GREMLIN Database
ATPA - ATP synthase subunit alpha
UniProt: P37808 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 502 (428)
Sequences: 7713 (2597)
Seq/√Len: 125.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_N113_Q7.9771.00
161_R255_H4.5361.00
196_V242_G4.4541.00
345_Q358_N4.1641.00
41_V73_I3.8291.00
429_P432_K3.7171.00
152_A357_I3.3421.00
51_E90_R3.3261.00
374_A438_Y3.1551.00
382_L416_T3.0611.00
53_V73_I3.0251.00
106_R116_D2.8111.00
93_R96_E2.8091.00
53_V88_V2.7161.00
54_E89_K2.6061.00
47_C63_A2.5961.00
61_G73_I2.5961.00
194_V246_A2.5401.00
144_E161_R2.5291.00
101_E254_K2.4931.00
243_V317_P2.4271.00
102_E124_S2.4091.00
96_E126_T2.3631.00
246_A313_I2.3411.00
159_I316_L2.3201.00
151_K428_L2.2981.00
177_S424_L2.2691.00
381_T384_L2.2681.00
371_Q376_K2.2481.00
215_H219_D2.1911.00
155_A433_Q2.1641.00
41_V88_V2.1621.00
108_V245_M2.1461.00
348_L353_V2.1411.00
224_V245_M2.1381.00
326_I343_F2.1031.00
127_R131_S2.1021.00
40_R70_N2.0871.00
210_E213_R2.0471.00
216_G219_D1.9931.00
390_R393_E1.9861.00
210_E214_K1.9841.00
31_V82_I1.9821.00
381_T408_A1.9821.00
373_K377_K1.9801.00
118_L213_R1.9691.00
156_L382_L1.9671.00
48_M51_E1.9331.00
206_R210_E1.9271.00
209_V223_V1.8691.00
33_Q40_R1.8621.00
159_I342_I1.8601.00
378_V438_Y1.8531.00
28_V87_E1.8401.00
413_G417_V1.8391.00
222_I245_M1.7861.00
144_E303_K1.7711.00
32_I42_H1.7711.00
127_R244_T1.7671.00
127_R248_E1.7611.00
147_Q154_D1.7501.00
151_K457_E1.7451.00
247_E300_R1.7391.00
449_P452_D1.7241.00
353_V417_V1.7201.00
106_R118_L1.7111.00
443_G446_D1.7021.00
351_S417_V1.6841.00
51_E92_G1.6801.00
155_A419_V1.6621.00
98_P126_T1.6531.00
353_V421_K1.6531.00
418_E421_K1.6491.00
125_K252_N1.6251.00
27_D90_R1.6211.00
439_A444_Y1.6171.00
319_V334_V1.6141.00
396_A410_L1.6141.00
393_E397_Q1.6021.00
352_G380_G1.5981.00
250_M304_L1.5851.00
448_I452_D1.5821.00
97_V245_M1.5761.00
452_D455_R1.5751.00
114_P119_G1.5741.00
170_D173_T1.5711.00
194_V245_M1.5491.00
378_V434_V1.5481.00
108_V224_V1.5181.00
103_L245_M1.5161.00
146_L191_M1.5091.00
30_T87_E1.5001.00
411_N414_A1.4821.00
158_P367_G1.4811.00
31_V86_D1.4781.00
55_F61_G1.4751.00
102_E122_L1.4531.00
255_H312_S1.4521.00
423_D426_K1.4471.00
439_A445_L1.4471.00
101_E248_E1.4441.00
41_V44_L1.4321.00
95_M129_I1.4311.00
166_L338_T1.4281.00
448_I456_F1.4061.00
264_S268_A1.4051.00
32_I70_N1.4051.00
198_I238_A1.3991.00
196_V260_Y1.3981.00
375_M434_V1.3931.00
248_E252_N1.3891.00
367_G379_S1.3891.00
102_E123_T1.3811.00
106_R119_G1.3771.00
177_S425_N1.3751.00
388_S391_E1.3731.00
388_S406_T1.3651.00
54_E91_T1.3651.00
213_R218_L1.3581.00
47_C71_V1.3441.00
239_P297_L1.3441.00
127_R251_Y1.3411.00
148_T159_I1.3381.00
93_R126_T1.3351.00
26_Q89_K1.3311.00
97_V241_A1.3311.00
109_N230_Q1.3281.00
256_V313_I1.3221.00
211_T369_S1.3221.00
243_V301_A1.3201.00
106_R114_P1.3161.00
328_A331_P1.3141.00
47_C53_V1.3131.00
253_G310_A1.3111.00
384_L405_A1.3031.00
435_A439_A1.3021.00
131_S251_Y1.3021.00
351_S393_E1.2961.00
34_V82_I1.2891.00
380_G383_R1.2821.00
298_L337_I1.2591.00
56_S86_D1.2521.00
197_A205_V1.2471.00
79_F82_I1.2391.00
60_L113_Q1.2340.99
392_L406_T1.2340.99
142_V160_G1.2260.99
294_H334_V1.2250.99
270_Y293_L1.2100.99
214_K217_A1.2070.99
432_K436_I1.2060.99
347_D350_F1.2020.99
107_I209_V1.2010.99
147_Q430_V1.1940.99
404_Q408_A1.1920.99
53_V61_G1.1900.99
190_D254_K1.1880.99
438_Y442_K1.1820.99
243_V313_I1.1810.99
42_H69_S1.1750.99
104_I222_I1.1740.99
361_L390_R1.1730.99
368_G376_K1.1650.99
366_V370_A1.1620.99
153_I183_I1.1610.99
140_K143_H1.1570.99
123_T126_T1.1560.99
138_D309_G1.1550.99
381_T385_D1.1500.99
30_T42_H1.1490.99
159_I314_T1.1430.99
372_I430_V1.1370.99
157_I342_I1.1350.99
42_H70_N1.1300.99
274_S282_G1.1280.99
416_T440_L1.1250.99
110_P241_A1.1200.99
408_A412_R1.1130.99
298_L334_V1.1130.99
153_I342_I1.1110.99
75_I79_F1.1040.99
263_L334_V1.1030.99
412_R446_D1.0990.99
191_M249_F1.0850.99
54_E60_L1.0840.99
222_I249_F1.0830.99
202_E227_S1.0760.99
148_T316_L1.0700.99
106_R121_I1.0670.99
445_L456_F1.0580.98
191_M254_K1.0540.98
101_E252_N1.0530.98
170_D346_S1.0480.98
106_R115_V1.0430.98
40_R67_E1.0410.98
125_K248_E1.0400.98
367_G371_Q1.0350.98
240_Y293_L1.0340.98
184_L221_T1.0320.98
196_V258_V1.0310.98
321_T328_A1.0310.98
321_T331_P1.0280.98
353_V420_L1.0250.98
251_Y304_L1.0220.98
77_G234_L1.0170.98
127_R252_N1.0170.98
358_N361_L1.0160.98
376_K380_G1.0090.98
110_P115_V1.0080.98
165_E316_L1.0080.98
150_I178_V1.0060.98
100_G103_L1.0040.98
170_D324_G1.0030.98
41_V53_V0.9970.98
230_Q234_L0.9940.98
98_P123_T0.9880.98
397_Q403_D0.9810.97
445_L448_I0.9780.97
150_I153_I0.9740.97
263_L298_L0.9710.97
252_N256_V0.9690.97
404_Q407_Q0.9690.97
324_G327_S0.9670.97
411_N415_R0.9670.97
452_D456_F0.9610.97
155_A437_L0.9600.97
148_T154_D0.9580.97
324_G346_S0.9580.97
103_L108_V0.9550.97
347_D390_R0.9540.97
198_I260_Y0.9530.97
110_P234_L0.9510.97
145_P370_A0.9490.97
184_L187_K0.9480.97
455_R458_E0.9380.97
159_I165_E0.9360.97
403_D406_T0.9330.97
348_L421_K0.9320.97
384_L388_S0.9300.96
326_I361_L0.9290.96
103_L222_I0.9290.96
428_L436_I0.9250.96
38_I277_L0.9250.96
152_A420_L0.9210.96
294_H337_I0.9110.96
343_F346_S0.9090.96
55_F86_D0.9020.96
382_L441_T0.9010.96
116_D119_G0.9010.96
243_V258_V0.8990.96
250_M256_V0.8980.96
113_Q120_P0.8950.96
408_A411_N0.8940.96
101_E249_F0.8930.96
209_V213_R0.8920.96
235_L272_E0.8850.95
28_V89_K0.8850.95
108_V121_I0.8830.95
193_C196_V0.8780.95
144_E255_H0.8770.95
268_A286_F0.8730.95
95_M237_L0.8730.95
77_G113_Q0.8660.95
158_P430_V0.8650.95
451_A454_R0.8610.95
52_L91_T0.8610.95
255_H303_K0.8600.95
326_I331_P0.8590.94
170_D332_T0.8580.94
83_R86_D0.8570.94
331_P343_F0.8570.94
389_Y413_G0.8540.94
201_K204_T0.8500.94
135_G138_D0.8460.94
294_H333_N0.8450.94
303_K312_S0.8430.94
147_Q427_P0.8400.94
140_K303_K0.8370.94
419_V436_I0.8360.94
301_A315_A0.8360.94
198_I239_P0.8350.94
190_D255_H0.8340.94
340_G365_R0.8330.94
160_G366_V0.8330.94
217_A221_T0.8330.94
292_Y295_S0.8320.94
242_G258_V0.8310.93
367_G375_M0.8290.93
207_G369_S0.8270.93
268_A322_Q0.8250.93
62_M76_L0.8240.93
200_Q204_T0.8220.93
110_P230_Q0.8210.93
217_A220_Y0.8150.93
51_E154_D0.8130.93
38_I72_G0.8110.93
382_L437_L0.8100.93
34_V129_I0.8070.92
378_V441_T0.8060.92
262_D318_F0.8050.92
118_L121_I0.8040.92
51_E94_I0.8010.92
392_L396_A0.8010.92
267_A294_H0.8010.92
373_K455_R0.8010.92
194_V222_I0.7990.92
428_L433_Q0.7980.92
266_Q297_L0.7970.92
184_L195_Y0.7930.92
59_V77_G0.7920.92
53_V71_V0.7910.92
50_G63_A0.7880.92
388_S392_L0.7860.91
372_I434_V0.7860.91
170_D325_D0.7840.91
257_L316_L0.7830.91
450_V454_R0.7790.91
402_L410_L0.7770.91
154_D433_Q0.7760.91
184_L220_Y0.7740.91
102_E125_K0.7720.91
109_N115_V0.7710.91
290_V293_L0.7710.91
368_G383_R0.7680.90
148_T153_I0.7670.90
168_I331_P0.7660.90
350_F361_L0.7660.90
412_R443_G0.7650.90
145_P158_P0.7630.90
256_V272_E0.7630.90
286_F325_D0.7620.90
96_E128_P0.7620.90
74_V273_L0.7600.90
248_E251_Y0.7590.90
51_E91_T0.7570.90
219_D222_I0.7530.90
106_R120_P0.7520.90
31_V39_A0.7520.90
99_V244_T0.7510.89
158_P371_Q0.7500.89
385_D416_T0.7500.89
405_A414_A0.7490.89
454_R457_E0.7480.89
389_Y417_V0.7480.89
115_V120_P0.7460.89
104_I218_L0.7450.89
241_A244_T0.7430.89
371_Q434_V0.7420.89
115_V225_T0.7410.89
366_V371_Q0.7390.89
449_P458_E0.7390.89
157_I357_I0.7370.89
323_A328_A0.7360.89
129_I241_A0.7350.88
147_Q429_P0.7350.88
325_D332_T0.7340.88
240_Y266_Q0.7310.88
378_V437_L0.7300.88
98_P124_S0.7300.88
386_L416_T0.7300.88
158_P375_M0.7280.88
384_L421_K0.7270.88
95_M154_D0.7260.88
184_L259_V0.7250.88
111_L114_P0.7240.88
432_K435_A0.7220.88
156_L379_S0.7210.88
447_D456_F0.7200.87
134_P304_L0.7180.87
231_P234_L0.7170.87
94_I128_P0.7160.87
266_Q293_L0.7140.87
385_D408_A0.7140.87
140_K310_A0.7130.87
375_M430_V0.7120.87
238_A242_G0.7110.87
39_A55_F0.7110.87
260_Y297_L0.7100.87
259_V318_F0.7090.87
200_Q265_K0.7080.87
76_L234_L0.7070.86
108_V111_L0.7060.86
213_R219_D0.7040.86
389_Y393_E0.7020.86
146_L159_I0.7020.86
104_I254_K0.7010.86
170_D285_A0.7000.86
377_K381_T0.6990.86
77_G231_P0.6990.86
153_I157_I0.6980.86
54_E58_G0.6950.86
157_I363_V0.6940.85
381_T441_T0.6930.85
55_F88_V0.6910.85
454_R458_E0.6890.85
393_E417_V0.6870.85
57_N81_E0.6850.85
145_P366_V0.6850.85
448_I451_A0.6850.85
141_S369_S0.6840.85
146_L187_K0.6790.84
448_I458_E0.6790.84
104_I191_M0.6790.84
235_L247_E0.6770.84
304_L309_G0.6770.84
40_R72_G0.6750.84
95_M241_A0.6750.84
205_V225_T0.6740.84
183_I316_L0.6740.84
388_S405_A0.6740.84
226_A230_Q0.6730.84
377_K380_G0.6730.84
343_F361_L0.6730.84
39_A79_F0.6690.83
386_L390_R0.6690.83
401_D407_Q0.6690.83
101_E124_S0.6680.83
375_M379_S0.6680.83
214_K218_L0.6680.83
258_V301_A0.6670.83
116_D121_I0.6670.83
25_V89_K0.6660.83
236_Y270_Y0.6650.83
386_L413_G0.6640.83
453_I456_F0.6630.83
173_T346_S0.6600.82
180_I225_T0.6600.82
122_L125_K0.6590.82
161_R312_S0.6590.82
193_C221_T0.6570.82
171_R337_I0.6570.82
107_I115_V0.6570.82
174_G261_D0.6570.82
406_T410_L0.6560.82
47_C90_R0.6540.82
67_E72_G0.6540.82
283_R333_N0.6540.82
106_R117_G0.6540.82
184_L188_D0.6540.82
52_L60_L0.6530.82
180_I208_V0.6500.82
450_V455_R0.6480.81
327_S334_V0.6480.81
92_G95_M0.6450.81
123_T248_E0.6440.81
452_D458_E0.6440.81
442_K445_L0.6430.81
247_E250_M0.6430.81
385_D409_K0.6430.81
201_K265_K0.6430.81
395_F398_F0.6410.81
66_L84_E0.6390.80
150_I182_A0.6390.80
74_V277_L0.6380.80
332_T335_I0.6370.80
97_V100_G0.6360.80
267_A330_I0.6360.80
449_P455_R0.6350.80
59_V81_E0.6340.80
113_Q126_T0.6340.80
184_L193_C0.6320.80
78_P81_E0.6310.80
142_V366_V0.6290.79
183_I257_L0.6280.79
52_L95_M0.6280.79
245_M249_F0.6280.79
394_A397_Q0.6260.79
359_A386_L0.6240.79
27_D46_N0.6240.79
148_T301_A0.6240.79
243_V260_Y0.6230.79
132_P296_R0.6220.79
126_T408_A0.6210.79
41_V71_V0.6190.78
193_C259_V0.6190.78
167_I342_I0.6190.78
239_P260_Y0.6160.78
345_Q361_L0.6150.78
66_L72_G0.6140.78
56_S87_E0.6120.78
279_R302_A0.6110.77
374_A378_V0.6110.77
447_D454_R0.6100.77
304_L310_A0.6100.77
333_N400_S0.6090.77
155_A158_P0.6080.77
72_G277_L0.6080.77
160_G365_R0.6070.77
59_V78_P0.6060.77
165_E340_G0.6060.77
114_P118_L0.6050.77
195_Y205_V0.6040.77
450_V453_I0.6020.76
268_A333_N0.6020.76
394_A400_S0.6010.76
64_Q277_L0.6010.76
419_V433_Q0.6010.76
442_K453_I0.6000.76
35_G38_I0.5990.76
415_R418_E0.5980.76
114_P120_P0.5980.76
412_R415_R0.5970.76
143_H303_K0.5970.76
175_K261_D0.5970.76
60_L63_A0.5960.76
103_L123_T0.5950.76
128_P244_T0.5950.76
147_Q433_Q0.5910.75
449_P453_I0.5900.75
211_T214_K0.5900.75
451_A455_R0.5870.75
453_I457_E0.5870.75
396_A406_T0.5840.74
360_G386_L0.5830.74
118_L218_L0.5830.74
415_R450_V0.5820.74
430_V434_V0.5810.74
150_I424_L0.5780.73
45_D56_S0.5780.73
117_G120_P0.5740.73
236_Y273_L0.5740.73
244_T248_E0.5730.73
143_H310_A0.5720.73
108_V112_G0.5710.73
65_N72_G0.5710.73
145_P430_V0.5710.73
271_R330_I0.5710.73
152_A359_A0.5710.73
336_S363_V0.5700.72
385_D441_T0.5690.72
27_D45_D0.5680.72
44_L47_C0.5670.72
158_P363_V0.5660.72
76_L240_Y0.5640.72
114_P121_I0.5640.72
110_P113_Q0.5620.71
140_K304_L0.5620.71
58_G89_K0.5610.71
121_I124_S0.5610.71
115_V230_Q0.5610.71
371_Q379_S0.5610.71
372_I375_M0.5600.71
128_P131_S0.5590.71
436_I439_A0.5580.71
147_Q431_E0.5570.71
250_M313_I0.5570.71
43_G47_C0.5550.70
148_T168_I0.5550.70
392_L397_Q0.5510.70
140_K309_G0.5500.70
125_K128_P0.5480.69
153_I178_V0.5470.69
184_L215_H0.5470.69
102_E119_G0.5470.69
185_N209_V0.5470.69
100_G123_T0.5470.69
430_V433_Q0.5460.69
243_V247_E0.5460.69
55_F60_L0.5450.69
263_L297_L0.5420.69
442_K448_I0.5420.69
188_D255_H0.5410.68
373_K423_D0.5410.68
38_I276_L0.5390.68
372_I438_Y0.5390.68
233_P273_L0.5380.68
348_L365_R0.5380.68
77_G111_L0.5370.68
151_K436_I0.5360.68
180_I259_V0.5360.68
240_Y277_L0.5350.68
144_E310_A0.5350.68
110_P114_P0.5350.68
410_L414_A0.5340.68
213_R221_T0.5340.68
235_L268_A0.5330.67
426_K458_E0.5330.67
168_I338_T0.5330.67
124_S127_R0.5320.67
448_I455_R0.5320.67
414_A417_V0.5320.67
453_I458_E0.5320.67
402_L406_T0.5320.67
161_R292_Y0.5310.67
451_A458_E0.5310.67
172_Q272_E0.5300.67
243_V246_A0.5290.67
130_E240_Y0.5290.67
272_E286_F0.5290.67
322_Q327_S0.5290.67
442_K454_R0.5280.67
171_R335_I0.5280.67
190_D220_Y0.5280.67
31_V34_V0.5270.66
154_D186_Q0.5270.66
212_L217_A0.5260.66
266_Q270_Y0.5250.66
211_T244_T0.5240.66
170_D321_T0.5230.66
418_E454_R0.5230.66
224_V241_A0.5230.66
339_D365_R0.5210.66
167_I316_L0.5190.65
385_D388_S0.5190.65
48_M66_L0.5190.65
444_Y447_D0.5190.65
107_I225_T0.5180.65
182_A185_N0.5180.65
216_G221_T0.5180.65
393_E410_L0.5170.65
40_R65_N0.5160.65
176_T261_D0.5150.65
131_S247_E0.5150.65
99_V103_L0.5140.65
449_P457_E0.5140.65
431_E435_A0.5140.65
167_I391_E0.5140.65
381_T449_P0.5130.64
167_I318_F0.5130.64
452_D457_E0.5130.64
434_V438_Y0.5110.64
286_F394_A0.5110.64
231_P235_L0.5100.64
171_R268_A0.5100.64
429_P435_A0.5100.64
53_V63_A0.5090.64
62_M95_M0.5090.64
163_Q365_R0.5080.64
165_E342_I0.5080.64
76_L111_L0.5080.64
298_L317_P0.5070.64
74_V394_A0.5070.64
357_I448_I0.5060.63
91_T94_I0.5050.63
172_Q399_G0.5040.63
171_R336_S0.5040.63
48_M83_R0.5030.63
352_G384_L0.5020.63
108_V241_A0.5020.63
407_Q411_N0.5010.63
102_E121_I0.5010.63
346_S350_F0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qe7A 1 0.9442 100 0.055 Contact Map
3oaaA 2 0.9462 100 0.065 Contact Map
1fx0A 1 0.9462 100 0.079 Contact Map
2ck3A 1 0.9502 100 0.084 Contact Map
2r9vA 1 0.9641 100 0.088 Contact Map
3mfyA 1 0.7928 100 0.159 Contact Map
3j9tA 1 0.9402 100 0.166 Contact Map
3vr4A 1 0.9462 100 0.173 Contact Map
3gqbA 1 0.9402 100 0.174 Contact Map
3vr4D 1 0.8625 100 0.177 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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