95
107_G110_D0.6220.95
292_A402_V0.6160.94
10_Q14_S0.6160.94
190_S193_G0.6150.94
11_L49_V0.6150.94
337_G358_Y0.6150.94
300_P337_G0.6140.94
199_V275_A0.6130.94
18_G40_V0.6120.94
38_A49_V0.6120.94
4_E7_T0.6100.94
253_F341_V0.6090.94
100_N103_A0.6090.94
340_T360_Q0.6080.94
34_Y54_T0.6070.94
86_E90_E0.6040.94
21_S65_G0.6040.94
379_G385_D0.6020.94
27_P76_K0.6020.94
139_G145_T0.6000.94
412_Q419_E0.6000.94
253_F289_I0.5990.93
301_V337_G0.5990.93
253_F346_S0.5990.93
36_P50_P0.5980.93
224_M407_L0.5970.93
97_A101_P0.5960.93
264_L270_M0.5960.93
231_M414_L0.5950.93
261_A265_K0.5950.93
79_T82_A0.5950.93
259_A414_L0.5940.93
351_Q354_G0.5940.93
207_A274_W0.5900.93
192_A283_K0.5900.93
263_A413_I0.5890.93
180_E183_E0.5880.93
89_Q93_A0.5860.93
232_V369_I0.5850.93
235_R239_K0.5850.93
15_V70_V0.5840.93
289_I341_V0.5830.93
21_S24_L0.5810.92
89_Q92_P0.5810.92
351_Q390_C0.5810.92
97_A100_N0.5780.92
6_M52_S0.5780.92
150_Q153_I0.5770.92
354_G390_C0.5770.92
153_I157_G0.5770.92
371_K376_M0.5770.92
372_R388_N0.5760.92
18_G42_T0.5750.92
124_L153_I0.5730.92
109_A112_P0.5720.92
88_K91_Q0.5720.92
262_Q409_R0.5710.92
18_G45_V0.5710.92
330_T335_Q0.5700.92
39_E46_N0.5690.92
142_G148_D0.5680.92
93_A96_E0.5670.91
4_E77_I0.5650.91
8_M74_I0.5640.91
7_T71_G0.5610.91
371_K381_I0.5600.91
303_K333_D0.5600.91
316_D323_K0.5590.91
93_A97_A0.5590.91
98_A104_K0.5580.91
134_Q156_G0.5570.91
87_Q90_E0.5550.91
88_K93_A0.5550.91
120_A124_L0.5550.91
20_I52_S0.5530.90
130_I134_Q0.5520.90
211_K218_P0.5510.90
88_K92_P0.5490.90
352_S367_E0.5470.90
221_W365_Q0.5470.90
58_T79_T0.5460.90
417_I420_K0.5460.90
203_R207_A0.5460.90
128_H154_E0.5450.90
135_V144_I0.5440.90
227_D230_N0.5430.90
88_K94_A0.5420.90
192_A286_N0.5420.90
273_M280_I0.5410.89
144_I149_I0.5410.89
269_Q279_I0.5400.89
367_E404_G0.5390.89
8_M75_C0.5390.89
30_K57_I0.5390.89
92_P96_E0.5390.89
365_Q392_S0.5390.89
402_V405_R0.5380.89
285_I338_T0.5370.89
96_E107_G0.5370.89
253_F343_N0.5360.89
290_A297_L0.5360.89
347_F404_G0.5360.89
89_Q95_S0.5360.89
20_I68_L0.5350.89
264_L362_A0.5350.89
86_E92_P0.5350.89
218_P396_R0.5340.89
61_V72_E0.5320.89
135_V149_I0.5310.89
198_P201_G0.5300.89
356_I392_S0.5300.89
96_E99_E0.5300.89
313_I320_L0.5300.89
316_D320_L0.5300.89
23_W62_G0.5290.88
149_I153_I0.5280.88
405_R408_G0.5280.88
370_V374_V0.5270.88
202_V205_A0.5270.88
373_P384_R0.5270.88
291_V320_L0.5260.88
209_N359_P0.5250.88
251_T314_A0.5250.88
90_E95_S0.5250.88
282_K338_T0.5240.88
91_Q95_S0.5240.88
78_E81_G0.5230.88
193_G304_N0.5230.88
315_K319_G0.5220.88
156_G161_Q0.5220.88
331_A334_M0.5210.88
99_E103_A0.5210.88
227_D374_V0.5200.88
23_W38_A0.5180.87
25_V75_C0.5170.87
289_I342_N0.5170.87
187_Y190_S0.5160.87
234_Y418_D0.5150.87
118_S124_L0.5150.87
185_T188_P0.5140.87
96_E102_V0.5140.87
105_S111_Q0.5140.87
27_P57_I0.5130.87
353_M393_L0.5130.87
344_T367_E0.5110.87
209_N358_Y0.5110.87
96_E100_N0.5110.87
192_A304_N0.5100.87
34_Y121_V0.5090.86
223_M388_N0.5080.86
197_I279_I0.5070.86
344_T366_V0.5070.86
413_I419_E0.5060.86
84_P92_P0.5060.86
95_S103_A0.5050.86
61_V74_I0.5050.86
287_I313_I0.5050.86
380_M383_V0.5040.86
368_S408_G0.5030.86
99_E107_G0.5020.86
8_M47_A0.5010.86
294_E326_D0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dvaI 1 0.0991 100 0.172 Contact Map
2ii3A 4 0.5448 100 0.462 Contact Map
3maeA 3 0.5637 100 0.468 Contact Map
1sczA 4 0.5495 100 0.469 Contact Map
4n72A 3 0.5755 100 0.47 Contact Map
1dpbA 4 0.5684 100 0.471 Contact Map
3b8kA 1 0.5613 100 0.476 Contact Map
3l60A 3 0.5307 100 0.485 Contact Map
3rqcA 4 0.5142 100 0.501 Contact Map
2xt6A 2 0.4505 100 0.516 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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