GREMLIN Database
ODBB - 2-oxoisovalerate dehydrogenase subunit beta
UniProt: P37941 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (301)
Sequences: 14256 (8111)
Seq/√Len: 467.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_D322_R4.6641.00
19_E47_Q3.7591.00
223_R318_E3.3961.00
313_N316_K2.9741.00
205_I321_M2.8581.00
67_G79_A2.8441.00
196_A246_A2.6631.00
218_L233_V2.4651.00
200_R221_A2.4611.00
15_K47_Q2.3641.00
221_A233_V2.3051.00
200_R222_E2.3021.00
15_K48_F2.2201.00
219_Q314_P2.2041.00
146_V157_L2.1831.00
314_P318_E2.1681.00
223_R314_P2.1611.00
203_D230_S2.1371.00
244_K276_I2.0611.00
205_I231_A2.0291.00
308_K313_N2.0281.00
206_T254_T1.9911.00
70_A75_M1.8951.00
248_I276_I1.8921.00
216_F314_P1.8861.00
76_R110_S1.8641.00
290_K323_E1.8561.00
265_K293_A1.8491.00
223_R226_K1.8141.00
290_K320_A1.8051.00
217_A260_V1.7901.00
204_D230_S1.7811.00
19_E48_F1.7601.00
232_H253_K1.7481.00
232_H250_A1.7451.00
225_E230_S1.7441.00
135_A263_D1.7301.00
68_I98_A1.7191.00
223_R315_D1.7131.00
64_A98_A1.7101.00
200_R225_E1.7081.00
209_T217_A1.6841.00
207_V217_A1.6751.00
198_V232_H1.6671.00
271_S275_A1.6651.00
232_H254_T1.6441.00
318_E322_R1.6361.00
144_K164_D1.6251.00
244_K280_H1.6071.00
248_I280_H1.6061.00
143_L169_L1.6031.00
201_E232_H1.5961.00
219_Q222_E1.5961.00
204_D255_G1.5911.00
16_E155_K1.5851.00
108_D142_G1.5821.00
305_T308_K1.5741.00
144_K166_D1.5621.00
25_F70_A1.5541.00
138_A272_E1.5521.00
279_E291_R1.5441.00
319_A323_E1.5351.00
161_A168_V1.5321.00
192_P195_K1.5281.00
216_F219_Q1.5261.00
17_E159_K1.5231.00
274_A289_I1.5201.00
78_I162_V1.5191.00
64_A113_I1.5131.00
8_D36_G1.4741.00
209_T214_V1.4731.00
112_P161_A1.4651.00
320_A323_E1.4291.00
138_A275_A1.4201.00
208_I236_L1.4161.00
258_L324_L1.4131.00
308_K315_D1.3891.00
13_A155_K1.3871.00
64_A79_A1.3871.00
215_H219_Q1.3841.00
234_V246_A1.3821.00
316_K320_A1.3821.00
222_E226_K1.3771.00
216_F317_V1.3761.00
220_A318_E1.3731.00
137_F169_L1.3691.00
207_V321_M1.3511.00
159_K163_R1.3361.00
13_A159_K1.3331.00
196_A236_L1.3311.00
64_A90_A1.3161.00
21_D76_R1.3141.00
197_D235_D1.3071.00
17_E163_R1.3041.00
43_G46_E1.2951.00
110_S166_D1.2891.00
249_E254_T1.2881.00
153_D235_D1.2861.00
223_R227_D1.2851.00
98_A113_I1.2731.00
249_E253_K1.2711.00
243_D276_I1.2591.00
8_D12_L1.2581.00
76_R112_P1.2581.00
27_L67_G1.2571.00
17_E24_V1.2491.00
191_L194_G1.2451.00
144_K238_T1.2451.00
198_V201_E1.2411.00
94_I143_L1.2351.00
146_V238_T1.2281.00
23_R75_M1.2231.00
14_M78_I1.2221.00
206_T250_A1.2221.00
248_I252_S1.2171.00
222_E225_E1.2111.00
18_M44_L1.2051.00
17_E162_V1.2031.00
149_S214_V1.1981.00
245_E249_E1.1971.00
242_L247_I1.1921.00
236_L269_I1.1841.00
12_L155_K1.1801.00
160_A193_I1.1791.00
27_L56_T1.1741.00
274_A278_S1.1691.00
261_T270_M1.1681.00
153_D237_R1.1611.00
234_V250_A1.1561.00
208_I257_V1.1451.00
207_V231_A1.1411.00
149_S235_D1.1351.00
199_K214_V1.1331.00
110_S165_E1.1271.00
17_E20_R1.1231.00
25_F75_M1.1221.00
9_A151_P1.1201.00
13_A16_E1.1061.00
258_L321_M1.0981.00
200_R230_S1.0971.00
135_A139_N1.0911.00
12_L16_E1.0861.00
231_A321_M1.0841.00
244_K248_I1.0771.00
276_I280_H1.0701.00
146_V168_V1.0671.00
258_L292_L1.0641.00
257_V277_I1.0631.00
316_K319_A1.0621.00
198_V234_V1.0531.00
259_L262_E1.0491.00
213_C216_F1.0461.00
290_K324_L1.0441.00
196_A234_V1.0441.00
282_L287_A1.0431.00
85_D133_V1.0411.00
248_I281_C1.0391.00
16_E159_K1.0381.00
278_S289_I1.0351.00
20_R159_K1.0311.00
195_K245_E1.0261.00
71_A77_P1.0251.00
43_G47_Q1.0231.00
134_E210_Y1.0211.00
91_V136_I1.0201.00
251_A277_I1.0201.00
21_D24_V1.0181.00
15_K19_E1.0111.00
260_V317_V1.0081.00
61_S93_Q0.9921.00
198_V246_A0.9881.00
42_A46_E0.9881.00
12_L43_G0.9831.00
274_A291_R0.9791.00
21_D162_V0.9781.00
16_E20_R0.9781.00
144_K168_V0.9691.00
256_K324_L0.9661.00
220_A317_V0.9631.00
84_A171_F0.9631.00
240_Y296_D0.9611.00
16_E19_E0.9501.00
18_M24_V0.9471.00
210_Y239_V0.9451.00
227_D318_E0.9451.00
67_G111_C0.9451.00
250_A253_K0.9401.00
275_A291_R0.9321.00
134_E171_F0.9241.00
259_L270_M0.9191.00
26_V31_V0.9181.00
8_D11_N0.9181.00
282_L323_E0.9171.00
292_L320_A0.9171.00
149_S197_D0.9131.00
151_P179_L0.9101.00
44_L49_G0.9081.00
144_K241_P0.9011.00
98_A111_C0.8981.00
206_T232_H0.8931.00
315_D319_A0.8891.00
56_T66_V0.8881.00
63_I79_A0.8881.00
32_G53_V0.8871.00
269_I273_V0.8861.00
311_M316_K0.8851.00
224_L321_M0.8821.00
35_G80_E0.8791.00
256_K288_P0.8761.00
8_D176_A0.8721.00
217_A233_V0.8711.00
23_R76_R0.8681.00
178_R215_H0.8641.00
277_I286_D0.8621.00
94_I137_F0.8621.00
206_T234_V0.8591.00
131_Q294_G0.8561.00
204_D229_I0.8531.00
76_R165_E0.8531.00
48_F52_R0.8531.00
266_E296_D0.8521.00
108_D166_D0.8511.00
146_V193_I0.8501.00
294_G310_F0.8461.00
202_G230_S0.8451.00
229_I322_R0.8451.00
135_A267_G0.8441.00
282_L286_D0.8441.00
158_L170_F0.8441.00
134_E263_D0.8321.00
321_M324_L0.8311.00
25_F54_M0.8291.00
249_E252_S0.8281.00
154_A172_E0.8271.00
45_Y48_F0.8261.00
258_L261_T0.8261.00
147_M210_Y0.8161.00
120_G307_E0.8131.00
184_V187_D0.8111.00
26_V78_I0.8101.00
66_V70_A0.8091.00
143_L167_P0.8081.00
159_K188_D0.8031.00
242_L276_I0.7971.00
246_A250_A0.7971.00
247_I276_I0.7971.00
27_L54_M0.7961.00
205_I258_L0.7951.00
216_F313_N0.7951.00
319_A322_R0.7941.00
224_L318_E0.7941.00
62_A66_V0.7931.00
84_A137_F0.7931.00
87_I137_F0.7921.00
208_I234_V0.7871.00
221_A225_E0.7871.00
305_T309_Y0.7871.00
236_L239_V0.7861.00
79_A82_Q0.7861.00
160_A192_P0.7851.00
209_T213_C0.7771.00
13_A17_E0.7751.00
308_K316_K0.7731.00
216_F307_E0.7681.00
13_A158_L0.7611.00
160_A163_R0.7611.00
225_E231_A0.7591.00
247_I277_I0.7581.00
144_K193_I0.7581.00
258_L262_E0.7581.00
116_R172_E0.7571.00
306_M310_F0.7541.00
219_Q223_R0.7541.00
201_E253_K0.7531.00
243_D275_A0.7491.00
29_E35_G0.7461.00
112_P168_V0.7351.00
138_A239_V0.7351.00
10_I80_E0.7311.00
200_R218_L0.7311.00
45_Y53_V0.7301.00
65_G93_Q0.7271.00
136_I140_Q0.7181.00
156_G159_K0.7181.00
257_V261_T0.7171.00
250_A254_T0.7151.00
239_V243_D0.7151.00
29_E63_I0.7121.00
97_E113_I0.7101.00
11_N15_K0.7071.00
282_L320_A0.7031.00
71_A111_C0.7021.00
46_E49_G0.7001.00
133_V171_F0.7001.00
150_T199_K0.6991.00
27_L66_V0.6951.00
99_A140_Q0.6941.00
160_A190_V0.6911.00
247_I252_S0.6891.00
144_K240_Y0.6881.00
71_A109_W0.6871.00
320_A324_L0.6841.00
297_I309_Y0.6831.00
94_I115_V0.6831.00
98_A167_P0.6791.00
27_L63_I0.6791.00
173_H177_Y0.6781.00
272_E275_A0.6771.00
126_A129_H0.6761.00
138_A267_G0.6721.00
134_E145_I0.6711.00
42_A45_Y0.6691.00
210_Y236_L0.6681.00
87_I117_A0.6671.00
157_L237_R0.6671.00
152_Y185_P0.6631.00
9_A13_A0.6611.00
220_A260_V0.6611.00
22_S52_R0.6611.00
220_A321_M0.6601.00
247_I251_A0.6601.00
67_G80_E0.6591.00
251_A257_V0.6581.00
199_K218_L0.6571.00
44_L53_V0.6571.00
72_M109_W0.6561.00
100_K126_A0.6551.00
146_V160_A0.6531.00
24_V162_V0.6511.00
278_S281_C0.6481.00
44_L48_F0.6451.00
88_M133_V0.6441.00
265_K279_E0.6421.00
32_G45_Y0.6411.00
270_M275_A0.6391.00
90_A94_I0.6371.00
152_Y156_G0.6351.00
295_P310_F0.6351.00
248_I282_L0.6341.00
92_N96_S0.6310.99
198_V249_E0.6290.99
183_E186_A0.6240.99
99_A298_P0.6230.99
140_Q143_L0.6230.99
204_D231_A0.6210.99
11_N36_G0.6200.99
70_A77_P0.6200.99
94_I113_I0.6180.99
270_M293_A0.6170.99
195_K243_D0.6100.99
279_E290_K0.6080.99
156_G160_A0.6070.99
120_G306_M0.6070.99
244_K279_E0.6070.99
258_L290_K0.6060.99
146_V161_A0.6060.99
78_I158_L0.6050.99
79_A113_I0.6040.99
145_I169_L0.6040.99
261_T268_S0.6010.99
156_G190_V0.5980.99
24_V78_I0.5950.99
84_A133_V0.5950.99
259_L273_V0.5920.99
183_E187_D0.5900.99
152_Y179_L0.5900.99
220_A314_P0.5860.99
173_H212_L0.5850.99
112_P158_L0.5840.99
178_R219_Q0.5840.99
295_P316_K0.5820.99
43_G55_D0.5820.99
188_D191_L0.5810.99
54_M66_V0.5810.99
91_V139_N0.5800.99
59_A62_A0.5790.99
266_E288_P0.5790.99
185_P189_Y0.5760.99
138_A145_I0.5750.99
161_A170_F0.5740.99
15_K53_V0.5740.99
31_V83_F0.5730.99
95_I140_Q0.5710.99
26_V37_V0.5690.99
163_R188_D0.5690.99
255_G286_D0.5680.99
201_E249_E0.5650.99
312_V316_K0.5640.99
214_V233_V0.5630.99
271_S291_R0.5620.99
155_K159_K0.5610.99
144_K244_K0.5610.99
201_E230_S0.5600.99
33_R55_D0.5600.99
189_Y192_P0.5590.99
31_V82_Q0.5590.99
209_T236_L0.5580.99
108_D165_E0.5580.99
10_I158_L0.5570.99
138_A269_I0.5550.99
156_G188_D0.5540.99
265_K291_R0.5510.99
224_L231_A0.5510.99
256_K259_L0.5500.99
164_D168_V0.5480.99
147_M211_G0.5460.99
8_D43_G0.5460.99
99_A143_L0.5450.99
272_E291_R0.5440.99
205_I256_K0.5420.98
307_E312_V0.5410.98
261_T264_T0.5400.98
164_D193_I0.5390.98
149_S153_D0.5390.98
88_M136_I0.5380.98
238_T241_P0.5370.98
152_Y189_Y0.5360.98
131_Q264_T0.5360.98
212_L216_F0.5350.98
191_L195_K0.5310.98
18_M53_V0.5310.98
144_K194_G0.5290.98
292_L312_V0.5290.98
268_S271_S0.5290.98
159_K190_V0.5280.98
217_A317_V0.5270.98
196_A243_D0.5260.98
253_K256_K0.5250.98
315_D318_E0.5220.98
239_V269_I0.5210.98
221_A231_A0.5200.98
311_M320_A0.5180.98
206_T256_K0.5170.98
115_V169_L0.5160.98
213_C260_V0.5140.98
267_G271_S0.5110.98
147_M212_L0.5100.98
270_M291_R0.5100.98
260_V292_L0.5090.98
300_M310_F0.5080.98
304_P308_K0.5070.98
207_V221_A0.5060.98
292_L316_K0.5060.98
56_T63_I0.5050.98
257_V289_I0.5050.98
157_L160_A0.5040.98
194_G238_T0.5040.98
95_I132_S0.5030.98
206_T257_V0.5030.98
157_L168_V0.5030.98
197_D237_R0.5000.97
20_R163_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w85B 2 0.9817 100 0.204 Contact Map
1umdB 2 0.9786 100 0.205 Contact Map
1ik6A 3 0.8532 100 0.212 Contact Map
1qs0B 2 0.9786 100 0.239 Contact Map
2bfdB 2 0.9786 100 0.246 Contact Map
2o1xA 2 0.9297 100 0.249 Contact Map
4kxvA 2 0.9327 100 0.254 Contact Map
2ozlB 2 0.9817 100 0.257 Contact Map
2o1sA 2 0.9205 100 0.263 Contact Map
1gpuA 2 0.9083 100 0.306 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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