GREMLIN Database
ENO - Enolase
UniProt: P37869 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 430 (417)
Sequences: 3443 (1550)
Seq/√Len: 75.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
326_E330_N4.0301.00
11_E58_R3.7271.00
12_V36_L3.6341.00
335_S362_T3.5211.00
23_V113_G3.4081.00
268_A300_L3.2091.00
101_E322_K3.2081.00
168_M240_A3.0901.00
275_E304_R3.0651.00
86_E89_A3.0621.00
74_I105_K3.0501.00
325_S329_K2.9641.00
266_T269_E2.9121.00
46_Y323_K2.8791.00
250_N253_D2.8121.00
185_I237_V2.7161.00
355_M359_A2.6431.00
172_A181_M2.6341.00
179_L407_L2.6031.00
69_N73_E2.5971.00
195_A228_K2.5761.00
29_T125_F2.5421.00
379_D405_Q2.5091.00
216_E280_K2.4951.00
90_I118_C2.4821.00
149_I222_I2.4811.00
213_G217_E2.4711.00
324_L336_I2.3741.00
232_K235_E2.3531.00
219_L223_V2.2841.00
299_K303_E2.2621.00
186_F395_S2.2571.00
116_M346_L2.2541.00
88_N351_D2.2531.00
405_Q408_R2.2421.00
170_V238_K2.2271.00
175_F179_L2.2191.00
227_E232_K2.2071.00
196_K224_E2.2001.00
350_F384_T2.1561.00
45_E293_N2.1211.00
365_I386_A2.1101.00
92_Q96_E2.0721.00
82_F93_L2.0651.00
46_Y293_N2.0581.00
317_F333_G2.0531.00
310_Q388_Q2.0441.00
73_E77_P2.0051.00
273_W277_L1.9881.00
120_R376_T1.9871.00
317_F327_G1.9751.00
272_D304_R1.9721.00
220_Q281_Y1.9111.00
27_T84_V1.8981.00
131_Y412_Q1.8871.00
147_M182_G1.8761.00
10_R411_D1.8721.00
75_I97_L1.8551.00
22_E408_R1.8511.00
223_V233_P1.8501.00
250_N254_G1.8451.00
271_V290_L1.8311.00
293_N323_K1.8241.00
177_E180_R1.8201.00
271_V300_L1.8111.00
34_R405_Q1.7741.00
186_F393_A1.7681.00
257_H264_V1.7571.00
7_V79_L1.7521.00
24_E34_R1.7071.00
60_L188_S1.7021.00
186_F394_P1.6831.00
226_I239_L1.6671.00
279_S308_K1.6581.00
181_M237_V1.6551.00
10_R22_E1.6521.00
243_A274_Y1.6491.00
276_E280_K1.6401.00
255_K264_V1.6251.00
175_F407_L1.6151.00
8_Y411_D1.5870.99
45_E246_S1.5850.99
289_G301_L1.5780.99
224_E227_E1.5750.99
49_V104_G1.5680.99
353_I365_I1.5670.99
196_K221_T1.5640.99
240_A285_S1.5560.99
270_M274_Y1.5460.99
324_L352_A1.5410.99
353_I384_T1.5110.99
275_E279_S1.5050.99
238_K284_I1.5040.99
119_A346_L1.4920.99
97_L106_L1.4710.99
36_L372_T1.4640.99
11_E176_R1.4580.99
354_E358_R1.4520.99
267_S297_G1.4420.99
265_K270_M1.4160.99
299_K332_V1.4100.99
22_E405_Q1.4090.99
191_S194_S1.4070.99
66_T69_N1.4060.99
82_F89_A1.4020.99
250_N257_H1.3900.99
180_R184_Q1.3890.99
134_L383_A1.3800.99
258_L265_K1.3720.98
190_K208_F1.3690.98
88_N347_T1.3690.98
11_E63_G1.3670.98
24_E408_R1.3600.98
376_T380_I1.3540.98
365_I381_A1.3500.98
111_I345_T1.3500.98
269_E272_D1.3500.98
75_I114_V1.3450.98
354_E357_K1.3390.98
373_E401_A1.3380.98
74_I77_P1.3250.98
216_E220_Q1.3200.98
134_L350_F1.3130.98
51_L66_T1.3120.98
301_L305_L1.3030.98
332_V361_Y1.3010.98
226_I233_P1.2990.98
272_D275_E1.2930.98
325_S355_M1.2870.98
89_A93_L1.2790.98
289_G311_L1.2760.98
173_P181_M1.2710.97
340_V346_L1.2700.97
129_P132_Q1.2680.97
3_Y28_E1.2580.97
165_F218_A1.2550.97
12_V372_T1.2540.97
338_I353_I1.2510.97
37_V113_G1.2420.97
202_V395_S1.2410.97
305_L309_V1.2370.97
25_V118_C1.2330.97
75_I106_L1.2300.97
397_T400_V1.2250.97
317_F361_Y1.2180.97
94_L345_T1.2180.97
191_S195_A1.2120.97
70_N74_I1.2100.97
13_L59_Y1.2090.97
321_T352_A1.2080.97
146_M168_M1.2080.97
88_N140_K1.1950.96
298_H311_L1.1820.96
10_R24_E1.1730.96
221_T224_E1.1680.96
79_L82_F1.1640.96
270_M290_L1.1530.95
246_S291_D1.1510.95
340_V380_I1.1490.95
71_V113_G1.1480.95
331_G361_Y1.1410.95
296_E330_N1.1400.95
321_T355_M1.1390.95
146_M364_V1.1390.95
88_N92_Q1.1390.95
6_D76_A1.1360.95
350_F380_I1.1330.95
26_Y32_F1.1310.95
192_V221_T1.1270.95
84_V118_C1.1240.95
158_N211_N1.1130.94
294_D297_G1.1080.94
24_E411_D1.1070.94
34_R408_R1.1050.94
393_A400_V1.0990.94
85_T126_L1.0990.94
258_L270_M1.0970.94
253_D264_V1.0910.94
301_L311_L1.0880.94
224_E228_K1.0840.94
51_L70_N1.0760.93
119_A134_L1.0730.93
76_A80_L1.0710.93
162_I243_A1.0700.93
87_Q133_Y1.0590.93
414_A417_A1.0590.93
299_K330_N1.0540.93
68_V72_N1.0520.93
159_N215_N1.0500.93
188_S191_S1.0500.93
22_E34_R1.0470.92
303_E331_G1.0430.92
31_A125_F1.0430.92
58_R63_G1.0420.92
276_E279_S1.0410.92
272_D276_E1.0370.92
181_M231_F1.0290.92
295_W332_V1.0190.91
162_I277_L1.0160.91
300_L303_E1.0150.91
178_A419_Y1.0140.91
258_L261_E1.0130.91
278_V305_L1.0120.91
10_R408_R1.0120.91
191_S228_K1.0110.91
93_L96_E1.0060.91
103_K348_E1.0050.91
285_S310_Q1.0030.91
78_E97_L0.9980.91
173_P177_E0.9970.91
128_I133_Y0.9930.90
94_L111_I0.9920.90
150_V160_V0.9920.90
227_E233_P0.9910.90
302_T361_Y0.9910.90
323_K332_V0.9900.90
128_I136_G0.9890.90
84_V122_A0.9890.90
323_K326_E0.9790.90
321_T351_D0.9780.90
324_L361_Y0.9750.90
353_I357_K0.9730.89
188_S228_K0.9720.89
8_Y26_Y0.9680.89
168_M364_V0.9630.89
79_L118_C0.9630.89
136_G139_S0.9570.89
196_K217_E0.9530.88
290_L297_G0.9500.88
141_T420_H0.9460.88
408_R411_D0.9440.88
300_L304_R0.9430.88
159_N212_L0.9410.88
35_A116_M0.9380.88
363_A386_A0.9380.88
216_E276_E0.9370.88
49_V102_N0.9300.87
116_M350_F0.9300.87
215_N277_L0.9250.87
27_T30_G0.9250.87
9_A71_V0.9230.87
357_K363_A0.9200.87
27_T31_A0.9190.87
120_R375_S0.9160.86
25_V33_G0.9150.86
333_G361_Y0.9150.86
394_P400_V0.9140.86
100_T105_K0.9110.86
23_V71_V0.9100.86
353_I363_A0.9060.86
328_I359_A0.9050.86
24_E32_F0.9040.86
129_P412_Q0.9010.85
250_N255_K0.9000.85
126_L136_G0.8980.85
92_Q351_D0.8980.85
327_G333_G0.8930.85
82_F90_I0.8900.85
160_V215_N0.8880.85
268_A271_V0.8860.84
184_Q231_F0.8850.84
157_D194_S0.8840.84
134_L137_F0.8840.84
159_N211_N0.8780.84
277_L283_I0.8760.84
74_I78_E0.8730.84
373_E397_T0.8710.83
10_R34_R0.8700.83
55_D58_R0.8680.83
178_A182_G0.8660.83
135_G139_S0.8640.83
134_L376_T0.8620.83
316_L323_K0.8530.82
285_S388_Q0.8520.82
31_A124_D0.8510.82
65_L176_R0.8470.82
78_E93_L0.8450.82
245_S248_F0.8450.82
162_I273_W0.8440.82
172_A236_E0.8350.81
278_V309_V0.8350.81
138_N351_D0.8310.81
336_I356_A0.8310.81
10_R405_Q0.8300.80
324_L356_A0.8300.80
198_L201_A0.8280.80
253_D257_H0.8270.80
192_V224_E0.8260.80
46_Y326_E0.8220.80
157_D190_K0.8180.79
6_D26_Y0.8170.79
268_A272_D0.8120.79
338_I349_T0.8090.79
192_V228_K0.8070.79
181_M236_E0.8050.78
168_M238_K0.8050.78
174_N410_E0.8050.78
133_Y136_G0.8030.78
255_K266_T0.8020.78
219_L241_M0.7990.78
140_K385_N0.7950.77
223_V226_I0.7920.77
166_M312_V0.7910.77
85_T125_F0.7890.77
70_N106_L0.7880.77
290_L301_L0.7880.77
18_N187_H0.7860.77
375_S400_V0.7860.77
174_N177_E0.7850.77
220_Q223_V0.7850.77
72_N77_P0.7850.77
8_Y72_N0.7810.76
101_E104_G0.7790.76
326_E329_K0.7780.76
274_Y286_I0.7780.76
27_T32_F0.7770.76
55_D65_L0.7760.76
214_S217_E0.7760.76
350_F386_A0.7750.76
381_A389_I0.7750.76
173_P180_R0.7750.76
116_M376_T0.7750.76
198_L213_G0.7720.75
116_M120_R0.7680.75
162_I215_N0.7670.75
160_V211_N0.7590.74
375_S397_T0.7580.74
162_I241_M0.7580.74
159_N162_I0.7580.74
176_R410_E0.7560.74
346_L380_I0.7560.74
5_V28_E0.7530.74
132_Q412_Q0.7520.73
144_V419_Y0.7510.73
357_K385_N0.7510.73
275_E308_K0.7510.73
346_L376_T0.7500.73
232_K236_E0.7490.73
149_I185_I0.7460.73
336_I352_A0.7450.73
13_L179_L0.7430.73
258_L263_V0.7420.72
212_L218_A0.7420.72
154_E247_E0.7410.72
320_N343_I0.7400.72
243_A286_I0.7330.72
290_L305_L0.7310.71
217_E220_Q0.7300.71
79_L90_I0.7290.71
137_F350_F0.7270.71
141_T385_N0.7250.71
157_D160_V0.7220.70
140_K351_D0.7220.70
24_E405_Q0.7210.70
271_V304_R0.7190.70
108_A112_L0.7190.70
58_R180_R0.7160.70
93_L97_L0.7160.70
135_G140_K0.7140.70
352_A363_A0.7120.69
167_I237_V0.7120.69
79_L93_L0.7110.69
275_E278_V0.7100.69
186_F202_V0.7090.69
49_V95_I0.7070.69
176_R179_L0.7060.69
243_A248_F0.7060.69
176_R411_D0.7040.68
243_A291_D0.7030.68
7_V25_V0.7020.68
212_L221_T0.7000.68
120_R124_D0.7000.68
271_V301_L0.6990.68
37_V112_L0.6980.68
7_V76_A0.6960.68
33_G124_D0.6950.67
159_N214_S0.6930.67
24_E36_L0.6920.67
322_K326_E0.6920.67
154_E243_A0.6880.67
45_E323_K0.6880.67
335_S364_V0.6880.67
13_L180_R0.6870.67
144_V421_G0.6850.66
239_L243_A0.6850.66
271_V305_L0.6830.66
179_L183_A0.6820.66
233_P239_L0.6810.66
363_A384_T0.6770.65
45_E291_D0.6770.65
245_S291_D0.6760.65
21_V71_V0.6750.65
84_V90_I0.6750.65
340_V349_T0.6750.65
248_F274_Y0.6740.65
267_S290_L0.6730.65
60_L183_A0.6720.65
138_N385_N0.6720.65
167_I222_I0.6720.65
134_L365_I0.6720.65
157_D199_N0.6710.65
136_G385_N0.6700.65
273_W276_E0.6700.65
183_A394_P0.6700.65
167_I185_I0.6690.65
95_I345_T0.6690.65
27_T125_F0.6680.64
249_Y291_D0.6670.64
405_Q411_D0.6650.64
216_E281_Y0.6630.64
154_E194_S0.6630.64
149_I167_I0.6620.64
243_A270_M0.6610.64
222_I239_L0.6600.64
159_N213_G0.6600.64
31_A84_V0.6600.64
223_V281_Y0.6570.63
59_Y187_H0.6560.63
28_E84_V0.6560.63
365_I384_T0.6540.63
267_S271_V0.6540.63
289_G298_H0.6520.63
11_E65_L0.6490.62
6_D80_L0.6490.62
274_Y301_L0.6480.62
157_D193_L0.6460.62
365_I380_I0.6420.61
198_L217_E0.6410.61
58_R176_R0.6400.61
105_K345_T0.6390.61
278_V301_L0.6380.61
85_T122_A0.6370.61
268_A296_E0.6370.61
185_I188_S0.6360.61
150_V222_I0.6350.61
128_I132_Q0.6340.60
45_E292_E0.6310.60
223_V239_L0.6310.60
8_Y24_E0.6310.60
12_V34_R0.6300.60
164_E367_H0.6280.60
158_N260_G0.6270.60
21_V113_G0.6260.59
299_K331_G0.6260.59
162_I218_A0.6220.59
215_N260_G0.6220.59
89_A92_Q0.6220.59
9_A21_V0.6190.59
247_E391_T0.6190.59
296_E299_K0.6190.59
180_R231_F0.6190.59
119_A376_T0.6180.58
141_T418_Q0.6180.58
203_G367_H0.6170.58
29_T84_V0.6170.58
263_V269_E0.6140.58
310_Q364_V0.6130.58
245_S274_Y0.6060.57
260_G277_L0.6050.57
172_A178_A0.6030.57
33_G121_A0.6030.57
46_Y291_D0.6020.56
147_M394_P0.6010.56
311_L332_V0.5990.56
68_V71_V0.5990.56
150_V221_T0.5990.56
166_M240_A0.5980.56
212_L215_N0.5980.56
161_D257_H0.5970.56
32_F124_D0.5970.56
122_A133_Y0.5970.56
302_T331_G0.5960.56
310_Q387_G0.5960.56
95_I103_K0.5960.56
24_E33_G0.5960.56
328_I355_M0.5950.56
25_V117_A0.5940.55
83_D122_A0.5940.55
11_E183_A0.5940.55
140_K354_E0.5930.55
351_D354_E0.5930.55
85_T118_C0.5930.55
259_S262_G0.5910.55
118_C122_A0.5890.55
12_V21_V0.5880.55
321_T325_S0.5880.55
330_N361_Y0.5880.55
193_L221_T0.5880.55
329_K355_M0.5850.54
298_H333_G0.5850.54
274_Y277_L0.5840.54
12_V373_E0.5840.54
250_N259_S0.5820.54
250_N264_V0.5820.54
103_K111_I0.5810.54
78_E82_F0.5800.54
154_E291_D0.5800.54
182_G237_V0.5780.53
65_L69_N0.5770.53
316_L332_V0.5770.53
260_G263_V0.5750.53
27_T121_A0.5750.53
90_I95_I0.5750.53
272_D300_L0.5750.53
22_E411_D0.5740.53
148_N151_N0.5730.53
293_N326_E0.5720.53
92_Q347_T0.5700.52
165_F212_L0.5680.52
215_N258_L0.5670.52
7_V24_E0.5660.52
146_M240_A0.5660.52
275_E305_L0.5640.52
139_S385_N0.5640.52
29_T32_F0.5640.52
239_L283_I0.5620.51
13_L394_P0.5620.51
158_N208_F0.5610.51
247_E318_V0.5600.51
23_V118_C0.5600.51
5_V26_Y0.5590.51
168_M182_G0.5590.51
3_Y127_Q0.5590.51
29_T127_Q0.5580.51
248_F258_L0.5570.51
40_G44_G0.5570.51
248_F259_S0.5560.51
140_K418_Q0.5560.51
172_A179_L0.5550.51
139_S142_L0.5550.51
3_Y82_F0.5550.51
295_W326_E0.5540.50
168_M243_A0.5540.50
317_F332_V0.5530.50
247_E380_I0.5510.50
336_I361_Y0.5470.50
124_D127_Q0.5470.50
36_L411_D0.5470.50
159_N221_T0.5460.49
160_V178_A0.5450.49
321_T324_L0.5450.49
84_V125_F0.5440.49
132_Q136_G0.5440.49
136_G140_K0.5430.49
132_Q416_T0.5420.49
119_A383_A0.5420.49
258_L274_Y0.5410.49
159_N201_A0.5400.49
28_E83_D0.5400.49
58_R65_L0.5390.49
35_A117_A0.5380.48
150_V162_I0.5380.48
137_F358_R0.5370.48
176_R407_L0.5370.48
415_E418_Q0.5360.48
160_V221_T0.5360.48
23_V114_V0.5350.48
128_I137_F0.5350.48
413_L417_A0.5340.48
88_N138_N0.5320.48
350_F354_E0.5310.48
159_N198_L0.5300.47
353_I386_A0.5290.47
145_P178_A0.5270.47
155_H367_H0.5270.47
289_G332_V0.5270.47
74_I106_L0.5260.47
159_N260_G0.5250.47
70_N110_A0.5250.47
88_N354_E0.5250.47
3_Y83_D0.5250.47
403_Y406_L0.5240.47
192_V196_K0.5240.47
21_V373_E0.5240.47
227_E235_E0.5240.47
171_G181_M0.5240.47
338_I365_I0.5230.47
260_G274_Y0.5230.47
151_N164_E0.5220.46
295_W323_K0.5220.46
324_L338_I0.5220.46
272_D279_S0.5220.46
13_L183_A0.5220.46
106_L114_V0.5200.46
340_V365_I0.5200.46
157_D201_A0.5190.46
5_V9_A0.5190.46
217_E221_T0.5180.46
170_V284_I0.5180.46
57_D60_L0.5180.46
189_L203_G0.5180.46
72_N76_A0.5170.46
373_E389_I0.5170.46
380_I386_A0.5170.46
57_D195_A0.5160.46
87_Q345_T0.5160.46
34_R411_D0.5150.46
265_K269_E0.5150.46
258_L262_G0.5130.45
94_L106_L0.5130.45
11_E59_Y0.5120.45
83_D125_F0.5120.45
278_V308_K0.5120.45
7_V94_L0.5110.45
42_S47_E0.5100.45
377_I380_I0.5100.45
83_D86_E0.5090.45
255_K269_E0.5090.45
119_A130_L0.5080.45
151_N203_G0.5070.45
198_L221_T0.5070.45
67_A110_A0.5070.45
195_A235_E0.5060.44
73_E80_L0.5060.44
192_V225_A0.5050.44
246_S323_K0.5050.44
22_E36_L0.5050.44
248_F393_A0.5050.44
185_I238_K0.5040.44
346_L350_F0.5030.44
164_E203_G0.5030.44
172_A177_E0.5020.44
88_N416_T0.5020.44
8_Y266_T0.5000.44
158_N217_E0.5000.44
26_Y412_Q0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mksA 3 0.9302 100 0.276 Contact Map
1w6tA 3 0.9884 100 0.306 Contact Map
3otrA 2 0.993 100 0.323 Contact Map
3tqpA 2 0.9698 100 0.325 Contact Map
2akzA 2 0.9791 100 0.332 Contact Map
4ywsA 2 0.9535 100 0.351 Contact Map
4ropA 3 0.9791 100 0.354 Contact Map
3uj2A 3 0.9814 100 0.354 Contact Map
2pa6A 5 0.9721 100 0.355 Contact Map
2fymA 3 0.9907 100 0.365 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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