GREMLIN Database
ATPE - ATP synthase epsilon chain
UniProt: P37812 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 132 (127)
Sequences: 3013 (1959)
Seq/√Len: 173.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_R101_Q3.0841.00
27_A32_L2.8571.00
5_K19_D2.5151.00
7_N17_D2.3721.00
98_Q102_E2.3651.00
25_V68_V2.3391.00
6_V20_I2.2911.00
95_A98_Q2.2771.00
49_A129_V2.1671.00
22_M33_G2.0711.00
53_K58_T2.0391.00
83_E126_R1.9721.00
91_E94_E1.9661.00
95_A99_R1.9651.00
102_E106_S1.9621.00
97_R120_L1.9301.00
70_V75_V1.8541.00
32_L41_T1.8081.00
94_E97_R1.7901.00
51_R58_T1.7481.00
54_K59_E1.7171.00
26_R48_G1.7141.00
4_V36_P1.7131.00
26_R31_D1.6911.00
90_K94_E1.6851.00
22_M53_K1.5931.00
54_K57_Q1.5341.00
89_D92_R1.5211.00
92_R96_A1.5191.00
13_G87_G1.5101.00
25_V32_L1.4681.00
91_E95_A1.4361.00
90_K127_L1.4311.00
94_E98_Q1.4271.00
3_T21_E1.4221.00
43_A68_V1.4121.00
3_T19_D1.4081.00
101_Q105_N1.3911.00
37_G73_D1.3881.00
27_A43_A1.3751.00
7_N74_H1.3401.00
31_D46_K1.3401.00
22_M35_L1.3271.00
117_E121_Q1.3001.00
50_V77_I1.2941.00
109_D112_D1.2741.00
64_S81_A1.2711.00
7_N14_P1.2611.00
52_L61_V1.2561.00
59_E84_T1.2541.00
50_V63_V1.2381.00
98_Q101_Q1.2271.00
59_E86_E1.2181.00
61_V84_T1.2091.00
23_V75_V1.1761.00
28_E44_P1.1361.00
21_E53_K1.1341.00
61_V82_A1.0981.00
21_E55_D1.0741.00
93_A123_A1.0651.00
102_E105_N1.0611.00
4_V75_V1.0541.00
96_A99_R1.0511.00
125_N129_V1.0330.99
88_I93_A1.0290.99
62_A125_N1.0220.99
84_T87_G1.0220.99
41_T70_V0.9880.99
18_A54_K0.9870.99
93_A97_R0.9760.99
24_S51_R0.9750.99
60_M85_A0.9740.99
99_R119_A0.9720.99
111_T115_R0.9670.99
23_V50_V0.9650.99
24_S31_D0.9500.99
103_R119_A0.9420.99
103_R106_S0.9370.99
15_V61_V0.9290.99
118_L122_R0.9160.99
5_K17_D0.9120.99
25_V45_L0.9080.99
100_A116_A0.8970.98
96_A100_A0.8940.98
26_R46_K0.8810.98
62_A129_V0.8730.98
24_S53_K0.8580.98
42_V69_E0.8530.98
34_I70_V0.8520.98
21_E54_K0.8490.98
46_K121_Q0.8490.98
83_E88_I0.8430.98
113_I117_E0.8410.98
26_R68_V0.8350.98
99_R103_R0.8340.98
83_E92_R0.8300.97
97_R124_L0.8230.97
16_Y52_L0.8160.97
107_Q113_I0.8120.97
64_S80_Q0.8010.97
12_D78_L0.7940.97
20_I52_L0.7910.97
5_K74_H0.7890.97
8_I61_V0.7890.97
92_R126_R0.7790.96
14_P17_D0.7750.96
15_V82_A0.7630.96
16_Y54_K0.7540.95
6_V52_L0.7440.95
65_G79_A0.7350.95
93_A127_L0.7170.94
63_V77_I0.7150.94
122_R126_R0.7120.94
106_S109_D0.7080.94
34_I68_V0.7050.94
124_L128_D0.7010.93
42_V71_R0.6970.93
8_I50_V0.6960.93
47_I125_N0.6930.93
116_A120_L0.6900.93
92_R95_A0.6900.93
6_V75_V0.6720.92
110_D113_I0.6710.92
31_D51_R0.6610.91
108_S112_D0.6610.91
9_V17_D0.6600.91
24_S33_G0.6600.91
92_R99_R0.6590.91
119_A122_R0.6530.91
123_A126_R0.6520.91
60_M129_V0.6520.91
15_V84_T0.6490.90
79_A82_A0.6480.90
93_A126_R0.6460.90
51_R60_M0.6420.90
27_A41_T0.6410.90
64_S125_N0.6370.90
10_T20_I0.6350.90
43_A70_V0.6190.88
52_L65_G0.6160.88
23_V52_L0.6120.88
96_A123_A0.6090.87
114_R117_E0.6070.87
11_P47_I0.6050.87
9_V76_T0.5940.86
26_R63_V0.5940.86
83_E96_A0.5920.86
62_A122_R0.5860.85
112_D115_R0.5850.85
69_E76_T0.5800.85
62_A88_I0.5790.85
93_A96_A0.5790.85
54_K86_E0.5760.84
101_Q104_L0.5670.84
4_V22_M0.5610.83
63_V82_A0.5610.83
10_T88_I0.5570.82
100_A103_R0.5470.81
121_Q124_L0.5470.81
110_D114_R0.5430.81
45_L77_I0.5420.81
114_R118_L0.5410.81
25_V50_V0.5390.80
71_R76_T0.5360.80
104_L113_I0.5340.80
99_R112_D0.5330.80
21_E56_G0.5320.80
63_V79_A0.5290.79
121_Q125_N0.5290.79
9_V14_P0.5270.79
107_Q110_D0.5270.79
49_A60_M0.5240.78
28_E43_A0.5240.78
92_R119_A0.5240.78
24_S39_I0.5230.78
65_G80_Q0.5230.78
107_Q112_D0.5220.78
89_D104_L0.5210.78
116_A123_A0.5200.78
8_I52_L0.5160.77
25_V48_G0.5140.77
120_L124_L0.5110.77
68_V75_V0.5110.77
99_R115_R0.5110.77
117_E124_L0.5060.76
92_R122_R0.5060.76
112_D116_A0.5020.76
115_R119_A0.5020.76
25_V34_I0.5000.75
12_D29_S0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e5yA 2 1 100 0.046 Contact Map
2qe7H 1 1 100 0.047 Contact Map
1aqtA 2 0.9924 100 0.073 Contact Map
2rq6A 1 0.9924 100 0.073 Contact Map
2w6jH 1 0.6288 100 0.09 Contact Map
2ck3H 1 0.6288 100 0.106 Contact Map
3ziaH 1 0.9318 100 0.159 Contact Map
2xokH 1 0.8939 100 0.169 Contact Map
3m6cA 1 0.8636 17.2 0.925 Contact Map
1vf7A 5 0.7576 14.1 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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