GREMLIN Database
CYSK - Cysteine synthase
UniProt: P37887 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (282)
Sequences: 21317 (11217)
Seq/√Len: 668.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_A91_A3.8411.00
30_D287_K3.3011.00
129_K132_E3.1741.00
19_K30_D3.0611.00
173_A201_Y2.6111.00
248_E277_Q2.5831.00
255_R259_E2.5711.00
162_I289_L2.5511.00
101_M105_N2.5141.00
55_A59_E2.4851.00
206_S245_K2.3761.00
90_K113_E2.3211.00
55_A149_S2.3161.00
97_D118_P2.3021.00
92_I113_E2.2531.00
199_K240_E2.2391.00
14_N164_E2.2371.00
67_T92_I2.2291.00
132_E136_K2.1871.00
57_E89_L2.1821.00
94_V133_L2.1351.00
188_G237_V2.0191.00
212_S216_P2.0181.00
32_Y287_K2.0161.00
54_E87_K2.0161.00
92_I115_V2.0161.00
245_K248_E2.0071.00
207_D246_N1.9961.00
188_G200_I1.9801.00
160_K190_V1.9671.00
14_N165_Q1.9651.00
271_A290_A1.9411.00
283_G286_K1.9321.00
146_N231_D1.9171.00
17_I289_L1.8401.00
195_Y198_I1.8381.00
155_R193_E1.8001.00
203_V274_A1.7881.00
57_E60_G1.7791.00
143_Q146_N1.7771.00
174_F191_L1.7511.00
201_Y240_E1.7441.00
178_I202_A1.7251.00
256_A264_G1.7071.00
209_P213_G1.6871.00
155_R189_E1.6771.00
41_G82_M1.6761.00
255_R276_L1.6431.00
131_E135_E1.6421.00
32_Y166_F1.6351.00
19_K32_Y1.6231.00
252_Y273_Y1.6051.00
256_A272_I1.5881.00
19_K24_A1.5641.00
171_L289_L1.5631.00
174_F187_A1.5571.00
104_R116_L1.5381.00
172_D286_K1.5371.00
224_I270_A1.5331.00
50_L54_E1.5261.00
240_E281_K1.5241.00
192_K239_D1.5221.00
33_L292_I1.4721.00
172_D287_K1.4701.00
159_G187_A1.4641.00
127_I131_E1.4421.00
57_E87_K1.4421.00
173_A286_K1.4221.00
105_N108_R1.4041.00
104_R108_R1.3931.00
252_Y276_L1.3901.00
72_T77_G1.3761.00
175_V278_V1.3661.00
231_D234_N1.3661.00
213_G216_P1.3631.00
101_M104_R1.3561.00
184_I238_Y1.3561.00
26_E255_R1.3561.00
134_A141_V1.3501.00
159_G191_L1.3421.00
115_V129_K1.3321.00
273_Y277_Q1.3271.00
248_E273_Y1.3261.00
173_A283_G1.3221.00
173_A199_K1.3151.00
52_M147_N1.3091.00
26_E259_E1.2811.00
51_A156_Q1.2791.00
122_G125_G1.2781.00
169_D287_K1.2631.00
175_V203_V1.2611.00
206_S243_P1.2491.00
54_E58_K1.2461.00
278_V281_K1.2381.00
159_G190_V1.2351.00
20_L33_L1.2231.00
190_V194_A1.2211.00
95_M107_L1.2201.00
264_G292_I1.2201.00
212_S243_P1.2171.00
107_L112_A1.2091.00
67_T90_K1.2071.00
22_R260_E1.2051.00
124_K128_K1.2041.00
55_A58_K1.2011.00
166_F171_L1.2011.00
163_V194_A1.1911.00
251_E255_R1.1901.00
128_K131_E1.1811.00
252_Y272_I1.1801.00
131_E134_A1.1661.00
18_V35_L1.1641.00
213_G217_G1.1561.00
160_K164_E1.1541.00
163_V195_Y1.1541.00
191_L198_I1.1521.00
163_V190_V1.1521.00
242_F274_A1.1491.00
268_S292_I1.1481.00
184_I200_I1.1451.00
104_R114_L1.1441.00
16_P38_M1.1381.00
53_I68_I1.1211.00
209_P243_P1.1201.00
282_L286_K1.1121.00
189_E234_N1.1071.00
94_V129_K1.1041.00
170_Q287_K1.1021.00
244_V273_Y1.0991.00
77_G107_L1.0931.00
97_D119_G1.0921.00
257_A263_L1.0901.00
17_I166_F1.0901.00
201_Y242_F1.0891.00
202_A241_I1.0871.00
248_E251_E1.0841.00
51_A153_I1.0821.00
125_G128_K1.0771.00
221_I249_A1.0661.00
220_K250_F1.0631.00
17_I162_I1.0591.00
128_K132_E1.0541.00
98_T119_G1.0481.00
277_Q280_K1.0351.00
184_I202_A1.0301.00
51_A55_A1.0271.00
31_V275_A1.0211.00
209_P214_G1.0181.00
68_I84_A1.0141.00
51_A54_E1.0121.00
21_N25_D1.0111.00
166_F289_L1.0071.00
80_L91_A1.0051.00
254_R258_R1.0021.00
28_S284_K1.0011.00
59_E149_S1.0001.00
95_M116_L0.9981.00
247_E251_E0.9911.00
53_I87_K0.9911.00
173_A288_V0.9881.00
253_A269_G0.9881.00
123_M126_A0.9871.00
162_I171_L0.9751.00
275_A290_A0.9741.00
53_I83_V0.9691.00
52_M142_P0.9661.00
129_K133_L0.9651.00
82_M110_Y0.9631.00
85_A91_A0.9611.00
49_G79_G0.9591.00
69_I139_Y0.9571.00
215_K241_I0.9561.00
187_A291_I0.9551.00
22_R259_E0.9451.00
199_K239_D0.9371.00
242_F277_Q0.9351.00
81_A112_A0.9341.00
29_A286_K0.9301.00
264_G268_S0.9301.00
79_G83_V0.9121.00
22_R25_D0.9101.00
219_H225_G0.9101.00
108_R113_E0.9081.00
190_V193_E0.9071.00
156_Q160_K0.9061.00
29_A285_G0.9061.00
167_G170_Q0.8991.00
132_E135_E0.8971.00
56_A140_F0.8911.00
69_I130_A0.8901.00
175_V275_A0.8891.00
66_N138_G0.8871.00
134_A139_Y0.8771.00
133_L137_H0.8731.00
178_I184_I0.8651.00
176_A187_A0.8631.00
11_L50_L0.8611.00
24_A27_N0.8601.00
209_P212_S0.8591.00
70_E93_L0.8591.00
155_R190_V0.8591.00
224_I267_S0.8521.00
175_V201_Y0.8481.00
268_S293_P0.8451.00
69_I133_L0.8431.00
252_Y255_R0.8351.00
272_I292_I0.8321.00
211_L241_I0.8291.00
105_N109_A0.8221.00
15_T39_N0.8191.00
35_L292_I0.8161.00
160_K194_A0.8131.00
92_I139_Y0.8061.00
185_T232_I0.8041.00
151_P232_I0.8031.00
271_A293_P0.8031.00
108_R116_L0.8011.00
263_L296_G0.8011.00
220_K246_N0.7991.00
56_A60_G0.7971.00
154_H158_T0.7961.00
67_T139_Y0.7881.00
66_N90_K0.7881.00
82_M86_A0.7881.00
163_V191_L0.7851.00
173_A282_L0.7841.00
208_S214_G0.7821.00
175_V274_A0.7821.00
153_I156_Q0.7821.00
158_T187_A0.7801.00
170_Q195_Y0.7751.00
212_S241_I0.7741.00
173_A278_V0.7731.00
199_K286_K0.7691.00
227_G230_P0.7661.00
85_A110_Y0.7661.00
51_A149_S0.7651.00
92_I133_L0.7641.00
158_T291_I0.7631.00
20_L272_I0.7631.00
189_E193_E0.7621.00
35_L38_M0.7551.00
242_F281_K0.7551.00
210_V213_G0.7541.00
130_A141_V0.7531.00
27_N255_R0.7511.00
158_T183_T0.7511.00
166_F287_K0.7481.00
133_L136_K0.7481.00
69_I134_A0.7461.00
276_L280_K0.7381.00
171_L198_I0.7361.00
163_V167_G0.7361.00
57_E61_K0.7291.00
65_G138_G0.7241.00
130_A134_A0.7221.00
93_L107_L0.7211.00
23_L276_L0.7191.00
272_I290_A0.7181.00
20_L260_E0.7181.00
250_F266_I0.7161.00
264_G269_G0.7131.00
277_Q281_K0.7121.00
187_A191_L0.7091.00
78_I107_L0.7091.00
117_T129_K0.7061.00
78_I106_L0.7061.00
27_N276_L0.7041.00
158_T162_I0.7011.00
235_T238_Y0.6981.00
125_G129_K0.6971.00
166_F169_D0.6961.00
90_K139_Y0.6951.00
29_A288_V0.6951.00
178_I241_I0.6941.00
25_D28_S0.6941.00
143_Q147_N0.6931.00
30_D285_G0.6931.00
61_K89_L0.6911.00
21_N24_A0.6871.00
210_V227_G0.6861.00
151_P189_E0.6861.00
249_A270_A0.6861.00
94_V115_V0.6831.00
49_G83_V0.6811.00
240_E278_V0.6781.00
13_G40_P0.6711.00
123_M127_I0.6691.00
24_A30_D0.6681.00
68_I89_L0.6671.00
148_P151_P0.6651.00
91_A112_A0.6641.00
71_P123_M0.6621.00
33_L290_A0.6621.00
71_P141_V0.6571.00
279_A282_L0.6571.00
42_S295_N0.6541.00
52_M149_S0.6531.00
171_L287_K0.6501.00
211_L229_V0.6501.00
12_I46_D0.6491.00
44_V183_T0.6491.00
33_L272_I0.6451.00
205_P224_I0.6391.00
140_F147_N0.6371.00
184_I234_N0.6361.00
174_F198_I0.6361.00
164_E194_A0.6321.00
282_L288_V0.6311.00
99_M104_R0.6311.00
174_F291_I0.6291.00
55_A61_K0.6281.00
177_G293_P0.6281.00
178_I211_L0.6261.00
94_V117_T0.6261.00
176_A184_I0.6241.00
17_I32_Y0.6241.00
101_M108_R0.6211.00
256_A260_E0.6211.00
97_D116_L0.6211.00
68_I142_P0.6211.00
65_G90_K0.6201.00
34_K161_E0.6191.00
48_I52_M0.6181.00
52_M150_N0.6161.00
246_N250_F0.6121.00
99_M222_Q0.6091.00
95_M104_R0.6091.00
177_G271_A0.6081.00
210_V214_G0.6081.00
256_A292_I0.6071.00
201_Y278_V0.6021.00
103_R222_Q0.6011.00
253_A266_I0.6011.00
185_T189_E0.5991.00
192_K237_V0.5981.00
131_E141_V0.5971.00
175_V288_V0.5961.00
278_V282_L0.5961.00
122_G126_A0.5931.00
61_K140_F0.5931.00
203_V242_F0.5931.00
77_G93_L0.5921.00
162_I187_A0.5921.00
127_I130_A0.5911.00
221_I224_I0.5881.00
23_L272_I0.5881.00
20_L23_L0.5871.00
95_M99_M0.5871.00
35_L262_I0.5851.00
192_K236_E0.5851.00
119_G125_G0.5841.00
46_D82_M0.5831.00
174_F200_I0.5831.00
234_N237_V0.5831.00
68_I91_A0.5751.00
29_A279_A0.5751.00
23_L27_N0.5721.00
69_I94_V0.5711.00
37_Y295_N0.5701.00
24_A31_V0.5701.00
256_A262_I0.5701.00
274_A278_V0.5651.00
23_L252_Y0.5651.00
52_M140_F0.5641.00
24_A29_A0.5631.00
203_V270_A0.5621.00
12_I50_L0.5621.00
272_I276_L0.5611.00
106_L109_A0.5601.00
74_G77_G0.5581.00
202_A238_Y0.5541.00
163_V166_F0.5541.00
149_S153_I0.5531.00
153_I189_E0.5531.00
29_A284_K0.5531.00
23_L255_R0.5491.00
40_P46_D0.5481.00
17_I165_Q0.5461.00
268_S271_A0.5461.00
13_G39_N0.5461.00
231_D235_T0.5461.00
81_A107_L0.5421.00
124_K127_I0.5421.00
81_A91_A0.5421.00
166_F170_Q0.5401.00
41_G110_Y0.5381.00
212_S215_K0.5381.00
80_L142_P0.5371.00
206_S209_P0.5351.00
11_L38_M0.5331.00
223_G267_S0.5331.00
151_P185_T0.5321.00
126_A130_A0.5311.00
163_V169_D0.5311.00
133_L139_Y0.5301.00
48_I76_T0.5301.00
211_L215_K0.5301.00
244_V270_A0.5291.00
60_G140_F0.5291.00
11_L54_E0.5271.00
26_E276_L0.5260.99
72_T93_L0.5260.99
70_E80_L0.5250.99
162_I291_I0.5250.99
251_E254_R0.5240.99
234_N238_Y0.5230.99
20_L24_A0.5220.99
71_P130_A0.5200.99
29_A283_G0.5180.99
92_I137_H0.5180.99
58_K65_G0.5150.99
151_P233_L0.5130.99
153_I157_T0.5130.99
33_L256_A0.5110.99
23_L259_E0.5110.99
245_K277_Q0.5100.99
24_A28_S0.5090.99
60_G66_N0.5080.99
37_Y262_I0.5080.99
113_E137_H0.5060.99
187_A190_V0.5020.99
204_E210_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eguA 2 0.8766 100 0.13 Contact Map
2q3bA 2 0.9675 100 0.137 Contact Map
2pqmA 2 0.9935 100 0.139 Contact Map
4r2vA 2 0.9838 100 0.139 Contact Map
4ql4A 2 0.8831 100 0.14 Contact Map
1y7lA 2 0.974 100 0.143 Contact Map
3tbhA 2 0.9935 100 0.147 Contact Map
3x44A 3 0.987 100 0.147 Contact Map
1ve1A 2 0.9708 100 0.149 Contact Map
4lmbA 2 0.987 100 0.154 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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