GREMLIN Database
CSAA - Protein CsaA
UniProt: P37584 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 110 (105)
Sequences: 3530 (2038)
Seq/√Len: 198.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_K34_V3.1511.00
16_T63_Q2.8651.00
16_T105_N2.7841.00
22_E51_T2.7581.00
6_D9_K2.7111.00
55_K58_G2.4251.00
26_A76_A1.9931.00
21_E32_K1.9111.00
62_K98_Q1.8961.00
12_I65_I1.8941.00
37_F66_A1.8521.00
15_G35_I1.8201.00
3_V6_D1.7561.00
34_V43_I1.7551.00
23_F32_K1.6691.00
47_S78_F1.6261.00
18_V43_I1.6001.00
46_S82_V1.5991.00
22_E56_P1.5701.00
19_K60_I1.5691.00
4_I8_E1.5671.00
46_S66_A1.5251.00
31_I56_P1.5241.00
63_Q102_P1.4861.00
45_Q78_F1.4271.00
32_K78_F1.4191.00
65_I97_L1.3961.00
34_V45_Q1.3911.00
47_S75_I1.3861.00
2_A10_L1.3771.00
33_L84_V1.3341.00
10_L67_V1.3211.00
15_G66_A1.2831.00
20_A56_P1.2821.00
17_I64_V1.2721.00
52_K93_D1.2721.00
27_R76_A1.2601.00
13_R68_V1.2261.00
97_L109_I1.2151.00
33_L86_G1.2141.00
89_P93_D1.2021.00
5_D8_E1.1851.00
11_D108_K1.1801.00
14_T63_Q1.1311.00
36_D105_N1.1221.00
74_R79_K1.0981.00
65_I87_G1.0931.00
35_I82_V1.0791.00
14_T65_I1.0741.00
20_A31_I1.0671.00
12_I85_L1.0491.00
25_E77_G1.0381.00
37_F68_V1.0371.00
37_F42_G1.0291.00
62_K100_D1.0081.00
87_G109_I1.0031.00
63_Q105_N0.9981.00
20_A60_I0.9981.00
32_K45_Q0.9891.00
35_I64_V0.9871.00
23_F78_F0.9700.99
16_T36_D0.9640.99
104_P107_T0.9630.99
20_A33_L0.9480.99
12_I67_V0.9470.99
27_R52_K0.9320.99
88_I92_G0.9310.99
25_E76_A0.9180.99
88_I94_V0.9110.99
87_G107_T0.9050.99
46_S84_V0.8980.99
36_D41_I0.8940.99
36_D43_I0.8860.99
95_V101_Q0.8780.99
98_Q101_Q0.8780.99
18_V36_D0.8730.99
21_E34_V0.8680.99
16_T102_P0.8640.99
33_L48_A0.8590.99
88_I107_T0.8520.99
47_S73_R0.8510.99
3_V71_P0.8440.99
87_G103_V0.8410.98
87_G97_L0.8370.98
74_R77_G0.8320.98
48_A86_G0.8310.98
42_G81_E0.8260.98
56_P60_I0.8180.98
53_R89_P0.8100.98
53_R94_V0.8050.98
15_G37_F0.7980.98
35_I66_A0.7970.98
11_D68_V0.7960.98
35_I84_V0.7940.98
72_P81_E0.7940.98
89_P92_G0.7910.98
26_A51_T0.7800.98
23_F77_G0.7720.97
4_I73_R0.7690.97
66_A82_V0.7560.97
65_I109_I0.7510.97
31_I51_T0.7450.97
64_V84_V0.7370.97
49_Q75_I0.7130.96
37_F41_I0.7100.96
33_L59_L0.6840.95
95_V103_V0.6740.94
14_T99_P0.6680.94
14_T103_V0.6660.94
13_R108_K0.6610.94
86_G96_L0.6480.93
45_Q77_G0.6400.93
45_Q79_K0.6390.93
95_V100_D0.6340.92
85_L109_I0.6300.92
44_K81_E0.6200.91
55_K59_L0.6140.91
44_K82_V0.6040.90
30_A49_Q0.6040.90
53_R93_D0.6020.90
35_I46_S0.6000.90
54_Y59_L0.6000.90
49_Q83_L0.5960.90
103_V107_T0.5930.90
33_L46_S0.5870.89
37_F43_I0.5820.89
44_K68_V0.5800.89
72_P79_K0.5780.88
95_V99_P0.5770.88
85_L97_L0.5750.88
63_Q99_P0.5700.88
20_A48_A0.5590.87
24_P27_R0.5560.86
15_G43_I0.5560.86
25_E32_K0.5540.86
59_L96_L0.5520.86
89_P107_T0.5500.86
54_Y96_L0.5490.86
23_F26_A0.5480.86
53_R88_I0.5470.85
67_V70_F0.5410.85
63_Q103_V0.5390.85
17_I59_L0.5310.84
99_P103_V0.5290.84
34_V78_F0.5280.83
102_P105_N0.5220.83
73_R82_V0.5200.83
17_I96_L0.5200.83
6_D10_L0.5180.82
63_Q98_Q0.5170.82
36_D42_G0.5150.82
84_V96_L0.5110.81
66_A84_V0.5080.81
52_K91_Q0.5080.81
62_K96_L0.5060.81
18_V34_V0.5020.80
30_A47_S0.5010.80
12_I68_V0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3g48A 2 0.9909 100 0.207 Contact Map
2nzhA 5 1 100 0.21 Contact Map
1gd7A 2 0.9818 100 0.212 Contact Map
2cwpA 2 0.9727 100 0.222 Contact Map
2q2hA 2 1 100 0.222 Contact Map
2q2iA 2 1 100 0.223 Contact Map
3ersX 2 0.9727 100 0.23 Contact Map
1mkhA 2 0.9545 100 0.233 Contact Map
1pybA 2 0.9636 100 0.237 Contact Map
1rqgA 2 0 100 0.259 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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