GREMLIN Database
ATP6 - ATP synthase subunit a
UniProt: P37813 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 244 (209)
Sequences: 6253 (3380)
Seq/√Len: 233.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_T115_I3.6801.00
78_L123_V3.6011.00
87_F222_A3.3901.00
145_L152_L3.0781.00
79_G229_T2.7371.00
14_T18_T2.6451.00
155_K158_E2.4111.00
128_H159_E2.3631.00
82_L86_I2.2801.00
32_L36_L2.2731.00
47_K50_N2.1661.00
108_S174_I2.1561.00
93_G108_S2.0761.00
117_L167_G2.0721.00
89_S109_P2.0651.00
107_K112_D2.0471.00
152_L156_I2.0191.00
71_T134_M1.9931.00
116_T171_Y1.9781.00
15_F20_I1.9641.00
31_L35_I1.9531.00
139_E142_K1.9321.00
19_N115_I1.9141.00
129_Y133_K1.7881.00
149_P153_P1.7821.00
83_L225_A1.7761.00
60_R76_L1.7641.00
24_T27_S1.7411.00
26_A89_S1.7071.00
61_N65_S1.7001.00
150_F153_P1.6611.00
225_A229_T1.6551.00
123_V232_T1.6411.00
87_F91_M1.6371.00
26_A92_L1.6361.00
128_H140_Y1.5911.00
19_N23_I1.5911.00
164_L167_G1.5771.00
33_I37_T1.5671.00
135_K143_D1.5651.00
200_L204_I1.5501.00
79_G233_M1.5281.00
168_L172_G1.5081.00
64_G69_L1.5021.00
50_N54_W1.4891.00
38_T41_L1.4751.00
49_Q53_E1.4591.00
55_I84_M1.4571.00
64_G73_A1.4461.00
113_P167_G1.4291.00
117_L121_V1.4101.00
19_N112_D1.3981.00
116_T167_G1.3881.00
94_L218_L1.3761.00
45_P49_Q1.3411.00
91_M221_G1.3331.00
34_A38_T1.3291.00
91_M218_L1.3261.00
132_V141_S1.3191.00
16_N19_N1.3171.00
113_P117_L1.3121.00
127_T236_M1.2951.00
58_F61_N1.2941.00
177_G217_S1.2881.00
178_E217_S1.2791.00
64_G72_G1.2731.00
39_R43_I1.2641.00
141_S145_L1.2601.00
149_P152_L1.2441.00
28_V32_L1.2301.00
75_F130_Y1.2251.00
201_V205_G1.2181.00
164_L168_L1.2101.00
45_P53_E1.2081.00
175_F179_I1.2011.00
120_A167_G1.1991.00
48_A52_M1.1981.00
50_N57_D1.1961.00
135_K139_E1.1871.00
165_T235_Y1.1841.00
213_W216_F1.1801.00
37_T48_A1.1731.00
131_G140_Y1.1701.00
117_L120_A1.1651.00
59_V83_L1.1531.00
125_A129_Y1.1511.00
145_L148_V1.1261.00
142_K146_R1.1211.00
78_L122_M1.1211.00
91_M222_A1.1171.00
36_L40_T1.1151.00
32_L35_I1.1101.00
111_A178_E1.1021.00
23_I27_S1.1011.00
113_P168_L1.1001.00
86_I170_L1.0971.00
184_L213_W1.0971.00
35_I39_R1.0961.00
146_R152_L1.0871.00
36_L48_A1.0841.00
132_V140_Y1.0741.00
79_G232_T1.0611.00
57_D61_N1.0601.00
111_A174_I1.0511.00
157_I161_A1.0491.00
40_T43_I1.0471.00
54_W57_D1.0451.00
30_V88_V1.0431.00
155_K159_E1.0421.00
85_Y89_S1.0331.00
120_A166_L1.0241.00
144_Y159_E1.0211.00
22_M105_W1.0211.00
71_T74_N1.0061.00
127_T235_Y1.0021.00
16_N20_I0.9951.00
217_S220_I0.9931.00
137_L141_S0.9911.00
24_T28_V0.9851.00
86_I119_L0.9831.00
162_N238_H0.9801.00
37_T52_M0.9771.00
36_L39_R0.9731.00
42_S46_G0.9631.00
60_R64_G0.9561.00
66_T230_M0.9471.00
180_L213_W0.9451.00
27_S31_L0.9441.00
76_L80_V0.9411.00
199_G204_I0.9401.00
57_D60_R0.9391.00
124_V163_T0.9311.00
223_I227_I0.9301.00
63_I66_T0.9211.00
114_A118_T0.9181.00
60_R73_A0.9171.00
87_F225_A0.9141.00
165_T181_L0.9141.00
198_L201_V0.9111.00
177_G220_I0.9061.00
38_T42_S0.9041.00
123_V127_T0.9021.00
86_I228_F0.8950.99
153_P157_I0.8920.99
78_L232_T0.8800.99
108_S178_E0.8710.99
159_E162_N0.8610.99
115_I118_T0.8590.99
184_L210_M0.8580.99
63_I233_M0.8570.99
30_V34_A0.8540.99
201_V204_I0.8490.99
95_P106_W0.8440.99
107_K111_A0.8420.99
188_A207_I0.8420.99
25_V29_I0.8420.99
146_R155_K0.8380.99
182_G187_L0.8310.99
172_G176_A0.8300.99
91_M95_P0.8290.99
160_F163_T0.8280.99
51_F55_I0.8260.99
35_I38_T0.8250.99
148_V152_L0.8240.99
51_F54_W0.8210.99
62_I230_M0.8210.99
212_A215_A0.8170.99
159_E238_H0.8170.99
29_I32_L0.8160.99
75_F236_M0.8130.99
174_I177_G0.8120.99
82_L123_V0.8110.99
29_I88_V0.8060.99
181_L185_A0.8060.99
67_M233_M0.8060.99
162_N166_L0.8040.99
202_G205_G0.8030.99
198_L202_G0.7990.99
128_H132_V0.7950.99
171_Y175_F0.7930.99
158_E162_N0.7910.99
188_A206_A0.7890.99
130_Y134_M0.7880.99
153_P156_I0.7790.99
213_W217_S0.7690.98
56_V80_V0.7680.98
94_L221_G0.7650.98
22_M25_V0.7610.98
173_N220_I0.7610.98
83_L87_F0.7610.98
207_I210_M0.7510.98
59_V80_V0.7490.98
126_L236_M0.7490.98
89_S110_T0.7450.98
166_L235_Y0.7420.98
182_G186_G0.7410.98
143_D155_K0.7330.98
19_N24_T0.7320.98
64_G76_L0.7310.98
148_V151_M0.7280.98
144_Y147_P0.7240.98
216_F219_F0.7140.97
43_I49_Q0.7130.97
134_M240_I0.7120.97
199_G202_G0.7040.97
205_G209_P0.7020.97
23_I26_A0.6990.97
146_R158_E0.6930.97
189_T204_I0.6880.97
130_Y133_K0.6880.97
124_V159_E0.6870.97
176_A220_I0.6870.97
94_L214_Q0.6820.97
74_N134_M0.6820.97
78_L82_L0.6810.97
75_F126_L0.6810.97
59_V62_I0.6800.97
230_M233_M0.6750.96
39_R53_E0.6740.96
183_L216_F0.6720.96
108_S217_S0.6700.96
212_A216_F0.6650.96
166_L173_N0.6600.96
166_L232_T0.6550.96
21_L24_T0.6530.96
124_V158_E0.6510.96
47_K51_F0.6500.96
110_T116_T0.6490.96
156_I160_F0.6460.95
15_F18_T0.6460.95
53_E57_D0.6460.95
25_V28_V0.6440.95
168_L226_F0.6430.95
145_L149_P0.6410.95
180_L210_M0.6390.95
85_Y115_I0.6360.95
40_T49_Q0.6220.94
234_V238_H0.6190.94
90_N93_G0.6170.94
183_L187_L0.6160.94
157_I201_V0.6140.94
41_L44_R0.6120.94
39_R42_S0.6110.94
127_T159_E0.6070.94
128_H131_G0.6050.94
203_T206_A0.6040.94
63_I67_M0.6040.94
220_I227_I0.5990.93
63_I229_T0.5950.93
93_G178_E0.5930.93
219_F223_I0.5910.93
23_I85_Y0.5870.93
69_L73_A0.5870.93
120_A163_T0.5850.92
91_M94_L0.5830.92
217_S221_G0.5830.92
184_L209_P0.5820.92
83_L229_T0.5790.92
126_L129_Y0.5790.92
209_P212_A0.5760.92
140_Y159_E0.5750.92
121_V125_A0.5740.92
225_A228_F0.5740.92
23_I115_I0.5740.92
228_F231_L0.5680.91
186_G190_S0.5670.91
154_M163_T0.5630.91
107_K178_E0.5630.91
175_F230_M0.5570.90
34_A41_L0.5520.90
52_M84_M0.5520.90
158_E161_A0.5510.90
67_M72_G0.5500.90
124_V127_T0.5490.90
114_A165_T0.5490.90
126_L130_Y0.5480.90
53_E88_V0.5470.90
165_T216_F0.5430.89
151_M161_A0.5420.89
67_M237_S0.5390.89
37_T43_I0.5380.89
190_S199_G0.5370.89
117_L164_L0.5370.89
63_I76_L0.5360.89
227_I237_S0.5340.89
124_V128_H0.5330.88
33_I52_M0.5320.88
22_M26_A0.5270.88
84_M88_V0.5270.88
135_K239_K0.5270.88
114_A203_T0.5270.88
124_V166_L0.5260.88
213_W220_I0.5260.88
108_S111_A0.5240.88
82_L232_T0.5230.88
93_G221_G0.5210.87
77_A81_T0.5210.87
83_L177_G0.5190.87
108_S221_G0.5190.87
136_G139_E0.5190.87
32_L69_L0.5170.87
124_V235_Y0.5160.87
143_D146_R0.5130.87
27_S41_L0.5130.87
15_F33_I0.5110.86
54_W58_F0.5100.86
205_G208_L0.5040.86
120_A228_F0.5040.86
113_P118_T0.5040.86
133_K137_L0.5020.85
178_E220_I0.5020.85
119_L170_L0.5010.85
136_G140_Y0.5010.85
223_I226_F0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1c17M 1 0.5451 100 0.355 Contact Map
2vpbB 1 0.1066 2.1 0.97 Contact Map
2jpkA 1 0.1434 1.8 0.971 Contact Map
3zpvB 2 0.1066 1.4 0.973 Contact Map
2l9uA 2 0.1516 1 0.975 Contact Map
2l6wA 2 0.1557 0.9 0.976 Contact Map
2mawA 1 0.3852 0.8 0.977 Contact Map
2rddB 1 0.1475 0.8 0.977 Contact Map
4tt0A 2 0.1598 0.8 0.977 Contact Map
2mofA 1 0.168 0.8 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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