GREMLIN Database
YACP - Uncharacterized protein YacP
UniProt: P37574 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 170 (162)
Sequences: 943 (719)
Seq/√Len: 56.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_I50_V4.5611.00
11_M121_A4.5111.00
101_A124_L3.8261.00
11_M101_A3.7731.00
112_F118_R3.0521.00
2_D97_Q2.9111.00
101_A121_A2.6511.00
39_E132_E2.4351.00
32_V36_K2.4201.00
17_Q32_V2.4161.00
103_S121_A2.3001.00
36_K128_V2.2941.00
154_S157_V2.2781.00
5_L87_L2.2571.00
25_S28_E2.2441.00
159_K163_K2.2301.00
78_E86_K2.2181.00
74_T83_R1.8871.00
83_R87_L1.8721.00
125_L129_E1.8631.00
5_L88_A1.8500.99
4_L101_A1.8060.99
89_Q114_Q1.7210.99
15_W18_L1.7000.99
17_Q125_L1.6860.99
161_F164_W1.6110.99
34_I52_F1.5940.98
73_F131_I1.5740.98
88_A114_Q1.5560.98
160_T164_W1.5370.98
34_I71_V1.5140.98
126_R130_T1.5110.98
4_L124_L1.4820.97
39_E42_S1.4680.97
88_A116_A1.4600.97
65_T70_E1.4180.97
87_L91_L1.3840.96
91_L98_I1.3770.96
13_G22_K1.3730.96
59_G76_E1.3560.96
16_P125_L1.3480.96
72_I83_R1.3480.96
27_E31_D1.3380.95
37_M128_V1.3310.95
18_L29_A1.3100.95
97_Q117_L1.3060.95
36_K132_E1.2970.95
50_V69_V1.2880.94
14_A73_F1.2780.94
112_F116_A1.2670.94
135_I139_V1.2510.93
54_A78_E1.2460.93
43_Y135_I1.2450.93
102_T107_E1.2270.93
131_I135_I1.2140.92
34_I64_Q1.2110.92
79_T107_E1.2060.92
47_R70_E1.2040.92
108_Q118_R1.1700.91
112_F123_E1.1640.91
41_Q68_R1.1580.90
133_R136_E1.1460.90
99_H119_K1.1420.90
6_V37_M1.1300.89
37_M50_V1.1220.89
107_E116_A1.1190.89
119_K127_E1.1100.88
107_E111_I1.0290.84
20_D23_A1.0160.84
137_R145_E1.0110.83
11_M64_Q1.0090.83
138_R143_T1.0000.83
153_L161_F0.9810.81
93_N96_T0.9790.81
154_S160_T0.9780.81
88_A111_I0.9710.81
21_L29_A0.9700.81
6_V101_A0.9700.81
157_V160_T0.9570.80
86_K90_A0.9550.80
19_K23_A0.9490.79
88_A109_W0.9380.78
13_G26_F0.9370.78
37_M48_V0.9220.77
82_E106_T0.9200.77
24_N28_E0.9190.77
150_K164_W0.9170.77
75_K78_E0.9140.76
107_E118_R0.9070.76
142_I147_P0.9020.76
2_D41_Q0.8970.75
88_A113_G0.8860.74
99_H127_E0.8840.74
60_L63_K0.8840.74
56_L61_E0.8810.74
108_Q123_E0.8760.73
16_P19_K0.8750.73
7_D10_N0.8740.73
119_K163_K0.8720.73
136_E140_R0.8720.73
74_T79_T0.8710.73
50_V71_V0.8670.73
55_H74_T0.8660.73
41_Q101_A0.8610.72
88_A112_F0.8570.72
12_I26_F0.8540.71
126_R129_E0.8530.71
20_D32_V0.8500.71
110_A113_G0.8470.71
85_E107_E0.8460.71
67_H113_G0.8460.71
41_Q48_V0.8290.69
61_E75_K0.8260.69
107_E113_G0.8250.69
145_E155_E0.8210.68
129_E133_R0.8180.68
21_L32_V0.8150.68
61_E64_Q0.8150.68
150_K157_V0.7990.66
147_P150_K0.7940.66
26_F86_K0.7920.66
81_D104_D0.7900.65
44_T127_E0.7900.65
150_K153_L0.7890.65
11_M111_I0.7860.65
111_I132_E0.7840.65
3_I13_G0.7840.65
44_T82_E0.7810.65
137_R140_R0.7810.65
106_T110_A0.7760.64
34_I40_Y0.7750.64
57_V76_E0.7730.64
153_L158_L0.7660.63
57_V74_T0.7640.63
55_H77_N0.7550.62
59_G123_E0.7530.62
133_R137_R0.7530.62
90_A145_E0.7380.60
23_A143_T0.7360.60
15_W125_L0.7330.60
155_E160_T0.7330.60
34_I66_N0.7320.60
128_V148_A0.7300.59
68_R95_A0.7280.59
5_L49_I0.7140.58
143_T146_K0.7130.58
39_E135_I0.7070.57
54_A108_Q0.7050.57
15_W124_L0.6950.56
124_L127_E0.6870.55
108_Q112_F0.6830.54
79_T102_T0.6830.54
82_E88_A0.6810.54
119_K124_L0.6800.54
34_I65_T0.6790.54
15_W29_A0.6780.54
16_P26_F0.6730.53
8_G73_F0.6730.53
63_K110_A0.6700.53
16_P137_R0.6670.53
118_R123_E0.6650.52
42_S113_G0.6620.52
56_L92_N0.6590.52
38_A67_H0.6570.51
50_V55_H0.6560.51
132_E135_I0.6480.50
43_Y131_I0.6440.50
15_W128_V0.6420.50
122_R126_R0.6410.50
79_T85_E0.6380.49
23_A119_K0.6350.49
105_Y109_W0.6310.49
63_K70_E0.6300.49
8_G33_L0.6300.49
69_V113_G0.6240.48
20_D24_N0.6220.48
3_I76_E0.6210.48
61_E96_T0.6180.47
151_I161_F0.6170.47
54_A91_L0.6160.47
66_N71_V0.6140.47
98_I154_S0.6130.47
6_V124_L0.6110.46
11_M124_L0.6100.46
52_F71_V0.6090.46
5_L77_N0.6070.46
149_G152_A0.6060.46
136_E156_E0.6030.46
103_S120_S0.6030.46
3_I96_T0.5990.45
27_E110_A0.5970.45
141_K153_L0.5960.45
48_V69_V0.5950.45
46_N127_E0.5940.45
71_V78_E0.5930.45
73_F162_E0.5900.44
132_E164_W0.5840.44
156_E160_T0.5780.43
61_E118_R0.5780.43
138_R141_K0.5770.43
95_A98_I0.5770.43
139_V143_T0.5760.43
22_K55_H0.5760.43
43_Y116_A0.5750.43
130_T133_R0.5740.42
120_S127_E0.5730.42
4_L122_R0.5710.42
159_K164_W0.5700.42
134_R142_I0.5700.42
4_L40_Y0.5690.42
5_L51_V0.5680.42
20_D71_V0.5670.42
31_D133_R0.5660.42
140_R148_A0.5640.41
153_L157_V0.5590.41
138_R142_I0.5580.41
146_K151_I0.5570.41
5_L114_Q0.5550.40
18_L22_K0.5480.40
130_T144_S0.5450.39
85_E108_Q0.5450.39
5_L89_Q0.5380.39
74_T85_E0.5380.39
130_T134_R0.5350.38
76_E92_N0.5330.38
152_A161_F0.5320.38
14_A18_L0.5310.38
32_V35_Q0.5260.37
46_N113_G0.5250.37
11_M37_M0.5200.37
5_L113_G0.5150.36
73_F120_S0.5110.36
156_E159_K0.5110.36
8_G75_K0.5100.36
32_V152_A0.5080.36
62_K141_K0.5070.36
157_V162_E0.5040.35
137_R159_K0.5040.35
140_R163_K0.5030.35
26_F31_D0.5010.35
39_E83_R0.5000.35
3_I42_S0.5000.35
100_V123_E0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h7iA 1 0.8706 96.8 0.872 Contact Map
1exnA 1 0.8588 96 0.883 Contact Map
1bgxT 1 0.8471 96 0.884 Contact Map
3zdbA 1 0.8 96 0.884 Contact Map
3oryA 3 0.9294 91.3 0.905 Contact Map
2izoA 1 0.8412 89.8 0.908 Contact Map
3v32B 1 0.7882 89.2 0.909 Contact Map
4q0wA 1 0.8529 89.1 0.91 Contact Map
1rxwA 1 0.9059 88.9 0.91 Contact Map
4wa8A 1 0.9059 88.2 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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