GREMLIN Database
ATPZ - ATP synthase protein I
UniProt: P37816 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (121)
Sequences: 182 (153)
Seq/√Len: 13.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_L95_F4.9341.00
45_S107_I3.9451.00
37_G99_S3.3270.99
36_L100_T3.0660.98
106_T110_V2.8800.96
82_I86_A2.6000.94
34_V87_V2.5550.93
29_T69_I2.5070.92
23_V27_G2.1680.85
84_A100_T2.1040.84
45_S49_F2.0780.83
23_V28_L1.9960.80
44_F60_D1.9070.77
40_L43_V1.8630.75
22_Y88_A1.7980.72
22_Y42_T1.7600.71
24_L28_L1.6780.67
96_H99_S1.6670.66
29_T108_Y1.6640.66
34_V99_S1.5990.63
83_L115_S1.5880.63
22_Y46_L1.5760.62
31_Y35_F1.5620.61
64_E85_V1.4480.55
22_Y92_P1.4190.54
25_G50_L1.3670.51
38_L103_G1.3620.51
25_G35_F1.3140.48
60_D83_L1.3100.48
89_Y102_I1.3070.48
66_G71_S1.3060.48
9_S102_I1.2360.44
56_M96_H1.2360.44
71_S85_V1.2330.44
59_F72_L1.2200.43
43_V56_M1.2120.43
33_T95_F1.1700.40
44_F84_A1.1610.40
18_I22_Y1.1340.38
116_F120_K1.1340.38
106_T113_I1.1170.38
4_P53_V1.1080.37
42_T106_T1.1030.37
33_T68_S1.0950.36
56_M66_G1.0850.36
105_M111_I1.0840.36
34_V66_G1.0840.36
10_R74_S1.0820.36
75_A96_H1.0740.35
30_A96_H1.0630.35
84_A104_L1.0590.35
80_N88_A1.0590.35
113_I116_F1.0420.34
32_K117_I1.0340.33
48_N80_N1.0160.33
8_F56_M1.0160.33
17_F95_F1.0040.32
14_Y110_V0.9940.32
59_F63_V0.9750.31
76_A80_N0.9720.31
61_R102_I0.9570.30
7_T66_G0.9530.30
85_V97_M0.9460.29
48_N88_A0.9430.29
32_K48_N0.9400.29
116_F119_L0.9370.29
49_F55_R0.9370.29
5_K39_I0.9250.28
84_A118_Q0.9230.28
29_T32_K0.9220.28
61_R101_V0.9210.28
48_N95_F0.9070.28
9_S109_P0.9010.27
24_L27_G0.8920.27
12_R39_I0.8880.27
9_S85_V0.8880.27
20_A109_P0.8830.27
9_S98_A0.8780.26
30_A87_V0.8660.26
60_D101_V0.8660.26
12_R53_V0.8550.25
74_S116_F0.8510.25
35_F103_G0.8500.25
38_L42_T0.8500.25
50_L67_K0.8470.25
23_V104_L0.8430.25
88_A100_T0.8400.25
47_F91_N0.8380.25
55_R85_V0.8370.25
110_V113_I0.8350.25
83_L120_K0.8340.25
86_A90_K0.8340.25
11_Q111_I0.8310.24
23_V37_G0.8250.24
22_Y116_F0.8150.24
53_V101_V0.8140.24
54_R91_N0.7950.23
37_G85_V0.7910.23
61_R83_L0.7880.23
76_A121_R0.7850.23
34_V117_I0.7850.23
13_K74_S0.7800.22
22_Y87_V0.7800.22
3_D66_G0.7730.22
2_D54_R0.7630.22
37_G48_N0.7630.22
118_Q121_R0.7620.22
61_R65_K0.7610.22
49_F100_T0.7600.22
2_D56_M0.7590.22
57_N61_R0.7520.21
11_Q53_V0.7390.21
49_F114_D0.7360.21
29_T47_F0.7300.21
43_V118_Q0.7280.21
18_I24_L0.7270.21
79_C109_P0.7250.20
26_Y107_I0.7240.20
25_G45_S0.7200.20
5_K54_R0.7120.20
100_T121_R0.7040.20
74_S119_L0.6990.20
17_F21_V0.6950.19
13_K27_G0.6950.19
2_D78_W0.6940.19
55_R76_A0.6920.19
58_A68_S0.6850.19
24_L116_F0.6800.19
54_R109_P0.6790.19
12_R16_L0.6740.19
101_V104_L0.6720.19
7_T13_K0.6710.19
81_A103_G0.6710.19
33_T61_R0.6690.19
49_F110_V0.6670.19
30_A71_S0.6460.18
34_V48_N0.6320.17
4_P56_M0.6250.17
25_G71_S0.6250.17
20_A79_C0.6210.17
59_F105_M0.6110.17
29_T82_I0.6060.17
92_P95_F0.6050.17
14_Y42_T0.6020.16
25_G108_Y0.6020.16
38_L113_I0.6010.16
15_L46_L0.5960.16
42_T66_G0.5930.16
29_T50_L0.5920.16
16_L84_A0.5880.16
88_A95_F0.5850.16
58_A75_A0.5780.16
37_G119_L0.5690.16
31_Y115_S0.5660.15
11_Q51_L0.5630.15
64_E121_R0.5630.15
17_F24_L0.5610.15
49_F91_N0.5590.15
18_I78_W0.5570.15
112_M115_S0.5570.15
80_N112_M0.5570.15
75_A117_I0.5530.15
58_A112_M0.5530.15
51_L55_R0.5510.15
16_L98_A0.5500.15
3_D71_S0.5440.15
45_S83_L0.5410.15
36_L119_L0.5390.15
69_I82_I0.5390.15
23_V39_I0.5340.15
14_Y34_V0.5300.14
57_N68_S0.5270.14
36_L81_A0.5250.14
39_I100_T0.5240.14
29_T35_F0.5240.14
65_K109_P0.5230.14
52_L73_G0.5190.14
82_I117_I0.5170.14
9_S84_A0.5160.14
62_A72_L0.5140.14
97_M117_I0.5040.14
45_S116_F0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.9134 29.9 0.93 Contact Map
3w4tA 1 0.9055 18.2 0.937 Contact Map
3mktA 1 0.9764 18 0.937 Contact Map
4humA 1 0.9606 15.3 0.939 Contact Map
1pw4A 1 0.9685 12.3 0.941 Contact Map
3j08A 2 0.874 12 0.942 Contact Map
4xnjA 1 0.8898 11.3 0.942 Contact Map
2m20A 2 0.2835 11.1 0.942 Contact Map
2m8rA 1 0.2992 10.4 0.943 Contact Map
2cfqA 1 0.9685 10 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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