GREMLIN Database
ATPB - ATP synthase subunit beta
UniProt: P37809 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 473 (409)
Sequences: 7672 (2697)
Seq/√Len: 133.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_N101_E8.2391.00
150_K246_D4.9001.00
186_A232_G4.6291.00
332_E345_D4.5531.00
141_V344_V3.4731.00
370_V406_I3.3861.00
28_N78_D3.1961.00
89_D243_Q3.1501.00
81_A84_S2.8611.00
94_R104_D2.8221.00
49_E61_T2.8021.00
419_Q422_G2.7931.00
89_D245_Q2.7391.00
184_V236_A2.6591.00
133_E150_K2.5771.00
84_S115_K2.5451.00
148_Y303_I2.5391.00
233_L304_Q2.5321.00
178_E181_G2.4841.00
236_A300_V2.4531.00
359_V364_Y2.4361.00
166_V414_F2.4231.00
140_K418_E2.3501.00
369_E372_S2.3351.00
90_V112_D2.2931.00
205_S209_N2.2531.00
96_F235_M2.2391.00
214_V235_M2.2211.00
26_I61_T2.1641.00
116_D120_R2.1551.00
313_Y330_N2.1401.00
196_N200_Y2.1221.00
378_K381_Q2.1151.00
335_L340_I2.0931.00
16_V76_A2.0841.00
403_A407_Q2.0821.00
206_G209_N2.0121.00
145_L370_V2.0091.00
200_Y203_S2.0081.00
361_E365_A1.9741.00
199_F213_M1.9601.00
113_A116_D1.9571.00
238_H243_Q1.9321.00
106_N203_S1.9171.00
200_Y204_D1.9151.00
25_E28_N1.9061.00
116_D234_T1.8931.00
148_Y329_T1.8851.00
381_Q385_A1.8751.00
237_E291_R1.8741.00
31_K77_V1.8681.00
136_E143_D1.8641.00
429_P432_E1.8511.00
144_L409_F1.8481.00
182_I245_Q1.8251.00
212_A235_M1.7961.00
116_D238_H1.7911.00
340_I411_S1.7831.00
16_V19_E1.7471.00
340_I407_Q1.7461.00
31_K46_L1.7451.00
30_I76_A1.7321.00
384_I400_V1.7291.00
338_M407_Q1.7221.00
392_L401_H1.7031.00
32_I51_A1.6761.00
339_G368_R1.6681.00
159_G162_V1.6571.00
94_R107_E1.6431.00
240_R295_T1.6341.00
94_R106_N1.6271.00
16_V61_T1.6211.00
306_I321_T1.6191.00
144_L423_Q1.6181.00
96_F214_V1.6041.00
133_E294_S1.5971.00
30_I61_T1.5971.00
147_P354_L1.5791.00
184_V235_M1.5741.00
89_D238_H1.5681.00
86_P115_K1.5681.00
85_V235_M1.5471.00
406_I430_V1.5381.00
90_V110_P1.5201.00
401_H404_R1.5131.00
91_T235_M1.5131.00
17_R58_T1.5071.00
246_D299_S1.5051.00
354_L367_A1.4811.00
90_V111_A1.4801.00
182_I239_F1.4781.00
186_A251_I1.4721.00
155_G325_L1.4511.00
142_V171_L1.4401.00
15_D58_T1.4391.00
116_D241_D1.4351.00
33_S77_V1.4331.00
188_V228_V1.4271.00
366_V428_V1.4211.00
97_N220_E1.4111.00
28_N80_G1.4051.00
102_N107_E1.4041.00
408_F411_S1.3941.00
255_F259_Q1.3931.00
94_R102_N1.3931.00
83_I118_I1.3851.00
142_V329_T1.3811.00
137_T148_Y1.3801.00
81_A115_K1.3771.00
67_T70_V1.3681.00
95_V199_F1.3621.00
85_V231_T1.3561.00
413_N416_V1.3491.00
229_A288_L1.3461.00
233_L292_I1.3411.00
127_Q296_N1.3401.00
247_V300_V1.3141.00
338_M381_Q1.3131.00
104_D107_E1.3131.00
376_R379_E1.3091.00
182_I212_A1.3071.00
289_Q324_H1.2991.00
355_A364_Y1.2981.00
187_G195_G1.2981.00
261_G284_E1.2891.00
124_S127_Q1.2781.00
388_G391_E1.2771.00
204_D207_V1.2741.00
372_S397_K1.2741.00
172_I211_T1.2731.00
315_D318_P1.2711.00
220_E224_A1.2671.00
368_R371_Q1.2581.00
120_R241_D1.2571.00
369_E373_T1.2561.00
203_S208_I1.2511.00
201_E357_E1.2491.00
166_V415_H1.2401.00
376_R398_L1.2351.00
146_A329_T1.2331.00
48_L101_E1.2321.00
233_L300_V1.2261.00
285_M321_T1.2241.00
360_G420_F1.2241.00
244_G297_V1.2101.00
111_A115_K1.2031.00
31_K79_T1.2031.00
86_P111_A1.1950.99
92_L212_A1.1930.99
422_G426_S1.1860.99
340_I410_L1.1810.99
334_K337_E1.1730.99
405_R408_F1.1660.99
14_V32_I1.1630.99
17_R57_D1.1620.99
154_I303_I1.1540.99
134_I358_I1.1510.99
98_V231_T1.1500.99
129_S132_V1.1460.99
33_S75_E1.1300.99
348_A378_K1.1290.99
186_A249_F1.1190.99
192_T217_Q1.1190.99
265_S273_S1.1180.99
254_I321_T1.1120.99
353_A358_I1.1110.99
63_A67_T1.0890.99
139_I167_L1.0890.99
243_Q247_V1.0790.99
380_L384_I1.0750.99
364_Y368_R1.0710.99
345_D348_A1.0660.99
289_Q321_T1.0590.99
173_N178_E1.0540.99
131_E149_I1.0510.99
148_Y301_T1.0480.99
230_L284_E1.0470.99
137_T303_I1.0440.99
311_D314_T1.0390.99
65_A224_A1.0390.99
181_G246_D1.0380.99
139_I142_V1.0380.99
44_I74_M1.0290.98
212_A239_F1.0240.98
23_L28_N1.0220.98
159_G333_R1.0220.98
91_T96_F1.0140.98
241_D295_T1.0130.98
179_H246_D1.0130.98
136_E420_F1.0100.98
308_V318_P1.0010.98
91_T212_A1.0010.98
98_V103_I0.9990.98
29_A79_T0.9980.98
285_M324_H0.9960.98
254_I289_Q0.9830.98
308_V315_D0.9810.98
113_A238_H0.9770.98
98_V224_A0.9770.98
233_L249_F0.9760.98
92_L182_I0.9750.98
394_E398_L0.9700.98
199_F203_S0.9690.98
159_G311_D0.9690.98
88_G91_T0.9650.98
109_V112_D0.9630.98
335_L411_S0.9630.98
172_I183_S0.9600.98
34_Q45_D0.9590.98
240_R247_V0.9490.97
137_T143_D0.9380.97
363_H420_F0.9340.97
354_L359_V0.9320.97
330_N333_R0.9320.97
311_D333_R0.9300.97
225_R263_E0.9300.97
334_K378_K0.9280.97
232_G249_F0.9280.97
188_V251_I0.9250.97
14_V19_E0.9250.97
94_R109_V0.9240.97
24_P59_V0.9220.97
401_H405_R0.9180.97
172_I250_F0.9170.97
24_P51_A0.9160.97
168_I250_F0.9150.97
363_H424_K0.9150.97
159_G319_A0.9150.97
156_L168_I0.9110.97
327_A352_R0.9080.97
135_L181_G0.9070.97
376_R380_L0.9070.97
190_E194_E0.9050.97
354_L363_H0.9050.97
172_I185_F0.9040.97
118_I231_T0.9040.97
362_E431_K0.9030.96
418_E426_S0.9030.96
283_T286_G0.9020.96
313_Y318_P0.9010.96
89_D239_F0.9000.96
285_M320_T0.8950.96
207_V211_T0.8950.96
294_S299_S0.8940.96
14_V28_N0.8910.96
355_A371_Q0.8900.96
94_R103_I0.8870.96
101_E108_P0.8850.96
171_L248_L0.8850.96
183_S186_A0.8830.96
337_E348_A0.8820.96
318_P330_N0.8780.96
148_Y154_I0.8780.96
253_N305_A0.8770.96
94_R108_P0.8750.96
30_I49_E0.8740.96
50_V64_M0.8730.96
184_V212_A0.8720.96
136_E179_H0.8720.96
13_V268_L0.8710.96
259_Q309_P0.8690.96
393_G396_D0.8690.96
106_N109_V0.8650.96
71_Q74_M0.8640.95
246_D294_S0.8640.95
257_F288_L0.8630.95
32_I74_M0.8610.95
374_L406_I0.8600.95
34_Q43_G0.8580.95
33_S46_L0.8570.95
207_V210_K0.8550.95
134_I147_P0.8530.95
330_N348_A0.8520.95
98_V220_E0.8500.95
149_I358_I0.8480.95
65_A101_E0.8470.95
34_Q46_L0.8460.95
129_S294_S0.8450.95
372_S411_S0.8440.95
313_Y348_A0.8430.95
292_I302_S0.8420.95
418_E423_Q0.8410.95
96_F109_V0.8390.95
372_S376_R0.8370.95
277_Y312_D0.8360.95
259_Q277_Y0.8360.95
420_F424_K0.8330.95
366_V427_Y0.8330.95
83_I227_R0.8320.94
178_E182_I0.8290.94
112_D115_K0.8290.94
113_A243_Q0.8260.94
147_P420_F0.8250.94
359_V424_K0.8210.94
32_I49_E0.8200.94
418_E424_K0.8200.94
377_Y403_A0.8190.94
142_V146_A0.8180.94
197_D357_E0.8160.94
312_D319_A0.8110.94
149_I353_A0.8040.93
28_N143_D0.8020.93
18_F23_L0.8010.93
191_R194_E0.8010.93
250_F305_A0.7970.93
133_E246_D0.7960.93
104_D109_V0.7940.93
124_S128_L0.7940.93
157_F318_P0.7930.93
362_E435_Q0.7910.93
281_L284_E0.7900.93
182_I210_K0.7890.93
366_V424_K0.7870.93
13_V60_R0.7860.93
150_K299_S0.7850.93
248_L303_I0.7840.93
360_G363_H0.7810.92
154_I327_A0.7780.92
258_T285_M0.7770.92
145_L367_A0.7770.92
209_N212_A0.7750.92
377_Y381_Q0.7710.92
188_V229_A0.7700.92
216_G220_E0.7640.92
94_R105_L0.7630.91
385_A395_E0.7630.91
108_P111_A0.7600.91
43_G49_E0.7600.91
90_V113_A0.7600.91
190_E256_R0.7590.91
173_N415_H0.7580.91
137_T142_V0.7570.91
147_P363_H0.7560.91
173_N210_K0.7540.91
141_V410_L0.7530.91
179_H182_I0.7530.91
104_D108_P0.7530.91
65_A221_P0.7510.91
64_M224_A0.7500.91
159_G312_D0.7500.91
247_V263_E0.7470.91
31_K48_L0.7460.91
230_L257_F0.7460.91
147_P359_V0.7450.91
373_T406_I0.7410.90
365_A368_R0.7380.90
238_H241_D0.7370.90
84_S117_P0.7360.90
87_V234_T0.7360.90
310_A315_D0.7340.90
125_F128_L0.7320.90
361_E413_N0.7290.90
221_P224_A0.7250.89
168_I305_A0.7240.89
251_I288_L0.7240.89
382_D385_A0.7230.89
103_I108_P0.7230.89
16_V30_I0.7220.89
101_E115_K0.7210.89
380_L398_L0.7210.89
80_G83_I0.7190.89
415_H426_S0.7180.89
108_P112_D0.7170.89
191_R256_R0.7160.89
402_R405_R0.7160.89
365_A369_E0.7160.89
181_G245_Q0.7130.89
99_L102_N0.7100.88
54_L60_R0.7090.88
47_T65_A0.7070.88
82_P117_P0.7070.88
257_F284_E0.7040.88
143_D423_Q0.7020.88
83_I143_D0.7020.88
12_P78_D0.7020.88
11_G14_V0.6920.87
183_S250_F0.6920.87
332_E348_A0.6920.87
395_E398_L0.6900.87
12_P31_K0.6890.87
423_Q426_S0.6880.87
422_G425_G0.6850.86
53_H60_R0.6850.86
249_F292_I0.6840.86
374_L378_K0.6840.86
149_I352_R0.6840.86
359_V367_A0.6830.86
146_A350_T0.6830.86
346_P374_L0.6820.86
397_K404_R0.6800.86
92_L208_I0.6790.86
48_L51_A0.6790.86
66_S69_G0.6790.86
226_M261_G0.6780.86
231_T234_T0.6770.86
233_L251_I0.6770.86
83_I231_T0.6750.86
131_E353_A0.6750.86
394_E397_K0.6740.86
14_V30_I0.6740.86
228_V232_G0.6720.85
204_D208_I0.6710.85
95_V103_I0.6710.85
160_A324_H0.6700.85
159_G276_G0.6690.85
418_E422_G0.6690.85
258_T317_A0.6690.85
92_L245_Q0.6690.85
319_A322_F0.6670.85
195_G215_F0.6660.85
129_S297_V0.6660.85
183_S211_T0.6650.85
96_F99_L0.6650.85
62_I264_V0.6640.85
360_G424_K0.6630.85
136_E427_Y0.6620.85
182_I247_V0.6620.85
128_L131_E0.6610.84
135_L148_Y0.6590.84
92_L95_V0.6570.84
15_D60_R0.6570.84
142_V167_L0.6560.84
381_Q407_Q0.6560.84
347_L374_L0.6560.84
54_L72_R0.6550.84
107_E111_A0.6540.84
86_P112_D0.6540.84
97_N103_I0.6530.84
28_N82_P0.6520.84
235_M239_F0.6520.84
144_L147_P0.6510.84
274_A320_T0.6510.84
225_R237_E0.6500.83
233_L236_A0.6500.83
102_N108_P0.6480.83
85_V88_G0.6480.83
84_S113_A0.6460.83
139_I414_F0.6450.83
259_Q320_T0.6440.83
270_R293_T0.6440.83
123_P295_T0.6430.83
156_L329_T0.6430.83
353_A359_V0.6400.83
43_G46_L0.6400.83
18_F24_P0.6380.82
110_P113_A0.6370.82
419_Q425_G0.6340.82
31_K45_D0.6340.82
362_E366_V0.6340.82
363_H367_A0.6340.82
59_V76_A0.6310.82
390_D393_G0.6310.82
46_L50_V0.6310.82
400_V404_R0.6210.81
234_T238_H0.6200.81
237_E240_R0.6170.80
137_T292_I0.6160.80
102_N106_N0.6160.80
14_V67_T0.6140.80
162_V333_R0.6130.80
150_K178_E0.6100.79
134_I353_A0.6100.79
163_G252_D0.6100.79
201_E204_D0.6090.79
47_T69_G0.6080.79
160_A322_F0.6050.79
229_A251_I0.6050.79
214_V231_T0.6020.79
382_D389_M0.6000.78
135_L178_E0.6000.78
12_P18_F0.5990.78
392_L400_V0.5990.78
35_P75_E0.5980.78
386_I389_M0.5970.78
55_G60_R0.5970.78
323_A350_T0.5940.78
117_P234_T0.5930.78
136_E423_Q0.5910.77
173_N205_S0.5900.77
381_Q404_R0.5890.77
174_N417_A0.5880.77
373_T399_V0.5870.77
421_T425_G0.5860.77
420_F423_Q0.5850.77
430_V434_V0.5850.77
47_T66_S0.5850.77
144_L427_Y0.5840.76
13_V172_I0.5840.76
32_I59_V0.5840.76
156_L331_L0.5840.76
395_E399_V0.5830.76
254_I288_L0.5830.76
15_D18_F0.5810.76
87_V112_D0.5810.76
14_V18_F0.5810.76
226_M264_V0.5790.76
60_R268_L0.5790.76
62_I382_D0.5780.76
159_G308_V0.5780.76
263_E277_Y0.5780.76
373_T376_R0.5770.76
380_L385_A0.5770.76
130_T357_E0.5770.76
102_N109_V0.5770.76
185_F195_G0.5760.75
35_P71_Q0.5750.75
274_A398_L0.5740.75
106_N208_I0.5730.75
19_E24_P0.5720.75
270_R280_T0.5710.75
121_Q287_Q0.5710.75
50_V83_I0.5680.74
240_R300_V0.5660.74
120_R123_P0.5660.74
314_T321_T0.5660.74
377_Y407_Q0.5650.74
355_A414_F0.5650.74
120_R234_T0.5630.74
146_A344_V0.5630.74
409_F430_V0.5630.74
14_V23_L0.5630.74
79_T82_P0.5610.74
18_F172_I0.5610.74
262_S317_A0.5600.73
99_L386_I0.5590.73
335_L338_M0.5580.73
409_F426_S0.5580.73
419_Q423_Q0.5560.73
394_E400_V0.5560.73
225_R259_Q0.5540.73
25_E54_L0.5540.73
164_K252_D0.5540.73
339_G372_S0.5530.72
19_E29_A0.5520.72
203_S211_T0.5510.72
428_V432_E0.5500.72
154_I329_T0.5490.72
160_A259_Q0.5490.72
90_V107_E0.5490.72
129_S296_N0.5490.72
202_M207_V0.5480.72
23_L267_L0.5450.71
404_R407_Q0.5430.71
23_L27_Y0.5420.71
169_Q215_F0.5410.71
29_A83_I0.5410.71
64_M230_L0.5410.71
103_I215_F0.5400.71
323_A328_T0.5390.71
257_F261_G0.5380.70
157_F325_L0.5380.70
16_V59_V0.5370.70
132_V297_V0.5370.70
398_L402_R0.5360.70
200_Y205_S0.5350.70
203_S209_N0.5350.70
35_P43_G0.5330.70
46_L51_A0.5320.70
119_H230_L0.5320.70
271_M279_P0.5320.70
432_E435_Q0.5320.70
29_A35_P0.5300.69
365_A431_K0.5300.69
195_G217_Q0.5290.69
87_V91_T0.5280.69
23_L26_I0.5270.69
152_G352_R0.5270.69
62_I268_L0.5270.69
241_D247_V0.5250.69
408_F429_P0.5250.69
208_I213_M0.5240.68
133_E297_V0.5240.68
160_A323_A0.5240.68
184_V214_V0.5230.68
171_L303_I0.5230.68
105_L408_F0.5210.68
156_L305_A0.5190.68
181_G210_K0.5190.68
370_V427_Y0.5180.68
91_T111_A0.5180.68
28_N79_T0.5170.67
17_R394_E0.5170.67
61_T76_A0.5170.67
310_A319_A0.5170.67
144_L363_H0.5160.67
99_L224_A0.5160.67
266_A271_M0.5140.67
426_S429_P0.5140.67
28_N83_I0.5140.67
140_K426_S0.5140.67
326_D352_R0.5130.67
147_P350_T0.5130.67
230_L268_L0.5120.67
59_V72_R0.5120.67
65_A208_I0.5110.67
169_Q198_L0.5110.67
120_R125_F0.5100.66
187_G190_E0.5100.66
120_R237_E0.5090.66
308_V314_T0.5070.66
414_F418_E0.5070.66
119_H287_Q0.5060.66
258_T262_S0.5060.66
362_E428_V0.5060.66
333_R337_E0.5050.66
233_L237_E0.5050.66
141_V340_I0.5050.66
139_I170_E0.5040.66
52_L268_L0.5030.65
425_G429_P0.5030.65
158_G170_E0.5020.65
363_H366_V0.5020.65
18_F30_I0.5010.65
165_T252_D0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q4lA 1 0.9175 100 0.111 Contact Map
1fx0B 3 0.9704 100 0.111 Contact Map
3oaaA 2 0.9556 100 0.112 Contact Map
2qe7A 1 0.9556 100 0.117 Contact Map
2ck3A 1 0.9619 100 0.13 Contact Map
2r9vA 1 0.9619 100 0.131 Contact Map
1fx0A 1 0.9598 100 0.132 Contact Map
3vr4D 1 0.9239 100 0.139 Contact Map
3gqbB 1 0.9239 100 0.143 Contact Map
2c61A 2 0.8879 100 0.144 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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