GREMLIN Database
MURG - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
UniProt: P37585 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (316)
Sequences: 18151 (14127)
Seq/√Len: 794.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
302_L308_A3.4501.00
267_A284_L3.3101.00
337_E340_E3.1841.00
23_E26_R2.9201.00
5_I21_I2.8311.00
284_L299_A2.8251.00
283_V328_I2.7801.00
303_G310_V2.7611.00
214_T322_I2.7521.00
335_L339_S2.6991.00
85_K113_K2.6951.00
327_R334_T2.6251.00
23_E27_R2.6241.00
322_I326_D2.5881.00
300_R304_Q2.5541.00
44_K48_E2.5441.00
309_I327_R2.5391.00
34_L55_R2.4611.00
263_I275_I2.4441.00
275_I282_S2.3321.00
337_E341_R2.3081.00
145_F149_K2.2911.00
210_D318_G2.2831.00
341_R344_S2.2461.00
342_T346_G2.1971.00
336_K340_E2.1941.00
86_S90_E2.1301.00
98_G118_T2.1201.00
207_D318_G2.0871.00
327_R331_N2.0801.00
34_L91_F2.0731.00
149_K152_F2.0181.00
89_A114_M2.0001.00
312_K315_E1.9971.00
326_D330_L1.9731.00
265_A282_S1.9651.00
272_I302_L1.9611.00
309_I324_A1.9431.00
188_T218_Q1.9011.00
320_K324_A1.8771.00
247_K250_L1.8621.00
252_Q255_E1.8441.00
263_I271_T1.8151.00
262_V325_L1.8081.00
262_V328_I1.8021.00
183_S218_Q1.7941.00
186_K218_Q1.7751.00
338_M341_R1.7731.00
334_T337_E1.7701.00
339_S342_T1.7641.00
300_R303_G1.7291.00
340_E344_S1.7151.00
3_I95_A1.7081.00
331_N334_T1.7061.00
309_I334_T1.6991.00
190_L260_I1.6741.00
334_T338_M1.6411.00
85_K114_M1.6391.00
4_A36_I1.6281.00
3_I24_V1.6231.00
189_V264_V1.6201.00
263_I280_I1.5991.00
146_E149_K1.5981.00
333_Q336_K1.5831.00
215_R326_D1.5261.00
189_V262_V1.5221.00
67_S70_N1.5211.00
96_V111_A1.4931.00
5_I17_A1.4661.00
83_K86_S1.4601.00
283_V324_A1.4461.00
303_G309_I1.4451.00
184_E218_Q1.4321.00
301_S304_Q1.4321.00
4_A93_P1.4121.00
128_G144_C1.4081.00
318_G322_I1.3981.00
333_Q337_E1.3911.00
206_I210_D1.3821.00
212_L219_V1.3791.00
302_L307_A1.3721.00
177_L181_G1.3661.00
72_K76_R1.3621.00
323_E327_R1.3411.00
145_F148_A1.3401.00
220_L256_Y1.3391.00
147_E150_S1.3171.00
213_K243_N1.3141.00
45_K49_R1.3141.00
108_V118_T1.3111.00
186_K216_D1.3091.00
5_I97_I1.3041.00
12_G16_P1.2861.00
21_I52_I1.2771.00
309_I328_I1.2701.00
222_I250_L1.2641.00
317_S320_K1.2561.00
190_L222_I1.2561.00
279_G343_K1.2551.00
210_D213_K1.2541.00
45_K48_E1.2461.00
320_K323_E1.2441.00
214_T318_G1.2441.00
343_K346_G1.2421.00
332_E336_K1.2421.00
111_A118_T1.2411.00
11_G15_Y1.2391.00
4_A88_L1.2371.00
211_V322_I1.2321.00
296_E312_K1.2311.00
341_R345_L1.2291.00
340_E343_K1.2251.00
86_S89_A1.2241.00
311_L324_A1.2171.00
110_A114_M1.2111.00
332_E335_L1.1971.00
95_A119_I1.1921.00
22_K52_I1.1921.00
82_K85_K1.1911.00
307_A341_R1.1901.00
119_I142_A1.1851.00
148_A152_F1.1711.00
85_K89_A1.1661.00
296_E300_R1.1651.00
202_N206_I1.1621.00
339_S343_K1.1611.00
187_K261_D1.1601.00
284_L302_L1.1501.00
218_Q245_V1.1441.00
211_V318_G1.1391.00
82_K86_S1.1351.00
283_V309_I1.1341.00
225_E248_P1.1341.00
300_R310_V1.1291.00
15_Y249_F1.1281.00
190_L252_Q1.1251.00
73_T76_R1.1221.00
336_K339_S1.1191.00
142_A160_T1.1171.00
328_I334_T1.1171.00
334_T341_R1.1141.00
55_R90_E1.1141.00
188_T260_I1.1131.00
276_T307_A1.1101.00
324_A327_R1.1081.00
217_Y326_D1.1081.00
75_M79_K1.0981.00
319_E323_E1.0971.00
25_Q52_I1.0901.00
70_N73_T1.0891.00
176_S179_E1.0871.00
158_V162_N1.0861.00
306_D337_E1.0821.00
160_T163_P1.0821.00
76_R79_K1.0811.00
58_E83_K1.0791.00
39_E56_S1.0781.00
207_D210_D1.0751.00
22_K25_Q1.0681.00
74_V77_F1.0681.00
190_L256_Y1.0641.00
146_E150_S1.0611.00
10_T196_R1.0481.00
200_P313_E1.0381.00
343_K347_V1.0351.00
282_S308_A1.0281.00
279_G342_T1.0261.00
272_I282_S1.0181.00
69_E73_T1.0161.00
301_S305_H1.0141.00
187_K329_V1.0141.00
199_A203_R1.0091.00
264_V321_L1.0031.00
240_A243_N0.9981.00
22_K50_E0.9971.00
335_L341_R0.9951.00
228_Y232_M0.9901.00
272_I298_N0.9841.00
22_K26_R0.9781.00
229_E232_M0.9711.00
264_V285_I0.9641.00
65_K68_F0.9621.00
315_E320_K0.9611.00
34_L37_G0.9571.00
22_K167_E0.9531.00
188_T220_L0.9501.00
148_A151_H0.9491.00
306_D341_R0.9471.00
96_V116_I0.9471.00
17_A35_Y0.9431.00
211_V321_L0.9351.00
240_A246_T0.9321.00
338_M342_T0.9301.00
18_L22_K0.9261.00
98_G107_V0.9211.00
200_P203_R0.9191.00
299_A310_V0.9091.00
158_V161_G0.9091.00
178_A181_G0.9081.00
284_L308_A0.8991.00
145_F152_F0.8961.00
30_N53_P0.8951.00
334_T342_T0.8891.00
220_L245_V0.8881.00
197_G287_S0.8871.00
316_L321_L0.8831.00
279_G338_M0.8811.00
16_P270_T0.8811.00
87_Y90_E0.8801.00
165_A168_V0.8791.00
241_A244_M0.8781.00
177_L259_A0.8761.00
209_Q244_M0.8701.00
335_L342_T0.8691.00
13_H99_T0.8691.00
191_I212_L0.8671.00
213_K242_D0.8591.00
335_L338_M0.8571.00
267_A299_A0.8501.00
174_G178_A0.8491.00
73_T77_F0.8491.00
240_A244_M0.8471.00
44_K54_F0.8461.00
189_V217_Y0.8431.00
83_K87_Y0.8411.00
260_I280_I0.8411.00
282_S302_L0.8381.00
216_D326_D0.8371.00
66_L69_E0.8331.00
7_G17_A0.8331.00
84_S88_L0.8291.00
69_E72_K0.8251.00
297_V300_R0.8191.00
87_Y91_F0.8161.00
74_V78_L0.8151.00
209_Q221_Y0.8151.00
289_Y294_H0.8131.00
5_I24_V0.8111.00
189_V219_V0.8021.00
277_A346_G0.8021.00
244_M247_K0.8011.00
179_E218_Q0.7951.00
77_F80_G0.7941.00
191_I219_V0.7921.00
178_A182_L0.7891.00
190_L257_L0.7871.00
68_F72_K0.7861.00
211_V319_E0.7861.00
295_Q298_N0.7851.00
24_V29_P0.7841.00
3_I29_P0.7811.00
59_I62_F0.7711.00
187_K332_E0.7701.00
19_A22_K0.7701.00
217_Y329_V0.7631.00
309_I312_K0.7621.00
25_Q33_F0.7611.00
88_L114_M0.7611.00
159_F162_N0.7601.00
49_R52_I0.7561.00
72_K75_M0.7541.00
66_L70_N0.7491.00
76_R80_G0.7461.00
266_R295_Q0.7461.00
6_S107_V0.7441.00
252_Q274_E0.7411.00
156_K162_N0.7411.00
285_I316_L0.7411.00
123_Q126_L0.7391.00
323_E326_D0.7361.00
192_F271_T0.7341.00
192_F263_I0.7331.00
177_L183_S0.7321.00
43_E47_V0.7291.00
146_E159_F0.7281.00
75_M78_L0.7261.00
70_N78_L0.7261.00
253_M278_L0.7261.00
250_L256_Y0.7261.00
173_T178_A0.7201.00
203_R206_I0.7161.00
20_F99_T0.7131.00
185_D258_K0.7131.00
173_T177_L0.7061.00
122_E126_L0.7051.00
55_R91_F0.7031.00
205_V223_T0.7031.00
89_A113_K0.7031.00
165_A169_V0.7021.00
104_C107_V0.7011.00
48_E54_F0.6991.00
191_I264_V0.6981.00
166_S169_V0.6981.00
265_A271_T0.6961.00
276_T302_L0.6901.00
192_F253_M0.6851.00
43_E48_E0.6851.00
20_F163_P0.6851.00
286_P299_A0.6841.00
185_D188_T0.6831.00
85_K88_L0.6801.00
257_L263_I0.6771.00
68_F75_M0.6761.00
275_I284_L0.6761.00
203_R207_D0.6761.00
71_V75_M0.6751.00
17_A99_T0.6751.00
208_M212_L0.6751.00
34_L53_P0.6741.00
37_G43_E0.6721.00
156_K160_T0.6711.00
66_L71_V0.6711.00
66_L73_T0.6701.00
40_N44_K0.6681.00
279_G339_S0.6661.00
228_Y231_V0.6651.00
24_V28_H0.6611.00
49_R251_H0.6591.00
67_S73_T0.6591.00
4_A34_L0.6571.00
283_V311_L0.6571.00
188_T259_A0.6531.00
99_T103_V0.6451.00
311_L320_K0.6441.00
164_R277_A0.6421.00
46_I49_R0.6411.00
143_I159_F0.6411.00
208_M321_L0.6411.00
44_K56_S0.6381.00
176_S180_F0.6381.00
211_V214_T0.6361.00
213_K239_G0.6361.00
207_D211_V0.6361.00
331_N336_K0.6351.00
162_N165_A0.6341.00
211_V325_L0.6341.00
19_A165_A0.6331.00
276_T342_T0.6311.00
265_A284_L0.6301.00
176_S259_A0.6271.00
71_V74_V0.6251.00
239_G242_D0.6231.00
4_A91_F0.6221.00
252_Q257_L0.6211.00
7_G99_T0.6211.00
92_K116_I0.6191.00
20_F97_I0.6181.00
67_S74_V0.6171.00
84_S87_Y0.6151.00
159_F163_P0.6151.00
184_E187_K0.6141.00
26_R166_S0.6141.00
265_A272_I0.6141.00
257_L280_I0.6111.00
66_L72_K0.6081.00
68_F71_V0.6071.00
177_L182_L0.6071.00
97_I119_I0.6071.00
171_I255_E0.6061.00
190_L250_L0.6031.00
270_T274_E0.6021.00
48_E51_N0.6001.00
78_L81_V0.6001.00
316_L320_K0.6001.00
19_A23_E0.5991.00
342_T345_L0.5981.00
182_L218_Q0.5961.00
280_I335_L0.5951.00
347_V350_A0.5911.00
4_A7_G0.5911.00
325_L329_V0.5901.00
78_L82_K0.5861.00
170_S173_T0.5851.00
108_V111_A0.5851.00
261_D329_V0.5831.00
221_Y224_G0.5831.00
223_T246_T0.5821.00
98_G120_V0.5811.00
190_L263_I0.5811.00
39_E44_K0.5811.00
68_F77_F0.5811.00
214_T319_E0.5791.00
55_R87_Y0.5791.00
345_L348_P0.5781.00
47_V50_E0.5771.00
192_F222_I0.5761.00
47_V51_N0.5741.00
187_K217_Y0.5701.00
44_K49_R0.5691.00
319_E322_I0.5681.00
265_A275_I0.5681.00
65_K69_E0.5651.00
251_H255_E0.5621.00
60_T64_R0.5621.00
220_L260_I0.5621.00
179_E245_V0.5611.00
57_I61_G0.5611.00
180_F188_T0.5581.00
210_D214_T0.5581.00
269_A273_A0.5571.00
123_Q127_P0.5571.00
39_E58_E0.5561.00
219_V222_I0.5561.00
222_I249_F0.5541.00
266_R294_H0.5531.00
53_P91_F0.5501.00
99_T123_Q0.5481.00
312_K320_K0.5481.00
262_V283_V0.5471.00
276_T338_M0.5471.00
47_V54_F0.5471.00
108_V112_A0.5461.00
186_K243_N0.5441.00
190_L193_G0.5441.00
10_T13_H0.5431.00
195_S294_H0.5431.00
36_I84_S0.5411.00
213_K241_A0.5401.00
283_V325_L0.5401.00
266_R270_T0.5391.00
30_N34_L0.5371.00
344_S347_V0.5361.00
112_A115_G0.5361.00
18_L21_I0.5331.00
297_V301_S0.5311.00
59_I63_K0.5311.00
121_H163_P0.5301.00
208_M211_V0.5291.00
216_D243_N0.5291.00
262_V329_V0.5281.00
70_N77_F0.5281.00
179_E252_Q0.5271.00
307_A342_T0.5271.00
37_G54_F0.5261.00
98_G108_V0.5251.00
286_P295_Q0.5251.00
256_Y260_I0.5251.00
215_R322_I0.5241.00
60_T63_K0.5241.00
299_A303_G0.5241.00
200_P204_A0.5241.00
228_Y248_P0.5241.00
22_K166_S0.5241.00
288_P294_H0.5221.00
3_I33_F0.5211.00
107_V118_T0.5201.00
221_Y244_M0.5191.00
199_A227_H0.5191.00
128_G143_I0.5191.00
195_S295_Q0.5171.00
48_E53_P0.5171.00
306_D333_Q0.5171.00
109_Y113_K0.5171.00
88_L91_F0.5161.00
162_N270_T0.5161.00
193_G198_A0.5151.00
202_N205_V0.5141.00
112_A118_T0.5131.00
218_Q243_N0.5121.00
89_A92_K0.5121.00
164_R167_E0.5111.00
107_V111_A0.5101.00
311_L316_L0.5091.00
83_K88_L0.5081.00
287_S313_E0.5071.00
33_F52_I0.5071.00
262_V335_L0.5061.00
146_E151_H0.5051.00
39_E43_E0.5041.00
271_T275_I0.5031.00
204_A207_D0.5021.00
208_M322_I0.5021.00
272_I284_L0.5011.00
21_I33_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iyaA 1 0.9311 100 0.329 Contact Map
2vchA 1 0.9559 100 0.33 Contact Map
3hbfA 1 0.9669 100 0.333 Contact Map
2c1xA 1 0.9421 100 0.336 Contact Map
3rscA 1 0.9394 100 0.34 Contact Map
2pq6A 1 0.9201 100 0.341 Contact Map
1rrvA 1 0.9339 100 0.343 Contact Map
2iyfA 1 0.9339 100 0.355 Contact Map
3ia7A 2 0.9284 100 0.355 Contact Map
2acvA 1 0.9669 100 0.357 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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