GREMLIN Database
ODBA - 2-oxoisovalerate dehydrogenase subunit alpha
UniProt: P37940 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (297)
Sequences: 7620 (4040)
Seq/√Len: 234.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_H207_Y3.9761.00
21_R300_E3.5621.00
232_R237_E3.0951.00
212_V228_E2.9641.00
202_D205_I2.9331.00
290_S293_I2.9291.00
291_D295_Q2.8671.00
230_R234_R2.7261.00
177_I233_A2.6771.00
70_L135_I2.5861.00
218_D221_E2.4631.00
210_P232_R2.4411.00
147_A230_R2.3861.00
232_R238_G2.2781.00
199_N202_D2.2771.00
152_F180_C2.2371.00
212_V240_T2.1931.00
231_E235_R2.1721.00
133_V165_G2.1381.00
258_D262_R2.1341.00
58_A151_T2.1191.00
213_T245_I2.0911.00
269_E272_K2.0901.00
87_K311_E2.0711.00
173_K196_A2.0531.00
41_K313_E2.0231.00
139_G148_A2.0011.00
25_L304_I1.9951.00
26_A77_G1.9881.00
92_S95_A1.9531.00
284_K291_D1.9421.00
310_D314_N1.9191.00
280_Q284_K1.9071.00
232_R240_T1.8971.00
257_D262_R1.8931.00
296_T300_E1.8281.00
277_L281_A1.8151.00
166_A204_A1.7711.00
129_V162_F1.7661.00
223_Y227_K1.7401.00
265_E268_E1.7151.00
280_Q298_L1.6581.00
212_V225_A1.6391.00
162_F166_A1.6291.00
153_G156_S1.6261.00
87_K307_E1.6161.00
259_S262_R1.6121.00
281_A285_E1.6111.00
66_M146_I1.6111.00
139_G144_K1.6101.00
137_L141_M1.6031.00
120_T131_H1.6021.00
139_G146_I1.5971.00
289_L294_E1.5941.00
168_F172_H1.5781.00
264_R268_E1.5771.00
233_A240_T1.5671.00
210_P240_T1.5571.00
184_K245_I1.5571.00
175_P210_P1.5481.00
303_A307_E1.5311.00
204_A211_G1.5021.00
152_F156_S1.4981.00
256_D262_R1.4961.00
58_A226_V1.4921.00
268_E272_K1.4861.00
293_I296_T1.4741.00
201_S213_T1.4671.00
214_V225_A1.4521.00
177_I181_E1.4521.00
258_D261_Y1.4461.00
280_Q294_E1.4451.00
227_K231_E1.4351.00
295_Q299_D1.4201.00
256_D261_Y1.4181.00
217_N249_L1.4111.00
275_P278_T1.4061.00
201_S243_E1.3991.00
301_I305_V1.3981.00
300_E304_I1.3831.00
213_T243_E1.3801.00
160_G164_E1.3591.00
311_E315_A1.3551.00
155_G186_A1.3521.00
278_T282_Y1.3501.00
98_A315_A1.3421.00
306_N310_D1.3381.00
147_A178_F1.3361.00
307_E311_E1.3301.00
289_L293_I1.3301.00
292_E296_T1.3291.00
58_A149_F1.3161.00
284_K294_E1.3091.00
133_V178_F1.3051.00
299_D303_A1.2981.00
294_E298_L1.2971.00
166_A207_Y1.2851.00
276_L280_Q1.2651.00
270_A273_S1.2591.00
229_A240_T1.2521.00
267_V271_K1.2451.00
152_F179_M1.2421.00
277_L280_Q1.2341.00
171_V196_A1.2301.00
279_Y282_Y1.2291.00
282_Y286_T1.2281.00
180_C200_I1.2251.00
136_A176_V1.2251.00
210_P238_G1.2231.00
224_Q228_E1.2081.00
275_P279_Y1.1991.00
176_V181_E1.1961.00
201_S211_G1.1941.00
257_D261_Y1.1931.00
275_P280_Q1.1921.00
129_V165_G1.1841.00
179_M244_T1.1721.00
73_Y153_G1.1601.00
276_L279_Y1.1481.00
24_L301_I1.1401.00
94_F97_A1.1391.00
225_A242_I1.1341.00
85_T88_D1.1311.00
31_E49_Q1.1261.00
232_R236_G1.1231.00
79_V118_I1.1191.00
129_V166_A1.1131.00
132_A150_V1.1061.00
175_P232_R1.0991.00
175_P237_E1.0971.00
182_N243_E1.0951.00
68_Y139_G1.0901.00
228_E231_E1.0881.00
173_K237_E1.0871.00
108_P115_K1.0831.00
275_P282_Y1.0831.00
166_A209_M1.0771.00
308_A312_A1.0701.00
292_E295_Q1.0691.00
152_F157_S1.0691.00
214_V221_E1.0631.00
295_Q298_L1.0601.00
226_V242_I1.0551.00
22_T60_F1.0531.00
268_E271_K1.0501.00
217_N246_S1.0421.00
149_F177_I1.0421.00
195_V200_I1.0361.00
149_F226_V1.0321.00
302_M313_E1.0251.00
148_A176_V1.0191.00
201_S205_I1.0121.00
210_P228_E1.0111.00
57_G222_V1.0081.00
222_V244_T1.0071.00
310_D313_E1.0011.00
170_A209_M0.9891.00
25_L86_A0.9871.00
122_S127_T0.9841.00
58_A179_M0.9831.00
265_E269_E0.9821.00
61_A180_C0.9701.00
21_R25_L0.9671.00
274_D282_Y0.9651.00
135_I148_A0.9621.00
279_Y283_L0.9561.00
91_M98_A0.9511.00
297_M300_E0.9491.00
24_L298_L0.9481.00
93_G97_A0.9461.00
54_A76_M0.9451.00
28_K302_M0.9411.00
32_R306_N0.9401.00
54_A244_T0.9391.00
53_A57_G0.9351.00
32_R35_L0.9331.00
306_N309_T0.9321.00
220_L224_Q0.9271.00
113_Q116_N0.9241.00
274_D278_T0.9241.00
70_L119_V0.9221.00
256_D259_S0.9161.00
177_I180_C0.9121.00
281_A284_K0.9111.00
247_Y256_D0.9101.00
300_E303_A0.9041.00
173_K238_G0.9041.00
247_Y257_D0.8991.00
34_W38_R0.8991.00
216_G246_S0.8980.99
61_A223_Y0.8970.99
137_L172_H0.8910.99
249_L271_K0.8900.99
176_V180_C0.8840.99
24_L28_K0.8810.99
204_A241_L0.8800.99
184_K192_D0.8780.99
302_M306_N0.8740.99
211_G243_E0.8710.99
92_S99_D0.8680.99
179_M226_V0.8650.99
304_I308_A0.8630.99
28_K31_E0.8610.99
124_P127_T0.8600.99
68_Y119_V0.8550.99
211_G241_L0.8520.99
58_A61_A0.8500.99
178_F181_E0.8500.99
299_D302_M0.8490.99
65_E116_N0.8430.99
158_N203_R0.8430.99
44_F253_S0.8420.99
255_D260_S0.8410.99
147_A233_A0.8410.99
252_H270_A0.8410.99
96_K317_Y0.8330.99
221_E224_Q0.8330.99
296_T299_D0.8300.99
303_A306_N0.8250.99
73_Y151_T0.8170.99
216_G222_V0.8160.99
149_F179_M0.8160.99
266_E269_E0.8160.99
28_K298_L0.8160.99
133_V176_V0.8110.99
54_A179_M0.8090.99
226_V230_R0.8080.99
274_D277_L0.8080.99
91_M96_K0.8030.99
167_N195_V0.8010.99
305_V309_T0.8000.99
36_L309_T0.8000.99
158_N194_Q0.8000.99
60_F223_Y0.7950.99
307_E310_D0.7940.99
170_A208_G0.7890.99
66_M145_D0.7870.99
289_L297_M0.7860.99
297_M301_I0.7850.99
177_I230_R0.7830.99
62_L149_F0.7830.99
129_V152_F0.7820.99
157_S162_F0.7800.99
305_V308_A0.7800.99
97_A316_P0.7780.99
93_G96_K0.7750.99
212_V229_A0.7730.98
212_V242_I0.7720.98
278_T281_A0.7710.98
145_D235_R0.7660.98
92_S96_K0.7580.98
171_V194_Q0.7580.98
61_A227_K0.7570.98
130_P161_D0.7560.98
282_Y285_E0.7540.98
140_R175_P0.7520.98
96_K99_D0.7510.98
54_A151_T0.7500.98
225_A229_A0.7490.98
304_I307_E0.7480.98
262_R266_E0.7480.98
269_E273_S0.7450.98
61_A230_R0.7440.98
22_T81_A0.7400.98
229_A233_A0.7340.98
190_P193_K0.7340.98
298_L302_M0.7320.98
33_M93_G0.7320.98
133_V174_L0.7310.98
140_R173_K0.7280.98
70_L132_A0.7260.98
22_T56_V0.7250.98
301_I304_I0.7250.98
180_C241_L0.7230.98
252_H256_D0.7210.98
66_M82_F0.7160.98
57_G61_A0.7160.98
79_V84_M0.7150.97
255_D261_Y0.7120.97
215_N218_D0.7120.97
147_A234_R0.7110.97
181_E243_E0.7110.97
158_N186_A0.7100.97
229_A242_I0.7100.97
221_E225_A0.7090.97
180_C244_T0.7050.97
227_K230_R0.7030.97
86_A304_I0.7030.97
60_F219_P0.7030.97
23_M53_A0.7030.97
264_R267_V0.7030.97
185_Y266_E0.7020.97
204_A209_M0.7000.97
32_R309_T0.7000.97
263_G269_E0.7000.97
276_L282_Y0.6980.97
91_M100_P0.6970.97
126_T162_F0.6950.97
125_V159_Q0.6910.97
274_D279_Y0.6900.97
91_M95_A0.6890.97
282_Y288_L0.6890.97
141_M144_K0.6880.97
95_A98_A0.6880.97
184_K190_P0.6860.97
205_I213_T0.6840.97
28_K305_V0.6830.97
247_Y270_A0.6810.97
87_K315_A0.6810.97
147_A177_I0.6800.97
62_L69_V0.6770.97
93_G100_P0.6770.97
90_M116_N0.6740.96
97_A100_P0.6680.96
23_M276_L0.6670.96
24_L276_L0.6660.96
197_C200_I0.6650.96
215_N221_E0.6640.96
88_D100_P0.6640.96
149_F230_R0.6630.96
298_L309_T0.6600.96
40_G43_P0.6550.96
132_A176_V0.6550.96
197_C202_D0.6530.96
54_A73_Y0.6510.96
265_E270_A0.6510.96
140_R176_V0.6510.96
266_E270_A0.6500.96
294_E297_M0.6490.96
199_N213_T0.6470.96
263_G270_A0.6460.95
22_T25_L0.6450.95
62_L230_R0.6410.95
280_Q291_D0.6400.95
254_S269_E0.6400.95
170_A173_K0.6400.95
199_N245_I0.6390.95
96_K100_P0.6390.95
186_A194_Q0.6370.95
267_V270_A0.6350.95
262_R270_A0.6350.95
54_A58_A0.6340.95
224_Q227_K0.6300.95
136_A174_L0.6300.95
25_L301_I0.6290.95
139_G176_V0.6280.95
311_E314_N0.6280.95
90_M106_Q0.6240.95
56_V270_A0.6240.95
283_L289_L0.6200.94
57_G219_P0.6200.94
91_M99_D0.6200.94
130_P165_G0.6190.94
91_M97_A0.6180.94
36_L39_S0.6180.94
157_S200_I0.6150.94
220_L279_Y0.6140.94
177_I226_V0.6110.94
145_D230_R0.6110.94
69_V78_V0.6110.94
44_F254_S0.6090.94
50_G53_A0.6080.94
84_M100_P0.6060.94
308_A311_E0.6040.94
215_N278_T0.6040.94
257_D260_S0.6030.94
132_A148_A0.6020.93
194_Q197_C0.6000.93
97_A103_G0.5990.93
48_C55_Q0.5980.93
252_H269_E0.5970.93
126_T156_S0.5950.93
91_M315_A0.5950.93
92_S97_A0.5920.93
36_L94_F0.5880.93
187_I190_P0.5850.92
170_A196_A0.5850.92
37_N254_S0.5830.92
254_S266_E0.5820.92
262_R267_V0.5800.92
251_P258_D0.5770.92
287_G294_E0.5760.92
298_L305_V0.5740.92
214_V244_T0.5730.92
200_I241_L0.5730.92
139_G142_E0.5730.92
48_C77_G0.5720.92
56_V219_P0.5700.91
301_I306_N0.5700.91
21_R297_M0.5700.91
283_L288_L0.5680.91
117_R146_I0.5680.91
228_E232_R0.5680.91
88_D115_K0.5670.91
175_P236_G0.5660.91
54_A246_S0.5660.91
176_V179_M0.5650.91
93_G99_D0.5630.91
316_P319_A0.5630.91
165_G178_F0.5600.91
158_N195_V0.5600.91
177_I240_T0.5580.91
92_S101_N0.5510.90
61_A244_T0.5510.90
263_G266_E0.5500.90
293_I297_M0.5480.90
210_P237_E0.5470.90
50_G57_G0.5440.89
135_I138_A0.5420.89
188_S194_Q0.5410.89
288_L292_E0.5410.89
214_V222_V0.5380.89
80_L86_A0.5380.89
191_Y200_I0.5370.89
21_R304_I0.5370.89
66_M117_R0.5370.89
32_R36_L0.5350.89
180_C226_V0.5340.89
175_P240_T0.5320.88
191_Y195_V0.5320.88
58_A244_T0.5310.88
100_P111_F0.5310.88
276_L283_L0.5300.88
80_L89_L0.5290.88
284_K289_L0.5290.88
126_T129_V0.5270.88
49_Q250_T0.5230.88
28_K301_I0.5230.88
70_L128_Q0.5230.88
252_H266_E0.5200.87
66_M144_K0.5200.87
150_V179_M0.5190.87
256_D266_E0.5170.87
78_V151_T0.5160.87
163_H166_A0.5110.86
287_G291_D0.5110.86
92_S100_P0.5080.86
48_C51_Q0.5080.86
92_S98_A0.5040.86
87_K308_A0.5040.86
276_L285_E0.5030.86
265_E271_K0.5020.85
225_A228_E0.5020.85
273_S278_T0.5010.85
71_P118_I0.5000.85
68_Y146_I0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bfdA 2 0.9242 100 0.225 Contact Map
1qs0A 2 0.9909 100 0.226 Contact Map
1umdA 2 0.9909 100 0.231 Contact Map
2ozlA 2 0.9818 100 0.265 Contact Map
1w85A 2 0.9667 100 0.274 Contact Map
2xt6A 2 0.9061 100 0.371 Contact Map
2yicA 2 0.9152 100 0.371 Contact Map
2jgdA 2 0.8879 100 0.393 Contact Map
3uk1A 2 0.9061 100 0.592 Contact Map
1itzA 2 0.9242 100 0.593 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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