GREMLIN Database
ACKA - Acetate kinase
UniProt: P37877 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 395 (385)
Sequences: 4305 (2928)
Seq/√Len: 149.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_E130_K3.8901.00
258_T261_E3.3631.00
351_Y370_H3.3481.00
339_E354_P3.3131.00
286_V334_S3.2641.00
188_R191_E3.1041.00
365_F374_K2.8451.00
103_L143_A2.8241.00
308_H344_G2.7471.00
275_I302_V2.6341.00
235_A302_V2.5971.00
307_I341_V2.5641.00
214_A221_S2.5421.00
264_N269_K2.5051.00
305_S317_R2.4841.00
232_A242_N2.4101.00
161_S235_A2.4091.00
356_L369_P2.3981.00
164_Y295_R2.3781.00
188_R363_E2.3071.00
183_K389_D2.2931.00
14_L63_A2.2871.00
108_I133_K2.1801.00
253_E260_D2.1761.00
350_V375_V2.1761.00
303_F330_I2.1641.00
90_V129_I2.1591.00
96_K110_E2.1521.00
201_R320_G2.1311.00
304_A337_V2.1061.00
156_Q301_E2.1061.00
288_A293_N2.0971.00
297_E301_E2.0961.00
365_F376_M2.0941.00
287_E291_E2.0841.00
169_K255_T2.0831.00
351_Y368_Y2.0681.00
150_H221_S2.0651.00
165_E169_K2.0431.00
105_D133_K2.0091.00
240_S266_L1.9781.00
59_D62_V1.9581.00
16_F44_I1.9481.00
157_S305_S1.9351.00
65_K69_N1.9231.00
100_S389_D1.9121.00
108_I126_I1.8861.00
209_N237_G1.8801.00
182_H204_S1.8621.00
289_T300_L1.8431.00
339_E343_R1.8421.00
102_L393_L1.7961.00
288_A296_A1.7861.00
110_E113_D1.7841.00
195_R200_L1.7831.00
166_Y265_T1.7801.00
315_A347_F1.7691.00
248_I262_V1.7201.00
24_E388_R1.7181.00
286_V336_E1.7151.00
165_E269_K1.7121.00
368_Y371_S1.7121.00
189_A376_M1.7011.00
163_P274_G1.6921.00
91_V118_A1.6771.00
37_I280_S1.6751.00
61_A134_E1.6701.00
204_S325_I1.6451.00
108_I130_K1.6381.00
87_G386_I1.6361.00
381_D384_V1.6331.00
155_E294_E1.6301.00
203_I321_V1.6291.00
304_A340_R1.6141.00
252_M262_V1.5941.00
264_N268_K1.5931.00
278_F293_N1.5891.00
253_E263_L1.5891.00
367_S375_V1.5861.00
289_T297_E1.5751.00
385_M389_D1.5741.00
189_A325_I1.5701.00
3_K82_E1.5641.00
300_L340_R1.5561.00
111_I143_A1.5451.00
109_K112_E1.5361.00
99_D392_R1.5351.00
185_V327_T1.5181.00
92_H177_F1.5161.00
282_L300_L1.5061.00
342_L375_V1.4981.00
340_R343_R1.4931.00
90_V143_A1.4831.00
199_D218_G1.4521.00
192_L376_M1.4491.00
324_I350_V1.4441.00
231_L266_L1.4401.00
205_C213_I1.4401.00
102_L140_P1.4331.00
269_K273_L1.4071.00
109_K113_D1.3951.00
202_L323_A1.3951.00
16_F30_G1.3941.00
257_Q265_T1.3891.00
162_L166_Y1.3851.00
201_R217_E1.3841.00
85_G390_V1.3811.00
196_P199_D1.3811.00
195_R199_D1.3781.00
251_I255_T1.3761.00
190_A200_L1.3741.00
235_A275_I1.3721.00
320_G347_F1.3681.00
225_S314_Y1.3641.00
101_V107_T1.3621.00
204_S216_V1.3531.00
12_S209_N1.3451.00
193_L376_M1.3401.00
315_A321_V1.3351.00
96_K113_D1.3221.00
164_Y298_T1.3111.00
159_L167_Y1.3081.00
252_M259_A1.3051.00
321_V324_I1.3031.00
203_I311_I1.3011.00
189_A193_L1.2901.00
183_K385_M1.2891.00
213_I225_S1.2751.00
156_Q305_S1.2711.00
319_S344_G1.2681.00
211_A303_F1.2641.00
312_G316_A1.2611.00
284_D287_E1.2561.00
158_Y173_R1.2551.00
308_H316_A1.2551.00
355_A358_N1.2551.00
116_E254_K1.2521.00
182_H214_A1.2441.00
159_L164_Y1.2381.00
159_L302_V1.2341.00
103_L107_T1.2231.00
90_V125_N1.2201.00
237_G280_S1.2081.00
342_L352_W1.2071.00
164_Y168_E1.2031.00
342_L350_V1.2001.00
309_K317_R1.1851.00
58_P62_V1.1781.00
162_L240_S1.1751.00
111_I126_I1.1711.00
384_V388_R1.1701.00
336_E340_R1.1671.00
278_F288_A1.1671.00
32_V67_L1.1631.00
223_D309_K1.1591.00
294_E297_E1.1581.00
351_Y372_P1.1571.00
204_S214_A1.1551.00
211_A234_V1.1511.00
103_L129_I1.1501.00
105_D109_K1.1481.00
159_L298_T1.1441.00
212_S227_G1.1421.00
243_I247_L1.1421.00
188_R192_L1.1321.00
157_S222_I1.1260.99
277_G295_R1.1240.99
193_L323_A1.1240.99
172_I247_L1.1180.99
297_E340_R1.1170.99
275_I298_T1.1090.99
136_L139_V1.1030.99
112_E115_S1.1020.99
183_K187_E1.1010.99
272_L282_L1.0980.99
323_A376_M1.0910.99
207_L330_I1.0710.99
261_E269_K1.0710.99
17_Q29_K1.0680.99
184_Y188_R1.0660.99
304_A308_H1.0650.99
225_S310_Y1.0640.99
29_K45_S1.0610.99
32_V57_I1.0570.99
371_S375_V1.0570.99
186_T204_S1.0470.99
242_N310_Y1.0460.99
186_T216_V1.0440.99
213_I311_I1.0430.99
132_F136_L1.0420.99
155_E159_L1.0380.99
142_V390_V1.0320.99
249_P263_L1.0260.99
217_E318_M1.0210.99
356_L365_F1.0210.99
160_Y232_A1.0170.99
106_E110_E1.0110.99
189_A378_I0.9980.99
276_S285_I0.9970.99
41_V52_T0.9950.99
20_E23_S0.9950.99
46_V49_E0.9910.99
3_K20_E0.9910.99
157_S317_R0.9860.99
187_E388_R0.9830.99
249_P252_M0.9770.99
14_L67_L0.9750.98
125_N128_G0.9750.98
86_I141_A0.9740.98
97_F110_E0.9730.98
164_Y274_G0.9730.98
66_M69_N0.9720.98
335_V358_N0.9700.98
282_L330_I0.9700.98
61_A65_K0.9690.98
286_V337_V0.9670.98
162_L265_T0.9650.98
209_N280_S0.9650.98
187_E385_M0.9600.98
207_L307_I0.9590.98
43_T50_K0.9570.98
144_V180_T0.9560.98
190_A195_R0.9540.98
278_F296_A0.9540.98
288_A292_G0.9520.98
257_Q261_E0.9510.98
153_M158_Y0.9480.98
240_S243_I0.9480.98
34_R284_D0.9470.98
202_L325_I0.9450.98
215_A318_M0.9420.98
95_E167_Y0.9400.98
69_N73_E0.9350.98
301_E340_R0.9340.98
223_D317_R0.9330.98
306_R310_Y0.9190.98
166_Y251_I0.9150.98
205_C311_I0.9150.98
213_I234_V0.9130.98
290_K336_E0.9120.98
90_V111_I0.9090.98
132_F141_A0.9040.98
213_I314_Y0.9000.97
309_K313_S0.8980.97
300_L304_A0.8970.97
308_H346_E0.8920.97
360_R364_A0.8910.97
39_D54_V0.8860.97
160_Y275_I0.8860.97
155_E158_Y0.8850.97
33_E283_R0.8820.97
339_E358_N0.8820.97
308_H345_L0.8820.97
177_F221_S0.8820.97
319_S343_R0.8810.97
300_L337_V0.8810.97
189_A202_L0.8770.97
315_A348_M0.8730.97
226_M229_T0.8710.97
230_P267_N0.8700.97
310_Y314_Y0.8640.97
151_Q158_Y0.8630.97
126_I130_K0.8580.97
181_S380_T0.8570.97
129_I143_A0.8560.97
190_A197_L0.8560.97
17_Q381_D0.8470.96
200_L218_G0.8470.96
363_E379_P0.8440.96
232_A306_R0.8430.96
133_K141_A0.8410.96
158_Y167_Y0.8380.96
98_S151_Q0.8380.96
130_K133_K0.8350.96
288_A291_E0.8350.96
337_V340_R0.8330.96
38_A56_D0.8250.96
350_V373_V0.8210.96
174_K232_A0.8210.96
217_E222_I0.8200.96
359_V364_A0.8170.96
42_F70_K0.8170.96
355_A359_V0.8170.96
4_I391_V0.8140.95
257_Q262_V0.8130.95
184_Y380_T0.8090.95
293_N296_A0.8070.95
129_I133_K0.8070.95
86_I132_F0.8040.95
284_D288_A0.8030.95
115_S126_I0.8030.95
366_I377_I0.8030.95
310_Y313_S0.8000.95
319_S346_E0.7980.95
163_P167_Y0.7950.95
71_L76_I0.7930.95
162_L172_I0.7930.95
205_C324_I0.7850.94
155_E298_T0.7850.94
185_V204_S0.7840.94
68_L136_L0.7830.94
20_E25_T0.7810.94
323_A374_K0.7800.94
343_R354_P0.7790.94
282_L303_F0.7790.94
303_F337_V0.7790.94
337_V341_V0.7780.94
149_F176_G0.7780.94
166_Y255_T0.7750.94
249_P266_L0.7700.94
278_F285_I0.7700.94
7_I132_F0.7700.94
251_I265_T0.7670.94
286_V300_L0.7670.94
21_M391_V0.7660.94
87_G390_V0.7660.94
249_P259_A0.7640.94
55_T66_M0.7640.94
201_R347_F0.7640.94
352_W368_Y0.7620.94
86_I139_V0.7600.93
192_L363_E0.7560.93
324_I342_L0.7550.93
153_M223_D0.7530.93
31_L41_V0.7510.93
226_M230_P0.7510.93
104_T107_T0.7500.93
207_L211_A0.7490.93
367_S371_S0.7440.93
34_R39_D0.7440.93
316_A347_F0.7440.93
367_S374_K0.7430.93
95_E171_G0.7430.93
41_V54_V0.7420.93
273_L280_S0.7420.93
353_D357_N0.7420.93
70_K74_F0.7370.92
9_A14_L0.7330.92
286_V290_K0.7330.92
79_D82_E0.7290.92
111_I129_I0.7280.92
234_V306_R0.7270.92
304_A341_V0.7260.92
276_S288_A0.7240.92
60_H63_A0.7240.92
200_L323_A0.7210.92
201_R218_G0.7210.92
57_I63_A0.7210.92
289_T292_G0.7190.91
86_I136_L0.7190.91
97_F107_T0.7180.91
106_E109_K0.7180.91
252_M255_T0.7170.91
285_I289_T0.7150.91
354_P358_N0.7140.91
98_S148_A0.7110.91
21_M24_E0.7060.91
319_S347_F0.7060.91
190_A199_D0.7050.91
156_Q344_G0.7050.91
34_R37_I0.7050.91
186_T202_L0.6990.90
88_H141_A0.6990.90
248_I266_L0.6950.90
321_V373_V0.6940.90
55_T58_P0.6940.90
265_T270_S0.6940.90
207_L303_F0.6920.90
259_A262_V0.6920.90
356_L359_V0.6910.90
295_R298_T0.6900.90
83_I139_V0.6900.90
43_T52_T0.6860.89
315_A373_V0.6850.89
86_I131_A0.6840.89
83_I136_L0.6820.89
162_L266_L0.6810.89
42_F66_M0.6810.89
153_M224_T0.6800.89
213_I307_I0.6790.89
19_F381_D0.6770.89
3_K84_D0.6770.89
298_T302_V0.6760.89
30_G73_E0.6730.89
101_V104_T0.6670.88
165_E277_G0.6670.88
352_W366_I0.6650.88
51_N74_F0.6630.88
228_F250_Y0.6610.88
304_A307_I0.6590.87
152_T220_K0.6580.87
189_A192_L0.6580.87
305_S309_K0.6540.87
131_A134_E0.6530.87
240_S245_P0.6510.87
301_E304_A0.6500.87
338_R357_N0.6500.87
131_A135_V0.6480.87
152_T221_S0.6470.87
222_I317_R0.6460.86
172_I250_Y0.6410.86
100_S183_K0.6410.86
249_P253_E0.6400.86
235_A303_F0.6380.86
157_S223_D0.6360.86
316_A319_S0.6330.85
203_I315_A0.6320.85
18_L83_I0.6320.85
154_P217_E0.6310.85
282_L334_S0.6300.85
254_K257_Q0.6270.85
95_E158_Y0.6270.85
303_F307_I0.6270.85
203_I318_M0.6260.85
315_A320_G0.6260.85
26_V29_K0.6250.85
201_R319_S0.6230.84
330_I337_V0.6220.84
68_L72_T0.6220.84
161_S302_V0.6220.84
168_E295_R0.6190.84
138_N141_A0.6180.84
130_K134_E0.6160.84
306_R309_K0.6160.84
40_S57_I0.6160.84
328_A366_I0.6160.84
124_A128_G0.6140.84
166_Y257_Q0.6140.84
133_K138_N0.6100.83
200_L376_M0.6090.83
163_P166_Y0.6070.83
100_S145_F0.6060.83
10_G15_K0.6050.83
261_E264_N0.6040.83
365_F375_V0.6030.82
166_Y172_I0.6010.82
13_S209_N0.6010.82
222_I318_M0.6000.82
17_Q26_V0.5990.82
66_M70_K0.5980.82
251_I257_Q0.5970.82
180_T183_K0.5970.82
65_K134_E0.5960.82
45_S50_K0.5940.82
365_F371_S0.5920.81
87_G145_F0.5910.81
223_D305_S0.5900.81
197_L216_V0.5890.81
335_V339_E0.5890.81
154_P157_S0.5870.81
315_A318_M0.5850.81
24_E384_V0.5830.80
326_F341_V0.5820.80
229_T246_A0.5810.80
32_V63_A0.5800.80
321_V348_M0.5800.80
189_A353_D0.5800.80
321_V347_F0.5790.80
192_L365_F0.5790.80
333_N360_R0.5790.80
112_E126_I0.5780.80
153_M157_S0.5770.80
232_A309_K0.5770.80
252_M257_Q0.5760.80
276_S299_A0.5760.80
164_Y167_Y0.5760.80
6_A386_I0.5750.79
308_H317_R0.5740.79
249_P260_D0.5720.79
368_Y375_V0.5720.79
4_I390_V0.5710.79
81_N138_N0.5710.79
253_E259_A0.5700.79
17_Q359_V0.5700.79
44_I74_F0.5690.79
318_M321_V0.5680.79
182_H186_T0.5680.79
186_T190_A0.5670.78
96_K106_E0.5660.78
181_S327_T0.5660.78
274_G285_I0.5630.78
45_S52_T0.5630.78
125_N246_A0.5620.78
60_H209_N0.5620.78
114_I126_I0.5600.78
300_L336_E0.5600.78
64_V132_F0.5600.78
265_T269_K0.5590.77
150_H214_A0.5580.77
70_K73_E0.5580.77
298_T301_E0.5580.77
185_V189_A0.5570.77
272_L285_I0.5560.77
150_H153_M0.5540.77
275_I299_A0.5530.77
125_N177_F0.5530.77
198_K218_G0.5520.77
289_T340_R0.5520.77
285_I288_A0.5520.77
30_G74_F0.5520.77
286_V289_T0.5510.76
226_M231_L0.5510.76
312_G317_R0.5500.76
153_M173_R0.5500.76
316_A344_G0.5500.76
22_P391_V0.5490.76
151_Q173_R0.5490.76
311_I341_V0.5480.76
37_I40_S0.5470.76
15_K329_G0.5460.76
366_I375_V0.5450.76
334_S337_V0.5450.76
160_Y227_G0.5450.76
110_E114_I0.5440.76
202_L216_V0.5440.76
53_E66_M0.5420.75
364_A377_I0.5410.75
262_V265_T0.5410.75
127_V131_A0.5400.75
172_I228_F0.5390.75
389_D392_R0.5390.75
195_R322_D0.5390.75
388_R391_V0.5390.75
149_F216_V0.5390.75
97_F114_I0.5390.75
201_R318_M0.5380.75
111_I144_V0.5360.74
263_L267_N0.5360.74
89_R146_D0.5350.74
88_H128_G0.5340.74
161_S232_A0.5330.74
282_L285_I0.5330.74
102_L142_V0.5310.74
186_T197_L0.5300.74
91_V148_A0.5290.74
6_A132_F0.5270.73
85_G140_P0.5270.73
353_D356_L0.5270.73
14_L124_A0.5260.73
328_A379_P0.5250.73
386_I390_V0.5230.73
285_I300_L0.5220.73
61_A127_V0.5210.72
108_I112_E0.5200.72
231_L246_A0.5190.72
336_E339_E0.5190.72
345_L350_V0.5190.72
311_I324_I0.5190.72
108_I129_I0.5190.72
95_E114_I0.5190.72
182_H216_V0.5180.72
275_I295_R0.5180.72
6_A16_F0.5180.72
211_A214_A0.5170.72
367_S376_M0.5160.72
207_L326_F0.5150.72
278_F295_R0.5140.71
14_L32_V0.5140.71
278_F284_D0.5130.71
161_S234_V0.5120.71
62_V65_K0.5120.71
149_F230_P0.5100.71
331_G338_R0.5100.71
300_L334_S0.5090.71
365_F369_P0.5080.71
167_Y275_I0.5060.70
240_S270_S0.5060.70
117_L177_F0.5050.70
186_T327_T0.5050.70
149_F177_F0.5040.70
351_Y371_S0.5040.70
308_H312_G0.5030.70
214_A225_S0.5020.70
338_R352_W0.5020.70
305_S344_G0.5020.70
235_A306_R0.5010.70
108_I111_I0.5000.69
189_A323_A0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sk3A 2 0.9722 100 0.04 Contact Map
4h0pA 2 0.9873 100 0.051 Contact Map
4h0oA 6 0.9646 100 0.068 Contact Map
2iirA 2 0.9975 100 0.13 Contact Map
1g99A 2 0.9975 100 0.135 Contact Map
2e1zA 2 0.9848 100 0.141 Contact Map
3khyA 2 0.9722 100 0.195 Contact Map
3r9pA 2 0.9595 100 0.331 Contact Map
4ijnA 2 0.9468 100 0.486 Contact Map
1sazA 3 0.8684 100 0.517 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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