GREMLIN Database
FHUD - Iron(3+)-hydroxamate-binding protein FhuD
UniProt: P37580 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 315 (279)
Sequences: 13762 (10903)
Seq/√Len: 652.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_K166_E3.9531.00
149_I173_D3.9131.00
251_A279_N3.8381.00
156_A165_A3.7531.00
161_T164_K3.3181.00
46_K51_N3.1701.00
279_N283_N3.0561.00
157_K162_E3.0351.00
175_K307_E2.8351.00
153_K169_L2.7871.00
63_V69_Y2.7831.00
44_T51_N2.6671.00
164_K167_K2.5941.00
177_A181_T2.5341.00
246_K249_D2.4761.00
110_K113_D2.4541.00
170_A174_K2.4241.00
217_Y222_L2.4071.00
166_E170_A2.3651.00
175_K303_E2.3591.00
62_V111_V2.1631.00
214_S218_K2.1381.00
47_A52_V2.1371.00
173_D177_A2.0351.00
174_K178_A2.0221.00
72_F159_T2.0041.00
61_V159_T2.0041.00
270_F284_G1.9951.00
71_Y152_L1.9891.00
77_I159_T1.9821.00
191_T223_Q1.9671.00
253_D279_N1.9431.00
178_A182_K1.9411.00
131_K134_K1.9301.00
267_G271_E1.9271.00
77_I161_T1.8721.00
42_T53_K1.8461.00
44_T53_K1.8251.00
167_K171_K1.7771.00
60_R80_V1.7691.00
129_I133_E1.7691.00
120_I155_F1.7551.00
254_Y287_Y1.7401.00
278_L281_V1.7331.00
163_D167_K1.7061.00
150_E153_K1.6311.00
177_A180_K1.6191.00
254_Y285_H1.5961.00
171_K175_K1.5831.00
277_N282_K1.5791.00
279_N282_K1.5761.00
43_F157_K1.5501.00
130_K134_K1.5391.00
267_G270_F1.5241.00
150_E154_E1.5091.00
100_E110_K1.4931.00
106_T111_V1.4801.00
164_K168_W1.4781.00
244_L272_S1.4751.00
81_G114_L1.4121.00
147_D150_E1.4091.00
190_K254_Y1.3991.00
107_S110_K1.3941.00
112_I135_I1.3931.00
181_T184_K1.3891.00
149_I169_L1.3781.00
126_G130_K1.3781.00
62_V114_L1.3681.00
80_V114_L1.3661.00
255_I280_A1.3651.00
189_D223_Q1.3601.00
201_D241_S1.3541.00
246_K250_F1.3521.00
62_V81_G1.3271.00
75_L161_T1.3241.00
162_E166_E1.3231.00
192_I222_L1.3161.00
47_A50_G1.3131.00
154_E157_K1.3081.00
308_F311_E1.3051.00
175_K178_A1.2991.00
139_V154_E1.2991.00
168_W171_K1.2941.00
90_P93_K1.2881.00
83_P86_V1.2781.00
179_A310_T1.2781.00
275_W281_V1.2781.00
108_V131_K1.2741.00
121_V140_A1.2681.00
130_K133_E1.2661.00
174_K177_A1.2651.00
152_L165_A1.2611.00
170_A173_D1.2601.00
178_A181_T1.2581.00
207_K218_K1.2551.00
139_V158_M1.2551.00
63_V72_F1.2391.00
109_E245_E1.2271.00
163_D166_E1.2221.00
228_T250_F1.2091.00
125_Q128_D1.2081.00
179_A306_L1.2081.00
226_K250_F1.2041.00
72_F77_I1.2021.00
16_L19_A1.1961.00
225_T250_F1.1851.00
59_K117_D1.1721.00
54_I57_H1.1651.00
58_P117_D1.1601.00
171_K174_K1.1491.00
118_L139_V1.1481.00
307_E311_E1.1481.00
153_K173_D1.1441.00
17_L20_A1.1321.00
169_L173_D1.1161.00
193_S196_Q1.1141.00
180_K219_D1.1131.00
100_E103_G1.1051.00
60_R115_N1.0971.00
182_K310_T1.0941.00
74_T168_W1.0781.00
194_I217_Y1.0761.00
42_T56_K1.0621.00
183_I186_A1.0621.00
223_Q227_L1.0611.00
47_A129_I1.0611.00
306_L310_T1.0591.00
290_D293_G1.0581.00
61_V118_L1.0531.00
128_D131_K1.0471.00
268_G271_E1.0201.00
251_A255_I1.0111.00
180_K184_K1.0081.00
59_K78_N1.0051.00
153_K157_K1.0001.00
94_G97_N0.9961.00
91_Y94_G0.9951.00
84_E101_N0.9871.00
225_T228_T0.9811.00
191_T253_D0.9801.00
190_K285_H0.9791.00
42_T57_H0.9781.00
96_T99_V0.9751.00
303_E307_E0.9741.00
273_S276_K0.9731.00
226_K246_K0.9721.00
15_L19_A0.9671.00
209_F214_S0.9671.00
176_V180_K0.9541.00
72_F120_I0.9511.00
215_I218_K0.9501.00
270_F286_V0.9491.00
75_L168_W0.9481.00
275_W278_L0.9481.00
95_K99_V0.9471.00
192_I195_M0.9411.00
49_N140_A0.9311.00
306_L311_E0.9301.00
41_E160_G0.9301.00
165_A169_L0.9271.00
154_E158_M0.9251.00
65_A122_W0.9211.00
14_A18_I0.9101.00
175_K179_A0.9031.00
195_M198_N0.9021.00
71_Y155_F0.9011.00
82_A99_V0.8991.00
54_I137_P0.8991.00
193_S197_T0.8971.00
281_V286_V0.8961.00
172_W219_D0.8951.00
79_V99_V0.8941.00
49_N133_E0.8921.00
57_H161_T0.8921.00
61_V72_F0.8901.00
123_T142_K0.8891.00
41_E56_K0.8891.00
156_A169_L0.8881.00
195_M272_S0.8871.00
193_S204_V0.8871.00
64_M119_I0.8851.00
252_G255_I0.8771.00
192_I196_Q0.8761.00
155_F159_T0.8751.00
96_T100_E0.8741.00
119_I136_A0.8741.00
78_N161_T0.8741.00
305_Q311_E0.8661.00
205_F209_F0.8651.00
42_T55_P0.8641.00
279_N285_H0.8631.00
141_V154_E0.8621.00
215_I219_D0.8581.00
24_C28_S0.8551.00
70_G300_I0.8511.00
176_V306_L0.8451.00
47_A51_N0.8441.00
73_K79_V0.8421.00
120_I158_M0.8401.00
17_L21_L0.8341.00
116_P119_I0.8341.00
247_L278_L0.8331.00
301_S305_Q0.8311.00
167_K170_A0.8271.00
45_Y139_V0.8231.00
18_I21_L0.8231.00
149_I153_K0.8221.00
166_E169_L0.8211.00
298_D301_S0.8201.00
73_K96_T0.8161.00
257_A288_K0.8141.00
24_C27_N0.8131.00
18_I22_A0.8091.00
256_F287_Y0.8091.00
272_S276_K0.8051.00
58_P118_L0.8001.00
294_F297_T0.8001.00
41_E57_H0.7971.00
88_K92_Y0.7961.00
54_I58_P0.7961.00
300_I303_E0.7941.00
133_E138_T0.7941.00
242_I250_F0.7941.00
172_W176_V0.7901.00
276_K281_V0.7891.00
14_A20_A0.7881.00
43_F54_I0.7871.00
155_F158_M0.7861.00
68_Y120_I0.7831.00
74_T152_L0.7831.00
82_A101_N0.7791.00
194_I213_G0.7771.00
57_H160_G0.7771.00
193_S252_G0.7721.00
192_I217_Y0.7701.00
72_F79_V0.7681.00
193_S247_L0.7671.00
19_A22_A0.7661.00
168_W172_W0.7651.00
224_A228_T0.7611.00
75_L159_T0.7611.00
63_V79_V0.7541.00
182_K185_K0.7511.00
153_K156_A0.7501.00
151_Q154_E0.7451.00
56_K59_K0.7411.00
205_F239_Y0.7371.00
207_K227_L0.7351.00
118_L158_M0.7341.00
79_V82_A0.7301.00
204_V226_K0.7281.00
81_G103_G0.7281.00
176_V219_D0.7251.00
149_I176_V0.7141.00
260_W291_P0.7141.00
76_G164_K0.7111.00
248_P278_L0.7111.00
75_L164_K0.7101.00
70_G298_D0.7081.00
175_K310_T0.7081.00
74_T300_I0.7061.00
159_T162_E0.7051.00
95_K98_G0.7021.00
179_A183_I0.7011.00
127_A130_K0.6981.00
22_A25_G0.6941.00
172_W175_K0.6931.00
248_P277_N0.6901.00
257_A286_V0.6871.00
15_L18_I0.6861.00
190_K222_L0.6861.00
52_V139_V0.6841.00
45_Y54_I0.6831.00
97_N100_E0.6821.00
256_F309_I0.6811.00
289_M294_F0.6761.00
102_I114_L0.6731.00
75_L156_A0.6691.00
76_G161_T0.6681.00
68_Y141_V0.6681.00
62_V116_P0.6671.00
243_S246_K0.6601.00
255_I258_G0.6601.00
152_L168_W0.6601.00
111_V132_L0.6521.00
259_P288_K0.6471.00
305_Q310_T0.6451.00
153_K162_E0.6441.00
109_E112_I0.6411.00
186_A189_D0.6411.00
141_V155_F0.6391.00
189_D193_S0.6381.00
100_E114_L0.6321.00
255_I275_W0.6311.00
60_R117_D0.6301.00
183_I310_T0.6301.00
75_L152_L0.6301.00
119_I135_I0.6291.00
189_D192_I0.6281.00
54_I118_L0.6281.00
203_Y241_S0.6251.00
141_V151_Q0.6231.00
307_E310_T0.6221.00
194_I258_G0.6221.00
254_Y258_G0.6181.00
129_I140_A0.6061.00
41_E55_P0.6001.00
171_K303_E0.6001.00
298_D302_L0.5961.00
176_V302_L0.5961.00
41_E58_P0.5951.00
49_N126_G0.5921.00
193_S255_I0.5901.00
258_G289_M0.5901.00
181_T185_K0.5881.00
126_G129_I0.5881.00
15_L20_A0.5861.00
43_F56_K0.5861.00
14_A17_L0.5851.00
152_L169_L0.5851.00
24_C30_S0.5841.00
192_I197_T0.5831.00
149_I219_D0.5831.00
63_V68_Y0.5811.00
57_H117_D0.5801.00
112_I245_E0.5781.00
108_V135_I0.5761.00
248_P252_G0.5751.00
108_V128_D0.5741.00
149_I172_W0.5731.00
16_L22_A0.5731.00
89_N92_Y0.5721.00
129_I138_T0.5711.00
20_A23_A0.5711.00
73_K99_V0.5711.00
27_N30_S0.5711.00
244_L275_W0.5701.00
65_A68_Y0.5701.00
248_P274_I0.5691.00
168_W299_P0.5681.00
75_L165_A0.5661.00
62_V80_V0.5651.00
205_F214_S0.5641.00
58_P159_T0.5621.00
48_E154_E0.5611.00
72_F155_F0.5611.00
190_K194_I0.5601.00
24_C29_E0.5601.00
64_M121_V0.5601.00
305_Q309_I0.5581.00
119_I132_L0.5571.00
214_S227_L0.5571.00
143_Y151_Q0.5571.00
226_K242_I0.5551.00
195_M255_I0.5541.00
180_K220_L0.5531.00
68_Y71_Y0.5521.00
272_S275_W0.5521.00
179_A182_K0.5511.00
269_V272_S0.5511.00
169_L172_W0.5481.00
69_Y82_A0.5461.00
173_D176_V0.5451.00
68_Y155_F0.5441.00
299_P303_E0.5411.00
214_S224_A0.5411.00
45_Y154_E0.5401.00
23_A26_N0.5401.00
193_S225_T0.5391.00
81_G102_I0.5391.00
208_D214_S0.5371.00
179_A220_L0.5361.00
278_L282_K0.5361.00
207_K228_T0.5351.00
55_P137_P0.5351.00
110_K114_L0.5341.00
108_V111_V0.5330.99
203_Y239_Y0.5330.99
194_I197_T0.5310.99
128_D132_L0.5310.99
73_K95_K0.5300.99
132_L138_T0.5290.99
192_I256_F0.5270.99
127_A131_K0.5270.99
133_E137_P0.5260.99
242_I247_L0.5260.99
302_L305_Q0.5240.99
275_W286_V0.5240.99
16_L20_A0.5220.99
58_P61_V0.5220.99
176_V179_A0.5210.99
290_D308_F0.5200.99
251_A278_L0.5180.99
206_G214_S0.5170.99
129_I132_L0.5160.99
172_W302_L0.5150.99
63_V82_A0.5120.99
303_E306_L0.5110.99
85_N101_N0.5100.99
217_Y220_L0.5090.99
23_A27_N0.5090.99
54_I158_M0.5080.99
148_N172_W0.5080.99
161_T165_A0.5070.99
247_L250_F0.5070.99
186_A310_T0.5050.99
71_Y74_T0.5050.99
191_T225_T0.5050.99
224_A227_L0.5050.99
62_V102_I0.5040.99
220_L310_T0.5040.99
204_V242_I0.5040.99
235_Q240_T0.5030.99
52_V137_P0.5030.99
274_I277_N0.5030.99
62_V119_I0.5010.99
42_T54_I0.5010.99
93_K97_N0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n01A 1 0.8571 100 0.234 Contact Map
3tnyA 1 0.8476 100 0.251 Contact Map
3tlkA 1 0.8667 100 0.259 Contact Map
4mx8A 1 0.8667 100 0.271 Contact Map
4mlzA 1 0.8476 100 0.273 Contact Map
3lhsA 1 0.8667 100 0.273 Contact Map
3tefA 1 0.8381 100 0.277 Contact Map
2x4lA 1 0.8508 100 0.283 Contact Map
3mwfA 1 0.8571 100 0.283 Contact Map
4hn9A 1 0.8698 100 0.286 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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