SP2B - BACSU - GREMLIN Contacts

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SP2B - Stage II sporulation protein B

UniProt:	P37575	Sequences: MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTFSNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKTGAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSADKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYTYVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILDEDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	332 (273)
Sequences:	161 (144)
Seq/√Len:	8.7

BACSU - SP2B

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
182_A	328_L	3.094	0.91
59_A	62_E	2.842	0.87
192_K	224_L	2.644	0.83
121_I	328_L	2.553	0.80
208_A	220_V	2.541	0.80
178_Y	185_A	2.457	0.77
183_V	193_G	2.444	0.77
222_A	238_L	2.348	0.74
185_A	201_L	2.341	0.74
229_E	232_Q	2.319	0.73
132_I	266_T	2.317	0.73
274_I	320_G	2.279	0.72
147_S	188_F	2.267	0.71
207_S	321_W	2.227	0.70
118_A	184_Q	2.153	0.67
193_G	220_V	2.146	0.67
183_V	219_Y	2.119	0.66
130_L	186_G	2.068	0.64
117_F	183_V	2.065	0.64
67_D	71_W	2.049	0.63
185_A	220_V	2.045	0.63
262_S	277_E	2.033	0.62
228_K	232_Q	1.992	0.61
219_Y	249_K	1.961	0.60
217_Y	238_L	1.928	0.58
118_A	122_G	1.901	0.57
122_G	184_Q	1.901	0.57
249_K	327_L	1.890	0.57
126_G	184_Q	1.859	0.55
118_A	126_G	1.859	0.55
56_E	60_S	1.859	0.55
106_K	125_L	1.847	0.55
114_T	183_V	1.844	0.55
324_Q	327_L	1.828	0.54
91_K	173_Q	1.815	0.53
117_F	133_S	1.803	0.53
228_K	321_W	1.778	0.52
127_L	241_S	1.760	0.51
270_A	324_Q	1.756	0.51
117_F	193_G	1.736	0.50
266_T	324_Q	1.730	0.50
82_D	172_A	1.710	0.49
72_D	77_K	1.687	0.48
207_S	220_V	1.687	0.48
328_L	331_V	1.683	0.48
69_F	74_E	1.677	0.48
325_Q	328_L	1.670	0.47
119_A	288_E	1.667	0.47
132_I	140_A	1.659	0.47
229_E	322_K	1.651	0.46
68_E	276_D	1.645	0.46
251_L	328_L	1.624	0.45
179_K	304_A	1.623	0.45
220_V	321_W	1.596	0.44
122_G	126_G	1.579	0.43
267_A	271_A	1.559	0.43
129_A	133_S	1.542	0.42
205_G	321_W	1.529	0.41
232_Q	322_K	1.522	0.41
117_F	123_T	1.520	0.41
187_K	246_W	1.519	0.41
183_V	320_G	1.498	0.40
129_A	193_G	1.494	0.40
126_G	223_G	1.485	0.39
260_T	313_E	1.443	0.38
228_K	247_G	1.438	0.38
167_A	258_D	1.434	0.37
180_T	221_I	1.432	0.37
56_E	59_A	1.428	0.37
125_L	328_L	1.412	0.37
122_G	188_F	1.406	0.36
254_S	263_F	1.396	0.36
294_T	298_E	1.368	0.35
225_A	327_L	1.362	0.35
190_N	242_D	1.350	0.34
182_A	325_Q	1.349	0.34
225_A	308_A	1.327	0.33
118_A	186_G	1.326	0.33
99_K	287_I	1.324	0.33
119_A	314_D	1.318	0.33
108_V	117_F	1.293	0.32
43_T	83_P	1.291	0.32
133_S	321_W	1.288	0.32
185_A	244_E	1.279	0.31
110_R	114_T	1.275	0.31
185_A	316_S	1.271	0.31
106_K	112_A	1.264	0.31
185_A	188_F	1.260	0.31
194_A	249_K	1.258	0.31
320_G	323_A	1.255	0.31
201_L	220_V	1.254	0.31
182_A	219_Y	1.252	0.30
71_W	74_E	1.242	0.30
285_E	329_A	1.241	0.30
141_P	179_K	1.238	0.30
188_F	256_E	1.227	0.30
136_K	244_E	1.224	0.29
174_T	208_A	1.218	0.29
215_D	239_I	1.215	0.29
117_F	120_V	1.210	0.29
211_L	225_A	1.209	0.29
188_F	244_E	1.209	0.29
121_I	178_Y	1.203	0.29
124_G	181_Y	1.199	0.29
112_A	170_Q	1.192	0.28
130_L	201_L	1.190	0.28
138_A	199_E	1.190	0.28
134_G	253_L	1.188	0.28
140_A	234_L	1.184	0.28
209_V	239_I	1.181	0.28
223_G	314_D	1.173	0.28
243_F	247_G	1.173	0.28
284_V	309_L	1.172	0.28
137_E	242_D	1.166	0.27
84_K	92_K	1.165	0.27
187_K	220_V	1.159	0.27
261_D	316_S	1.142	0.27
67_D	73_S	1.140	0.27
141_P	204_K	1.133	0.26
133_S	246_W	1.132	0.26
81_E	257_S	1.130	0.26
220_V	294_T	1.123	0.26
124_G	219_Y	1.120	0.26
234_L	283_S	1.116	0.26
270_A	286_K	1.111	0.26
232_Q	245_A	1.107	0.25
224_L	244_E	1.100	0.25
105_A	114_T	1.096	0.25
187_K	206_Y	1.092	0.25
99_K	124_G	1.084	0.25
57_V	68_E	1.071	0.24
105_A	225_A	1.067	0.24
185_A	249_K	1.057	0.24
76_D	317_A	1.053	0.24
247_G	320_G	1.047	0.24
182_A	196_T	1.045	0.23
187_K	250_E	1.040	0.23
149_G	216_G	1.036	0.23
92_K	183_V	1.035	0.23
99_K	125_L	1.028	0.23
69_F	73_S	1.023	0.23
107_P	116_A	1.022	0.23
228_K	313_E	1.021	0.23
185_A	209_V	1.021	0.23
46_N	54_E	1.000	0.22
184_Q	188_F	0.998	0.22
118_A	188_F	0.998	0.22
215_D	246_W	0.995	0.22
169_K	277_E	0.992	0.22
68_E	74_E	0.991	0.22
105_A	112_A	0.987	0.22
312_L	325_Q	0.986	0.22
112_A	331_V	0.985	0.22
113_A	307_Q	0.980	0.22
117_F	124_G	0.977	0.21
122_G	186_G	0.974	0.21
245_A	249_K	0.973	0.21
120_V	132_I	0.963	0.21
56_E	66_E	0.959	0.21
183_V	306_L	0.958	0.21
213_K	216_G	0.956	0.21
291_L	319_A	0.949	0.21
234_L	278_D	0.940	0.20
126_G	186_G	0.938	0.20
320_G	325_Q	0.938	0.20
98_A	167_A	0.937	0.20
234_L	274_I	0.934	0.20
109_K	323_A	0.932	0.20
239_I	330_V	0.931	0.20
215_D	223_G	0.924	0.20
183_V	270_A	0.924	0.20
209_V	217_Y	0.924	0.20
321_W	324_Q	0.924	0.20
42_M	60_S	0.923	0.20
144_L	296_A	0.918	0.20
181_Y	219_Y	0.915	0.20
129_A	217_Y	0.913	0.20
114_T	220_V	0.910	0.20
100_G	290_S	0.908	0.20
172_A	287_I	0.902	0.19
102_T	287_I	0.899	0.19
263_F	306_L	0.897	0.19
132_I	179_K	0.896	0.19
111_V	188_F	0.894	0.19
81_E	198_T	0.889	0.19
129_A	220_V	0.889	0.19
124_G	245_A	0.881	0.19
237_V	274_I	0.881	0.19
270_A	320_G	0.881	0.19
133_S	176_G	0.880	0.19
203_E	276_D	0.877	0.19
127_L	132_I	0.875	0.19
194_A	220_V	0.875	0.19
58_A	66_E	0.874	0.19
204_K	287_I	0.869	0.19
211_L	250_E	0.865	0.18
211_L	221_I	0.863	0.18
82_D	90_Q	0.863	0.18
166_G	170_Q	0.857	0.18
175_E	330_V	0.856	0.18
109_K	291_L	0.852	0.18
305_I	324_Q	0.849	0.18
183_V	304_A	0.848	0.18
292_G	331_V	0.841	0.18
171_A	288_E	0.838	0.18
43_T	54_E	0.838	0.18
185_A	212_S	0.838	0.18
174_T	291_L	0.838	0.18
183_V	233_Q	0.834	0.18
233_Q	291_L	0.831	0.18
216_G	302_K	0.829	0.18
81_E	285_E	0.827	0.17
251_L	325_Q	0.825	0.17
285_E	318_E	0.824	0.17
121_I	180_T	0.824	0.17
110_R	321_W	0.822	0.17
121_I	294_T	0.822	0.17
109_K	121_I	0.821	0.17
238_L	265_E	0.819	0.17
118_A	130_L	0.816	0.17
130_L	184_Q	0.816	0.17
175_E	301_E	0.816	0.17
212_S	218_T	0.811	0.17
255_I	296_A	0.808	0.17
195_E	253_L	0.806	0.17
232_Q	330_V	0.804	0.17
247_G	321_W	0.802	0.17
235_G	306_L	0.800	0.17
113_A	289_K	0.794	0.17
232_Q	239_I	0.793	0.17
218_T	290_S	0.792	0.17
58_A	216_G	0.788	0.17
245_A	305_I	0.786	0.16
58_A	69_F	0.785	0.16
177_T	306_L	0.784	0.16
253_L	327_L	0.783	0.16
215_D	247_G	0.781	0.16
125_L	205_G	0.778	0.16
133_S	228_K	0.778	0.16
114_T	127_L	0.778	0.16
196_T	296_A	0.777	0.16
255_I	314_D	0.773	0.16
219_Y	244_E	0.772	0.16
250_E	326_E	0.772	0.16
44_F	54_E	0.771	0.16
118_A	249_K	0.770	0.16
184_Q	249_K	0.770	0.16
47_W	234_L	0.770	0.16
82_D	273_A	0.765	0.16
187_K	217_Y	0.764	0.16
233_Q	288_E	0.764	0.16
67_D	86_V	0.763	0.16
169_K	223_G	0.762	0.16
191_E	195_E	0.758	0.16
173_Q	256_E	0.750	0.16
133_S	326_E	0.747	0.16
200_Q	235_G	0.745	0.16
269_L	321_W	0.745	0.16
132_I	188_F	0.744	0.16
76_D	82_D	0.738	0.15
292_G	295_K	0.737	0.15
231_S	247_G	0.734	0.15
225_A	301_E	0.734	0.15
97_Y	244_E	0.731	0.15
110_R	193_G	0.730	0.15
162_K	277_E	0.728	0.15
87_P	166_G	0.727	0.15
77_K	80_K	0.726	0.15
256_E	271_A	0.724	0.15
84_K	166_G	0.719	0.15
119_A	270_A	0.714	0.15
86_V	90_Q	0.710	0.15
231_S	330_V	0.708	0.15
147_S	221_I	0.705	0.15
167_A	270_A	0.702	0.15
216_G	268_E	0.701	0.15
125_L	199_E	0.694	0.14
117_F	251_L	0.692	0.14
222_A	225_A	0.691	0.14
209_V	218_T	0.689	0.14
307_Q	315_P	0.689	0.14
193_G	251_L	0.687	0.14
190_N	199_E	0.687	0.14
209_V	249_K	0.686	0.14
173_Q	212_S	0.682	0.14
86_V	89_F	0.682	0.14
185_A	261_D	0.680	0.14
185_A	222_A	0.679	0.14
249_K	311_E	0.677	0.14
105_A	111_V	0.677	0.14
223_G	312_L	0.676	0.14
69_F	215_D	0.675	0.14
92_K	325_Q	0.675	0.14
183_V	235_G	0.674	0.14
291_L	306_L	0.674	0.14
71_W	239_I	0.673	0.14
182_A	303_K	0.672	0.14
324_Q	328_L	0.670	0.14
73_S	193_G	0.668	0.14
109_K	270_A	0.667	0.14
119_A	322_K	0.667	0.14
194_A	198_T	0.662	0.14
183_V	328_L	0.660	0.14
114_T	274_I	0.655	0.14
150_S	236_Q	0.655	0.14
222_A	245_A	0.653	0.14
192_K	285_E	0.653	0.14
183_V	316_S	0.652	0.14
175_E	329_A	0.651	0.14
144_L	147_S	0.650	0.14
189_S	262_S	0.649	0.13
68_E	71_W	0.647	0.13
225_A	270_A	0.646	0.13
223_G	231_S	0.642	0.13
192_K	296_A	0.642	0.13
112_A	327_L	0.631	0.13
105_A	115_I	0.630	0.13
78_V	90_Q	0.627	0.13
238_L	316_S	0.621	0.13
41_S	55_Q	0.618	0.13
180_T	238_L	0.617	0.13
280_T	283_S	0.608	0.13
120_V	218_T	0.606	0.13
187_K	193_G	0.606	0.13
184_Q	223_G	0.605	0.13
118_A	223_G	0.605	0.13
245_A	250_E	0.603	0.13
121_I	331_V	0.603	0.13
207_S	271_A	0.602	0.13
121_I	124_G	0.601	0.13
41_S	270_A	0.601	0.13
125_L	187_K	0.601	0.13
76_D	143_S	0.601	0.13
323_A	330_V	0.600	0.13
185_A	219_Y	0.597	0.12
142_A	148_L	0.597	0.12
92_K	187_K	0.596	0.12
65_D	75_E	0.594	0.12
246_W	293_E	0.592	0.12
265_E	305_I	0.589	0.12
108_V	180_T	0.586	0.12
81_E	323_A	0.585	0.12
239_I	243_F	0.584	0.12
66_E	221_I	0.583	0.12
135_N	310_K	0.583	0.12
218_T	233_Q	0.581	0.12
259_M	283_S	0.580	0.12
238_L	244_E	0.577	0.12
117_F	301_E	0.577	0.12
119_A	242_D	0.577	0.12
138_A	281_K	0.571	0.12
183_V	238_L	0.571	0.12
70_N	222_A	0.571	0.12
127_L	276_D	0.571	0.12
217_Y	239_I	0.569	0.12
107_P	114_T	0.568	0.12
189_S	304_A	0.568	0.12
133_S	180_T	0.568	0.12
183_V	189_S	0.567	0.12
115_I	125_L	0.567	0.12
128_F	200_Q	0.566	0.12
243_F	320_G	0.566	0.12
179_K	201_L	0.564	0.12
66_E	79_F	0.562	0.12
251_L	287_I	0.560	0.12
108_V	245_A	0.558	0.12
262_S	288_E	0.558	0.12
83_P	88_P	0.558	0.12
119_A	226_S	0.554	0.12
253_L	307_Q	0.552	0.12
121_I	132_I	0.550	0.12
124_G	178_Y	0.550	0.12
163_Q	280_T	0.546	0.12
311_E	323_A	0.545	0.12
111_V	131_N	0.542	0.11
325_Q	331_V	0.541	0.11
229_E	245_A	0.540	0.11
94_T	169_K	0.538	0.11
237_V	295_K	0.536	0.11
45_S	63_H	0.536	0.11
206_Y	243_F	0.535	0.11
77_K	282_A	0.535	0.11
79_F	83_P	0.535	0.11
150_S	238_L	0.533	0.11
220_V	249_K	0.530	0.11
260_T	302_K	0.530	0.11
74_E	90_Q	0.529	0.11
207_S	235_G	0.529	0.11
200_Q	246_W	0.528	0.11
180_T	295_K	0.526	0.11
134_G	185_A	0.526	0.11
196_T	242_D	0.525	0.11
159_S	276_D	0.525	0.11
112_A	189_S	0.524	0.11
46_N	60_S	0.523	0.11
59_A	68_E	0.521	0.11
78_V	86_V	0.520	0.11
235_G	250_E	0.518	0.11
280_T	289_K	0.518	0.11
307_Q	331_V	0.516	0.11
315_P	331_V	0.514	0.11
126_G	188_F	0.513	0.11
117_F	217_Y	0.513	0.11
285_E	289_K	0.512	0.11
102_T	120_V	0.510	0.11
150_S	159_S	0.508	0.11
127_L	219_Y	0.507	0.11
221_I	294_T	0.501	0.11
135_N	294_T	0.501	0.11
207_S	324_Q	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1x60A	1	0.238	98.1	0.89	Contact Map
1utaA	1	0.2319	98	0.894	Contact Map
2lfvA	1	0.3072	62.7	0.952	Contact Map
4ogqF	1	0.0964	38	0.959	Contact Map
1q90M	1	0.1024	31.4	0.96	Contact Map
2ls4A	1	0.0723	12.9	0.967	Contact Map
4i7zE	1	0.0843	11.4	0.968	Contact Map
2kwhA	1	0.1506	10.6	0.968	Contact Map
4hddA	6	0.1958	8.5	0.969	Contact Map
3rfyA	2	0.3343	8.4	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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