YTXK - BACSU - GREMLIN Contacts

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YTXK - Uncharacterized protein YtxK

UniProt:	P37876	Sequences: MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKTDQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTIGLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIAYAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSFAHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFKDEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	329 (279)
Sequences:	7411 (4592)
Seq/√Len:	274.9

ECOLI - T1MK
BACSU - YTXK YEEA
HALSA - Q9HSR9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
231_T	237_L	5.051	1.00
256_Q	260_D	4.164	1.00
188_D	232_K	3.740	1.00
227_S	237_L	3.508	1.00
106_I	238_F	3.149	1.00
108_Y	139_Q	2.940	1.00
104_L	135_T	2.875	1.00
253_K	256_Q	2.868	1.00
228_V	262_V	2.866	1.00
238_F	286_V	2.747	1.00
265_N	288_Q	2.721	1.00
127_L	160_A	2.642	1.00
257_F	261_K	2.593	1.00
126_A	223_F	2.562	1.00
224_I	241_I	2.552	1.00
122_I	136_V	2.441	1.00
207_A	212_A	2.431	1.00
127_L	149_G	2.427	1.00
95_R	153_D	2.379	1.00
151_E	157_L	2.311	1.00
126_A	192_C	2.211	1.00
227_S	239_F	2.211	1.00
236_Y	288_Q	2.198	1.00
207_A	211_K	2.164	1.00
208_F	212_A	2.133	1.00
106_I	191_I	2.129	1.00
130_G	160_A	2.108	1.00
120_L	189_T	2.025	1.00
123_L	230_H	1.987	1.00
243_N	269_Q	1.980	1.00
231_T	235_G	1.909	1.00
157_L	173_L	1.839	1.00
33_A	36_G	1.832	1.00
226_Q	229_K	1.832	1.00
209_E	212_A	1.799	1.00
103_G	132_L	1.799	1.00
120_L	236_Y	1.789	1.00
252_G	256_Q	1.758	1.00
123_L	190_V	1.725	1.00
204_G	207_A	1.719	1.00
197_G	219_A	1.697	1.00
192_C	227_S	1.665	1.00
120_L	188_D	1.605	1.00
204_G	209_E	1.581	1.00
61_L	64_K	1.577	1.00
151_E	156_L	1.570	1.00
236_Y	265_N	1.562	1.00
237_L	287_L	1.550	1.00
29_I	32_L	1.542	1.00
111_N	139_Q	1.529	1.00
37_E	40_F	1.525	1.00
270_L	274_I	1.507	1.00
205_A	208_F	1.486	1.00
221_H	251_S	1.481	1.00
29_I	33_A	1.476	1.00
30_E	33_A	1.471	1.00
225_E	229_K	1.457	1.00
179_L	223_F	1.441	1.00
246_F	267_L	1.437	1.00
204_G	208_F	1.431	1.00
123_L	187_V	1.430	1.00
272_K	281_A	1.421	1.00
135_T	138_N	1.418	1.00
264_I	267_L	1.412	1.00
104_L	108_Y	1.411	1.00
37_E	41_L	1.408	1.00
243_N	281_A	1.405	1.00
127_L	173_L	1.402	1.00
107_S	136_V	1.384	1.00
107_S	191_I	1.379	1.00
273_S	279_A	1.368	1.00
148_F	187_V	1.351	1.00
189_T	236_Y	1.346	1.00
111_N	116_D	1.341	1.00
97_M	156_L	1.336	1.00
56_K	60_A	1.335	1.00
133_L	149_G	1.328	1.00
110_V	189_T	1.315	1.00
196_V	280_H	1.281	1.00
271_P	275_F	1.276	1.00
107_S	139_Q	1.275	1.00
228_V	258_F	1.271	1.00
121_T	148_F	1.260	1.00
240_M	284_I	1.259	1.00
272_K	279_A	1.259	1.00
268_L	272_K	1.257	1.00
202_D	205_A	1.252	1.00
150_I	176_Q	1.247	1.00
125_P	227_S	1.238	1.00
53_Q	57_Q	1.236	1.00
233_P	289_K	1.231	1.00
224_I	285_L	1.228	1.00
205_A	209_E	1.223	1.00
244_H	251_S	1.215	1.00
138_N	167_L	1.205	1.00
121_T	185_D	1.202	1.00
38_M	41_L	1.188	1.00
225_E	257_F	1.185	1.00
48_K	51_A	1.177	1.00
51_A	54_K	1.159	1.00
106_I	132_L	1.158	1.00
177_D	180_E	1.158	1.00
33_A	44_T	1.155	1.00
196_V	282_K	1.154	1.00
241_I	283_S	1.152	1.00
208_F	211_K	1.149	1.00
241_I	285_L	1.147	1.00
186_P	233_P	1.143	1.00
190_V	227_S	1.140	1.00
117_K	120_L	1.137	1.00
123_L	150_I	1.133	1.00
103_G	135_T	1.130	1.00
109_L	116_D	1.111	1.00
265_N	268_L	1.101	1.00
106_I	284_I	1.096	1.00
207_A	210_L	1.093	1.00
192_C	239_F	1.092	1.00
272_K	275_F	1.086	1.00
33_A	39_Y	1.085	1.00
270_L	275_F	1.083	1.00
73_E	163_Q	1.082	1.00
270_L	273_S	1.080	1.00
103_G	131_N	1.077	1.00
193_D	275_F	1.076	1.00
248_S	251_S	1.074	1.00
157_L	175_H	1.067	1.00
302_L	305_L	1.064	1.00
244_H	248_S	1.063	1.00
205_A	212_A	1.063	1.00
226_Q	230_H	1.058	1.00
220_H	242_P	1.057	1.00
103_G	107_S	1.056	1.00
93_P	153_D	1.055	1.00
110_V	238_F	1.053	1.00
51_A	55_T	1.042	1.00
57_Q	61_L	1.036	1.00
228_V	263_H	1.031	1.00
278_E	281_A	1.029	1.00
125_P	192_C	1.024	1.00
57_Q	60_A	1.024	1.00
258_F	263_H	1.005	1.00
160_A	173_L	1.003	1.00
238_F	284_I	1.001	1.00
121_T	146_N	0.999	1.00
205_A	211_K	0.993	1.00
268_L	284_I	0.991	1.00
130_G	133_L	0.986	1.00
206_E	210_L	0.977	1.00
163_Q	167_L	0.976	1.00
43_K	46_Q	0.976	1.00
245_L	248_S	0.969	1.00
100_D	135_T	0.967	1.00
311_Q	315_L	0.967	1.00
234_G	290_Q	0.965	1.00
266_A	286_V	0.963	1.00
224_I	239_F	0.961	1.00
278_E	282_K	0.957	1.00
203_E	206_E	0.954	1.00
228_V	289_K	0.947	1.00
39_Y	44_T	0.945	1.00
204_G	212_A	0.943	1.00
203_E	209_E	0.938	1.00
42_E	45_D	0.937	1.00
190_V	231_T	0.936	1.00
102_I	274_I	0.935	1.00
73_E	77_K	0.930	1.00
33_A	43_K	0.926	1.00
48_K	52_D	0.925	1.00
224_I	258_F	0.923	1.00
121_T	188_D	0.923	1.00
40_F	45_D	0.919	1.00
98_T	193_D	0.917	1.00
105_F	109_L	0.915	1.00
100_D	131_N	0.914	1.00
203_E	207_A	0.911	1.00
33_A	40_F	0.908	1.00
76_R	80_Q	0.903	1.00
264_I	287_L	0.901	1.00
84_L	88_K	0.894	1.00
200_P	217_S	0.886	1.00
127_L	151_E	0.885	1.00
200_P	219_A	0.884	1.00
55_T	62_L	0.879	1.00
265_N	286_V	0.877	1.00
148_F	172_E	0.873	1.00
123_L	178_S	0.868	1.00
206_E	209_E	0.860	1.00
198_Y	219_A	0.857	1.00
40_F	44_T	0.847	1.00
271_P	274_I	0.847	1.00
38_M	42_E	0.845	1.00
92_H	153_D	0.844	1.00
262_V	291_G	0.838	1.00
58_L	62_L	0.835	1.00
133_L	164_A	0.831	1.00
137_L	141_S	0.830	1.00
79_F	95_R	0.827	0.99
81_L	85_K	0.819	0.99
73_E	76_R	0.816	0.99
122_I	191_I	0.807	0.99
215_G	222_L	0.807	0.99
136_V	191_I	0.800	0.99
202_D	207_A	0.800	0.99
150_I	178_S	0.797	0.99
49_L	52_D	0.791	0.99
299_Q	302_L	0.790	0.99
164_A	171_L	0.789	0.99
104_L	138_N	0.787	0.99
39_Y	45_D	0.784	0.99
107_S	132_L	0.782	0.99
121_T	186_P	0.781	0.99
32_L	35_A	0.774	0.99
48_K	56_K	0.771	0.99
39_Y	43_K	0.770	0.99
246_F	250_Q	0.770	0.99
126_A	178_S	0.769	0.99
132_L	191_I	0.767	0.99
111_N	117_K	0.767	0.99
262_V	289_K	0.767	0.99
205_A	210_L	0.763	0.99
307_S	310_N	0.763	0.99
67_F	72_H	0.763	0.99
55_T	59_Q	0.762	0.99
79_F	131_N	0.762	0.99
35_A	40_F	0.760	0.99
234_G	288_Q	0.759	0.99
149_G	173_L	0.758	0.99
202_D	206_E	0.758	0.99
176_Q	181_P	0.758	0.99
164_A	173_L	0.757	0.99
122_I	140_L	0.755	0.99
196_V	220_H	0.751	0.99
55_T	58_L	0.748	0.99
310_N	313_A	0.748	0.99
202_D	208_F	0.746	0.99
203_E	208_F	0.741	0.99
290_Q	293_N	0.739	0.99
244_H	281_A	0.738	0.99
134_F	163_Q	0.737	0.99
76_R	129_T	0.736	0.99
71_E	74_W	0.732	0.99
271_P	282_K	0.730	0.99
243_N	247_E	0.727	0.99
269_Q	281_A	0.725	0.99
220_H	241_I	0.724	0.99
263_H	288_Q	0.722	0.99
305_L	309_S	0.721	0.99
197_G	220_H	0.719	0.99
35_A	45_D	0.719	0.99
137_L	169_K	0.718	0.99
40_F	43_K	0.717	0.99
39_Y	42_E	0.715	0.99
149_G	160_A	0.715	0.99
259_K	300_I	0.710	0.98
273_S	281_A	0.708	0.98
30_E	35_A	0.708	0.98
38_M	44_T	0.706	0.98
30_E	34_E	0.701	0.98
204_G	211_K	0.700	0.98
99_P	274_I	0.698	0.98
174_F	183_F	0.698	0.98
244_H	250_Q	0.697	0.98
199_Y	217_S	0.697	0.98
36_G	39_Y	0.696	0.98
59_Q	62_L	0.695	0.98
228_V	231_T	0.694	0.98
259_K	264_I	0.688	0.98
29_I	35_A	0.687	0.98
34_E	37_E	0.687	0.98
97_M	193_D	0.686	0.98
121_T	187_V	0.684	0.98
312_K	315_L	0.684	0.98
54_K	59_Q	0.684	0.98
178_S	226_Q	0.683	0.98
268_L	286_V	0.682	0.98
246_F	283_S	0.679	0.98
267_L	285_L	0.679	0.98
67_F	70_Y	0.679	0.98
116_D	120_L	0.675	0.98
76_R	131_N	0.675	0.98
218_F	242_P	0.675	0.98
243_N	280_H	0.672	0.98
267_L	300_I	0.671	0.98
269_Q	272_K	0.669	0.98
257_F	260_D	0.668	0.98
35_A	43_K	0.664	0.98
136_V	140_L	0.663	0.98
211_K	214_E	0.663	0.98
127_L	133_L	0.661	0.98
204_G	210_L	0.659	0.97
269_Q	302_L	0.659	0.97
244_H	247_E	0.657	0.97
221_H	250_Q	0.657	0.97
206_E	211_K	0.654	0.97
300_I	304_N	0.652	0.97
221_H	244_H	0.651	0.97
197_G	243_N	0.649	0.97
140_L	145_A	0.649	0.97
34_E	38_M	0.649	0.97
78_A	82_A	0.644	0.97
80_Q	97_M	0.640	0.97
221_H	248_S	0.640	0.97
41_L	44_T	0.639	0.97
33_A	37_E	0.639	0.97
52_D	56_K	0.638	0.97
59_Q	63_E	0.636	0.97
97_M	192_C	0.635	0.97
301_L	305_L	0.634	0.97
233_P	291_G	0.634	0.97
121_T	145_A	0.632	0.97
200_P	222_L	0.628	0.97
98_T	275_F	0.626	0.97
242_P	280_H	0.624	0.97
176_Q	183_F	0.622	0.96
134_F	167_L	0.622	0.96
37_E	44_T	0.620	0.96
81_L	84_L	0.619	0.96
305_L	311_Q	0.617	0.96
29_I	43_K	0.617	0.96
36_G	40_F	0.616	0.96
129_T	278_E	0.613	0.96
48_K	54_K	0.610	0.96
219_A	222_L	0.610	0.96
37_E	42_E	0.609	0.96
32_L	45_D	0.609	0.96
294_T	298_G	0.609	0.96
199_Y	222_L	0.608	0.96
240_M	282_K	0.608	0.96
245_L	249_S	0.606	0.96
156_L	159_I	0.601	0.96
94_N	193_D	0.598	0.96
245_L	285_L	0.598	0.96
243_N	251_S	0.598	0.96
291_G	294_T	0.597	0.96
245_L	250_Q	0.595	0.95
122_I	133_L	0.593	0.95
127_L	157_L	0.589	0.95
220_H	244_H	0.588	0.95
221_H	224_I	0.587	0.95
38_M	46_Q	0.587	0.95
217_S	254_L	0.585	0.95
214_E	253_K	0.584	0.95
35_A	39_Y	0.584	0.95
268_L	271_P	0.583	0.95
35_A	38_M	0.580	0.95
235_G	289_K	0.578	0.95
50_P	62_L	0.578	0.95
291_G	298_G	0.578	0.95
210_L	225_E	0.575	0.95
100_D	138_N	0.574	0.95
224_I	254_L	0.574	0.95
176_Q	180_E	0.573	0.94
33_A	38_M	0.573	0.94
30_E	38_M	0.572	0.94
79_F	162_A	0.571	0.94
34_E	40_F	0.571	0.94
31_A	34_E	0.570	0.94
221_H	254_L	0.570	0.94
206_E	212_A	0.569	0.94
71_E	100_D	0.568	0.94
266_A	301_L	0.567	0.94
267_L	283_S	0.566	0.94
125_P	190_V	0.564	0.94
203_E	212_A	0.564	0.94
30_E	39_Y	0.562	0.94
44_T	48_K	0.562	0.94
30_E	42_E	0.562	0.94
202_D	210_L	0.557	0.94
107_S	135_T	0.556	0.94
271_P	276_K	0.556	0.94
153_D	156_L	0.554	0.93
228_V	287_L	0.554	0.93
197_G	218_F	0.554	0.93
89_D	92_H	0.553	0.93
84_L	87_M	0.552	0.93
29_I	34_E	0.551	0.93
250_Q	253_K	0.551	0.93
300_I	303_A	0.551	0.93
54_K	61_L	0.550	0.93
199_Y	215_G	0.549	0.93
158_K	161_Y	0.547	0.93
62_L	67_F	0.544	0.93
224_I	245_L	0.544	0.93
35_A	41_L	0.538	0.92
228_V	257_F	0.538	0.92
50_P	54_K	0.538	0.92
222_L	225_E	0.537	0.92
301_L	304_N	0.534	0.92
58_L	61_L	0.534	0.92
306_P	311_Q	0.533	0.92
186_P	232_K	0.531	0.92
197_G	271_P	0.530	0.92
29_I	38_M	0.529	0.92
53_Q	56_K	0.528	0.92
51_A	56_K	0.528	0.92
94_N	124_D	0.527	0.92
263_H	289_K	0.523	0.91
304_N	307_S	0.522	0.91
243_N	271_P	0.520	0.91
138_N	141_S	0.519	0.91
199_Y	216_H	0.517	0.91
274_I	282_K	0.517	0.91
193_D	196_V	0.516	0.91
50_P	53_Q	0.515	0.91
76_R	103_G	0.513	0.91
31_A	35_A	0.512	0.90
225_E	228_V	0.511	0.90
100_D	104_L	0.511	0.90
264_I	300_I	0.507	0.90
241_I	245_L	0.506	0.90
36_G	43_K	0.505	0.90
276_K	279_A	0.504	0.90
197_G	200_P	0.503	0.90
198_Y	218_F	0.502	0.90
110_V	116_D	0.502	0.90
262_V	298_G	0.502	0.90
35_A	44_T	0.501	0.89
125_P	239_F	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3khkA	1	0.9605	100	0.271	Contact Map
2ar0A	1	0.8845	100	0.279	Contact Map
3lkdA	1	0.9878	100	0.284	Contact Map
3ufbA	1	0.9635	100	0.304	Contact Map
2okcA	1	0.9544	100	0.327	Contact Map
2f8lA	1	0.9726	100	0.335	Contact Map
3s1sA	1	0.9635	100	0.411	Contact Map
2ih2A	1	0.6474	100	0.529	Contact Map
3v97A	1	0.8328	99.9	0.648	Contact Map
1o9gA	1	0.6079	99.8	0.713	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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