GREMLIN Database
YTXK - Uncharacterized protein YtxK
UniProt: P37876 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 329 (279)
Sequences: 7411 (4592)
Seq/√Len: 274.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
231_T237_L5.0511.00
256_Q260_D4.1641.00
188_D232_K3.7401.00
227_S237_L3.5081.00
106_I238_F3.1491.00
108_Y139_Q2.9401.00
104_L135_T2.8751.00
253_K256_Q2.8681.00
228_V262_V2.8661.00
238_F286_V2.7471.00
265_N288_Q2.7211.00
127_L160_A2.6421.00
257_F261_K2.5931.00
126_A223_F2.5621.00
224_I241_I2.5521.00
122_I136_V2.4411.00
207_A212_A2.4311.00
127_L149_G2.4271.00
95_R153_D2.3791.00
151_E157_L2.3111.00
126_A192_C2.2111.00
227_S239_F2.2111.00
236_Y288_Q2.1981.00
207_A211_K2.1641.00
208_F212_A2.1331.00
106_I191_I2.1291.00
130_G160_A2.1081.00
120_L189_T2.0251.00
123_L230_H1.9871.00
243_N269_Q1.9801.00
231_T235_G1.9091.00
157_L173_L1.8391.00
33_A36_G1.8321.00
226_Q229_K1.8321.00
209_E212_A1.7991.00
103_G132_L1.7991.00
120_L236_Y1.7891.00
252_G256_Q1.7581.00
123_L190_V1.7251.00
204_G207_A1.7191.00
197_G219_A1.6971.00
192_C227_S1.6651.00
120_L188_D1.6051.00
204_G209_E1.5811.00
61_L64_K1.5771.00
151_E156_L1.5701.00
236_Y265_N1.5621.00
237_L287_L1.5501.00
29_I32_L1.5421.00
111_N139_Q1.5291.00
37_E40_F1.5251.00
270_L274_I1.5071.00
205_A208_F1.4861.00
221_H251_S1.4811.00
29_I33_A1.4761.00
30_E33_A1.4711.00
225_E229_K1.4571.00
179_L223_F1.4411.00
246_F267_L1.4371.00
204_G208_F1.4311.00
123_L187_V1.4301.00
272_K281_A1.4211.00
135_T138_N1.4181.00
264_I267_L1.4121.00
104_L108_Y1.4111.00
37_E41_L1.4081.00
243_N281_A1.4051.00
127_L173_L1.4021.00
107_S136_V1.3841.00
107_S191_I1.3791.00
273_S279_A1.3681.00
148_F187_V1.3511.00
189_T236_Y1.3461.00
111_N116_D1.3411.00
97_M156_L1.3361.00
56_K60_A1.3351.00
133_L149_G1.3281.00
110_V189_T1.3151.00
196_V280_H1.2811.00
271_P275_F1.2761.00
107_S139_Q1.2751.00
228_V258_F1.2711.00
121_T148_F1.2601.00
240_M284_I1.2591.00
272_K279_A1.2591.00
268_L272_K1.2571.00
202_D205_A1.2521.00
150_I176_Q1.2471.00
125_P227_S1.2381.00
53_Q57_Q1.2361.00
233_P289_K1.2311.00
224_I285_L1.2281.00
205_A209_E1.2231.00
244_H251_S1.2151.00
138_N167_L1.2051.00
121_T185_D1.2021.00
38_M41_L1.1881.00
225_E257_F1.1851.00
48_K51_A1.1771.00
51_A54_K1.1591.00
106_I132_L1.1581.00
177_D180_E1.1581.00
33_A44_T1.1551.00
196_V282_K1.1541.00
241_I283_S1.1521.00
208_F211_K1.1491.00
241_I285_L1.1471.00
186_P233_P1.1431.00
190_V227_S1.1401.00
117_K120_L1.1371.00
123_L150_I1.1331.00
103_G135_T1.1301.00
109_L116_D1.1111.00
265_N268_L1.1011.00
106_I284_I1.0961.00
207_A210_L1.0931.00
192_C239_F1.0921.00
272_K275_F1.0861.00
33_A39_Y1.0851.00
270_L275_F1.0831.00
73_E163_Q1.0821.00
270_L273_S1.0801.00
103_G131_N1.0771.00
193_D275_F1.0761.00
248_S251_S1.0741.00
157_L175_H1.0671.00
302_L305_L1.0641.00
244_H248_S1.0631.00
205_A212_A1.0631.00
226_Q230_H1.0581.00
220_H242_P1.0571.00
103_G107_S1.0561.00
93_P153_D1.0551.00
110_V238_F1.0531.00
51_A55_T1.0421.00
57_Q61_L1.0361.00
228_V263_H1.0311.00
278_E281_A1.0291.00
125_P192_C1.0241.00
57_Q60_A1.0241.00
258_F263_H1.0051.00
160_A173_L1.0031.00
238_F284_I1.0011.00
121_T146_N0.9991.00
205_A211_K0.9931.00
268_L284_I0.9911.00
130_G133_L0.9861.00
206_E210_L0.9771.00
163_Q167_L0.9761.00
43_K46_Q0.9761.00
245_L248_S0.9691.00
100_D135_T0.9671.00
311_Q315_L0.9671.00
234_G290_Q0.9651.00
266_A286_V0.9631.00
224_I239_F0.9611.00
278_E282_K0.9571.00
203_E206_E0.9541.00
228_V289_K0.9471.00
39_Y44_T0.9451.00
204_G212_A0.9431.00
203_E209_E0.9381.00
42_E45_D0.9371.00
190_V231_T0.9361.00
102_I274_I0.9351.00
73_E77_K0.9301.00
33_A43_K0.9261.00
48_K52_D0.9251.00
224_I258_F0.9231.00
121_T188_D0.9231.00
40_F45_D0.9191.00
98_T193_D0.9171.00
105_F109_L0.9151.00
100_D131_N0.9141.00
203_E207_A0.9111.00
33_A40_F0.9081.00
76_R80_Q0.9031.00
264_I287_L0.9011.00
84_L88_K0.8941.00
200_P217_S0.8861.00
127_L151_E0.8851.00
200_P219_A0.8841.00
55_T62_L0.8791.00
265_N286_V0.8771.00
148_F172_E0.8731.00
123_L178_S0.8681.00
206_E209_E0.8601.00
198_Y219_A0.8571.00
40_F44_T0.8471.00
271_P274_I0.8471.00
38_M42_E0.8451.00
92_H153_D0.8441.00
262_V291_G0.8381.00
58_L62_L0.8351.00
133_L164_A0.8311.00
137_L141_S0.8301.00
79_F95_R0.8270.99
81_L85_K0.8190.99
73_E76_R0.8160.99
122_I191_I0.8070.99
215_G222_L0.8070.99
136_V191_I0.8000.99
202_D207_A0.8000.99
150_I178_S0.7970.99
49_L52_D0.7910.99
299_Q302_L0.7900.99
164_A171_L0.7890.99
104_L138_N0.7870.99
39_Y45_D0.7840.99
107_S132_L0.7820.99
121_T186_P0.7810.99
32_L35_A0.7740.99
48_K56_K0.7710.99
39_Y43_K0.7700.99
246_F250_Q0.7700.99
126_A178_S0.7690.99
132_L191_I0.7670.99
111_N117_K0.7670.99
262_V289_K0.7670.99
205_A210_L0.7630.99
307_S310_N0.7630.99
67_F72_H0.7630.99
55_T59_Q0.7620.99
79_F131_N0.7620.99
35_A40_F0.7600.99
234_G288_Q0.7590.99
149_G173_L0.7580.99
202_D206_E0.7580.99
176_Q181_P0.7580.99
164_A173_L0.7570.99
122_I140_L0.7550.99
196_V220_H0.7510.99
55_T58_L0.7480.99
310_N313_A0.7480.99
202_D208_F0.7460.99
203_E208_F0.7410.99
290_Q293_N0.7390.99
244_H281_A0.7380.99
134_F163_Q0.7370.99
76_R129_T0.7360.99
71_E74_W0.7320.99
271_P282_K0.7300.99
243_N247_E0.7270.99
269_Q281_A0.7250.99
220_H241_I0.7240.99
263_H288_Q0.7220.99
305_L309_S0.7210.99
197_G220_H0.7190.99
35_A45_D0.7190.99
137_L169_K0.7180.99
40_F43_K0.7170.99
39_Y42_E0.7150.99
149_G160_A0.7150.99
259_K300_I0.7100.98
273_S281_A0.7080.98
30_E35_A0.7080.98
38_M44_T0.7060.98
30_E34_E0.7010.98
204_G211_K0.7000.98
99_P274_I0.6980.98
174_F183_F0.6980.98
244_H250_Q0.6970.98
199_Y217_S0.6970.98
36_G39_Y0.6960.98
59_Q62_L0.6950.98
228_V231_T0.6940.98
259_K264_I0.6880.98
29_I35_A0.6870.98
34_E37_E0.6870.98
97_M193_D0.6860.98
121_T187_V0.6840.98
312_K315_L0.6840.98
54_K59_Q0.6840.98
178_S226_Q0.6830.98
268_L286_V0.6820.98
246_F283_S0.6790.98
267_L285_L0.6790.98
67_F70_Y0.6790.98
116_D120_L0.6750.98
76_R131_N0.6750.98
218_F242_P0.6750.98
243_N280_H0.6720.98
267_L300_I0.6710.98
269_Q272_K0.6690.98
257_F260_D0.6680.98
35_A43_K0.6640.98
136_V140_L0.6630.98
211_K214_E0.6630.98
127_L133_L0.6610.98
204_G210_L0.6590.97
269_Q302_L0.6590.97
244_H247_E0.6570.97
221_H250_Q0.6570.97
206_E211_K0.6540.97
300_I304_N0.6520.97
221_H244_H0.6510.97
197_G243_N0.6490.97
140_L145_A0.6490.97
34_E38_M0.6490.97
78_A82_A0.6440.97
80_Q97_M0.6400.97
221_H248_S0.6400.97
41_L44_T0.6390.97
33_A37_E0.6390.97
52_D56_K0.6380.97
59_Q63_E0.6360.97
97_M192_C0.6350.97
301_L305_L0.6340.97
233_P291_G0.6340.97
121_T145_A0.6320.97
200_P222_L0.6280.97
98_T275_F0.6260.97
242_P280_H0.6240.97
176_Q183_F0.6220.96
134_F167_L0.6220.96
37_E44_T0.6200.96
81_L84_L0.6190.96
305_L311_Q0.6170.96
29_I43_K0.6170.96
36_G40_F0.6160.96
129_T278_E0.6130.96
48_K54_K0.6100.96
219_A222_L0.6100.96
37_E42_E0.6090.96
32_L45_D0.6090.96
294_T298_G0.6090.96
199_Y222_L0.6080.96
240_M282_K0.6080.96
245_L249_S0.6060.96
156_L159_I0.6010.96
94_N193_D0.5980.96
245_L285_L0.5980.96
243_N251_S0.5980.96
291_G294_T0.5970.96
245_L250_Q0.5950.95
122_I133_L0.5930.95
127_L157_L0.5890.95
220_H244_H0.5880.95
221_H224_I0.5870.95
38_M46_Q0.5870.95
217_S254_L0.5850.95
214_E253_K0.5840.95
35_A39_Y0.5840.95
268_L271_P0.5830.95
35_A38_M0.5800.95
235_G289_K0.5780.95
50_P62_L0.5780.95
291_G298_G0.5780.95
210_L225_E0.5750.95
100_D138_N0.5740.95
224_I254_L0.5740.95
176_Q180_E0.5730.94
33_A38_M0.5730.94
30_E38_M0.5720.94
79_F162_A0.5710.94
34_E40_F0.5710.94
31_A34_E0.5700.94
221_H254_L0.5700.94
206_E212_A0.5690.94
71_E100_D0.5680.94
266_A301_L0.5670.94
267_L283_S0.5660.94
125_P190_V0.5640.94
203_E212_A0.5640.94
30_E39_Y0.5620.94
44_T48_K0.5620.94
30_E42_E0.5620.94
202_D210_L0.5570.94
107_S135_T0.5560.94
271_P276_K0.5560.94
153_D156_L0.5540.93
228_V287_L0.5540.93
197_G218_F0.5540.93
89_D92_H0.5530.93
84_L87_M0.5520.93
29_I34_E0.5510.93
250_Q253_K0.5510.93
300_I303_A0.5510.93
54_K61_L0.5500.93
199_Y215_G0.5490.93
158_K161_Y0.5470.93
62_L67_F0.5440.93
224_I245_L0.5440.93
35_A41_L0.5380.92
228_V257_F0.5380.92
50_P54_K0.5380.92
222_L225_E0.5370.92
301_L304_N0.5340.92
58_L61_L0.5340.92
306_P311_Q0.5330.92
186_P232_K0.5310.92
197_G271_P0.5300.92
29_I38_M0.5290.92
53_Q56_K0.5280.92
51_A56_K0.5280.92
94_N124_D0.5270.92
263_H289_K0.5230.91
304_N307_S0.5220.91
243_N271_P0.5200.91
138_N141_S0.5190.91
199_Y216_H0.5170.91
274_I282_K0.5170.91
193_D196_V0.5160.91
50_P53_Q0.5150.91
76_R103_G0.5130.91
31_A35_A0.5120.90
225_E228_V0.5110.90
100_D104_L0.5110.90
264_I300_I0.5070.90
241_I245_L0.5060.90
36_G43_K0.5050.90
276_K279_A0.5040.90
197_G200_P0.5030.90
198_Y218_F0.5020.90
110_V116_D0.5020.90
262_V298_G0.5020.90
35_A44_T0.5010.89
125_P239_F0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3khkA 1 0.9605 100 0.271 Contact Map
2ar0A 1 0.8845 100 0.279 Contact Map
3lkdA 1 0.9878 100 0.284 Contact Map
3ufbA 1 0.9635 100 0.304 Contact Map
2okcA 1 0.9544 100 0.327 Contact Map
2f8lA 1 0.9726 100 0.335 Contact Map
3s1sA 1 0.9635 100 0.411 Contact Map
2ih2A 1 0.6474 100 0.529 Contact Map
3v97A 1 0.8328 99.9 0.648 Contact Map
1o9gA 1 0.6079 99.8 0.713 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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