GREMLIN Database
3MGA - DNA-3-methyladenine glycosylase
UniProt: P37878 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (277)
Sequences: 2722 (2083)
Seq/√Len: 125.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_D178_R4.1341.00
90_H96_D4.0231.00
175_P178_R3.9141.00
150_S154_Q3.4151.00
221_N224_D3.4051.00
226_E241_N3.1781.00
285_V288_K3.0991.00
259_V263_H3.0871.00
228_N231_K2.7331.00
44_T57_Q2.7171.00
134_L243_V2.7091.00
183_T186_D2.5231.00
201_I205_R2.4711.00
138_V203_I2.3951.00
230_I240_A2.3911.00
155_F179_I2.3631.00
144_N147_F2.3631.00
98_D101_P2.3461.00
131_F176_Y2.3291.00
134_L203_I2.2901.00
276_T279_E2.2541.00
42_I57_Q2.2431.00
198_E202_G2.1861.00
230_I237_P2.0961.00
226_E230_I2.0571.00
252_T291_Q2.0261.00
139_L152_K2.0201.00
222_F250_F2.0161.00
158_A186_D1.9861.00
109_D287_W1.9681.00
35_M156_V1.9101.00
48_A161_D1.8601.00
162_S169_K1.8591.00
135_C200_I1.8371.00
91_E96_D1.8181.00
86_V90_H1.7811.00
131_F204_A1.7611.00
226_E240_A1.7571.00
142_Q147_F1.7491.00
57_Q69_Q1.7421.00
153_K157_E1.7301.00
245_M292_S1.6901.00
205_R209_S1.6741.00
135_C173_F1.6591.00
159_F186_D1.6471.00
159_F182_L1.6421.00
94_D97_N1.6181.00
139_L151_L1.6011.00
202_G206_L1.6011.00
202_G205_R1.5871.00
154_Q191_K1.5801.00
226_E244_L1.5641.00
225_A244_L1.5591.00
213_S216_K1.5561.00
253_A292_S1.5471.00
134_L235_I1.5281.00
202_G232_I1.5221.00
151_L192_M1.5121.00
126_G249_R1.4981.00
131_F135_C1.4921.00
206_L211_E1.4831.00
206_L232_I1.4691.00
109_D269_R1.4621.00
184_P197_S1.4451.00
207_M214_R1.4451.00
151_L154_Q1.4451.00
61_I67_I1.4311.00
137_G242_Y1.4271.00
19_D22_A1.4081.00
131_F207_M1.4051.00
180_A208_A1.3971.00
144_N259_V1.3911.00
224_D227_K1.3871.00
68_V89_I1.3821.00
256_I281_L1.3761.00
198_E233_R1.3591.00
261_L295_T1.3561.00
193_T196_K1.3461.00
220_M224_D1.3341.00
147_F150_S1.3261.00
184_P198_E1.3041.00
45_K132_E1.2941.00
177_E208_A1.2751.00
184_P201_I1.2691.00
225_A248_L1.2681.00
180_A205_R1.2641.00
287_W294_A1.2571.00
66_M93_F1.2561.00
199_Y202_G1.2511.00
157_E171_W1.2511.00
224_D228_N1.2481.00
59_S67_I1.2481.00
159_F179_I1.2461.00
127_I133_A1.2431.00
244_L250_F1.2360.99
50_G84_E1.2330.99
222_F244_L1.2250.99
46_V169_K1.2090.99
280_I284_S1.2080.99
275_P279_E1.1970.99
91_E126_G1.1950.99
21_N41_N1.1950.99
222_F252_T1.1940.99
39_E42_I1.1940.99
265_I280_I1.1930.99
140_G143_I1.1820.99
222_F253_A1.1820.99
20_M60_V1.1810.99
176_Y204_A1.1810.99
196_K236_G1.1790.99
288_K291_Q1.1760.99
143_I238_W1.1670.99
255_P261_L1.1660.99
100_T104_E1.1640.99
70_F85_I1.1620.99
18_F23_N1.1590.99
143_I147_F1.1580.99
187_L200_I1.1560.99
216_K228_N1.1500.99
250_F253_A1.1440.99
260_G264_S1.1360.99
136_W152_K1.1340.99
97_N102_F1.1220.99
244_L248_L1.1160.99
142_Q193_T1.1140.99
141_Q238_W1.1090.99
99_L103_Y1.0860.99
46_V172_V1.0790.99
203_I232_I1.0790.99
91_E249_R1.0740.99
114_M118_K1.0720.99
237_P294_A1.0690.99
284_S287_W1.0690.99
282_E285_V1.0570.98
156_V171_W1.0560.98
223_K227_K1.0480.98
148_A238_W1.0410.98
33_E153_K1.0410.98
176_Y207_M1.0370.98
37_E44_T1.0350.98
14_L18_F1.0320.98
255_P295_T1.0300.98
210_G213_S1.0290.98
133_A247_C1.0190.98
30_E137_G1.0180.98
97_N293_Y1.0160.98
49_I52_I1.0160.98
147_F191_K1.0160.98
143_I148_A1.0140.98
84_E87_K1.0110.98
154_Q157_E0.9980.98
225_A250_F0.9930.98
47_I128_P0.9840.97
138_V199_Y0.9820.97
222_F225_A0.9820.97
140_G242_Y0.9780.97
211_E231_K0.9760.97
107_K117_R0.9740.97
194_V198_E0.9700.97
24_L38_I0.9680.97
220_M228_N0.9650.97
261_L298_L0.9530.97
180_A204_A0.9520.97
92_W128_P0.9510.97
164_E169_K0.9510.97
255_P292_S0.9490.97
113_K117_R0.9480.97
132_E173_F0.9470.97
160_G172_V0.9420.97
202_G233_R0.9410.97
165_W169_K0.9400.97
139_L192_M0.9350.97
181_R201_I0.9300.96
185_T189_D0.9300.96
178_R181_R0.9210.96
292_S295_T0.9140.96
220_M225_A0.9120.96
50_G53_R0.9030.96
162_S171_W0.9000.96
242_Y246_R0.8970.96
147_F151_L0.8940.96
184_P188_A0.8840.95
42_I59_S0.8830.95
146_A149_Y0.8830.95
119_F300_R0.8740.95
143_I239_T0.8720.95
262_I266_K0.8690.95
182_L186_D0.8670.95
294_A298_L0.8650.95
263_H266_K0.8620.95
142_Q238_W0.8610.95
55_L61_I0.8540.94
194_V197_S0.8490.94
102_F293_Y0.8480.94
61_I64_K0.8450.94
57_Q60_V0.8390.94
145_L242_Y0.8270.93
192_M200_I0.8260.93
197_S201_I0.8250.93
133_A136_W0.8240.93
115_P297_Y0.8220.93
109_D294_A0.8200.93
254_F284_S0.8060.92
151_L190_I0.8000.92
94_D293_Y0.7950.92
276_T280_I0.7910.92
216_K220_M0.7880.91
120_Y252_T0.7870.91
14_L20_M0.7860.91
206_L209_S0.7820.91
141_Q239_T0.7710.91
143_I196_K0.7630.90
81_K84_E0.7570.90
103_Y116_A0.7490.89
133_A137_G0.7490.89
278_D282_E0.7460.89
134_L232_I0.7460.89
106_A113_K0.7400.89
14_L60_V0.7380.89
192_M197_S0.7380.89
60_V64_K0.7370.89
260_G297_Y0.7330.88
140_G299_W0.7320.88
147_F196_K0.7300.88
102_F106_A0.7280.88
94_D251_P0.7250.88
256_I295_T0.7220.87
148_A239_T0.7200.87
82_R86_V0.7200.87
142_Q259_V0.7200.87
222_F226_E0.7190.87
242_Y255_P0.7190.87
83_E87_K0.7170.87
58_V68_V0.7150.87
140_G148_A0.7150.87
143_I192_M0.7140.87
48_A53_R0.7130.87
238_W258_D0.7130.87
118_K219_K0.7110.87
30_E242_Y0.7100.87
154_Q190_I0.7080.86
90_H95_L0.7040.86
245_M255_P0.7030.86
47_I173_F0.7020.86
280_I283_I0.7000.86
277_K281_L0.6950.85
143_I151_L0.6910.85
45_K48_A0.6900.85
151_L191_K0.6880.85
241_N255_P0.6860.85
244_L247_C0.6840.85
245_M295_T0.6800.84
296_F300_R0.6800.84
212_L232_I0.6790.84
30_E145_L0.6760.84
185_T194_V0.6750.84
133_A249_R0.6740.84
223_K281_L0.6740.84
180_A201_I0.6730.84
142_Q151_L0.6730.84
24_L294_A0.6710.83
166_N170_Y0.6700.83
142_Q260_G0.6670.83
43_I54_S0.6640.83
166_N169_K0.6640.83
260_G263_H0.6620.83
161_D172_V0.6620.83
244_L253_A0.6610.82
238_W242_Y0.6600.82
151_L197_S0.6600.82
54_S60_V0.6580.82
134_L138_V0.6560.82
101_P290_W0.6550.82
283_I286_P0.6550.82
188_A197_S0.6540.82
21_N61_I0.6540.82
130_L247_C0.6510.82
58_V66_M0.6500.81
140_G238_W0.6490.81
60_V63_N0.6490.81
56_V68_V0.6400.80
247_C254_F0.6390.80
222_F241_N0.6390.80
26_Y296_F0.6370.80
206_L212_L0.6350.80
209_S216_K0.6350.80
97_N249_R0.6340.80
29_R146_A0.6330.80
73_D80_W0.6330.80
46_V170_Y0.6320.80
143_I259_V0.6310.79
240_A244_L0.6290.79
55_L68_V0.6280.79
179_I204_A0.6280.79
186_D189_D0.6280.79
295_T299_W0.6270.79
237_P241_N0.6230.79
251_P293_Y0.6230.79
279_E282_E0.6220.79
243_V247_C0.6200.78
140_G145_L0.6190.78
254_F257_D0.6180.78
25_G29_R0.6160.78
230_I241_N0.6140.78
142_Q194_V0.6140.78
235_I243_V0.6090.77
160_G178_R0.6070.77
138_V151_L0.6060.77
156_V174_P0.6050.77
58_V89_I0.6030.76
25_G28_T0.6000.76
48_A51_E0.5990.76
53_R161_D0.5940.75
238_W260_G0.5910.75
31_K149_Y0.5910.75
39_E43_I0.5900.75
183_T188_A0.5900.75
14_L63_N0.5900.75
119_F297_Y0.5900.75
30_E43_I0.5880.75
137_G239_T0.5870.74
92_W261_L0.5860.74
142_Q237_P0.5860.74
281_L284_S0.5850.74
103_Y297_Y0.5840.74
251_P290_W0.5840.74
141_Q199_Y0.5840.74
176_Y201_I0.5820.74
152_K173_F0.5820.74
212_L215_E0.5820.74
46_V49_I0.5810.74
141_Q236_G0.5790.73
106_A116_A0.5790.73
58_V62_N0.5790.73
215_E219_K0.5780.73
238_W259_V0.5740.73
135_C179_I0.5740.73
247_C296_F0.5730.73
135_C203_I0.5720.73
103_Y119_F0.5700.72
26_Y137_G0.5690.72
141_Q151_L0.5680.72
27_L31_K0.5660.72
29_R32_N0.5650.72
22_A29_R0.5630.71
145_L196_K0.5620.71
241_N256_I0.5600.71
187_L192_M0.5600.71
131_F197_S0.5590.71
144_N190_I0.5580.71
261_L264_S0.5550.70
28_T40_N0.5540.70
232_I235_I0.5500.70
283_I287_W0.5500.70
255_P262_I0.5470.69
208_A232_I0.5470.69
144_N151_L0.5460.69
155_F158_A0.5450.69
85_I93_F0.5440.69
26_Y242_Y0.5430.69
27_L32_N0.5430.69
49_I56_V0.5420.69
239_T299_W0.5400.68
132_E137_G0.5390.68
54_S57_Q0.5390.68
44_T55_L0.5380.68
196_K258_D0.5380.68
145_L236_G0.5380.68
49_I54_S0.5380.68
57_Q67_I0.5380.68
206_L231_K0.5380.68
180_A187_L0.5350.68
104_E107_K0.5350.68
99_L248_L0.5350.68
58_V93_F0.5350.68
88_Y91_E0.5350.68
182_L189_D0.5330.67
82_R90_H0.5290.67
24_L28_T0.5280.67
66_M72_N0.5280.67
292_S299_W0.5270.66
52_I81_K0.5270.66
122_L160_G0.5270.66
122_L296_F0.5270.66
264_S298_L0.5270.66
215_E220_M0.5260.66
26_Y148_A0.5260.66
99_L290_W0.5250.66
50_G55_L0.5250.66
45_K49_I0.5240.66
94_D99_L0.5240.66
179_I183_T0.5230.66
90_H100_T0.5220.66
142_Q239_T0.5210.65
293_Y296_F0.5210.65
26_Y246_R0.5200.65
106_A294_A0.5190.65
16_E23_N0.5180.65
252_T289_E0.5170.65
142_Q264_S0.5150.65
270_N275_P0.5130.64
188_A192_M0.5110.64
136_W148_A0.5100.64
144_N193_T0.5100.64
56_V287_W0.5080.64
44_T47_I0.5070.63
148_A259_V0.5070.63
83_E86_V0.5070.63
198_E201_I0.5050.63
140_G239_T0.5040.63
101_P180_A0.5040.63
227_K230_I0.5040.63
120_Y289_E0.5040.63
192_M196_K0.5020.63
199_Y239_T0.5010.63
112_L254_F0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jhnA 1 0.934 100 0.258 Contact Map
3i0wA 1 0.9307 100 0.268 Contact Map
4ejyA 1 0.9307 100 0.27 Contact Map
1mpgA 1 0.9076 100 0.276 Contact Map
2xhiA 1 0.9538 100 0.288 Contact Map
4b21A 2 0.6667 100 0.396 Contact Map
2yg9A 1 0.6502 100 0.442 Contact Map
2h56A 1 0.6667 100 0.443 Contact Map
3s6iA 1 0.6436 100 0.463 Contact Map
3fhgA 2 0.6205 100 0.611 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0097 seconds.