ODBB - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

ODBB - 2-oxoisovalerate dehydrogenase subunit beta

UniProt:	P37941	Sequences: MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGLYEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIRYRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKAAVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFALQAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAIISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	327 (301)
Sequences:	14256 (8111)
Seq/√Len:	467.5

ECOLI - DXS TKT1 TKT2
BACSU - ODBB ODPB ACOB DXS TKT
HALSA - Q9HN76
SULSO - Q97Y22 Q97YF5 Q980J2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
227_D	322_R	4.664	1.00
19_E	47_Q	3.759	1.00
223_R	318_E	3.396	1.00
313_N	316_K	2.974	1.00
205_I	321_M	2.858	1.00
67_G	79_A	2.844	1.00
196_A	246_A	2.663	1.00
218_L	233_V	2.465	1.00
200_R	221_A	2.461	1.00
15_K	47_Q	2.364	1.00
221_A	233_V	2.305	1.00
200_R	222_E	2.302	1.00
15_K	48_F	2.220	1.00
219_Q	314_P	2.204	1.00
146_V	157_L	2.183	1.00
314_P	318_E	2.168	1.00
223_R	314_P	2.161	1.00
203_D	230_S	2.137	1.00
244_K	276_I	2.061	1.00
205_I	231_A	2.029	1.00
308_K	313_N	2.028	1.00
206_T	254_T	1.991	1.00
70_A	75_M	1.895	1.00
248_I	276_I	1.892	1.00
216_F	314_P	1.886	1.00
76_R	110_S	1.864	1.00
290_K	323_E	1.856	1.00
265_K	293_A	1.849	1.00
223_R	226_K	1.814	1.00
290_K	320_A	1.805	1.00
217_A	260_V	1.790	1.00
204_D	230_S	1.781	1.00
19_E	48_F	1.760	1.00
232_H	253_K	1.748	1.00
232_H	250_A	1.745	1.00
225_E	230_S	1.744	1.00
135_A	263_D	1.730	1.00
68_I	98_A	1.719	1.00
223_R	315_D	1.713	1.00
64_A	98_A	1.710	1.00
200_R	225_E	1.708	1.00
209_T	217_A	1.684	1.00
207_V	217_A	1.675	1.00
198_V	232_H	1.667	1.00
271_S	275_A	1.665	1.00
232_H	254_T	1.644	1.00
318_E	322_R	1.636	1.00
144_K	164_D	1.625	1.00
244_K	280_H	1.607	1.00
248_I	280_H	1.606	1.00
143_L	169_L	1.603	1.00
201_E	232_H	1.596	1.00
219_Q	222_E	1.596	1.00
204_D	255_G	1.591	1.00
16_E	155_K	1.585	1.00
108_D	142_G	1.582	1.00
305_T	308_K	1.574	1.00
144_K	166_D	1.562	1.00
25_F	70_A	1.554	1.00
138_A	272_E	1.552	1.00
279_E	291_R	1.544	1.00
319_A	323_E	1.535	1.00
161_A	168_V	1.532	1.00
192_P	195_K	1.528	1.00
216_F	219_Q	1.526	1.00
17_E	159_K	1.523	1.00
274_A	289_I	1.520	1.00
78_I	162_V	1.519	1.00
64_A	113_I	1.513	1.00
8_D	36_G	1.474	1.00
209_T	214_V	1.473	1.00
112_P	161_A	1.465	1.00
320_A	323_E	1.429	1.00
138_A	275_A	1.420	1.00
208_I	236_L	1.416	1.00
258_L	324_L	1.413	1.00
308_K	315_D	1.389	1.00
13_A	155_K	1.387	1.00
64_A	79_A	1.387	1.00
215_H	219_Q	1.384	1.00
234_V	246_A	1.382	1.00
316_K	320_A	1.382	1.00
222_E	226_K	1.377	1.00
216_F	317_V	1.376	1.00
220_A	318_E	1.373	1.00
137_F	169_L	1.369	1.00
207_V	321_M	1.351	1.00
159_K	163_R	1.336	1.00
13_A	159_K	1.333	1.00
196_A	236_L	1.331	1.00
64_A	90_A	1.316	1.00
21_D	76_R	1.314	1.00
197_D	235_D	1.307	1.00
17_E	163_R	1.304	1.00
43_G	46_E	1.295	1.00
110_S	166_D	1.289	1.00
249_E	254_T	1.288	1.00
153_D	235_D	1.286	1.00
223_R	227_D	1.285	1.00
98_A	113_I	1.273	1.00
249_E	253_K	1.271	1.00
243_D	276_I	1.259	1.00
8_D	12_L	1.258	1.00
76_R	112_P	1.258	1.00
27_L	67_G	1.257	1.00
17_E	24_V	1.249	1.00
191_L	194_G	1.245	1.00
144_K	238_T	1.245	1.00
198_V	201_E	1.241	1.00
94_I	143_L	1.235	1.00
146_V	238_T	1.228	1.00
23_R	75_M	1.223	1.00
14_M	78_I	1.222	1.00
206_T	250_A	1.222	1.00
248_I	252_S	1.217	1.00
222_E	225_E	1.211	1.00
18_M	44_L	1.205	1.00
17_E	162_V	1.203	1.00
149_S	214_V	1.198	1.00
245_E	249_E	1.197	1.00
242_L	247_I	1.192	1.00
236_L	269_I	1.184	1.00
12_L	155_K	1.180	1.00
160_A	193_I	1.179	1.00
27_L	56_T	1.174	1.00
274_A	278_S	1.169	1.00
261_T	270_M	1.168	1.00
153_D	237_R	1.161	1.00
234_V	250_A	1.156	1.00
208_I	257_V	1.145	1.00
207_V	231_A	1.141	1.00
149_S	235_D	1.135	1.00
199_K	214_V	1.133	1.00
110_S	165_E	1.127	1.00
17_E	20_R	1.123	1.00
25_F	75_M	1.122	1.00
9_A	151_P	1.120	1.00
13_A	16_E	1.106	1.00
258_L	321_M	1.098	1.00
200_R	230_S	1.097	1.00
135_A	139_N	1.091	1.00
12_L	16_E	1.086	1.00
231_A	321_M	1.084	1.00
244_K	248_I	1.077	1.00
276_I	280_H	1.070	1.00
146_V	168_V	1.067	1.00
258_L	292_L	1.064	1.00
257_V	277_I	1.063	1.00
316_K	319_A	1.062	1.00
198_V	234_V	1.053	1.00
259_L	262_E	1.049	1.00
213_C	216_F	1.046	1.00
290_K	324_L	1.044	1.00
196_A	234_V	1.044	1.00
282_L	287_A	1.043	1.00
85_D	133_V	1.041	1.00
248_I	281_C	1.039	1.00
16_E	159_K	1.038	1.00
278_S	289_I	1.035	1.00
20_R	159_K	1.031	1.00
195_K	245_E	1.026	1.00
71_A	77_P	1.025	1.00
43_G	47_Q	1.023	1.00
134_E	210_Y	1.021	1.00
91_V	136_I	1.020	1.00
251_A	277_I	1.020	1.00
21_D	24_V	1.018	1.00
15_K	19_E	1.011	1.00
260_V	317_V	1.008	1.00
61_S	93_Q	0.992	1.00
198_V	246_A	0.988	1.00
42_A	46_E	0.988	1.00
12_L	43_G	0.983	1.00
274_A	291_R	0.979	1.00
21_D	162_V	0.978	1.00
16_E	20_R	0.978	1.00
144_K	168_V	0.969	1.00
256_K	324_L	0.966	1.00
220_A	317_V	0.963	1.00
84_A	171_F	0.963	1.00
240_Y	296_D	0.961	1.00
16_E	19_E	0.950	1.00
18_M	24_V	0.947	1.00
210_Y	239_V	0.945	1.00
227_D	318_E	0.945	1.00
67_G	111_C	0.945	1.00
250_A	253_K	0.940	1.00
275_A	291_R	0.932	1.00
134_E	171_F	0.924	1.00
259_L	270_M	0.919	1.00
26_V	31_V	0.918	1.00
8_D	11_N	0.918	1.00
282_L	323_E	0.917	1.00
292_L	320_A	0.917	1.00
149_S	197_D	0.913	1.00
151_P	179_L	0.910	1.00
44_L	49_G	0.908	1.00
144_K	241_P	0.901	1.00
98_A	111_C	0.898	1.00
206_T	232_H	0.893	1.00
315_D	319_A	0.889	1.00
56_T	66_V	0.888	1.00
63_I	79_A	0.888	1.00
32_G	53_V	0.887	1.00
269_I	273_V	0.886	1.00
311_M	316_K	0.885	1.00
224_L	321_M	0.882	1.00
35_G	80_E	0.879	1.00
256_K	288_P	0.876	1.00
8_D	176_A	0.872	1.00
217_A	233_V	0.871	1.00
23_R	76_R	0.868	1.00
178_R	215_H	0.864	1.00
277_I	286_D	0.862	1.00
94_I	137_F	0.862	1.00
206_T	234_V	0.859	1.00
131_Q	294_G	0.856	1.00
204_D	229_I	0.853	1.00
76_R	165_E	0.853	1.00
48_F	52_R	0.853	1.00
266_E	296_D	0.852	1.00
108_D	166_D	0.851	1.00
146_V	193_I	0.850	1.00
294_G	310_F	0.846	1.00
202_G	230_S	0.845	1.00
229_I	322_R	0.845	1.00
135_A	267_G	0.844	1.00
282_L	286_D	0.844	1.00
158_L	170_F	0.844	1.00
134_E	263_D	0.832	1.00
321_M	324_L	0.831	1.00
25_F	54_M	0.829	1.00
249_E	252_S	0.828	1.00
154_A	172_E	0.827	1.00
45_Y	48_F	0.826	1.00
258_L	261_T	0.826	1.00
147_M	210_Y	0.816	1.00
120_G	307_E	0.813	1.00
184_V	187_D	0.811	1.00
26_V	78_I	0.810	1.00
66_V	70_A	0.809	1.00
143_L	167_P	0.808	1.00
159_K	188_D	0.803	1.00
242_L	276_I	0.797	1.00
246_A	250_A	0.797	1.00
247_I	276_I	0.797	1.00
27_L	54_M	0.796	1.00
205_I	258_L	0.795	1.00
216_F	313_N	0.795	1.00
319_A	322_R	0.794	1.00
224_L	318_E	0.794	1.00
62_A	66_V	0.793	1.00
84_A	137_F	0.793	1.00
87_I	137_F	0.792	1.00
208_I	234_V	0.787	1.00
221_A	225_E	0.787	1.00
305_T	309_Y	0.787	1.00
236_L	239_V	0.786	1.00
79_A	82_Q	0.786	1.00
160_A	192_P	0.785	1.00
209_T	213_C	0.777	1.00
13_A	17_E	0.775	1.00
308_K	316_K	0.773	1.00
216_F	307_E	0.768	1.00
13_A	158_L	0.761	1.00
160_A	163_R	0.761	1.00
225_E	231_A	0.759	1.00
247_I	277_I	0.758	1.00
144_K	193_I	0.758	1.00
258_L	262_E	0.758	1.00
116_R	172_E	0.757	1.00
306_M	310_F	0.754	1.00
219_Q	223_R	0.754	1.00
201_E	253_K	0.753	1.00
243_D	275_A	0.749	1.00
29_E	35_G	0.746	1.00
112_P	168_V	0.735	1.00
138_A	239_V	0.735	1.00
10_I	80_E	0.731	1.00
200_R	218_L	0.731	1.00
45_Y	53_V	0.730	1.00
65_G	93_Q	0.727	1.00
136_I	140_Q	0.718	1.00
156_G	159_K	0.718	1.00
257_V	261_T	0.717	1.00
250_A	254_T	0.715	1.00
239_V	243_D	0.715	1.00
29_E	63_I	0.712	1.00
97_E	113_I	0.710	1.00
11_N	15_K	0.707	1.00
282_L	320_A	0.703	1.00
71_A	111_C	0.702	1.00
46_E	49_G	0.700	1.00
133_V	171_F	0.700	1.00
150_T	199_K	0.699	1.00
27_L	66_V	0.695	1.00
99_A	140_Q	0.694	1.00
160_A	190_V	0.691	1.00
247_I	252_S	0.689	1.00
144_K	240_Y	0.688	1.00
71_A	109_W	0.687	1.00
320_A	324_L	0.684	1.00
297_I	309_Y	0.683	1.00
94_I	115_V	0.683	1.00
98_A	167_P	0.679	1.00
27_L	63_I	0.679	1.00
173_H	177_Y	0.678	1.00
272_E	275_A	0.677	1.00
126_A	129_H	0.676	1.00
138_A	267_G	0.672	1.00
134_E	145_I	0.671	1.00
42_A	45_Y	0.669	1.00
210_Y	236_L	0.668	1.00
87_I	117_A	0.667	1.00
157_L	237_R	0.667	1.00
152_Y	185_P	0.663	1.00
9_A	13_A	0.661	1.00
220_A	260_V	0.661	1.00
22_S	52_R	0.661	1.00
220_A	321_M	0.660	1.00
247_I	251_A	0.660	1.00
67_G	80_E	0.659	1.00
251_A	257_V	0.658	1.00
199_K	218_L	0.657	1.00
44_L	53_V	0.657	1.00
72_M	109_W	0.656	1.00
100_K	126_A	0.655	1.00
146_V	160_A	0.653	1.00
24_V	162_V	0.651	1.00
278_S	281_C	0.648	1.00
44_L	48_F	0.645	1.00
88_M	133_V	0.644	1.00
265_K	279_E	0.642	1.00
32_G	45_Y	0.641	1.00
270_M	275_A	0.639	1.00
90_A	94_I	0.637	1.00
152_Y	156_G	0.635	1.00
295_P	310_F	0.635	1.00
248_I	282_L	0.634	1.00
92_N	96_S	0.631	0.99
198_V	249_E	0.629	0.99
183_E	186_A	0.624	0.99
99_A	298_P	0.623	0.99
140_Q	143_L	0.623	0.99
204_D	231_A	0.621	0.99
11_N	36_G	0.620	0.99
70_A	77_P	0.620	0.99
94_I	113_I	0.618	0.99
270_M	293_A	0.617	0.99
195_K	243_D	0.610	0.99
279_E	290_K	0.608	0.99
156_G	160_A	0.607	0.99
120_G	306_M	0.607	0.99
244_K	279_E	0.607	0.99
258_L	290_K	0.606	0.99
146_V	161_A	0.606	0.99
78_I	158_L	0.605	0.99
79_A	113_I	0.604	0.99
145_I	169_L	0.604	0.99
261_T	268_S	0.601	0.99
156_G	190_V	0.598	0.99
24_V	78_I	0.595	0.99
84_A	133_V	0.595	0.99
259_L	273_V	0.592	0.99
183_E	187_D	0.590	0.99
152_Y	179_L	0.590	0.99
220_A	314_P	0.586	0.99
173_H	212_L	0.585	0.99
112_P	158_L	0.584	0.99
178_R	219_Q	0.584	0.99
295_P	316_K	0.582	0.99
43_G	55_D	0.582	0.99
188_D	191_L	0.581	0.99
54_M	66_V	0.581	0.99
91_V	139_N	0.580	0.99
59_A	62_A	0.579	0.99
266_E	288_P	0.579	0.99
185_P	189_Y	0.576	0.99
138_A	145_I	0.575	0.99
161_A	170_F	0.574	0.99
15_K	53_V	0.574	0.99
31_V	83_F	0.573	0.99
95_I	140_Q	0.571	0.99
26_V	37_V	0.569	0.99
163_R	188_D	0.569	0.99
255_G	286_D	0.568	0.99
201_E	249_E	0.565	0.99
312_V	316_K	0.564	0.99
214_V	233_V	0.563	0.99
271_S	291_R	0.562	0.99
155_K	159_K	0.561	0.99
144_K	244_K	0.561	0.99
201_E	230_S	0.560	0.99
33_R	55_D	0.560	0.99
189_Y	192_P	0.559	0.99
31_V	82_Q	0.559	0.99
209_T	236_L	0.558	0.99
108_D	165_E	0.558	0.99
10_I	158_L	0.557	0.99
138_A	269_I	0.555	0.99
156_G	188_D	0.554	0.99
265_K	291_R	0.551	0.99
224_L	231_A	0.551	0.99
256_K	259_L	0.550	0.99
164_D	168_V	0.548	0.99
147_M	211_G	0.546	0.99
8_D	43_G	0.546	0.99
99_A	143_L	0.545	0.99
272_E	291_R	0.544	0.99
205_I	256_K	0.542	0.98
307_E	312_V	0.541	0.98
261_T	264_T	0.540	0.98
164_D	193_I	0.539	0.98
149_S	153_D	0.539	0.98
88_M	136_I	0.538	0.98
238_T	241_P	0.537	0.98
152_Y	189_Y	0.536	0.98
131_Q	264_T	0.536	0.98
212_L	216_F	0.535	0.98
191_L	195_K	0.531	0.98
18_M	53_V	0.531	0.98
144_K	194_G	0.529	0.98
292_L	312_V	0.529	0.98
268_S	271_S	0.529	0.98
159_K	190_V	0.528	0.98
217_A	317_V	0.527	0.98
196_A	243_D	0.526	0.98
253_K	256_K	0.525	0.98
315_D	318_E	0.522	0.98
239_V	269_I	0.521	0.98
221_A	231_A	0.520	0.98
311_M	320_A	0.518	0.98
206_T	256_K	0.517	0.98
115_V	169_L	0.516	0.98
213_C	260_V	0.514	0.98
267_G	271_S	0.511	0.98
147_M	212_L	0.510	0.98
270_M	291_R	0.510	0.98
260_V	292_L	0.509	0.98
300_M	310_F	0.508	0.98
304_P	308_K	0.507	0.98
207_V	221_A	0.506	0.98
292_L	316_K	0.506	0.98
56_T	63_I	0.505	0.98
257_V	289_I	0.505	0.98
157_L	160_A	0.504	0.98
194_G	238_T	0.504	0.98
95_I	132_S	0.503	0.98
206_T	257_V	0.503	0.98
157_L	168_V	0.503	0.98
197_D	237_R	0.500	0.97
20_R	163_R	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1w85B	2	0.9817	100	0.204	Contact Map
1umdB	2	0.9786	100	0.205	Contact Map
1ik6A	3	0.8532	100	0.212	Contact Map
1qs0B	2	0.9786	100	0.239	Contact Map
2bfdB	2	0.9786	100	0.246	Contact Map
2o1xA	2	0.9297	100	0.249	Contact Map
4kxvA	2	0.9327	100	0.254	Contact Map
2ozlB	2	0.9817	100	0.257	Contact Map
2o1sA	2	0.9205	100	0.263	Contact Map
1gpuA	2	0.9083	100	0.306	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.