GREMLIN Database
ATPD - ATP synthase subunit delta
UniProt: P37811 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (171)
Sequences: 4185 (3180)
Seq/√Len: 243.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_N103_A3.9441.00
80_L92_L2.9911.00
110_I143_E2.7461.00
130_A137_S2.6681.00
122_M142_N2.5631.00
30_E70_S2.5091.00
153_K164_S2.4531.00
112_Y145_Q2.4331.00
110_I141_R2.2901.00
119_D123_L2.2111.00
63_Q78_F2.1931.00
119_D122_M2.1721.00
59_K82_D2.0481.00
118_T121_E2.0191.00
31_L93_T1.9961.00
123_L126_S1.9641.00
23_Q70_S1.9581.00
123_L127_Q1.9291.00
110_I155_R1.8201.00
30_E73_V1.8171.00
95_E98_K1.8151.00
112_Y143_E1.6881.00
108_D139_R1.6651.00
60_E64_N1.6501.00
148_L164_S1.6481.00
25_N104_R1.6461.00
100_A104_R1.6371.00
107_E135_V1.6221.00
113_S152_I1.6191.00
113_S142_N1.5881.00
57_K60_E1.5871.00
122_M126_S1.5641.00
167_G171_R1.5571.00
36_Q40_N1.5061.00
113_S117_L1.5021.00
114_V144_V1.4841.00
109_A156_I1.4491.00
81_I86_A1.4451.00
127_Q131_K1.4391.00
23_Q26_Q1.4341.00
111_V140_I1.4231.00
35_K94_D1.4161.00
18_A27_V1.3811.00
54_P57_K1.3781.00
150_G165_V1.3781.00
15_F103_A1.3741.00
32_I97_I1.3591.00
28_E97_I1.3541.00
112_Y153_K1.3431.00
148_L153_K1.3371.00
28_E100_A1.3361.00
56_A60_E1.3191.00
59_K78_F1.2951.00
47_V61_L1.2891.00
133_A156_I1.2891.00
126_S130_A1.2831.00
108_D141_R1.2751.00
76_T92_L1.2741.00
74_L78_F1.2581.00
112_Y148_L1.2461.00
111_V117_L1.2451.00
101_N108_D1.2371.00
44_L65_A1.2321.00
66_F69_L1.2111.00
152_I163_G1.2041.00
128_V131_K1.1941.00
28_E104_R1.1651.00
106_T137_S1.1631.00
124_P128_V1.1601.00
45_N49_N1.1581.00
63_Q74_L1.1431.00
101_N106_T1.1321.00
126_S140_I1.1271.00
107_E138_L1.1131.00
111_V154_V1.1121.00
109_A140_I1.1071.00
66_F77_I1.1041.00
69_L74_L1.1031.00
127_Q130_A1.1031.00
166_S170_Q1.0991.00
27_V73_V1.0771.00
125_L152_I1.0761.00
116_P122_M1.0661.00
35_K93_T1.0641.00
116_P144_V1.0611.00
128_V132_K1.0571.00
15_F19_N1.0541.00
17_I72_S1.0521.00
29_E32_I1.0511.00
28_E32_I1.0451.00
120_A123_L1.0381.00
67_G74_L1.0351.00
14_L76_T1.0331.00
35_K97_I1.0271.00
120_A124_P1.0171.00
48_L58_K1.0141.00
59_K63_Q1.0111.00
116_P119_D0.9981.00
60_E63_Q0.9881.00
25_N29_E0.9871.00
24_L96_F0.9801.00
12_S16_D0.9791.00
26_Q30_E0.9791.00
71_Q74_L0.9691.00
14_L17_I0.9691.00
15_F99_L0.9541.00
43_A46_D0.9441.00
23_Q27_V0.9441.00
97_I101_N0.9361.00
17_I21_S0.9321.00
26_Q70_S0.9271.00
133_A159_R0.9211.00
55_A84_H0.9181.00
96_F100_A0.9091.00
79_L83_R0.9081.00
23_Q72_S0.9041.00
80_L86_A0.8981.00
112_Y155_R0.8971.00
26_Q29_E0.8911.00
34_V69_L0.8911.00
21_S72_S0.8901.00
35_K39_Q0.8881.00
153_K160_I0.8831.00
31_L73_V0.8780.99
173_E177_A0.8730.99
29_E33_V0.8580.99
34_V66_F0.8550.99
102_V135_V0.8450.99
11_A99_L0.8420.99
35_K90_P0.8400.99
10_Y85_R0.8400.99
76_T80_L0.8390.99
75_N78_F0.8340.99
106_T139_R0.8260.99
58_K84_H0.8260.99
129_F138_L0.8250.99
109_A129_F0.8230.99
37_V66_F0.8220.99
21_S71_Q0.8190.99
101_N139_R0.8160.99
33_V36_Q0.8120.99
162_D167_G0.8090.99
71_Q75_N0.7980.99
6_V88_I0.7880.99
34_V77_I0.7880.99
125_L129_F0.7830.99
24_L103_A0.7810.99
147_D166_S0.7800.99
107_E133_A0.7780.99
45_N90_P0.7760.99
8_K95_E0.7610.99
155_R160_I0.7570.98
129_F133_A0.7560.98
135_V138_L0.7540.98
124_P127_Q0.7530.98
88_I91_E0.7470.98
131_K134_G0.7410.98
99_L102_V0.7370.98
55_A59_K0.7360.98
149_I165_V0.7180.98
170_Q174_R0.7170.98
69_L73_V0.7140.98
42_K45_N0.7080.98
129_F161_Y0.7080.98
113_S148_L0.7080.98
33_V37_V0.7070.98
18_A24_L0.7050.98
27_V70_S0.7050.98
7_S95_E0.7030.98
126_S137_S0.7000.97
24_L104_R0.6830.97
53_V57_K0.6800.97
42_K46_D0.6760.97
160_I163_G0.6740.97
95_E99_L0.6740.97
49_N87_A0.6710.97
62_I81_I0.6630.96
116_P142_N0.6630.96
44_L61_L0.6590.96
114_V148_L0.6540.96
39_Q90_P0.6540.96
38_F48_L0.6440.96
99_L103_A0.6420.96
50_H58_K0.6410.96
32_I36_Q0.6400.96
118_T122_M0.6390.96
57_K64_N0.6350.96
150_G162_D0.6310.95
14_L27_V0.6250.95
153_K166_S0.6210.95
171_R174_R0.6200.95
19_N24_L0.6150.95
77_I89_V0.6120.95
91_E95_E0.6030.94
34_V38_F0.6020.94
17_I27_V0.6010.94
30_E33_V0.6000.94
37_V41_E0.6000.94
109_A133_A0.5990.94
17_I20_E0.5980.94
107_E129_F0.5950.94
9_R173_E0.5930.94
100_A106_T0.5930.94
72_S75_N0.5880.93
44_L47_V0.5860.93
132_K159_R0.5810.93
38_F89_V0.5720.92
126_S139_R0.5710.92
47_V53_V0.5690.92
113_S121_E0.5680.92
122_M140_I0.5650.92
94_D98_K0.5650.92
113_S144_V0.5610.92
165_V169_L0.5610.92
142_N148_L0.5570.91
34_V73_V0.5560.91
174_R177_A0.5550.91
105_Q134_G0.5550.91
27_V72_S0.5520.91
125_L154_V0.5510.91
18_A96_F0.5460.90
18_A22_A0.5410.90
63_Q67_G0.5400.90
111_V142_N0.5400.90
132_K161_Y0.5370.90
14_L30_E0.5340.90
170_Q173_E0.5330.89
15_F24_L0.5330.89
50_H53_V0.5320.89
107_E157_G0.5300.89
171_R177_A0.5300.89
62_I74_L0.5270.89
105_Q137_S0.5250.89
38_F44_L0.5240.89
160_I176_L0.5230.89
83_R164_S0.5220.88
134_G138_L0.5210.88
171_R175_Q0.5210.88
105_Q135_V0.5180.88
87_A90_P0.5170.88
125_L161_Y0.5160.88
27_V30_E0.5160.88
145_Q166_S0.5160.88
93_T97_I0.5140.88
62_I77_I0.5140.88
97_I108_D0.5140.88
16_D20_E0.5120.87
48_L62_I0.5120.87
91_E94_D0.5100.87
169_L172_I0.5080.87
126_S142_N0.5070.87
24_L100_A0.5050.87
8_K102_V0.5050.87
165_V174_R0.5030.87
28_E96_F0.5010.86
19_N22_A0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wssS 1 0.8564 100 0.102 Contact Map
1abvA 1 0.5746 100 0.396 Contact Map
3lg8A 1 0.5304 93.8 0.869 Contact Map
3v6iA 1 0.8785 88.1 0.887 Contact Map
4efaE 1 0.9392 85.1 0.892 Contact Map
2dm9A 2 0.5912 72.6 0.904 Contact Map
2marA 1 0.4807 10.8 0.94 Contact Map
2nx4A 2 0.7293 8.4 0.943 Contact Map
2r9vA 1 0.7182 7.6 0.944 Contact Map
3he0A 2 0.7459 7.4 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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