CYSK - BACSU - GREMLIN Contacts

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CYSK - Cysteine synthase

UniProt:	P37887	Sequences: MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSVKDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSMERRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGKEIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGPHKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAALQVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	308 (282)
Sequences:	21317 (11217)
Seq/√Len:	668.0

ECOLI - CYSK CYSM ILVA TDCB SDHD TRPB DPAL DCYD THRC
BACSU - CYSK CYSM MCCA ILVA THRC TRPB SDHD
HALSA - Q9HNH6 Q9HQ70 Q9HRU4 Q9HMQ7 Q9HNH0 TRPB Q9HRP3
SULSO - Q980P1 TRPB1 Q97ZL6 TRPB2 Q980F2 Q97ZT5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
84_A	91_A	3.841	1.00
30_D	287_K	3.301	1.00
129_K	132_E	3.174	1.00
19_K	30_D	3.061	1.00
173_A	201_Y	2.611	1.00
248_E	277_Q	2.583	1.00
255_R	259_E	2.571	1.00
162_I	289_L	2.551	1.00
101_M	105_N	2.514	1.00
55_A	59_E	2.485	1.00
206_S	245_K	2.376	1.00
90_K	113_E	2.321	1.00
55_A	149_S	2.316	1.00
97_D	118_P	2.302	1.00
92_I	113_E	2.253	1.00
199_K	240_E	2.239	1.00
14_N	164_E	2.237	1.00
67_T	92_I	2.229	1.00
132_E	136_K	2.187	1.00
57_E	89_L	2.182	1.00
94_V	133_L	2.135	1.00
188_G	237_V	2.019	1.00
212_S	216_P	2.018	1.00
32_Y	287_K	2.016	1.00
54_E	87_K	2.016	1.00
92_I	115_V	2.016	1.00
245_K	248_E	2.007	1.00
207_D	246_N	1.996	1.00
188_G	200_I	1.980	1.00
160_K	190_V	1.967	1.00
14_N	165_Q	1.965	1.00
271_A	290_A	1.941	1.00
283_G	286_K	1.932	1.00
146_N	231_D	1.917	1.00
17_I	289_L	1.840	1.00
195_Y	198_I	1.838	1.00
155_R	193_E	1.800	1.00
203_V	274_A	1.788	1.00
57_E	60_G	1.779	1.00
143_Q	146_N	1.777	1.00
174_F	191_L	1.751	1.00
201_Y	240_E	1.744	1.00
178_I	202_A	1.725	1.00
256_A	264_G	1.707	1.00
209_P	213_G	1.687	1.00
155_R	189_E	1.677	1.00
41_G	82_M	1.676	1.00
255_R	276_L	1.643	1.00
131_E	135_E	1.642	1.00
32_Y	166_F	1.635	1.00
19_K	32_Y	1.623	1.00
252_Y	273_Y	1.605	1.00
256_A	272_I	1.588	1.00
19_K	24_A	1.564	1.00
171_L	289_L	1.563	1.00
174_F	187_A	1.557	1.00
104_R	116_L	1.538	1.00
172_D	286_K	1.537	1.00
224_I	270_A	1.533	1.00
50_L	54_E	1.526	1.00
240_E	281_K	1.524	1.00
192_K	239_D	1.522	1.00
33_L	292_I	1.472	1.00
172_D	287_K	1.470	1.00
159_G	187_A	1.464	1.00
127_I	131_E	1.442	1.00
57_E	87_K	1.442	1.00
173_A	286_K	1.422	1.00
105_N	108_R	1.404	1.00
104_R	108_R	1.393	1.00
252_Y	276_L	1.390	1.00
72_T	77_G	1.376	1.00
175_V	278_V	1.366	1.00
231_D	234_N	1.366	1.00
213_G	216_P	1.363	1.00
101_M	104_R	1.356	1.00
184_I	238_Y	1.356	1.00
26_E	255_R	1.356	1.00
134_A	141_V	1.350	1.00
159_G	191_L	1.342	1.00
115_V	129_K	1.332	1.00
273_Y	277_Q	1.327	1.00
248_E	273_Y	1.326	1.00
173_A	283_G	1.322	1.00
173_A	199_K	1.315	1.00
52_M	147_N	1.309	1.00
26_E	259_E	1.281	1.00
51_A	156_Q	1.279	1.00
122_G	125_G	1.278	1.00
169_D	287_K	1.263	1.00
175_V	203_V	1.261	1.00
206_S	243_P	1.249	1.00
54_E	58_K	1.246	1.00
278_V	281_K	1.238	1.00
159_G	190_V	1.235	1.00
20_L	33_L	1.223	1.00
190_V	194_A	1.221	1.00
95_M	107_L	1.220	1.00
264_G	292_I	1.220	1.00
212_S	243_P	1.217	1.00
107_L	112_A	1.209	1.00
67_T	90_K	1.207	1.00
22_R	260_E	1.205	1.00
124_K	128_K	1.204	1.00
55_A	58_K	1.201	1.00
166_F	171_L	1.201	1.00
163_V	194_A	1.191	1.00
251_E	255_R	1.190	1.00
128_K	131_E	1.181	1.00
252_Y	272_I	1.180	1.00
131_E	134_A	1.166	1.00
18_V	35_L	1.164	1.00
213_G	217_G	1.156	1.00
160_K	164_E	1.154	1.00
163_V	195_Y	1.154	1.00
191_L	198_I	1.152	1.00
163_V	190_V	1.152	1.00
242_F	274_A	1.149	1.00
268_S	292_I	1.148	1.00
184_I	200_I	1.145	1.00
104_R	114_L	1.144	1.00
16_P	38_M	1.138	1.00
53_I	68_I	1.121	1.00
209_P	243_P	1.120	1.00
282_L	286_K	1.112	1.00
189_E	234_N	1.107	1.00
94_V	129_K	1.104	1.00
170_Q	287_K	1.102	1.00
244_V	273_Y	1.099	1.00
77_G	107_L	1.093	1.00
97_D	119_G	1.092	1.00
257_A	263_L	1.090	1.00
17_I	166_F	1.090	1.00
201_Y	242_F	1.089	1.00
202_A	241_I	1.087	1.00
248_E	251_E	1.084	1.00
51_A	153_I	1.082	1.00
125_G	128_K	1.077	1.00
221_I	249_A	1.066	1.00
220_K	250_F	1.063	1.00
17_I	162_I	1.059	1.00
128_K	132_E	1.054	1.00
98_T	119_G	1.048	1.00
277_Q	280_K	1.035	1.00
184_I	202_A	1.030	1.00
51_A	55_A	1.027	1.00
31_V	275_A	1.021	1.00
209_P	214_G	1.018	1.00
68_I	84_A	1.014	1.00
51_A	54_E	1.012	1.00
21_N	25_D	1.011	1.00
166_F	289_L	1.007	1.00
80_L	91_A	1.005	1.00
254_R	258_R	1.002	1.00
28_S	284_K	1.001	1.00
59_E	149_S	1.000	1.00
95_M	116_L	0.998	1.00
247_E	251_E	0.991	1.00
53_I	87_K	0.991	1.00
173_A	288_V	0.988	1.00
253_A	269_G	0.988	1.00
123_M	126_A	0.987	1.00
162_I	171_L	0.975	1.00
275_A	290_A	0.974	1.00
53_I	83_V	0.969	1.00
52_M	142_P	0.966	1.00
129_K	133_L	0.965	1.00
82_M	110_Y	0.963	1.00
85_A	91_A	0.961	1.00
49_G	79_G	0.959	1.00
69_I	139_Y	0.957	1.00
215_K	241_I	0.956	1.00
187_A	291_I	0.955	1.00
22_R	259_E	0.945	1.00
199_K	239_D	0.937	1.00
242_F	277_Q	0.935	1.00
81_A	112_A	0.934	1.00
29_A	286_K	0.930	1.00
264_G	268_S	0.930	1.00
79_G	83_V	0.912	1.00
22_R	25_D	0.910	1.00
219_H	225_G	0.910	1.00
108_R	113_E	0.908	1.00
190_V	193_E	0.907	1.00
156_Q	160_K	0.906	1.00
29_A	285_G	0.906	1.00
167_G	170_Q	0.899	1.00
132_E	135_E	0.897	1.00
56_A	140_F	0.891	1.00
69_I	130_A	0.890	1.00
175_V	275_A	0.889	1.00
66_N	138_G	0.887	1.00
134_A	139_Y	0.877	1.00
133_L	137_H	0.873	1.00
178_I	184_I	0.865	1.00
176_A	187_A	0.863	1.00
11_L	50_L	0.861	1.00
24_A	27_N	0.860	1.00
209_P	212_S	0.859	1.00
70_E	93_L	0.859	1.00
155_R	190_V	0.859	1.00
224_I	267_S	0.852	1.00
175_V	201_Y	0.848	1.00
268_S	293_P	0.845	1.00
69_I	133_L	0.843	1.00
252_Y	255_R	0.835	1.00
272_I	292_I	0.832	1.00
211_L	241_I	0.829	1.00
105_N	109_A	0.822	1.00
15_T	39_N	0.819	1.00
35_L	292_I	0.816	1.00
160_K	194_A	0.813	1.00
92_I	139_Y	0.806	1.00
185_T	232_I	0.804	1.00
151_P	232_I	0.803	1.00
271_A	293_P	0.803	1.00
108_R	116_L	0.801	1.00
263_L	296_G	0.801	1.00
220_K	246_N	0.799	1.00
56_A	60_G	0.797	1.00
154_H	158_T	0.796	1.00
67_T	139_Y	0.788	1.00
66_N	90_K	0.788	1.00
82_M	86_A	0.788	1.00
163_V	191_L	0.785	1.00
173_A	282_L	0.784	1.00
208_S	214_G	0.782	1.00
175_V	274_A	0.782	1.00
153_I	156_Q	0.782	1.00
158_T	187_A	0.780	1.00
170_Q	195_Y	0.775	1.00
212_S	241_I	0.774	1.00
173_A	278_V	0.773	1.00
199_K	286_K	0.769	1.00
227_G	230_P	0.766	1.00
85_A	110_Y	0.766	1.00
51_A	149_S	0.765	1.00
92_I	133_L	0.764	1.00
158_T	291_I	0.763	1.00
20_L	272_I	0.763	1.00
189_E	193_E	0.762	1.00
35_L	38_M	0.755	1.00
242_F	281_K	0.755	1.00
210_V	213_G	0.754	1.00
130_A	141_V	0.753	1.00
27_N	255_R	0.751	1.00
158_T	183_T	0.751	1.00
166_F	287_K	0.748	1.00
133_L	136_K	0.748	1.00
69_I	134_A	0.746	1.00
276_L	280_K	0.738	1.00
171_L	198_I	0.736	1.00
163_V	167_G	0.736	1.00
57_E	61_K	0.729	1.00
65_G	138_G	0.724	1.00
130_A	134_A	0.722	1.00
93_L	107_L	0.721	1.00
23_L	276_L	0.719	1.00
272_I	290_A	0.718	1.00
20_L	260_E	0.718	1.00
250_F	266_I	0.716	1.00
264_G	269_G	0.713	1.00
277_Q	281_K	0.712	1.00
187_A	191_L	0.709	1.00
78_I	107_L	0.709	1.00
117_T	129_K	0.706	1.00
78_I	106_L	0.706	1.00
27_N	276_L	0.704	1.00
158_T	162_I	0.701	1.00
235_T	238_Y	0.698	1.00
125_G	129_K	0.697	1.00
166_F	169_D	0.696	1.00
90_K	139_Y	0.695	1.00
29_A	288_V	0.695	1.00
178_I	241_I	0.694	1.00
25_D	28_S	0.694	1.00
143_Q	147_N	0.693	1.00
30_D	285_G	0.693	1.00
61_K	89_L	0.691	1.00
21_N	24_A	0.687	1.00
210_V	227_G	0.686	1.00
151_P	189_E	0.686	1.00
249_A	270_A	0.686	1.00
94_V	115_V	0.683	1.00
49_G	83_V	0.681	1.00
240_E	278_V	0.678	1.00
13_G	40_P	0.671	1.00
123_M	127_I	0.669	1.00
24_A	30_D	0.668	1.00
68_I	89_L	0.667	1.00
148_P	151_P	0.665	1.00
91_A	112_A	0.664	1.00
71_P	123_M	0.662	1.00
33_L	290_A	0.662	1.00
71_P	141_V	0.657	1.00
279_A	282_L	0.657	1.00
42_S	295_N	0.654	1.00
52_M	149_S	0.653	1.00
171_L	287_K	0.650	1.00
211_L	229_V	0.650	1.00
12_I	46_D	0.649	1.00
44_V	183_T	0.649	1.00
33_L	272_I	0.645	1.00
205_P	224_I	0.639	1.00
140_F	147_N	0.637	1.00
184_I	234_N	0.636	1.00
174_F	198_I	0.636	1.00
164_E	194_A	0.632	1.00
282_L	288_V	0.631	1.00
99_M	104_R	0.631	1.00
174_F	291_I	0.629	1.00
55_A	61_K	0.628	1.00
177_G	293_P	0.628	1.00
178_I	211_L	0.626	1.00
94_V	117_T	0.626	1.00
176_A	184_I	0.624	1.00
17_I	32_Y	0.624	1.00
101_M	108_R	0.621	1.00
256_A	260_E	0.621	1.00
97_D	116_L	0.621	1.00
68_I	142_P	0.621	1.00
65_G	90_K	0.620	1.00
34_K	161_E	0.619	1.00
48_I	52_M	0.618	1.00
52_M	150_N	0.616	1.00
246_N	250_F	0.612	1.00
99_M	222_Q	0.609	1.00
95_M	104_R	0.609	1.00
177_G	271_A	0.608	1.00
210_V	214_G	0.608	1.00
256_A	292_I	0.607	1.00
201_Y	278_V	0.602	1.00
103_R	222_Q	0.601	1.00
253_A	266_I	0.601	1.00
185_T	189_E	0.599	1.00
192_K	237_V	0.598	1.00
131_E	141_V	0.597	1.00
175_V	288_V	0.596	1.00
278_V	282_L	0.596	1.00
122_G	126_A	0.593	1.00
61_K	140_F	0.593	1.00
203_V	242_F	0.593	1.00
77_G	93_L	0.592	1.00
162_I	187_A	0.592	1.00
127_I	130_A	0.591	1.00
221_I	224_I	0.588	1.00
23_L	272_I	0.588	1.00
20_L	23_L	0.587	1.00
95_M	99_M	0.587	1.00
35_L	262_I	0.585	1.00
192_K	236_E	0.585	1.00
119_G	125_G	0.584	1.00
46_D	82_M	0.583	1.00
174_F	200_I	0.583	1.00
234_N	237_V	0.583	1.00
68_I	91_A	0.575	1.00
29_A	279_A	0.575	1.00
23_L	27_N	0.572	1.00
69_I	94_V	0.571	1.00
37_Y	295_N	0.570	1.00
24_A	31_V	0.570	1.00
256_A	262_I	0.570	1.00
274_A	278_V	0.565	1.00
23_L	252_Y	0.565	1.00
52_M	140_F	0.564	1.00
24_A	29_A	0.563	1.00
203_V	270_A	0.562	1.00
12_I	50_L	0.562	1.00
272_I	276_L	0.561	1.00
106_L	109_A	0.560	1.00
74_G	77_G	0.558	1.00
202_A	238_Y	0.554	1.00
163_V	166_F	0.554	1.00
149_S	153_I	0.553	1.00
153_I	189_E	0.553	1.00
29_A	284_K	0.553	1.00
23_L	255_R	0.549	1.00
40_P	46_D	0.548	1.00
17_I	165_Q	0.546	1.00
268_S	271_A	0.546	1.00
13_G	39_N	0.546	1.00
231_D	235_T	0.546	1.00
81_A	107_L	0.542	1.00
124_K	127_I	0.542	1.00
81_A	91_A	0.542	1.00
166_F	170_Q	0.540	1.00
41_G	110_Y	0.538	1.00
212_S	215_K	0.538	1.00
80_L	142_P	0.537	1.00
206_S	209_P	0.535	1.00
11_L	38_M	0.533	1.00
223_G	267_S	0.533	1.00
151_P	185_T	0.532	1.00
126_A	130_A	0.531	1.00
163_V	169_D	0.531	1.00
133_L	139_Y	0.530	1.00
48_I	76_T	0.530	1.00
211_L	215_K	0.530	1.00
244_V	270_A	0.529	1.00
60_G	140_F	0.529	1.00
11_L	54_E	0.527	1.00
26_E	276_L	0.526	0.99
72_T	93_L	0.526	0.99
70_E	80_L	0.525	0.99
162_I	291_I	0.525	0.99
251_E	254_R	0.524	0.99
234_N	238_Y	0.523	0.99
20_L	24_A	0.522	0.99
71_P	130_A	0.520	0.99
29_A	283_G	0.518	0.99
92_I	137_H	0.518	0.99
58_K	65_G	0.515	0.99
151_P	233_L	0.513	0.99
153_I	157_T	0.513	0.99
33_L	256_A	0.511	0.99
23_L	259_E	0.511	0.99
245_K	277_Q	0.510	0.99
24_A	28_S	0.509	0.99
60_G	66_N	0.508	0.99
37_Y	262_I	0.508	0.99
113_E	137_H	0.506	0.99
187_A	190_V	0.502	0.99
204_E	210_V	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2eguA	2	0.8766	100	0.13	Contact Map
2q3bA	2	0.9675	100	0.137	Contact Map
2pqmA	2	0.9935	100	0.139	Contact Map
4r2vA	2	0.9838	100	0.139	Contact Map
4ql4A	2	0.8831	100	0.14	Contact Map
1y7lA	2	0.974	100	0.143	Contact Map
3tbhA	2	0.9935	100	0.147	Contact Map
3x44A	3	0.987	100	0.147	Contact Map
1ve1A	2	0.9708	100	0.149	Contact Map
4lmbA	2	0.987	100	0.154	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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