GREMLIN Database
ATPL - ATP synthase subunit c
UniProt: P37815 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 70 (65)
Sequences: 575 (292)
Seq/√Len: 36.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_R30_E4.6971.00
10_I60_A3.1431.00
13_G60_A2.8001.00
39_G43_R2.7131.00
56_L59_I2.3050.99
28_T42_L2.2060.99
17_A57_P1.9120.98
21_N54_E1.8170.97
55_A62_V1.6750.95
38_A42_L1.6720.95
62_V65_F1.6420.95
32_I42_L1.5890.94
29_V45_L1.4940.91
21_N25_V1.4900.91
18_G68_F1.4850.91
8_I12_L1.4650.91
25_V50_I1.4620.91
9_A64_A1.4370.90
32_I38_A1.4100.89
5_A9_A1.3880.88
23_L26_S1.3850.88
21_N50_I1.3310.86
29_V32_I1.2420.82
50_I53_V1.2060.80
21_N56_L1.1250.75
7_A23_L1.0870.72
53_V56_L1.0670.71
31_G53_V1.0630.70
4_I41_E1.0500.70
48_M51_A1.0260.68
35_Q54_E1.0190.67
25_V53_V0.9930.65
21_N55_A0.9880.65
21_N28_T0.9680.63
64_A68_F0.9540.62
46_M50_I0.9480.61
37_E40_K0.9160.59
34_R38_A0.9150.59
47_F52_L0.9110.58
30_E36_P0.9070.58
13_G52_L0.9010.58
39_G44_T0.8880.56
5_A63_I0.8870.56
15_L26_S0.8840.56
25_V49_G0.8430.53
52_L55_A0.8380.52
33_A46_M0.7820.47
21_N57_P0.7780.47
38_A54_E0.7750.47
21_N53_V0.7730.46
8_I49_G0.7690.46
14_A25_V0.7680.46
47_F50_I0.7460.44
3_L26_S0.7280.43
24_I59_I0.7250.42
14_A56_L0.7180.42
4_I18_G0.7040.41
16_G51_A0.7040.41
4_I44_T0.6940.40
10_I14_A0.6920.40
46_M49_G0.6860.39
6_A68_F0.6760.38
10_I64_A0.6690.38
14_A60_A0.6500.36
28_T46_M0.6390.35
28_T55_A0.6320.35
8_I62_V0.6120.33
48_M52_L0.6120.33
16_G20_G0.6080.33
8_I50_I0.6020.32
34_R37_E0.5980.32
61_V65_F0.5890.31
14_A19_I0.5850.31
41_E44_T0.5690.30
25_V52_L0.5670.30
19_I39_G0.5660.30
23_L60_A0.5660.30
28_T47_F0.5490.28
14_A49_G0.5470.28
7_A41_E0.5470.28
15_L34_R0.5470.28
51_A67_A0.5410.28
7_A60_A0.5410.28
45_L62_V0.5390.28
38_A63_I0.5370.28
19_I40_K0.5300.27
32_I45_L0.5290.27
51_A61_V0.5270.27
8_I29_V0.5250.27
6_A36_P0.5250.27
26_S45_L0.5240.27
7_A18_G0.5180.26
23_L31_G0.5130.26
38_A41_E0.5130.26
50_I56_L0.5080.26
47_F65_F0.5070.25
4_I8_I0.5050.25
34_R46_M0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cbkA 3 0.9857 99.7 0.258 Contact Map
4v1gA 3 1 99.7 0.286 Contact Map
1a91A 1 1 99.7 0.287 Contact Map
2xquA 3 1 99.7 0.292 Contact Map
1wu0A 1 1 99.7 0.294 Contact Map
4bemA 3 0.9857 99.6 0.308 Contact Map
2xndJ 3 0.9714 99.6 0.308 Contact Map
3zk1A 5 0.9857 99.6 0.309 Contact Map
4f4sA 3 0.9857 99.6 0.314 Contact Map
4bemJ 1 0.9857 99.6 0.32 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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