GREMLIN Database
SP2M - Stage II sporulation protein M
UniProt: P37873 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 214 (199)
Sequences: 368 (317)
Seq/√Len: 22.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_H21_Y5.1071.00
87_M149_G4.4211.00
104_I149_G3.7591.00
50_L117_F2.7780.99
80_N139_V2.7320.99
88_W181_A2.5630.98
106_L201_L2.4860.98
189_F193_I2.4720.98
88_W180_Y2.4470.98
184_L193_I2.2940.97
25_S186_V2.2680.97
107_K111_V2.2530.96
28_F142_I2.2510.96
152_A156_S2.1200.95
155_F174_I2.1130.95
108_G143_P2.1000.95
125_S149_G1.9910.93
43_T140_L1.9520.92
27_L107_K1.9320.92
24_V28_F1.9270.92
14_V179_R1.8920.91
95_I159_L1.7910.88
141_L191_A1.7670.88
135_L149_G1.7310.87
81_A183_V1.6940.85
88_W153_I1.6830.85
99_I134_V1.6590.84
73_F77_I1.6510.84
144_A187_I1.6420.84
140_L144_A1.6400.84
90_L96_G1.6240.83
25_S94_V1.6150.83
117_F156_S1.5980.82
36_A127_F1.5920.82
131_F207_E1.5750.81
27_L105_F1.5350.79
70_A140_L1.5320.79
34_F93_S1.5300.79
28_F129_L1.5090.78
46_Q82_K1.4900.77
90_L93_S1.4470.75
95_I105_F1.4410.75
34_F105_F1.4380.74
26_V34_F1.4180.73
54_L58_F1.4170.73
80_N92_I1.4170.73
181_A185_L1.3980.72
183_V197_F1.3960.72
32_V187_I1.3890.72
36_A116_G1.3880.72
83_Y163_L1.3860.72
102_I191_A1.3850.72
28_F143_P1.3720.71
139_V185_L1.3670.71
81_A142_I1.3310.68
66_Q192_L1.3250.68
73_F130_S1.3170.68
21_Y98_P1.3110.67
81_A139_V1.3090.67
23_F93_S1.3020.67
92_I139_V1.2770.65
138_N198_E1.2620.64
147_I183_V1.2600.64
85_G88_W1.2580.64
58_F93_S1.2500.63
134_V141_L1.2490.63
101_F203_P1.2480.63
62_S199_A1.2480.63
152_A184_L1.2470.63
24_V142_I1.2340.62
132_V209_L1.2250.62
70_A191_A1.2150.61
94_V199_A1.2010.60
81_A99_I1.1990.60
58_F127_F1.1940.60
50_L53_Y1.1910.60
146_L209_L1.1800.59
45_S193_I1.1760.59
89_I160_I1.1740.58
32_V48_E1.1730.58
53_Y57_F1.1670.58
80_N141_L1.1660.58
13_H29_F1.1580.57
23_F122_M1.1580.57
23_F105_F1.1430.56
45_S100_I1.1350.56
41_S104_I1.1220.55
73_F188_L1.1020.54
104_I110_V1.0990.53
160_I165_V1.0940.53
32_V89_I1.0890.53
61_L69_S1.0890.53
127_F130_S1.0850.52
182_F190_L1.0800.52
157_L161_R1.0750.52
196_L209_L1.0730.52
42_M173_P1.0670.51
37_I47_K1.0670.51
99_I172_A1.0640.51
122_M137_Q1.0500.50
80_N109_I1.0500.50
90_L203_P1.0470.50
99_I180_Y1.0450.50
33_I153_I1.0440.50
10_F193_I1.0410.49
93_S105_F1.0370.49
57_F76_S1.0360.49
42_M132_V1.0310.49
101_F153_I1.0280.49
186_V204_V1.0040.47
140_L197_F1.0040.47
108_G138_N1.0000.47
77_I81_A0.9890.46
26_V131_F0.9880.46
185_L193_I0.9850.46
148_M193_I0.9710.45
98_P101_F0.9700.45
42_M88_W0.9690.44
13_H17_H0.9680.44
21_Y101_F0.9670.44
36_A180_Y0.9650.44
154_A206_M0.9620.44
23_F27_L0.9510.43
144_A195_S0.9490.43
14_V182_F0.9350.42
159_L163_L0.9030.40
25_S146_L0.9010.40
20_L164_F0.8990.40
28_F63_D0.8880.39
42_M203_P0.8870.39
21_Y161_R0.8820.39
84_L184_L0.8720.38
29_F129_L0.8700.38
77_I87_M0.8700.38
38_I109_I0.8620.37
63_D139_V0.8590.37
84_L168_S0.8540.37
111_V206_M0.8490.37
27_L109_I0.8470.36
166_K184_L0.8470.36
73_F199_A0.8440.36
18_L135_L0.8410.36
145_Y152_A0.8410.36
173_P181_A0.8350.36
47_K107_K0.8310.35
144_A194_S0.8300.35
129_L152_A0.8250.35
26_V124_V0.8240.35
23_F67_A0.8220.35
34_F134_V0.8180.35
69_S199_A0.8140.34
93_S96_G0.8120.34
34_F177_F0.8110.34
27_L38_I0.8050.34
120_N184_L0.8020.34
57_F198_E0.8010.34
32_V124_V0.7980.33
83_Y171_D0.7940.33
103_M208_K0.7940.33
181_A188_L0.7870.33
95_I210_T0.7860.33
28_F197_F0.7830.32
102_I119_V0.7810.32
119_V144_A0.7800.32
88_W155_F0.7700.32
160_I195_S0.7620.31
36_A58_F0.7550.31
9_M192_L0.7500.31
12_R16_D0.7450.30
15_K123_G0.7450.30
133_S143_P0.7450.30
137_Q141_L0.7400.30
140_L207_E0.7390.30
157_L189_F0.7360.30
138_N143_P0.7340.30
45_S52_Y0.7340.30
23_F116_G0.7300.29
41_S107_K0.7290.29
14_V191_A0.7290.29
29_F75_Q0.7250.29
155_F177_F0.7220.29
136_P198_E0.7200.29
61_L78_F0.7150.29
10_F14_V0.7050.28
43_T160_I0.6950.27
83_Y110_V0.6910.27
129_L191_A0.6880.27
95_I177_F0.6830.27
205_L210_T0.6750.26
91_G146_L0.6740.26
34_F97_M0.6740.26
86_L116_G0.6690.26
73_F109_I0.6670.26
15_K178_G0.6600.26
12_R22_I0.6590.25
148_M155_F0.6570.25
168_S185_L0.6550.25
22_I95_I0.6550.25
77_I167_R0.6550.25
23_F102_I0.6540.25
15_K190_L0.6540.25
15_K45_S0.6520.25
60_Q122_M0.6500.25
113_F180_Y0.6480.25
46_Q118_L0.6450.25
70_A74_G0.6430.25
91_G180_Y0.6430.25
72_M83_Y0.6400.24
84_L207_E0.6400.24
87_M152_A0.6390.24
20_L86_L0.6360.24
193_I201_L0.6360.24
24_V138_N0.6320.24
22_I205_L0.6300.24
22_I33_I0.6290.24
48_E52_Y0.6290.24
42_M142_I0.6280.24
17_H48_E0.6270.24
21_Y39_V0.6260.24
15_K163_L0.6250.24
56_Q100_I0.6240.24
63_D186_V0.6240.24
106_L167_R0.6240.24
75_Q130_S0.6220.24
186_V201_L0.6140.23
100_I209_L0.6120.23
15_K139_V0.6110.23
39_V116_G0.6100.23
24_V153_I0.6070.23
136_P157_L0.6040.23
20_L145_Y0.6030.23
54_L113_F0.6020.23
120_N130_S0.6020.23
105_F195_S0.6020.23
69_S200_Y0.5990.22
15_K193_I0.5980.22
37_I70_A0.5970.22
19_S103_M0.5960.22
114_T207_E0.5960.22
91_G96_G0.5930.22
116_G121_Q0.5920.22
184_L190_L0.5910.22
142_I188_L0.5910.22
188_L201_L0.5900.22
33_I200_Y0.5900.22
182_F193_I0.5890.22
127_F142_I0.5880.22
23_F201_L0.5880.22
190_L194_S0.5860.22
35_G108_G0.5850.22
18_L22_I0.5850.22
146_L180_Y0.5810.22
151_C180_Y0.5780.21
107_K149_G0.5760.21
185_L189_F0.5760.21
24_V104_I0.5610.21
192_L197_F0.5580.21
114_T202_S0.5550.20
71_D199_A0.5550.20
106_L197_F0.5540.20
47_K58_F0.5530.20
15_K81_A0.5480.20
139_V165_V0.5470.20
20_L54_L0.5450.20
124_V206_M0.5420.20
93_S115_V0.5400.20
23_F34_F0.5390.20
58_F116_G0.5380.20
166_K199_A0.5380.20
92_I180_Y0.5350.20
27_L34_F0.5330.19
11_L15_K0.5320.19
99_I142_I0.5320.19
54_L115_V0.5290.19
69_S140_L0.5290.19
100_I152_A0.5260.19
51_Y135_L0.5230.19
82_K111_V0.5220.19
31_G35_G0.5200.19
174_I190_L0.5180.19
101_F207_E0.5170.19
36_A115_V0.5160.19
184_L188_L0.5140.19
26_V146_L0.5100.19
131_F153_I0.5090.18
44_I124_V0.5080.18
77_I109_I0.5080.18
72_M165_V0.5070.18
17_H70_A0.5070.18
37_I59_G0.5050.18
14_V178_G0.5050.18
71_D192_L0.5030.18
36_A86_L0.5010.18
116_G134_V0.5010.18
93_S108_G0.5010.18
129_L206_M0.5000.18
95_I98_P0.5000.18
50_L114_T0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1orqC 4 0.514 13.2 0.95 Contact Map
3wu2L 1 0.1729 8.4 0.954 Contact Map
2nwlA 3 0.8645 6.9 0.956 Contact Map
2m8rA 1 0.2009 6.2 0.956 Contact Map
3w4tA 1 0.6215 3.5 0.961 Contact Map
2y69J 1 0.2103 2.9 0.963 Contact Map
3mktA 1 0.6916 2.8 0.963 Contact Map
3d31C 2 0.8598 2.4 0.965 Contact Map
4lz6A 1 0.6308 2.2 0.965 Contact Map
4dxwA 3 0.5327 2.2 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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