ODBA - BACSU - GREMLIN Contacts

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ODBA - 2-oxoisovalerate dehydrogenase subunit alpha

UniProt:	P37940	Sequences: MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPFVISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNSGGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQGDFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGNDPLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPLLTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	330 (297)
Sequences:	7620 (4040)
Seq/√Len:	234.4

BACSU - ODBA ACOA ODPA
HALSA - Q9HN77 Q9HNV6
SULSO - Q97Y23 Q97YF6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
163_H	207_Y	3.976	1.00
21_R	300_E	3.562	1.00
232_R	237_E	3.095	1.00
212_V	228_E	2.964	1.00
202_D	205_I	2.933	1.00
290_S	293_I	2.929	1.00
291_D	295_Q	2.867	1.00
230_R	234_R	2.726	1.00
177_I	233_A	2.677	1.00
70_L	135_I	2.586	1.00
218_D	221_E	2.463	1.00
210_P	232_R	2.441	1.00
147_A	230_R	2.386	1.00
232_R	238_G	2.278	1.00
199_N	202_D	2.277	1.00
152_F	180_C	2.237	1.00
212_V	240_T	2.193	1.00
231_E	235_R	2.172	1.00
133_V	165_G	2.138	1.00
258_D	262_R	2.134	1.00
58_A	151_T	2.119	1.00
213_T	245_I	2.091	1.00
269_E	272_K	2.090	1.00
87_K	311_E	2.071	1.00
173_K	196_A	2.053	1.00
41_K	313_E	2.023	1.00
139_G	148_A	2.001	1.00
25_L	304_I	1.995	1.00
26_A	77_G	1.988	1.00
92_S	95_A	1.953	1.00
284_K	291_D	1.942	1.00
310_D	314_N	1.919	1.00
280_Q	284_K	1.907	1.00
232_R	240_T	1.897	1.00
257_D	262_R	1.893	1.00
296_T	300_E	1.828	1.00
277_L	281_A	1.815	1.00
166_A	204_A	1.771	1.00
129_V	162_F	1.766	1.00
223_Y	227_K	1.740	1.00
265_E	268_E	1.715	1.00
280_Q	298_L	1.658	1.00
212_V	225_A	1.639	1.00
162_F	166_A	1.629	1.00
153_G	156_S	1.626	1.00
87_K	307_E	1.616	1.00
259_S	262_R	1.612	1.00
281_A	285_E	1.611	1.00
66_M	146_I	1.611	1.00
139_G	144_K	1.610	1.00
137_L	141_M	1.603	1.00
120_T	131_H	1.602	1.00
139_G	146_I	1.597	1.00
289_L	294_E	1.594	1.00
168_F	172_H	1.578	1.00
264_R	268_E	1.577	1.00
233_A	240_T	1.567	1.00
210_P	240_T	1.557	1.00
184_K	245_I	1.557	1.00
175_P	210_P	1.548	1.00
303_A	307_E	1.531	1.00
204_A	211_G	1.502	1.00
152_F	156_S	1.498	1.00
256_D	262_R	1.496	1.00
58_A	226_V	1.492	1.00
268_E	272_K	1.486	1.00
293_I	296_T	1.474	1.00
201_S	213_T	1.467	1.00
214_V	225_A	1.452	1.00
177_I	181_E	1.452	1.00
258_D	261_Y	1.446	1.00
280_Q	294_E	1.445	1.00
227_K	231_E	1.435	1.00
295_Q	299_D	1.420	1.00
256_D	261_Y	1.418	1.00
217_N	249_L	1.411	1.00
275_P	278_T	1.406	1.00
201_S	243_E	1.399	1.00
301_I	305_V	1.398	1.00
300_E	304_I	1.383	1.00
213_T	243_E	1.380	1.00
160_G	164_E	1.359	1.00
311_E	315_A	1.355	1.00
155_G	186_A	1.352	1.00
278_T	282_Y	1.350	1.00
98_A	315_A	1.342	1.00
306_N	310_D	1.338	1.00
147_A	178_F	1.336	1.00
307_E	311_E	1.330	1.00
289_L	293_I	1.330	1.00
292_E	296_T	1.329	1.00
58_A	149_F	1.316	1.00
284_K	294_E	1.309	1.00
133_V	178_F	1.305	1.00
299_D	303_A	1.298	1.00
294_E	298_L	1.297	1.00
166_A	207_Y	1.285	1.00
276_L	280_Q	1.265	1.00
270_A	273_S	1.259	1.00
229_A	240_T	1.252	1.00
267_V	271_K	1.245	1.00
152_F	179_M	1.242	1.00
277_L	280_Q	1.234	1.00
171_V	196_A	1.230	1.00
279_Y	282_Y	1.229	1.00
282_Y	286_T	1.228	1.00
180_C	200_I	1.225	1.00
136_A	176_V	1.225	1.00
210_P	238_G	1.223	1.00
224_Q	228_E	1.208	1.00
275_P	279_Y	1.199	1.00
176_V	181_E	1.196	1.00
201_S	211_G	1.194	1.00
257_D	261_Y	1.193	1.00
275_P	280_Q	1.192	1.00
129_V	165_G	1.184	1.00
179_M	244_T	1.172	1.00
73_Y	153_G	1.160	1.00
276_L	279_Y	1.148	1.00
24_L	301_I	1.140	1.00
94_F	97_A	1.139	1.00
225_A	242_I	1.134	1.00
85_T	88_D	1.131	1.00
31_E	49_Q	1.126	1.00
232_R	236_G	1.123	1.00
79_V	118_I	1.119	1.00
129_V	166_A	1.113	1.00
132_A	150_V	1.106	1.00
175_P	232_R	1.099	1.00
175_P	237_E	1.097	1.00
182_N	243_E	1.095	1.00
68_Y	139_G	1.090	1.00
228_E	231_E	1.088	1.00
173_K	237_E	1.087	1.00
108_P	115_K	1.083	1.00
275_P	282_Y	1.083	1.00
166_A	209_M	1.077	1.00
308_A	312_A	1.070	1.00
292_E	295_Q	1.069	1.00
152_F	157_S	1.069	1.00
214_V	221_E	1.063	1.00
295_Q	298_L	1.060	1.00
226_V	242_I	1.055	1.00
22_T	60_F	1.053	1.00
268_E	271_K	1.050	1.00
217_N	246_S	1.042	1.00
149_F	177_I	1.042	1.00
195_V	200_I	1.036	1.00
149_F	226_V	1.032	1.00
302_M	313_E	1.025	1.00
148_A	176_V	1.019	1.00
201_S	205_I	1.012	1.00
210_P	228_E	1.011	1.00
57_G	222_V	1.008	1.00
222_V	244_T	1.007	1.00
310_D	313_E	1.001	1.00
170_A	209_M	0.989	1.00
25_L	86_A	0.987	1.00
122_S	127_T	0.984	1.00
58_A	179_M	0.983	1.00
265_E	269_E	0.982	1.00
61_A	180_C	0.970	1.00
21_R	25_L	0.967	1.00
274_D	282_Y	0.965	1.00
135_I	148_A	0.962	1.00
279_Y	283_L	0.956	1.00
91_M	98_A	0.951	1.00
297_M	300_E	0.949	1.00
24_L	298_L	0.948	1.00
93_G	97_A	0.946	1.00
54_A	76_M	0.945	1.00
28_K	302_M	0.941	1.00
32_R	306_N	0.940	1.00
54_A	244_T	0.939	1.00
53_A	57_G	0.935	1.00
32_R	35_L	0.933	1.00
306_N	309_T	0.932	1.00
220_L	224_Q	0.927	1.00
113_Q	116_N	0.924	1.00
274_D	278_T	0.924	1.00
70_L	119_V	0.922	1.00
256_D	259_S	0.916	1.00
177_I	180_C	0.912	1.00
281_A	284_K	0.911	1.00
247_Y	256_D	0.910	1.00
300_E	303_A	0.904	1.00
173_K	238_G	0.904	1.00
247_Y	257_D	0.899	1.00
34_W	38_R	0.899	1.00
216_G	246_S	0.898	0.99
61_A	223_Y	0.897	0.99
137_L	172_H	0.891	0.99
249_L	271_K	0.890	0.99
176_V	180_C	0.884	0.99
24_L	28_K	0.881	0.99
204_A	241_L	0.880	0.99
184_K	192_D	0.878	0.99
302_M	306_N	0.874	0.99
211_G	243_E	0.871	0.99
92_S	99_D	0.868	0.99
179_M	226_V	0.865	0.99
304_I	308_A	0.863	0.99
28_K	31_E	0.861	0.99
124_P	127_T	0.860	0.99
68_Y	119_V	0.855	0.99
211_G	241_L	0.852	0.99
58_A	61_A	0.850	0.99
178_F	181_E	0.850	0.99
299_D	302_M	0.849	0.99
65_E	116_N	0.843	0.99
158_N	203_R	0.843	0.99
44_F	253_S	0.842	0.99
255_D	260_S	0.841	0.99
147_A	233_A	0.841	0.99
252_H	270_A	0.841	0.99
96_K	317_Y	0.833	0.99
221_E	224_Q	0.833	0.99
296_T	299_D	0.830	0.99
303_A	306_N	0.825	0.99
73_Y	151_T	0.817	0.99
216_G	222_V	0.816	0.99
149_F	179_M	0.816	0.99
266_E	269_E	0.816	0.99
28_K	298_L	0.816	0.99
133_V	176_V	0.811	0.99
54_A	179_M	0.809	0.99
226_V	230_R	0.808	0.99
274_D	277_L	0.808	0.99
91_M	96_K	0.803	0.99
167_N	195_V	0.801	0.99
305_V	309_T	0.800	0.99
36_L	309_T	0.800	0.99
158_N	194_Q	0.800	0.99
60_F	223_Y	0.795	0.99
307_E	310_D	0.794	0.99
170_A	208_G	0.789	0.99
66_M	145_D	0.787	0.99
289_L	297_M	0.786	0.99
297_M	301_I	0.785	0.99
177_I	230_R	0.783	0.99
62_L	149_F	0.783	0.99
129_V	152_F	0.782	0.99
157_S	162_F	0.780	0.99
305_V	308_A	0.780	0.99
97_A	316_P	0.778	0.99
93_G	96_K	0.775	0.99
212_V	229_A	0.773	0.98
212_V	242_I	0.772	0.98
278_T	281_A	0.771	0.98
145_D	235_R	0.766	0.98
92_S	96_K	0.758	0.98
171_V	194_Q	0.758	0.98
61_A	227_K	0.757	0.98
130_P	161_D	0.756	0.98
282_Y	285_E	0.754	0.98
140_R	175_P	0.752	0.98
96_K	99_D	0.751	0.98
54_A	151_T	0.750	0.98
225_A	229_A	0.749	0.98
304_I	307_E	0.748	0.98
262_R	266_E	0.748	0.98
269_E	273_S	0.745	0.98
61_A	230_R	0.744	0.98
22_T	81_A	0.740	0.98
229_A	233_A	0.734	0.98
190_P	193_K	0.734	0.98
298_L	302_M	0.732	0.98
33_M	93_G	0.732	0.98
133_V	174_L	0.731	0.98
140_R	173_K	0.728	0.98
70_L	132_A	0.726	0.98
22_T	56_V	0.725	0.98
301_I	304_I	0.725	0.98
180_C	241_L	0.723	0.98
252_H	256_D	0.721	0.98
66_M	82_F	0.716	0.98
57_G	61_A	0.716	0.98
79_V	84_M	0.715	0.97
255_D	261_Y	0.712	0.97
215_N	218_D	0.712	0.97
147_A	234_R	0.711	0.97
181_E	243_E	0.711	0.97
158_N	186_A	0.710	0.97
229_A	242_I	0.710	0.97
221_E	225_A	0.709	0.97
180_C	244_T	0.705	0.97
227_K	230_R	0.703	0.97
86_A	304_I	0.703	0.97
60_F	219_P	0.703	0.97
23_M	53_A	0.703	0.97
264_R	267_V	0.703	0.97
185_Y	266_E	0.702	0.97
204_A	209_M	0.700	0.97
32_R	309_T	0.700	0.97
263_G	269_E	0.700	0.97
276_L	282_Y	0.698	0.97
91_M	100_P	0.697	0.97
126_T	162_F	0.695	0.97
125_V	159_Q	0.691	0.97
274_D	279_Y	0.690	0.97
91_M	95_A	0.689	0.97
282_Y	288_L	0.689	0.97
141_M	144_K	0.688	0.97
95_A	98_A	0.688	0.97
184_K	190_P	0.686	0.97
205_I	213_T	0.684	0.97
28_K	305_V	0.683	0.97
247_Y	270_A	0.681	0.97
87_K	315_A	0.681	0.97
147_A	177_I	0.680	0.97
62_L	69_V	0.677	0.97
93_G	100_P	0.677	0.97
90_M	116_N	0.674	0.96
97_A	100_P	0.668	0.96
23_M	276_L	0.667	0.96
24_L	276_L	0.666	0.96
197_C	200_I	0.665	0.96
215_N	221_E	0.664	0.96
88_D	100_P	0.664	0.96
149_F	230_R	0.663	0.96
298_L	309_T	0.660	0.96
40_G	43_P	0.655	0.96
132_A	176_V	0.655	0.96
197_C	202_D	0.653	0.96
54_A	73_Y	0.651	0.96
265_E	270_A	0.651	0.96
140_R	176_V	0.651	0.96
266_E	270_A	0.650	0.96
294_E	297_M	0.649	0.96
199_N	213_T	0.647	0.96
263_G	270_A	0.646	0.95
22_T	25_L	0.645	0.95
62_L	230_R	0.641	0.95
280_Q	291_D	0.640	0.95
254_S	269_E	0.640	0.95
170_A	173_K	0.640	0.95
199_N	245_I	0.639	0.95
96_K	100_P	0.639	0.95
186_A	194_Q	0.637	0.95
267_V	270_A	0.635	0.95
262_R	270_A	0.635	0.95
54_A	58_A	0.634	0.95
224_Q	227_K	0.630	0.95
136_A	174_L	0.630	0.95
25_L	301_I	0.629	0.95
139_G	176_V	0.628	0.95
311_E	314_N	0.628	0.95
90_M	106_Q	0.624	0.95
56_V	270_A	0.624	0.95
283_L	289_L	0.620	0.94
57_G	219_P	0.620	0.94
91_M	99_D	0.620	0.94
130_P	165_G	0.619	0.94
91_M	97_A	0.618	0.94
36_L	39_S	0.618	0.94
157_S	200_I	0.615	0.94
220_L	279_Y	0.614	0.94
177_I	226_V	0.611	0.94
145_D	230_R	0.611	0.94
69_V	78_V	0.611	0.94
44_F	254_S	0.609	0.94
50_G	53_A	0.608	0.94
84_M	100_P	0.606	0.94
308_A	311_E	0.604	0.94
215_N	278_T	0.604	0.94
257_D	260_S	0.603	0.94
132_A	148_A	0.602	0.93
194_Q	197_C	0.600	0.93
97_A	103_G	0.599	0.93
48_C	55_Q	0.598	0.93
252_H	269_E	0.597	0.93
126_T	156_S	0.595	0.93
91_M	315_A	0.595	0.93
92_S	97_A	0.592	0.93
36_L	94_F	0.588	0.93
187_I	190_P	0.585	0.92
170_A	196_A	0.585	0.92
37_N	254_S	0.583	0.92
254_S	266_E	0.582	0.92
262_R	267_V	0.580	0.92
251_P	258_D	0.577	0.92
287_G	294_E	0.576	0.92
298_L	305_V	0.574	0.92
214_V	244_T	0.573	0.92
200_I	241_L	0.573	0.92
139_G	142_E	0.573	0.92
48_C	77_G	0.572	0.92
56_V	219_P	0.570	0.91
301_I	306_N	0.570	0.91
21_R	297_M	0.570	0.91
283_L	288_L	0.568	0.91
117_R	146_I	0.568	0.91
228_E	232_R	0.568	0.91
88_D	115_K	0.567	0.91
175_P	236_G	0.566	0.91
54_A	246_S	0.566	0.91
176_V	179_M	0.565	0.91
93_G	99_D	0.563	0.91
316_P	319_A	0.563	0.91
165_G	178_F	0.560	0.91
158_N	195_V	0.560	0.91
177_I	240_T	0.558	0.91
92_S	101_N	0.551	0.90
61_A	244_T	0.551	0.90
263_G	266_E	0.550	0.90
293_I	297_M	0.548	0.90
210_P	237_E	0.547	0.90
50_G	57_G	0.544	0.89
135_I	138_A	0.542	0.89
188_S	194_Q	0.541	0.89
288_L	292_E	0.541	0.89
214_V	222_V	0.538	0.89
80_L	86_A	0.538	0.89
191_Y	200_I	0.537	0.89
21_R	304_I	0.537	0.89
66_M	117_R	0.537	0.89
32_R	36_L	0.535	0.89
180_C	226_V	0.534	0.89
175_P	240_T	0.532	0.88
191_Y	195_V	0.532	0.88
58_A	244_T	0.531	0.88
100_P	111_F	0.531	0.88
276_L	283_L	0.530	0.88
80_L	89_L	0.529	0.88
284_K	289_L	0.529	0.88
126_T	129_V	0.527	0.88
49_Q	250_T	0.523	0.88
28_K	301_I	0.523	0.88
70_L	128_Q	0.523	0.88
252_H	266_E	0.520	0.87
66_M	144_K	0.520	0.87
150_V	179_M	0.519	0.87
256_D	266_E	0.517	0.87
78_V	151_T	0.516	0.87
163_H	166_A	0.511	0.86
287_G	291_D	0.511	0.86
92_S	100_P	0.508	0.86
48_C	51_Q	0.508	0.86
92_S	98_A	0.504	0.86
87_K	308_A	0.504	0.86
276_L	285_E	0.503	0.86
265_E	271_K	0.502	0.85
225_A	228_E	0.502	0.85
273_S	278_T	0.501	0.85
71_P	118_I	0.500	0.85
68_Y	146_I	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2bfdA	2	0.9242	100	0.225	Contact Map
1qs0A	2	0.9909	100	0.226	Contact Map
1umdA	2	0.9909	100	0.231	Contact Map
2ozlA	2	0.9818	100	0.265	Contact Map
1w85A	2	0.9667	100	0.274	Contact Map
2xt6A	2	0.9061	100	0.371	Contact Map
2yicA	2	0.9152	100	0.371	Contact Map
2jgdA	2	0.8879	100	0.393	Contact Map
3uk1A	2	0.9061	100	0.592	Contact Map
1itzA	2	0.9242	100	0.593	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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