GREMLIN Database
SP5R - Stage V sporulation protein R
UniProt: P37875 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 468 (451)
Sequences: 679 (325)
Seq/√Len: 15.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
356_E360_R6.6551.00
399_L414_I5.6981.00
158_I435_L5.4861.00
26_D113_K5.0621.00
358_V383_V4.8941.00
418_Y422_E4.4831.00
136_I237_I4.3081.00
329_P335_K4.2861.00
96_I283_F3.8381.00
308_F336_M3.6461.00
154_A437_Q3.6281.00
29_P83_D3.6211.00
19_I22_G3.5100.99
331_S334_E3.2050.99
24_G334_E3.1530.99
223_I238_L3.0600.98
337_F341_E2.9960.98
22_G272_E2.9070.98
377_D382_S2.8530.97
40_I64_M2.8340.97
154_A434_Y2.8130.97
420_G423_L2.8040.97
416_H447_S2.8030.97
357_L360_R2.7510.97
413_Y446_E2.7380.96
261_W265_W2.6910.96
320_E324_K2.6670.96
312_E316_N2.6650.96
83_D124_D2.6390.96
307_I311_I2.6240.95
418_Y423_L2.5500.95
15_E18_E2.5070.94
313_K360_R2.5040.94
333_R337_F2.4280.93
24_G337_F2.4080.93
257_M311_I2.4060.93
419_E423_L2.3920.93
23_F272_E2.3630.92
18_E22_G2.3110.91
343_E352_Y2.3040.91
370_G421_I2.2910.91
291_V302_Y2.2840.91
143_H147_E2.2350.90
132_T240_M2.2020.89
150_S437_Q2.1890.89
402_N415_K2.1640.88
19_I273_L2.1210.87
298_I352_Y2.1060.87
307_I357_L2.0940.86
335_K352_Y2.0500.85
147_E150_S2.0270.84
302_Y306_K2.0270.84
415_K446_E1.9830.83
311_I314_R1.9620.82
264_Y312_E1.9290.81
110_D261_W1.9170.81
136_I240_M1.9090.80
65_K69_D1.8920.80
147_E152_L1.8880.80
85_C109_C1.8720.79
219_I435_L1.8440.78
19_I269_I1.8320.78
255_K395_G1.8040.76
392_V396_F1.8000.76
430_K433_P1.7730.75
324_K377_D1.7640.75
278_D416_H1.7540.74
320_E323_K1.7510.74
151_F234_Q1.7370.74
283_F287_N1.7280.73
191_D263_S1.6660.70
231_E407_M1.6390.69
89_L261_W1.6290.69
13_I102_V1.6210.68
135_R236_D1.6140.68
13_I106_L1.6050.67
19_I272_E1.5820.66
32_Y101_I1.5720.66
204_V274_D1.5540.65
308_F311_I1.5490.65
11_R14_E1.5430.64
196_D401_V1.5370.64
110_D340_R1.5270.63
419_E424_D1.5230.63
275_L279_E1.4920.62
184_E190_D1.4900.61
19_I275_L1.4840.61
94_S237_I1.4650.60
24_G333_R1.4620.60
28_Y123_R1.4610.60
183_E187_T1.4520.59
349_I360_R1.4390.59
449_L452_K1.4390.59
110_D265_W1.4220.58
327_V331_S1.4170.57
60_Q431_V1.4110.57
151_F155_I1.4060.57
96_I270_I1.4000.56
329_P352_Y1.3900.56
220_L241_M1.3900.56
71_G224_E1.3890.56
312_E333_R1.3770.55
322_M327_V1.3730.55
325_M331_S1.3720.55
318_P321_E1.3680.55
285_K374_K1.3660.55
400_T417_W1.3600.54
302_Y361_E1.3330.53
147_E234_Q1.3250.52
29_P291_V1.3230.52
85_C222_F1.3200.52
292_Q349_I1.3120.52
9_L418_Y1.3060.51
367_Q383_V1.2960.51
139_Y236_D1.2890.50
289_G350_R1.2870.50
414_I435_L1.2770.50
194_S197_E1.2770.50
38_E165_S1.2720.49
17_T27_F1.2700.49
51_R57_F1.2640.49
66_L70_L1.2540.48
37_A288_A1.2480.48
81_N251_Q1.2430.48
15_E274_D1.2420.48
220_L238_L1.2410.47
147_E435_L1.2330.47
268_R271_R1.2320.47
199_K401_V1.2320.47
101_I287_N1.2310.47
117_R344_S1.2220.46
287_N366_F1.2150.46
23_F265_W1.2130.46
13_I17_T1.2060.46
257_M308_F1.2050.45
28_Y85_C1.2040.45
306_K361_E1.2020.45
137_K431_V1.2020.45
267_Q287_N1.1950.45
333_R336_M1.1940.45
190_D195_L1.1840.44
355_K359_M1.1840.44
101_I286_L1.1800.44
420_G424_D1.1780.44
60_Q447_S1.1710.44
221_L224_E1.1710.44
411_E444_H1.1710.44
9_L89_L1.1700.43
360_R363_L1.1680.43
335_K339_V1.1600.43
270_I275_L1.1570.43
261_W340_R1.1540.43
224_E235_R1.1490.42
169_P264_Y1.1480.42
65_K306_K1.1480.42
212_P261_W1.1360.42
183_E216_E1.1350.42
66_L252_L1.1250.41
255_K423_L1.1180.41
358_V363_L1.1170.41
110_D337_F1.1130.40
310_D314_R1.1100.40
202_K205_K1.1080.40
306_K309_E1.0970.39
74_K102_V1.0910.39
198_K201_K1.0900.39
30_M109_C1.0890.39
51_R294_S1.0840.39
185_A188_P1.0840.39
9_L435_L1.0830.39
19_I357_L1.0830.39
53_S133_A1.0820.39
209_K213_P1.0820.39
319_T322_M1.0770.38
310_D313_K1.0740.38
307_I384_R1.0730.38
375_I378_K1.0720.38
31_R56_S1.0710.38
200_P452_K1.0550.37
324_K357_L1.0410.36
119_Q323_K1.0380.36
395_G447_S1.0380.36
238_L344_S1.0330.36
48_M59_K1.0320.36
216_E285_K1.0280.36
337_F340_R1.0270.36
60_Q137_K1.0260.36
117_R409_N1.0220.35
264_Y332_G1.0190.35
254_T283_F1.0150.35
436_F452_K1.0130.35
121_T251_Q1.0120.35
327_V330_D1.0110.35
60_Q252_L1.0100.35
223_I352_Y1.0100.35
257_M348_F1.0070.35
179_E204_V1.0020.34
35_C98_N1.0010.34
18_E21_K1.0010.34
17_T269_I1.0000.34
147_E231_E0.9990.34
245_M252_L0.9990.34
78_L255_K0.9950.34
71_G235_R0.9940.34
34_I328_Q0.9940.34
31_R42_T0.9930.34
209_K352_Y0.9920.34
87_A261_W0.9890.34
151_F375_I0.9860.34
220_L242_R0.9810.33
51_R292_Q0.9810.33
289_G361_E0.9740.33
155_I211_F0.9740.33
32_Y50_T0.9720.33
322_M325_M0.9700.33
89_L265_W0.9680.33
101_I344_S0.9680.33
155_I344_S0.9650.33
384_R388_V0.9620.32
112_F251_Q0.9610.32
33_E47_G0.9590.32
138_H204_V0.9590.32
75_I163_D0.9520.32
50_T433_P0.9520.32
160_E189_Y0.9510.32
363_L371_R0.9500.32
56_S82_S0.9470.32
51_R244_E0.9470.32
88_F98_N0.9460.32
107_A166_L0.9460.32
152_L220_L0.9430.31
10_Q40_I0.9420.31
107_A310_D0.9420.31
137_K386_Q0.9400.31
245_M364_Y0.9320.31
278_D297_G0.9280.31
44_G442_S0.9280.31
46_Y51_R0.9230.31
429_E435_L0.9200.30
204_V403_D0.9190.30
24_G95_L0.9130.30
350_R357_L0.9110.30
244_E312_E0.9100.30
201_K453_E0.9060.30
24_G323_K0.9050.30
162_I313_K0.9040.30
53_S428_L0.9030.30
451_D454_V0.9030.30
375_I442_S0.9000.29
291_V367_Q0.8990.29
29_P231_E0.8970.29
317_N451_D0.8950.29
30_M87_A0.8940.29
298_I367_Q0.8910.29
36_P307_I0.8860.29
237_I395_G0.8850.29
171_L350_R0.8830.29
51_R435_L0.8820.29
12_A16_I0.8820.29
29_P303_L0.8800.28
32_Y70_L0.8780.28
205_K276_T0.8740.28
74_K286_L0.8740.28
238_L274_D0.8730.28
37_A415_K0.8720.28
291_V355_K0.8670.28
237_I381_K0.8660.28
12_A34_I0.8660.28
68_Y80_I0.8650.28
71_G291_V0.8640.28
176_D200_P0.8560.27
366_F375_I0.8560.27
20_A144_G0.8560.27
99_K279_E0.8550.27
419_E422_E0.8510.27
205_K435_L0.8460.27
164_P288_A0.8440.27
101_I253_E0.8420.27
119_Q324_K0.8400.27
36_P94_S0.8380.27
250_P266_H0.8380.27
207_S210_P0.8370.27
32_Y362_D0.8350.26
223_I435_L0.8350.26
203_Q219_I0.8320.26
321_E326_G0.8290.26
81_N112_F0.8280.26
81_N254_T0.8270.26
39_I131_A0.8250.26
54_H58_G0.8240.26
331_S437_Q0.8220.26
352_Y435_L0.8200.26
136_I433_P0.8180.26
372_D454_V0.8170.26
133_A350_R0.8110.25
28_Y57_F0.8110.25
5_E143_H0.8110.25
179_E201_K0.8100.25
223_I438_L0.8100.25
39_I43_F0.8090.25
63_K255_K0.8090.25
74_K101_I0.8060.25
19_I23_F0.8060.25
265_W340_R0.8050.25
222_F247_Y0.8020.25
71_G386_Q0.8010.25
270_I280_A0.8000.25
160_E396_F0.7990.25
363_L445_I0.7940.25
219_I334_E0.7930.25
292_Q370_G0.7910.25
263_S306_K0.7910.25
243_E343_E0.7890.24
323_K331_S0.7880.24
23_F237_I0.7880.24
50_T308_F0.7870.24
265_W441_R0.7860.24
14_E455_M0.7850.24
70_L391_R0.7830.24
19_I94_S0.7820.24
35_C48_M0.7820.24
112_F255_K0.7770.24
363_L414_I0.7750.24
114_N395_G0.7730.24
251_Q254_T0.7730.24
253_E394_G0.7720.24
23_F341_E0.7700.24
185_A189_Y0.7700.24
95_L275_L0.7700.24
151_F187_T0.7680.24
228_R288_A0.7680.24
92_S327_V0.7680.24
201_K372_D0.7660.24
36_P133_A0.7650.23
435_L443_V0.7650.23
146_K150_S0.7640.23
202_K320_E0.7640.23
81_N255_K0.7620.23
190_D193_W0.7620.23
114_N388_V0.7620.23
165_S168_R0.7560.23
201_K237_I0.7540.23
334_E337_F0.7490.23
8_G126_V0.7480.23
176_D430_K0.7470.23
310_D359_M0.7450.23
36_P190_D0.7440.23
138_H453_E0.7430.23
177_D197_E0.7420.23
34_I211_F0.7420.23
199_K202_K0.7410.23
173_W219_I0.7380.22
60_Q63_K0.7380.22
388_V432_L0.7370.22
102_V170_K0.7330.22
238_L431_V0.7320.22
44_G114_N0.7310.22
96_I167_V0.7310.22
288_A431_V0.7310.22
189_Y369_Q0.7300.22
38_E273_L0.7300.22
298_I363_L0.7290.22
432_L435_L0.7290.22
315_Y327_V0.7270.22
76_Y251_Q0.7270.22
124_D366_F0.7250.22
418_Y424_D0.7210.22
74_K344_S0.7210.22
418_Y447_S0.7210.22
298_I455_M0.7190.22
63_K263_S0.7180.22
132_T243_E0.7180.22
35_C297_G0.7180.22
337_F447_S0.7170.22
176_D435_L0.7140.21
149_E153_D0.7140.21
187_T350_R0.7120.21
183_E210_P0.7110.21
312_E332_G0.7100.21
7_K34_I0.7090.21
309_E350_R0.7070.21
124_D444_H0.7070.21
147_E425_L0.7060.21
308_F393_N0.7050.21
34_I199_K0.7020.21
252_L285_K0.7010.21
20_A27_F0.6990.21
81_N121_T0.6970.21
178_E349_I0.6950.21
40_I143_H0.6920.21
419_E428_L0.6920.21
389_S421_I0.6900.21
374_K428_L0.6890.21
276_T454_V0.6880.20
436_F447_S0.6880.20
395_G416_H0.6880.20
7_K10_Q0.6870.20
425_L449_L0.6870.20
113_K234_Q0.6870.20
423_L428_L0.6860.20
167_V264_Y0.6850.20
48_M56_S0.6850.20
252_L395_G0.6840.20
39_I247_Y0.6830.20
207_S288_A0.6830.20
47_G54_H0.6820.20
220_L227_S0.6800.20
57_F234_Q0.6800.20
198_K435_L0.6790.20
286_L344_S0.6780.20
219_I420_G0.6750.20
220_L320_E0.6740.20
8_G95_L0.6740.20
402_N432_L0.6740.20
12_A99_K0.6740.20
123_R290_V0.6730.20
44_G245_M0.6710.20
405_D408_K0.6700.20
228_R408_K0.6700.20
272_E416_H0.6680.20
443_V451_D0.6680.20
43_F82_S0.6670.20
60_Q278_D0.6660.20
60_Q337_F0.6660.20
92_S315_Y0.6650.20
114_N337_F0.6650.20
99_K393_N0.6640.20
412_L432_L0.6640.20
34_I205_K0.6630.20
381_K445_I0.6610.20
322_M361_E0.6610.20
174_S241_M0.6610.20
319_T356_E0.6580.19
60_Q66_L0.6570.19
422_E447_S0.6570.19
150_S428_L0.6560.19
125_M247_Y0.6550.19
165_S409_N0.6550.19
15_E22_G0.6540.19
383_V453_E0.6520.19
383_V451_D0.6480.19
352_Y451_D0.6480.19
150_S154_A0.6460.19
181_E184_E0.6450.19
132_T267_Q0.6450.19
389_S394_G0.6430.19
308_F398_Y0.6430.19
232_P435_L0.6420.19
146_K402_N0.6410.19
106_L261_W0.6390.19
201_K204_V0.6380.19
24_G219_I0.6360.19
71_G74_K0.6360.19
252_L396_F0.6360.19
29_P290_V0.6340.19
74_K379_Q0.6340.19
325_M329_P0.6330.19
113_K348_F0.6310.18
152_L241_M0.6310.18
224_E321_E0.6300.18
9_L44_G0.6290.18
7_K328_Q0.6290.18
201_K324_K0.6280.18
65_K385_D0.6280.18
327_V361_E0.6270.18
209_K382_S0.6250.18
102_V363_L0.6250.18
23_F273_L0.6250.18
268_R385_D0.6240.18
124_D442_S0.6230.18
82_S85_C0.6230.18
22_G201_K0.6220.18
251_Q255_K0.6210.18
53_S130_A0.6200.18
92_S129_M0.6190.18
52_F81_N0.6170.18
87_A447_S0.6160.18
205_K209_K0.6140.18
11_R405_D0.6110.18
16_I95_L0.6100.18
56_S90_L0.6090.18
267_Q305_L0.6090.18
234_Q431_V0.6090.18
274_D358_V0.6070.18
151_F281_I0.6050.18
203_Q450_E0.6050.18
38_E355_K0.6040.18
49_P93_N0.6030.18
82_S290_V0.6020.17
268_R333_R0.6020.17
415_K448_V0.6020.17
210_P399_L0.6020.17
180_E383_V0.6000.17
156_L379_Q0.6000.17
49_P55_W0.6000.17
129_M253_E0.5980.17
202_K453_E0.5980.17
187_T269_I0.5980.17
319_T360_R0.5970.17
194_S220_L0.5970.17
252_L416_H0.5960.17
152_L176_D0.5960.17
46_Y395_G0.5930.17
320_E356_E0.5920.17
21_K202_K0.5920.17
179_E198_K0.5910.17
322_M331_S0.5890.17
75_I99_K0.5880.17
238_L375_I0.5880.17
273_L403_D0.5870.17
76_Y80_I0.5870.17
52_F251_Q0.5870.17
373_Y376_I0.5870.17
322_M408_K0.5870.17
110_D114_N0.5860.17
23_F261_W0.5860.17
276_T444_H0.5860.17
228_R322_M0.5850.17
94_S454_V0.5850.17
21_K449_L0.5850.17
270_I454_V0.5850.17
287_N298_I0.5840.17
50_T350_R0.5840.17
199_K209_K0.5840.17
281_I291_V0.5840.17
229_E408_K0.5830.17
221_L225_E0.5830.17
220_L313_K0.5830.17
285_K308_F0.5820.17
70_L291_V0.5820.17
164_P364_Y0.5820.17
76_Y112_F0.5780.17
223_I448_V0.5780.17
192_L405_D0.5760.17
146_K382_S0.5760.17
86_Y109_C0.5750.17
315_Y335_K0.5750.17
419_E440_G0.5750.17
87_A154_A0.5750.17
11_R238_L0.5740.17
198_K206_K0.5740.17
160_E252_L0.5740.17
176_D180_E0.5740.17
38_E42_T0.5720.17
337_F422_E0.5720.17
170_K206_K0.5720.17
21_K451_D0.5690.16
173_W176_D0.5690.16
24_G393_N0.5690.16
73_S86_Y0.5690.16
273_L438_L0.5670.16
399_L435_L0.5670.16
275_L436_F0.5670.16
14_E323_K0.5640.16
24_G226_H0.5640.16
256_I332_G0.5640.16
179_E317_N0.5630.16
87_A338_E0.5620.16
182_I190_D0.5610.16
40_I145_I0.5600.16
87_A365_L0.5600.16
10_Q320_E0.5590.16
62_H447_S0.5590.16
244_E291_V0.5580.16
176_D358_V0.5570.16
177_D241_M0.5560.16
265_W411_E0.5560.16
225_E240_M0.5550.16
181_E226_H0.5550.16
161_H275_L0.5520.16
361_E384_R0.5520.16
308_F373_Y0.5520.16
204_V219_I0.5500.16
50_T363_L0.5500.16
229_E407_M0.5490.16
70_L101_I0.5480.16
183_E451_D0.5470.16
60_Q395_G0.5470.16
56_S391_R0.5460.16
11_R450_E0.5440.16
119_Q341_E0.5440.16
201_K281_I0.5440.16
236_D239_T0.5440.16
225_E325_M0.5440.16
146_K453_E0.5440.16
177_D181_E0.5430.16
142_V145_I0.5420.16
161_H350_R0.5410.16
446_E453_E0.5410.16
121_T283_F0.5410.16
444_H450_E0.5400.16
181_E194_S0.5390.16
158_I368_K0.5390.16
30_M101_I0.5380.15
206_K417_W0.5380.15
189_Y193_W0.5370.15
11_R22_G0.5370.15
150_S213_P0.5360.15
20_A349_I0.5360.15
46_Y383_V0.5360.15
110_D344_S0.5360.15
178_E226_H0.5350.15
298_I307_I0.5340.15
307_I310_D0.5340.15
268_R272_E0.5340.15
170_K349_I0.5340.15
209_K389_S0.5330.15
201_K206_K0.5320.15
8_G116_C0.5320.15
63_K189_Y0.5320.15
315_Y330_D0.5310.15
119_Q328_Q0.5310.15
317_N419_E0.5310.15
212_P340_R0.5300.15
44_G252_L0.5300.15
188_P192_L0.5290.15
221_L303_L0.5280.15
272_E447_S0.5270.15
169_P360_R0.5260.15
53_S62_H0.5260.15
83_D367_Q0.5250.15
173_W179_E0.5250.15
309_E378_K0.5240.15
28_Y109_C0.5240.15
314_R354_T0.5240.15
36_P452_K0.5230.15
80_I251_Q0.5230.15
256_I265_W0.5230.15
32_Y131_A0.5220.15
44_G163_D0.5220.15
105_V218_D0.5220.15
71_G147_E0.5200.15
255_K298_I0.5200.15
201_K231_E0.5190.15
133_A244_E0.5190.15
18_E158_I0.5190.15
431_V435_L0.5190.15
248_F266_H0.5180.15
5_E383_V0.5180.15
343_E351_N0.5170.15
138_H324_K0.5160.15
103_A222_F0.5160.15
206_K317_N0.5150.15
152_L165_S0.5150.15
175_V452_K0.5150.15
5_E378_K0.5140.15
270_I279_E0.5140.15
124_D263_S0.5140.15
173_W220_L0.5130.15
68_Y81_N0.5130.15
217_K249_W0.5120.15
252_L447_S0.5120.15
26_D341_E0.5120.15
177_D185_A0.5110.15
14_E375_I0.5110.15
50_T133_A0.5100.15
306_K357_L0.5090.15
283_F347_S0.5090.15
46_Y309_E0.5080.15
315_Y322_M0.5080.15
8_G437_Q0.5070.15
322_M438_L0.5060.15
39_I125_M0.5060.15
170_K263_S0.5040.15
9_L349_I0.5040.15
67_H419_E0.5040.15
80_I121_T0.5030.14
102_V278_D0.5020.14
176_D203_Q0.5020.14
208_K320_E0.5020.14
102_V142_V0.5010.14
40_I126_V0.5010.14
317_N425_L0.5010.14
334_E448_V0.5010.14
91_D297_G0.5010.14
141_Q383_V0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cqbA 4 0.188 71.5 0.979 Contact Map
3rjoA 1 0.1154 24.6 0.984 Contact Map
4il3A 1 0.4209 23.1 0.984 Contact Map
4g54A 1 0.1132 22.9 0.984 Contact Map
3c7aA 1 0.3162 20.8 0.985 Contact Map
1i76A 1 0.2756 20.2 0.985 Contact Map
4qhjA 2 0.2222 13.5 0.986 Contact Map
3nkqA 1 0.1047 13.4 0.986 Contact Map
4aw6A 2 0.3419 13.3 0.986 Contact Map
4xctA 1 0.2863 11.8 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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