GREMLIN Database
SP2B - Stage II sporulation protein B
UniProt: P37575 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 332 (273)
Sequences: 161 (144)
Seq/√Len: 8.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_A328_L3.0940.91
59_A62_E2.8420.87
192_K224_L2.6440.83
121_I328_L2.5530.80
208_A220_V2.5410.80
178_Y185_A2.4570.77
183_V193_G2.4440.77
222_A238_L2.3480.74
185_A201_L2.3410.74
229_E232_Q2.3190.73
132_I266_T2.3170.73
274_I320_G2.2790.72
147_S188_F2.2670.71
207_S321_W2.2270.70
118_A184_Q2.1530.67
193_G220_V2.1460.67
183_V219_Y2.1190.66
130_L186_G2.0680.64
117_F183_V2.0650.64
67_D71_W2.0490.63
185_A220_V2.0450.63
262_S277_E2.0330.62
228_K232_Q1.9920.61
219_Y249_K1.9610.60
217_Y238_L1.9280.58
118_A122_G1.9010.57
122_G184_Q1.9010.57
249_K327_L1.8900.57
126_G184_Q1.8590.55
118_A126_G1.8590.55
56_E60_S1.8590.55
106_K125_L1.8470.55
114_T183_V1.8440.55
324_Q327_L1.8280.54
91_K173_Q1.8150.53
117_F133_S1.8030.53
228_K321_W1.7780.52
127_L241_S1.7600.51
270_A324_Q1.7560.51
117_F193_G1.7360.50
266_T324_Q1.7300.50
82_D172_A1.7100.49
72_D77_K1.6870.48
207_S220_V1.6870.48
328_L331_V1.6830.48
69_F74_E1.6770.48
325_Q328_L1.6700.47
119_A288_E1.6670.47
132_I140_A1.6590.47
229_E322_K1.6510.46
68_E276_D1.6450.46
251_L328_L1.6240.45
179_K304_A1.6230.45
220_V321_W1.5960.44
122_G126_G1.5790.43
267_A271_A1.5590.43
129_A133_S1.5420.42
205_G321_W1.5290.41
232_Q322_K1.5220.41
117_F123_T1.5200.41
187_K246_W1.5190.41
183_V320_G1.4980.40
129_A193_G1.4940.40
126_G223_G1.4850.39
260_T313_E1.4430.38
228_K247_G1.4380.38
167_A258_D1.4340.37
180_T221_I1.4320.37
56_E59_A1.4280.37
125_L328_L1.4120.37
122_G188_F1.4060.36
254_S263_F1.3960.36
294_T298_E1.3680.35
225_A327_L1.3620.35
190_N242_D1.3500.34
182_A325_Q1.3490.34
225_A308_A1.3270.33
118_A186_G1.3260.33
99_K287_I1.3240.33
119_A314_D1.3180.33
108_V117_F1.2930.32
43_T83_P1.2910.32
133_S321_W1.2880.32
185_A244_E1.2790.31
110_R114_T1.2750.31
185_A316_S1.2710.31
106_K112_A1.2640.31
185_A188_F1.2600.31
194_A249_K1.2580.31
320_G323_A1.2550.31
201_L220_V1.2540.31
182_A219_Y1.2520.30
71_W74_E1.2420.30
285_E329_A1.2410.30
141_P179_K1.2380.30
188_F256_E1.2270.30
136_K244_E1.2240.29
174_T208_A1.2180.29
215_D239_I1.2150.29
117_F120_V1.2100.29
211_L225_A1.2090.29
188_F244_E1.2090.29
121_I178_Y1.2030.29
124_G181_Y1.1990.29
112_A170_Q1.1920.28
130_L201_L1.1900.28
138_A199_E1.1900.28
134_G253_L1.1880.28
140_A234_L1.1840.28
209_V239_I1.1810.28
223_G314_D1.1730.28
243_F247_G1.1730.28
284_V309_L1.1720.28
137_E242_D1.1660.27
84_K92_K1.1650.27
187_K220_V1.1590.27
261_D316_S1.1420.27
67_D73_S1.1400.27
141_P204_K1.1330.26
133_S246_W1.1320.26
81_E257_S1.1300.26
220_V294_T1.1230.26
124_G219_Y1.1200.26
234_L283_S1.1160.26
270_A286_K1.1110.26
232_Q245_A1.1070.25
224_L244_E1.1000.25
105_A114_T1.0960.25
187_K206_Y1.0920.25
99_K124_G1.0840.25
57_V68_E1.0710.24
105_A225_A1.0670.24
185_A249_K1.0570.24
76_D317_A1.0530.24
247_G320_G1.0470.24
182_A196_T1.0450.23
187_K250_E1.0400.23
149_G216_G1.0360.23
92_K183_V1.0350.23
99_K125_L1.0280.23
69_F73_S1.0230.23
107_P116_A1.0220.23
228_K313_E1.0210.23
185_A209_V1.0210.23
46_N54_E1.0000.22
184_Q188_F0.9980.22
118_A188_F0.9980.22
215_D246_W0.9950.22
169_K277_E0.9920.22
68_E74_E0.9910.22
105_A112_A0.9870.22
312_L325_Q0.9860.22
112_A331_V0.9850.22
113_A307_Q0.9800.22
117_F124_G0.9770.21
122_G186_G0.9740.21
245_A249_K0.9730.21
120_V132_I0.9630.21
56_E66_E0.9590.21
183_V306_L0.9580.21
213_K216_G0.9560.21
291_L319_A0.9490.21
234_L278_D0.9400.20
126_G186_G0.9380.20
320_G325_Q0.9380.20
98_A167_A0.9370.20
234_L274_I0.9340.20
109_K323_A0.9320.20
239_I330_V0.9310.20
215_D223_G0.9240.20
183_V270_A0.9240.20
209_V217_Y0.9240.20
321_W324_Q0.9240.20
42_M60_S0.9230.20
144_L296_A0.9180.20
181_Y219_Y0.9150.20
129_A217_Y0.9130.20
114_T220_V0.9100.20
100_G290_S0.9080.20
172_A287_I0.9020.19
102_T287_I0.8990.19
263_F306_L0.8970.19
132_I179_K0.8960.19
111_V188_F0.8940.19
81_E198_T0.8890.19
129_A220_V0.8890.19
124_G245_A0.8810.19
237_V274_I0.8810.19
270_A320_G0.8810.19
133_S176_G0.8800.19
203_E276_D0.8770.19
127_L132_I0.8750.19
194_A220_V0.8750.19
58_A66_E0.8740.19
204_K287_I0.8690.19
211_L250_E0.8650.18
211_L221_I0.8630.18
82_D90_Q0.8630.18
166_G170_Q0.8570.18
175_E330_V0.8560.18
109_K291_L0.8520.18
305_I324_Q0.8490.18
183_V304_A0.8480.18
292_G331_V0.8410.18
171_A288_E0.8380.18
43_T54_E0.8380.18
185_A212_S0.8380.18
174_T291_L0.8380.18
183_V233_Q0.8340.18
233_Q291_L0.8310.18
216_G302_K0.8290.18
81_E285_E0.8270.17
251_L325_Q0.8250.17
285_E318_E0.8240.17
121_I180_T0.8240.17
110_R321_W0.8220.17
121_I294_T0.8220.17
109_K121_I0.8210.17
238_L265_E0.8190.17
118_A130_L0.8160.17
130_L184_Q0.8160.17
175_E301_E0.8160.17
212_S218_T0.8110.17
255_I296_A0.8080.17
195_E253_L0.8060.17
232_Q330_V0.8040.17
247_G321_W0.8020.17
235_G306_L0.8000.17
113_A289_K0.7940.17
232_Q239_I0.7930.17
218_T290_S0.7920.17
58_A216_G0.7880.17
245_A305_I0.7860.16
58_A69_F0.7850.16
177_T306_L0.7840.16
253_L327_L0.7830.16
215_D247_G0.7810.16
125_L205_G0.7780.16
133_S228_K0.7780.16
114_T127_L0.7780.16
196_T296_A0.7770.16
255_I314_D0.7730.16
219_Y244_E0.7720.16
250_E326_E0.7720.16
44_F54_E0.7710.16
118_A249_K0.7700.16
184_Q249_K0.7700.16
47_W234_L0.7700.16
82_D273_A0.7650.16
187_K217_Y0.7640.16
233_Q288_E0.7640.16
67_D86_V0.7630.16
169_K223_G0.7620.16
191_E195_E0.7580.16
173_Q256_E0.7500.16
133_S326_E0.7470.16
200_Q235_G0.7450.16
269_L321_W0.7450.16
132_I188_F0.7440.16
76_D82_D0.7380.15
292_G295_K0.7370.15
231_S247_G0.7340.15
225_A301_E0.7340.15
97_Y244_E0.7310.15
110_R193_G0.7300.15
162_K277_E0.7280.15
87_P166_G0.7270.15
77_K80_K0.7260.15
256_E271_A0.7240.15
84_K166_G0.7190.15
119_A270_A0.7140.15
86_V90_Q0.7100.15
231_S330_V0.7080.15
147_S221_I0.7050.15
167_A270_A0.7020.15
216_G268_E0.7010.15
125_L199_E0.6940.14
117_F251_L0.6920.14
222_A225_A0.6910.14
209_V218_T0.6890.14
307_Q315_P0.6890.14
193_G251_L0.6870.14
190_N199_E0.6870.14
209_V249_K0.6860.14
173_Q212_S0.6820.14
86_V89_F0.6820.14
185_A261_D0.6800.14
185_A222_A0.6790.14
249_K311_E0.6770.14
105_A111_V0.6770.14
223_G312_L0.6760.14
69_F215_D0.6750.14
92_K325_Q0.6750.14
183_V235_G0.6740.14
291_L306_L0.6740.14
71_W239_I0.6730.14
182_A303_K0.6720.14
324_Q328_L0.6700.14
73_S193_G0.6680.14
109_K270_A0.6670.14
119_A322_K0.6670.14
194_A198_T0.6620.14
183_V328_L0.6600.14
114_T274_I0.6550.14
150_S236_Q0.6550.14
222_A245_A0.6530.14
192_K285_E0.6530.14
183_V316_S0.6520.14
175_E329_A0.6510.14
144_L147_S0.6500.14
189_S262_S0.6490.13
68_E71_W0.6470.13
225_A270_A0.6460.13
223_G231_S0.6420.13
192_K296_A0.6420.13
112_A327_L0.6310.13
105_A115_I0.6300.13
78_V90_Q0.6270.13
238_L316_S0.6210.13
41_S55_Q0.6180.13
180_T238_L0.6170.13
280_T283_S0.6080.13
120_V218_T0.6060.13
187_K193_G0.6060.13
184_Q223_G0.6050.13
118_A223_G0.6050.13
245_A250_E0.6030.13
121_I331_V0.6030.13
207_S271_A0.6020.13
121_I124_G0.6010.13
41_S270_A0.6010.13
125_L187_K0.6010.13
76_D143_S0.6010.13
323_A330_V0.6000.13
185_A219_Y0.5970.12
142_A148_L0.5970.12
92_K187_K0.5960.12
65_D75_E0.5940.12
246_W293_E0.5920.12
265_E305_I0.5890.12
108_V180_T0.5860.12
81_E323_A0.5850.12
239_I243_F0.5840.12
66_E221_I0.5830.12
135_N310_K0.5830.12
218_T233_Q0.5810.12
259_M283_S0.5800.12
238_L244_E0.5770.12
117_F301_E0.5770.12
119_A242_D0.5770.12
138_A281_K0.5710.12
183_V238_L0.5710.12
70_N222_A0.5710.12
127_L276_D0.5710.12
217_Y239_I0.5690.12
107_P114_T0.5680.12
189_S304_A0.5680.12
133_S180_T0.5680.12
183_V189_S0.5670.12
115_I125_L0.5670.12
128_F200_Q0.5660.12
243_F320_G0.5660.12
179_K201_L0.5640.12
66_E79_F0.5620.12
251_L287_I0.5600.12
108_V245_A0.5580.12
262_S288_E0.5580.12
83_P88_P0.5580.12
119_A226_S0.5540.12
253_L307_Q0.5520.12
121_I132_I0.5500.12
124_G178_Y0.5500.12
163_Q280_T0.5460.12
311_E323_A0.5450.12
111_V131_N0.5420.11
325_Q331_V0.5410.11
229_E245_A0.5400.11
94_T169_K0.5380.11
237_V295_K0.5360.11
45_S63_H0.5360.11
206_Y243_F0.5350.11
77_K282_A0.5350.11
79_F83_P0.5350.11
150_S238_L0.5330.11
220_V249_K0.5300.11
260_T302_K0.5300.11
74_E90_Q0.5290.11
207_S235_G0.5290.11
200_Q246_W0.5280.11
180_T295_K0.5260.11
134_G185_A0.5260.11
196_T242_D0.5250.11
159_S276_D0.5250.11
112_A189_S0.5240.11
46_N60_S0.5230.11
59_A68_E0.5210.11
78_V86_V0.5200.11
235_G250_E0.5180.11
280_T289_K0.5180.11
307_Q331_V0.5160.11
315_P331_V0.5140.11
126_G188_F0.5130.11
117_F217_Y0.5130.11
285_E289_K0.5120.11
102_T120_V0.5100.11
150_S159_S0.5080.11
127_L219_Y0.5070.11
221_I294_T0.5010.11
135_N294_T0.5010.11
207_S324_Q0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1x60A 1 0.238 98.1 0.89 Contact Map
1utaA 1 0.2319 98 0.894 Contact Map
2lfvA 1 0.3072 62.7 0.952 Contact Map
4ogqF 1 0.0964 38 0.959 Contact Map
1q90M 1 0.1024 31.4 0.96 Contact Map
2ls4A 1 0.0723 12.9 0.967 Contact Map
4i7zE 1 0.0843 11.4 0.968 Contact Map
2kwhA 1 0.1506 10.6 0.968 Contact Map
4hddA 6 0.1958 8.5 0.969 Contact Map
3rfyA 2 0.3343 8.4 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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