DISA - BACSU - GREMLIN Contacts

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DISA - DNA integrity scanning protein DisA

UniProt:	P37573	Sequences: MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIVVGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATISSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAIQTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTEGHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKLLGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEGIGEVRAQKIKKGLKRLQEKHYLDRQL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	360 (348)
Sequences:	460 (281)
Seq/√Len:	15.1

BACSU - DISA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
74_A	80_I	5.054	1.00
195_M	273_V	4.433	1.00
104_S	109_M	4.228	1.00
64_A	88_K	3.986	1.00
102_I	119_K	3.772	1.00
304_P	339_R	3.616	0.99
188_F	279_Y	3.544	0.99
55_V	94_T	3.496	0.99
83_S	87_Q	3.304	0.99
207_E	220_H	3.007	0.98
103_S	119_K	2.834	0.97
81_I	134_V	2.733	0.96
233_M	342_K	2.594	0.95
336_G	339_R	2.485	0.94
31_M	196_H	2.465	0.93
315_F	332_V	2.449	0.93
165_K	224_L	2.424	0.93
47_Y	52_K	2.416	0.93
179_A	358_R	2.407	0.92
328_E	331_E	2.368	0.92
71_Y	131_R	2.290	0.90
192_L	273_V	2.283	0.90
37_A	132_R	2.093	0.86
202_L	292_R	2.092	0.86
71_Y	132_R	2.058	0.85
31_M	41_G	2.053	0.85
163_L	208_I	2.045	0.84
56_D	93_N	2.043	0.84
188_F	356_L	1.989	0.83
149_I	218_E	1.973	0.82
79_A	96_L	1.958	0.82
60_H	91_Y	1.943	0.81
55_V	91_Y	1.917	0.80
342_K	354_H	1.901	0.80
37_A	71_Y	1.897	0.79
304_P	307_I	1.887	0.79
307_I	339_R	1.885	0.79
236_E	299_K	1.852	0.78
66_S	154_T	1.832	0.77
263_S	266_D	1.826	0.77
18_L	21_V	1.824	0.77
31_M	135_I	1.780	0.75
64_A	309_E	1.756	0.74
12_L	88_K	1.746	0.73
109_M	127_A	1.732	0.73
124_L	131_R	1.698	0.71
194_V	346_G	1.683	0.71
165_K	228_E	1.662	0.70
104_S	331_E	1.643	0.69
172_K	194_V	1.636	0.68
227_I	260_Q	1.634	0.68
31_M	270_D	1.605	0.67
333_E	336_G	1.594	0.66
192_L	356_L	1.567	0.65
60_H	63_T	1.565	0.65
26_P	103_S	1.564	0.65
65_F	184_E	1.552	0.64
171_D	289_V	1.551	0.64
146_L	164_E	1.550	0.64
65_F	178_N	1.540	0.63
178_N	183_E	1.511	0.62
183_E	358_R	1.510	0.62
150_G	154_T	1.495	0.61
48_N	52_K	1.486	0.61
221_L	339_R	1.465	0.59
190_D	285_L	1.456	0.59
167_K	171_D	1.431	0.58
30_G	61_I	1.428	0.57
31_M	275_K	1.425	0.57
233_M	325_S	1.389	0.55
175_N	357_D	1.388	0.55
30_G	35_L	1.386	0.55
22_A	137_L	1.381	0.55
21_V	137_L	1.381	0.55
170_L	346_G	1.371	0.54
126_I	309_E	1.370	0.54
191_V	325_S	1.370	0.54
54_V	148_D	1.363	0.54
62_N	88_K	1.360	0.54
184_E	319_P	1.359	0.54
185_L	342_K	1.332	0.52
41_G	227_I	1.314	0.51
198_Y	237_A	1.310	0.51
22_A	186_V	1.306	0.51
197_R	220_H	1.305	0.50
83_S	203_R	1.302	0.50
180_L	185_L	1.300	0.50
172_K	357_D	1.295	0.50
195_M	230_I	1.282	0.49
324_A	332_V	1.280	0.49
17_I	139_Q	1.278	0.49
54_V	258_E	1.269	0.48
66_S	276_L	1.269	0.48
163_L	201_V	1.258	0.48
49_D	99_D	1.256	0.48
122_G	212_I	1.251	0.47
184_E	290_L	1.251	0.47
157_N	332_V	1.250	0.47
56_D	109_M	1.247	0.47
80_I	144_Y	1.245	0.47
132_R	182_F	1.240	0.47
289_V	326_A	1.238	0.47
126_I	333_E	1.229	0.46
196_H	270_D	1.224	0.46
126_I	227_I	1.219	0.46
66_S	69_H	1.211	0.45
221_L	304_P	1.210	0.45
47_Y	81_I	1.210	0.45
174_I	212_I	1.209	0.45
56_D	133_N	1.207	0.45
190_D	356_L	1.206	0.45
83_S	86_G	1.205	0.45
304_P	337_E	1.196	0.44
316_G	357_D	1.196	0.44
196_H	342_K	1.193	0.44
18_L	39_T	1.188	0.44
135_I	326_A	1.183	0.44
94_T	230_I	1.179	0.43
242_K	318_L	1.179	0.43
12_L	16_S	1.179	0.43
33_N	71_Y	1.178	0.43
124_L	132_R	1.176	0.43
230_I	308_V	1.176	0.43
159_A	166_Y	1.173	0.43
103_S	292_R	1.170	0.43
267_L	349_R	1.169	0.43
178_N	354_H	1.169	0.43
74_A	135_I	1.167	0.43
160_I	275_K	1.166	0.43
126_I	283_T	1.161	0.42
61_I	322_I	1.159	0.42
81_I	283_T	1.158	0.42
172_K	355_Y	1.151	0.42
131_R	169_I	1.150	0.42
16_S	350_L	1.150	0.42
47_Y	51_V	1.150	0.42
65_F	104_S	1.146	0.42
83_S	137_L	1.145	0.42
126_I	235_E	1.141	0.41
44_V	267_L	1.135	0.41
47_Y	212_I	1.123	0.40
14_L	258_E	1.119	0.40
138_Y	346_G	1.111	0.40
86_G	126_I	1.109	0.40
241_I	259_L	1.105	0.39
71_Y	124_L	1.105	0.39
212_I	226_V	1.104	0.39
206_N	266_D	1.099	0.39
41_G	310_N	1.091	0.39
107_T	212_I	1.089	0.39
86_G	210_M	1.087	0.38
26_P	66_S	1.084	0.38
29_A	115_E	1.080	0.38
33_N	131_R	1.078	0.38
152_I	167_K	1.075	0.38
18_L	146_L	1.075	0.38
143_K	311_V	1.074	0.38
113_T	117_V	1.074	0.38
39_T	130_E	1.074	0.38
254_V	257_K	1.072	0.38
49_D	53_E	1.071	0.38
32_E	36_R	1.070	0.38
53_E	357_D	1.066	0.37
56_D	104_S	1.064	0.37
96_L	318_L	1.059	0.37
258_E	261_D	1.059	0.37
197_R	207_E	1.056	0.37
128_I	169_I	1.054	0.37
33_N	169_I	1.049	0.36
107_T	202_L	1.047	0.36
269_D	303_L	1.042	0.36
56_D	82_L	1.042	0.36
93_N	136_T	1.036	0.36
74_A	326_A	1.035	0.36
31_M	342_K	1.035	0.36
161_Q	307_I	1.034	0.36
57_G	83_S	1.033	0.36
185_L	188_F	1.032	0.36
38_N	83_S	1.024	0.35
332_V	337_E	1.022	0.35
211_Y	221_L	1.014	0.35
104_S	262_M	1.012	0.35
81_I	312_V	1.007	0.34
316_G	335_I	1.002	0.34
285_L	356_L	1.001	0.34
179_A	354_H	1.000	0.34
80_I	90_L	0.998	0.34
304_P	333_E	0.997	0.34
109_M	196_H	0.993	0.34
133_N	154_T	0.992	0.34
188_F	289_V	0.986	0.33
65_F	358_R	0.984	0.33
231_T	298_N	0.982	0.33
57_G	203_R	0.981	0.33
74_A	144_Y	0.978	0.33
285_L	289_V	0.977	0.33
176_A	185_L	0.975	0.33
119_K	141_N	0.974	0.33
82_L	86_G	0.970	0.32
186_V	240_F	0.967	0.32
125_V	297_L	0.966	0.32
121_T	336_G	0.965	0.32
49_D	269_D	0.958	0.32
34_V	70_L	0.954	0.32
350_L	357_D	0.954	0.32
52_K	69_H	0.952	0.32
127_A	274_Y	0.952	0.32
43_I	168_T	0.947	0.31
61_I	160_I	0.946	0.31
242_K	309_E	0.941	0.31
64_A	85_S	0.940	0.31
130_E	146_L	0.940	0.31
132_R	310_N	0.939	0.31
34_V	195_M	0.939	0.31
183_E	231_T	0.934	0.31
274_Y	316_G	0.929	0.30
127_A	138_Y	0.929	0.30
127_A	319_P	0.928	0.30
185_L	201_V	0.928	0.30
25_T	54_V	0.927	0.30
262_M	276_L	0.919	0.30
174_I	338_V	0.918	0.30
241_I	252_P	0.917	0.30
113_T	339_R	0.917	0.30
122_G	292_R	0.916	0.30
15_S	210_M	0.911	0.30
113_T	135_I	0.910	0.30
50_K	88_K	0.908	0.29
212_I	349_R	0.908	0.29
32_E	355_Y	0.903	0.29
244_Y	291_P	0.903	0.29
33_N	132_R	0.898	0.29
247_E	265_Y	0.893	0.29
126_I	135_I	0.891	0.29
46_G	152_I	0.883	0.28
132_R	169_I	0.883	0.28
74_A	161_Q	0.874	0.28
227_I	286_D	0.872	0.28
26_P	62_N	0.872	0.28
146_L	236_E	0.871	0.28
126_I	145_T	0.870	0.28
20_F	137_L	0.868	0.28
62_N	84_D	0.866	0.28
159_A	211_Y	0.862	0.27
273_V	294_Y	0.860	0.27
107_T	353_K	0.858	0.27
136_T	343_I	0.856	0.27
138_Y	172_K	0.852	0.27
150_G	259_L	0.852	0.27
294_Y	311_V	0.847	0.27
54_V	86_G	0.847	0.27
180_L	221_L	0.847	0.27
167_K	333_E	0.843	0.26
172_K	179_A	0.840	0.26
274_Y	350_L	0.840	0.26
68_A	97_M	0.839	0.26
138_Y	208_I	0.838	0.26
44_V	67_P	0.835	0.26
313_E	316_G	0.829	0.26
224_L	310_N	0.828	0.26
43_I	298_N	0.826	0.26
199_E	208_I	0.823	0.26
310_N	330_D	0.823	0.26
27_L	348_K	0.822	0.26
86_G	298_N	0.821	0.26
308_V	312_V	0.817	0.25
85_S	126_I	0.815	0.25
70_L	155_K	0.807	0.25
164_E	214_E	0.806	0.25
91_Y	167_K	0.803	0.25
85_S	88_K	0.803	0.25
81_I	184_E	0.802	0.25
160_I	213_K	0.801	0.25
162_T	229_L	0.795	0.24
140_E	254_V	0.791	0.24
175_N	358_R	0.791	0.24
12_L	258_E	0.791	0.24
69_H	321_I	0.789	0.24
119_K	140_E	0.788	0.24
329_L	339_R	0.787	0.24
252_P	312_V	0.784	0.24
286_D	350_L	0.782	0.24
34_V	55_V	0.779	0.24
204_I	207_E	0.779	0.24
136_T	191_V	0.777	0.24
85_S	109_M	0.776	0.24
179_A	185_L	0.776	0.24
314_A	328_E	0.774	0.24
128_I	330_D	0.774	0.24
262_M	272_I	0.767	0.23
250_K	259_L	0.766	0.23
294_Y	312_V	0.764	0.23
45_V	124_L	0.763	0.23
332_V	336_G	0.762	0.23
132_R	224_L	0.761	0.23
109_M	342_K	0.760	0.23
185_L	303_L	0.758	0.23
130_E	299_K	0.755	0.23
204_I	266_D	0.755	0.23
178_N	311_V	0.753	0.23
170_L	198_Y	0.752	0.23
117_V	211_Y	0.752	0.23
210_M	227_I	0.750	0.23
45_V	313_E	0.750	0.23
69_H	107_T	0.749	0.23
33_N	124_L	0.744	0.22
124_L	202_L	0.744	0.22
179_A	313_E	0.742	0.22
38_N	133_N	0.741	0.22
310_N	332_V	0.739	0.22
23_P	40_G	0.735	0.22
24_G	40_G	0.735	0.22
163_L	222_I	0.733	0.22
35_L	332_V	0.732	0.22
312_V	322_I	0.731	0.22
146_L	291_P	0.730	0.22
311_V	332_V	0.729	0.22
63_T	143_K	0.729	0.22
104_S	303_L	0.726	0.22
30_G	196_H	0.723	0.22
56_D	169_I	0.722	0.22
172_K	358_R	0.721	0.21
83_S	356_L	0.720	0.21
35_L	184_E	0.719	0.21
116_R	225_Q	0.718	0.21
81_I	160_I	0.718	0.21
330_D	333_E	0.714	0.21
71_Y	165_K	0.714	0.21
91_Y	154_T	0.713	0.21
54_V	333_E	0.712	0.21
81_I	121_T	0.712	0.21
204_I	232_D	0.709	0.21
121_T	257_K	0.709	0.21
22_A	46_G	0.708	0.21
95_Q	157_N	0.708	0.21
147_K	222_I	0.706	0.21
149_I	222_I	0.705	0.21
340_A	343_I	0.705	0.21
128_I	131_R	0.705	0.21
113_T	221_L	0.703	0.21
196_H	354_H	0.703	0.21
63_T	328_E	0.703	0.21
323_E	328_E	0.701	0.21
304_P	340_A	0.700	0.21
242_K	300_I	0.699	0.21
153_L	163_L	0.693	0.20
132_R	165_K	0.692	0.20
29_A	34_V	0.691	0.20
289_V	317_V	0.690	0.20
303_L	308_V	0.689	0.20
227_I	319_P	0.688	0.20
14_L	313_E	0.688	0.20
88_K	113_T	0.688	0.20
179_A	183_E	0.687	0.20
148_D	347_L	0.687	0.20
122_G	126_I	0.686	0.20
99_D	117_V	0.685	0.20
29_A	233_M	0.684	0.20
69_H	217_T	0.683	0.20
180_L	264_S	0.681	0.20
154_T	300_I	0.681	0.20
84_D	312_V	0.675	0.20
172_K	189_S	0.675	0.20
167_K	338_V	0.672	0.20
235_E	312_V	0.671	0.20
229_L	239_L	0.670	0.20
153_L	207_E	0.670	0.20
171_D	267_L	0.667	0.20
64_A	69_H	0.667	0.20
200_M	211_Y	0.666	0.19
71_Y	310_N	0.664	0.19
125_V	138_Y	0.659	0.19
206_N	292_R	0.659	0.19
218_E	222_I	0.657	0.19
30_G	169_I	0.657	0.19
236_E	279_Y	0.657	0.19
279_Y	289_V	0.656	0.19
188_F	192_L	0.649	0.19
334_G	340_A	0.647	0.19
196_H	200_M	0.646	0.19
178_N	358_R	0.645	0.19
16_S	82_L	0.644	0.19
185_L	264_S	0.643	0.19
173_T	196_H	0.642	0.19
27_L	86_G	0.641	0.19
151_F	292_R	0.639	0.19
294_Y	343_I	0.639	0.19
21_V	167_K	0.639	0.19
35_L	199_E	0.639	0.19
240_F	259_L	0.637	0.18
304_P	329_L	0.635	0.18
324_A	346_G	0.633	0.18
204_I	322_I	0.631	0.18
134_V	288_Y	0.631	0.18
154_T	167_K	0.631	0.18
184_E	350_L	0.629	0.18
137_L	346_G	0.628	0.18
171_D	239_L	0.628	0.18
180_L	339_R	0.627	0.18
203_R	229_L	0.622	0.18
245_V	255_L	0.621	0.18
329_L	343_I	0.621	0.18
22_A	292_R	0.619	0.18
191_V	326_A	0.619	0.18
91_Y	94_T	0.616	0.18
54_V	259_L	0.616	0.18
27_L	356_L	0.614	0.18
71_Y	169_I	0.612	0.18
22_A	275_K	0.612	0.18
151_F	202_L	0.608	0.18
63_T	160_I	0.607	0.17
41_G	127_A	0.607	0.17
46_G	146_L	0.605	0.17
179_A	351_Q	0.602	0.17
95_Q	182_F	0.601	0.17
80_I	268_L	0.600	0.17
140_E	325_S	0.598	0.17
310_N	337_E	0.597	0.17
21_V	350_L	0.594	0.17
68_A	107_T	0.594	0.17
240_F	248_K	0.593	0.17
59_F	166_Y	0.592	0.17
46_G	197_R	0.591	0.17
57_G	156_A	0.590	0.17
346_G	350_L	0.588	0.17
158_Q	228_E	0.588	0.17
63_T	124_L	0.588	0.17
62_N	247_E	0.587	0.17
41_G	275_K	0.587	0.17
65_F	321_I	0.587	0.17
71_Y	182_F	0.587	0.17
298_N	311_V	0.586	0.17
26_P	70_L	0.586	0.17
158_Q	256_L	0.584	0.17
175_N	356_L	0.583	0.17
37_A	182_F	0.583	0.17
37_A	319_P	0.581	0.17
74_A	311_V	0.580	0.17
152_I	302_R	0.580	0.17
90_L	200_M	0.579	0.17
163_L	211_Y	0.577	0.17
220_H	345_K	0.576	0.16
188_F	273_V	0.575	0.16
39_T	162_T	0.575	0.16
304_P	336_G	0.574	0.16
30_G	157_N	0.574	0.16
85_S	273_V	0.573	0.16
81_I	332_V	0.573	0.16
170_L	194_V	0.572	0.16
226_V	303_L	0.569	0.16
88_K	253_F	0.569	0.16
14_L	252_P	0.569	0.16
142_M	194_V	0.566	0.16
11_E	184_E	0.565	0.16
47_Y	143_K	0.565	0.16
147_K	234_E	0.563	0.16
265_Y	309_E	0.562	0.16
200_M	347_L	0.562	0.16
80_I	284_N	0.560	0.16
66_S	123_C	0.559	0.16
35_L	311_V	0.558	0.16
62_N	189_S	0.558	0.16
314_A	327_E	0.558	0.16
240_F	345_K	0.557	0.16
81_I	236_E	0.556	0.16
247_E	257_K	0.554	0.16
80_I	280_P	0.554	0.16
53_E	137_L	0.554	0.16
121_T	201_V	0.554	0.16
43_I	263_S	0.548	0.16
83_S	97_M	0.548	0.16
70_L	245_V	0.545	0.16
240_F	268_L	0.543	0.15
251_D	257_K	0.543	0.15
267_L	347_L	0.543	0.15
153_L	353_K	0.542	0.15
37_A	131_R	0.539	0.15
188_F	210_M	0.539	0.15
184_E	299_K	0.537	0.15
101_T	317_V	0.535	0.15
49_D	60_H	0.535	0.15
185_L	356_L	0.530	0.15
161_Q	183_E	0.530	0.15
33_N	56_D	0.528	0.15
95_Q	298_N	0.527	0.15
307_I	337_E	0.527	0.15
65_F	183_E	0.526	0.15
22_A	32_E	0.526	0.15
149_I	155_K	0.525	0.15
235_E	288_Y	0.524	0.15
242_K	355_Y	0.522	0.15
24_G	28_R	0.521	0.15
23_P	28_R	0.521	0.15
30_G	199_E	0.521	0.15
112_R	197_R	0.520	0.15
154_T	328_E	0.519	0.15
99_D	356_L	0.518	0.15
11_E	253_F	0.517	0.15
58_G	75_K	0.517	0.15
162_T	226_V	0.516	0.15
145_T	213_K	0.516	0.15
173_T	270_D	0.514	0.15
11_E	88_K	0.512	0.15
217_T	288_Y	0.512	0.15
177_L	347_L	0.512	0.15
205_K	230_I	0.511	0.15
90_L	186_V	0.510	0.15
74_A	146_L	0.510	0.15
90_L	242_K	0.507	0.14
107_T	131_R	0.506	0.14
70_L	271_S	0.506	0.14
168_T	247_E	0.506	0.14
227_I	326_A	0.504	0.14
195_M	265_Y	0.504	0.14
13_D	226_V	0.503	0.14
147_K	152_I	0.503	0.14
344_K	352_E	0.502	0.14
14_L	306_P	0.502	0.14
54_V	130_E	0.500	0.14
281_A	351_Q	0.500	0.14
89_I	93_N	0.500	0.14
62_N	257_K	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3c1yA	5	0.9528	100	0.328	Contact Map
2fb5A	3	0.4028	100	0.764	Contact Map
4rv7A	1	0.4222	100	0.774	Contact Map
4gfjA	1	0.6833	99.2	0.914	Contact Map
1vq8Y	1	0	98.2	0.938	Contact Map
2a1jB	2	0.2194	98.1	0.941	Contact Map
1z00A	1	0.2278	98	0.942	Contact Map
1z00B	1	0.225	97.7	0.945	Contact Map
1kftA	1	0.1556	97.7	0.946	Contact Map
1x2iA	2	0.1889	97.7	0.946	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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