GREMLIN Database
ATPG - ATP synthase gamma chain
UniProt: P37810 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (283)
Sequences: 3891 (2414)
Seq/√Len: 143.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_T122_G6.0691.00
210_S213_E4.9111.00
91_F234_S4.2821.00
238_E242_R3.6831.00
247_K251_D3.4121.00
75_K112_E3.3491.00
174_H184_T3.2891.00
18_S254_K3.0591.00
28_S239_H3.0161.00
79_L156_T2.9501.00
75_K114_A2.8691.00
169_H187_K2.7781.00
77_A165_F2.7651.00
159_M164_A2.7061.00
98_S101_Q2.5931.00
103_M115_V2.5591.00
158_Q162_D2.5121.00
78_Y102_A2.5011.00
135_S155_Q2.4551.00
170_L230_A2.3991.00
167_E187_K2.3231.00
114_A134_I2.3031.00
71_R166_D2.2181.00
176_V182_E2.2051.00
255_E259_S2.1351.00
80_V99_A2.1091.00
99_A126_F2.0891.00
123_R136_E2.0861.00
239_H242_R2.0491.00
82_T96_L2.0171.00
36_E40_K1.9811.00
102_A105_E1.9261.00
155_Q159_M1.9151.00
25_Q247_K1.8781.00
48_K51_E1.8781.00
276_I280_V1.8521.00
91_F173_N1.8251.00
154_R158_Q1.8081.00
100_Y125_F1.7901.00
171_V185_E1.7781.00
165_F168_L1.7531.00
117_A122_G1.7291.00
177_S180_T1.7291.00
96_L125_F1.7041.00
176_V180_T1.6981.00
15_K261_S1.6921.00
99_A171_V1.6731.00
114_A132_P1.6591.00
102_A171_V1.6261.00
105_E109_S1.6241.00
73_V166_D1.6201.00
169_H185_E1.6111.00
74_K166_D1.6081.00
174_H182_E1.5911.00
117_A133_I1.5901.00
159_M165_F1.5821.00
15_K18_S1.5761.00
98_S102_A1.5641.00
10_R260_L1.5631.00
173_N237_S1.5591.00
153_A224_E1.5581.00
43_V233_D1.5371.00
149_I231_L1.5191.00
274_Q278_E1.5041.00
88_A242_R1.5031.00
76_T169_H1.4991.00
115_V131_I1.4841.00
79_L227_I1.4681.00
98_S183_V1.4111.00
95_V99_A1.3831.00
102_A169_H1.3621.00
114_A165_F1.3541.00
10_R266_R1.3471.00
274_Q277_T1.3461.00
278_E281_G1.3081.00
95_V171_V1.3051.00
14_T17_T1.2981.00
99_A103_M1.2931.00
98_S185_E1.2931.00
267_A271_A1.2841.00
263_S267_A1.2781.00
80_V95_V1.2701.00
155_Q158_Q1.2651.00
77_A116_I1.2551.00
36_E175_F1.2521.00
254_K258_D1.2511.00
17_T20_I1.2491.00
102_A106_R1.2471.00
17_T21_T1.2401.00
8_K12_T1.2361.00
18_S25_Q1.2321.00
260_L263_S1.2221.00
33_N37_N1.2091.00
88_A92_N1.1861.00
235_K239_H1.1851.00
277_T281_G1.1771.00
123_R138_T1.1771.00
96_L126_F1.1741.00
5_R9_S1.1561.00
83_S92_N1.1480.99
25_Q243_M1.1450.99
78_Y113_Y1.1430.99
114_A164_A1.1390.99
99_A115_V1.1370.99
77_A168_L1.1260.99
115_V126_F1.1180.99
222_Y226_L1.1120.99
7_I264_Y1.1110.99
117_A123_R1.1100.99
116_I134_I1.1100.99
173_N234_S1.1020.99
27_V31_K1.0920.99
280_V283_A1.0910.99
150_K154_R1.0910.99
76_T106_R1.0800.99
39_A236_A1.0770.99
100_Y126_F1.0680.99
80_V122_G1.0630.99
100_Y129_R1.0620.99
186_K226_L1.0590.99
75_K164_A1.0410.99
74_K112_E1.0400.99
178_A240_A1.0360.99
100_Y104_Q1.0360.99
71_R74_K1.0350.99
11_I257_I1.0290.99
106_R110_K1.0200.99
16_K42_F1.0200.99
77_A134_I1.0100.99
187_K192_S1.0060.99
2_A274_Q1.0020.99
106_R111_D0.9990.99
101_Q105_E0.9950.98
53_V215_L0.9940.98
77_A156_T0.9880.98
83_S91_F0.9850.98
114_A159_M0.9810.98
24_M87_L0.9790.98
76_T167_E0.9780.98
159_M162_D0.9750.98
66_P161_I0.9740.98
258_D262_L0.9730.98
19_Q88_A0.9660.98
188_L223_A0.9660.98
65_H68_L0.9640.98
103_M113_Y0.9560.98
255_E258_D0.9530.98
102_A185_E0.9510.98
32_L240_A0.9510.98
88_A238_E0.9460.98
84_D139_G0.9460.98
152_L227_I0.9450.98
158_Q161_I0.9430.98
78_Y99_A0.9410.98
252_N256_L0.9400.98
6_D9_S0.9350.98
116_I159_M0.9290.98
181_Q241_A0.9280.98
22_K25_Q0.9260.98
50_Q226_L0.9240.98
116_I156_T0.9220.98
79_L170_L0.9180.97
149_I153_A0.9170.97
79_L168_L0.9140.97
37_N41_S0.9100.97
79_L116_I0.9080.97
149_I227_I0.9030.97
127_K136_E0.9020.97
80_V126_F0.8940.97
3_S6_D0.8880.97
270_A278_E0.8840.97
75_K166_D0.8800.97
123_R127_K0.8780.97
46_M226_L0.8760.97
199_G202_T0.8750.97
212_E216_E0.8730.97
28_S121_V0.8680.96
81_I231_L0.8660.96
80_V96_L0.8600.96
251_D255_E0.8600.96
156_T168_L0.8600.96
171_V183_V0.8530.96
281_G284_A0.8520.96
175_F237_S0.8450.96
154_R224_E0.8450.96
146_F228_F0.8410.96
43_V47_D0.8350.96
67_M157_I0.8330.96
51_E120_R0.8310.95
7_I263_S0.8290.95
229_G233_D0.8270.95
281_G286_L0.8270.95
88_A277_T0.8250.95
35_A236_A0.8160.95
130_E133_I0.8100.95
42_F229_G0.8100.95
45_Y49_I0.8100.95
83_S173_N0.8090.95
78_Y171_V0.8060.95
172_Y237_S0.8050.95
29_A173_N0.7970.94
126_F131_I0.7930.94
101_Q104_Q0.7900.94
196_S200_K0.7880.94
85_R267_A0.7880.94
225_S229_G0.7850.94
148_E151_D0.7840.94
66_P69_L0.7830.94
10_R253_A0.7810.94
181_Q240_A0.7790.94
81_I91_F0.7790.94
174_H237_S0.7740.93
153_A227_I0.7730.93
137_L152_L0.7720.93
120_R124_D0.7650.93
4_L8_K0.7640.93
116_I135_S0.7610.93
118_I152_L0.7610.93
274_Q284_A0.7600.93
64_K69_L0.7470.92
14_T260_L0.7470.92
70_S192_S0.7450.92
39_A233_D0.7370.92
244_T248_N0.7310.91
141_G144_V0.7310.91
66_P70_S0.7290.91
20_I24_M0.7270.91
26_M36_E0.7250.91
110_K113_Y0.7250.91
78_Y106_R0.7230.91
84_D173_N0.7230.91
21_T250_T0.7230.91
246_M249_A0.7190.91
26_M30_A0.7130.90
83_S238_E0.7120.90
198_G201_R0.7110.90
153_A156_T0.7100.90
7_I266_R0.7100.90
11_I14_T0.7090.90
78_Y103_M0.7080.90
73_V167_E0.7060.90
97_R101_Q0.7060.90
237_S242_R0.7040.90
10_R14_T0.7040.90
109_S112_E0.7040.90
15_K257_I0.7030.90
29_A35_A0.7030.90
251_D256_L0.7010.89
95_V234_S0.7000.89
16_K19_Q0.6990.89
106_R113_Y0.6990.89
28_S40_K0.6970.89
63_V68_L0.6960.89
151_D155_Q0.6960.89
73_V76_T0.6960.89
120_R138_T0.6870.89
112_E132_P0.6810.88
157_I161_I0.6790.88
146_F221_Q0.6760.88
100_Y131_I0.6750.88
84_D142_D0.6730.88
221_Q225_S0.6720.87
150_K224_E0.6720.87
91_F237_S0.6680.87
7_I241_A0.6670.87
209_P214_V0.6640.87
93_S97_R0.6610.87
76_T111_D0.6610.87
96_L99_A0.6610.87
276_I281_G0.6580.86
78_Y169_H0.6570.86
175_F240_A0.6560.86
83_S235_K0.6550.86
70_S198_G0.6540.86
127_K133_I0.6530.86
195_G199_G0.6520.86
133_I136_E0.6520.86
29_A243_M0.6500.86
244_T247_K0.6480.85
142_D235_K0.6480.85
22_K250_T0.6470.85
91_F190_P0.6450.85
146_F150_K0.6410.85
283_A286_L0.6410.85
121_V175_F0.6400.85
24_M28_S0.6400.85
23_A208_E0.6390.85
53_V191_L0.6380.85
197_G200_K0.6350.84
33_N84_D0.6340.84
90_A93_S0.6340.84
254_K257_I0.6320.84
12_T15_K0.6310.84
21_T253_A0.6310.84
256_L259_S0.6290.84
47_D51_E0.6260.83
10_R220_P0.6240.83
76_T113_Y0.6230.83
262_L265_N0.6210.83
12_T16_K0.6210.83
14_T21_T0.6200.83
17_T92_N0.6180.83
25_Q32_L0.6170.83
257_I261_S0.6160.83
145_T148_E0.6100.82
27_V36_E0.6090.82
214_V226_L0.6020.81
67_M161_I0.6020.81
20_I87_L0.6010.81
96_L129_R0.6010.81
71_R160_F0.6000.81
81_I230_A0.6000.81
196_S199_G0.5990.81
153_A223_A0.5990.81
161_I168_L0.5980.81
51_E55_N0.5980.81
5_R85_R0.5980.81
14_T33_N0.5970.81
49_I222_Y0.5970.81
75_K165_F0.5950.80
74_K167_E0.5940.80
122_G126_F0.5940.80
81_I118_I0.5940.80
25_Q30_A0.5910.80
69_L72_E0.5890.80
244_T276_I0.5880.80
228_F232_L0.5880.80
106_R109_S0.5850.79
50_Q54_S0.5850.79
232_L235_K0.5840.79
2_A6_D0.5840.79
17_T31_K0.5830.79
245_A252_N0.5820.79
186_K229_G0.5820.79
194_L198_G0.5810.79
69_L111_D0.5810.79
55_N203_A0.5800.79
116_I137_L0.5790.78
99_A102_A0.5790.78
30_A61_G0.5780.78
27_V30_A0.5770.78
222_Y225_S0.5770.78
124_D276_I0.5760.78
66_P71_R0.5760.78
159_M163_G0.5740.78
181_Q237_S0.5740.78
172_Y186_K0.5720.78
181_Q223_A0.5710.78
268_R272_I0.5710.78
81_I234_S0.5700.77
91_F181_Q0.5700.77
24_M242_R0.5700.77
221_Q228_F0.5700.77
59_V205_Y0.5690.77
61_G202_T0.5690.77
117_A126_F0.5690.77
18_S257_I0.5690.77
151_D154_R0.5690.77
46_M229_G0.5670.77
79_L118_I0.5660.77
43_V174_H0.5650.77
259_S263_S0.5640.77
118_I137_L0.5620.76
56_V218_L0.5590.76
84_D141_G0.5590.76
76_T110_K0.5580.76
6_D241_A0.5560.76
282_G286_L0.5540.75
36_E39_A0.5540.75
31_K92_N0.5530.75
118_I122_G0.5530.75
270_A274_Q0.5520.75
192_S195_G0.5500.75
95_V183_V0.5490.75
248_N257_I0.5470.74
223_A230_A0.5470.74
74_K111_D0.5460.74
98_S171_V0.5440.74
87_L118_I0.5430.74
197_G201_R0.5420.74
179_I244_T0.5400.74
204_S212_E0.5400.74
59_V211_E0.5400.74
30_A141_G0.5380.73
34_R274_Q0.5360.73
227_I231_L0.5360.73
19_Q124_D0.5350.73
13_S17_T0.5350.73
157_I160_F0.5340.73
50_Q229_G0.5320.72
140_L148_E0.5320.72
179_I286_L0.5300.72
215_L232_L0.5290.72
37_N40_K0.5270.72
266_R271_A0.5260.72
129_R133_I0.5250.71
122_G278_E0.5250.71
43_V229_G0.5230.71
135_S138_T0.5230.71
41_S177_S0.5220.71
174_H186_K0.5220.71
153_A157_I0.5210.71
173_N183_V0.5200.71
32_L229_G0.5190.71
35_A44_P0.5190.71
33_N239_H0.5180.70
67_M219_L0.5180.70
23_A262_L0.5170.70
152_L156_T0.5160.70
243_M247_K0.5150.70
55_N59_V0.5150.70
10_R255_E0.5140.70
64_K198_G0.5130.70
281_G285_A0.5130.70
273_T279_I0.5120.70
221_Q224_E0.5110.69
96_L115_V0.5110.69
19_Q141_G0.5100.69
54_S192_S0.5090.69
26_M205_Y0.5070.69
56_V219_L0.5060.69
179_I281_G0.5050.69
16_K20_I0.5030.68
7_I27_V0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qe7G 1 0.7909 100 -0.025 Contact Map
3oaaG 2 0.9861 100 -0.011 Contact Map
2xokG 1 0.9164 100 0.032 Contact Map
3ziaG 1 0.9164 100 0.048 Contact Map
2ck3G 1 0.6272 100 0.061 Contact Map
1fs0G 2 0.7631 100 0.281 Contact Map
3b8oA 3 0.4216 13.5 0.965 Contact Map
1vw4Q 1 0.7666 10.8 0.966 Contact Map
4e29A 3 0.5192 8.8 0.967 Contact Map
2ec4A 1 0.4878 8.8 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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