GREMLIN Database
GLNR - HTH-type transcriptional regulator GlnR
UniProt: P37582 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 135 (113)
Sequences: 572 (386)
Seq/√Len: 36.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_I73_I3.6911.00
90_E93_K3.5111.00
68_V76_I3.0351.00
83_E86_Q2.4961.00
82_A87_K2.4791.00
97_K100_L2.4471.00
25_A45_N2.4361.00
88_Q92_T2.0290.99
12_F54_V2.0280.99
51_F54_V1.9720.98
59_E62_H1.9240.98
89_N92_T1.7820.97
69_N72_G1.7300.96
68_V72_G1.7030.96
24_S27_Q1.6940.96
36_L60_I1.6920.96
21_T30_Y1.6660.95
106_R109_L1.6570.95
20_L58_L1.6310.95
56_K77_L1.6220.94
71_A74_K1.5630.93
32_E64_I1.5530.93
72_G76_I1.5460.93
8_S52_H1.5170.92
82_A85_E1.4870.91
106_R112_E1.4780.91
12_F51_F1.4650.91
63_L72_G1.4580.90
66_Q75_Q1.3910.88
10_P50_S1.3870.88
65_E69_N1.3850.88
111_N118_R1.3840.88
82_A90_E1.3410.86
96_M99_D1.3320.86
56_K81_E1.3200.85
114_M117_G1.2920.84
12_F39_P1.2720.83
53_D56_K1.2700.83
7_R55_D1.2520.82
89_N94_K1.2510.82
11_L105_L1.2440.82
10_P70_M1.2330.81
100_L104_E1.2240.81
95_P98_H1.2020.80
61_K73_I1.1960.79
42_S45_N1.1960.79
32_E37_I1.1920.79
14_I39_P1.1830.78
76_I79_K1.1680.78
81_E85_E1.1620.77
43_E55_D1.1490.76
32_E61_K1.1260.75
27_Q64_I1.0810.72
24_S64_I1.0700.71
57_L73_I1.0630.71
115_Q118_R1.0460.69
68_V82_A1.0310.68
10_P30_Y1.0180.67
40_A65_E1.0150.67
44_G57_L1.0080.66
17_V21_T0.9950.65
14_I58_L0.9920.65
63_L76_I0.9880.65
20_L57_L0.9820.64
8_S55_D0.9780.64
21_T58_L0.9760.64
25_A30_Y0.9660.63
85_E89_N0.9640.63
42_S48_L0.9460.61
81_E92_T0.9310.60
45_N48_L0.9210.59
75_Q78_A0.9130.59
111_N114_M0.9130.59
75_Q80_A0.8950.57
79_K83_E0.8750.55
33_E76_I0.8670.55
8_S99_D0.8590.54
63_L68_V0.8530.53
106_R111_N0.8430.53
69_N74_K0.8430.53
20_L100_L0.8360.52
113_L118_R0.8330.52
44_G49_F0.8330.52
35_G38_F0.8280.51
105_L109_L0.8270.51
7_R45_N0.8260.51
22_E78_A0.8240.51
25_A74_K0.8150.50
65_E70_M0.8130.50
59_E80_A0.8070.49
32_E39_P0.8030.49
26_R33_E0.7900.48
42_S113_L0.7710.46
14_I28_I0.7650.46
86_Q90_E0.7630.46
63_L77_L0.7560.45
46_R49_F0.7560.45
88_Q94_K0.7480.44
25_A64_I0.7430.44
92_T96_M0.7390.44
55_D95_P0.7380.43
20_L109_L0.7360.43
10_P77_L0.7330.43
16_I60_I0.7320.43
21_T57_L0.7190.42
30_Y46_R0.7160.42
49_F76_I0.7090.41
15_G85_E0.6920.40
32_E46_R0.6800.39
38_F84_P0.6710.38
63_L79_K0.6690.38
24_S61_K0.6680.38
14_I68_V0.6650.37
91_K95_P0.6630.37
8_S62_H0.6620.37
72_G79_K0.6610.37
10_P118_R0.6610.37
9_M40_A0.6560.37
30_Y34_N0.6530.36
104_E107_Q0.6430.36
23_L30_Y0.6410.35
25_A71_A0.6340.35
20_L54_V0.6290.34
34_N63_L0.6290.34
22_E43_E0.6240.34
30_Y45_N0.6210.34
40_A87_K0.6210.34
35_G85_E0.6190.34
111_N115_Q0.6180.34
108_L111_N0.6180.34
75_Q79_K0.6150.33
16_I22_E0.6020.32
17_V58_L0.6000.32
96_M101_S0.5960.32
51_F55_D0.5940.32
105_L111_N0.5940.32
17_V23_L0.5890.31
9_M59_E0.5760.30
25_A46_R0.5740.30
10_P38_F0.5670.30
32_E66_Q0.5660.30
92_T107_Q0.5640.29
13_P58_L0.5590.29
18_M27_Q0.5510.29
8_S102_D0.5480.28
23_L37_I0.5460.28
53_D72_G0.5460.28
24_S33_E0.5420.28
30_Y37_I0.5420.28
30_Y61_K0.5390.28
83_E97_K0.5380.28
33_E54_V0.5380.28
27_Q34_N0.5350.27
43_E91_K0.5330.27
68_V77_L0.5330.27
83_E96_M0.5330.27
23_L27_Q0.5310.27
111_N116_A0.5300.27
93_K97_K0.5270.27
49_F99_D0.5260.27
40_A75_Q0.5260.27
94_K98_H0.5230.27
21_T54_V0.5220.27
17_V34_N0.5210.26
48_L66_Q0.5180.26
75_Q117_G0.5140.26
78_A83_E0.5070.26
113_L117_G0.5040.25
41_R57_L0.5020.25
26_R30_Y0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ucsA 2 0.7333 99.7 0.633 Contact Map
2zhgA 2 0.837 99.7 0.635 Contact Map
3qaoA 2 0.9111 99.7 0.636 Contact Map
3gpvA 2 0.7926 99.7 0.639 Contact Map
4r4eB 2 0.6222 99.7 0.639 Contact Map
2vz4A 2 0.7333 99.7 0.639 Contact Map
3gp4A 4 0.8889 99.7 0.64 Contact Map
4r24B 2 0.6296 99.7 0.649 Contact Map
2dg6A 2 0.837 99.7 0.655 Contact Map
3hh0A 4 0.8963 99.7 0.656 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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