GREMLIN Database
DISA - DNA integrity scanning protein DisA
UniProt: P37573 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 360 (348)
Sequences: 460 (281)
Seq/√Len: 15.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_A80_I5.0541.00
195_M273_V4.4331.00
104_S109_M4.2281.00
64_A88_K3.9861.00
102_I119_K3.7721.00
304_P339_R3.6160.99
188_F279_Y3.5440.99
55_V94_T3.4960.99
83_S87_Q3.3040.99
207_E220_H3.0070.98
103_S119_K2.8340.97
81_I134_V2.7330.96
233_M342_K2.5940.95
336_G339_R2.4850.94
31_M196_H2.4650.93
315_F332_V2.4490.93
165_K224_L2.4240.93
47_Y52_K2.4160.93
179_A358_R2.4070.92
328_E331_E2.3680.92
71_Y131_R2.2900.90
192_L273_V2.2830.90
37_A132_R2.0930.86
202_L292_R2.0920.86
71_Y132_R2.0580.85
31_M41_G2.0530.85
163_L208_I2.0450.84
56_D93_N2.0430.84
188_F356_L1.9890.83
149_I218_E1.9730.82
79_A96_L1.9580.82
60_H91_Y1.9430.81
55_V91_Y1.9170.80
342_K354_H1.9010.80
37_A71_Y1.8970.79
304_P307_I1.8870.79
307_I339_R1.8850.79
236_E299_K1.8520.78
66_S154_T1.8320.77
263_S266_D1.8260.77
18_L21_V1.8240.77
31_M135_I1.7800.75
64_A309_E1.7560.74
12_L88_K1.7460.73
109_M127_A1.7320.73
124_L131_R1.6980.71
194_V346_G1.6830.71
165_K228_E1.6620.70
104_S331_E1.6430.69
172_K194_V1.6360.68
227_I260_Q1.6340.68
31_M270_D1.6050.67
333_E336_G1.5940.66
192_L356_L1.5670.65
60_H63_T1.5650.65
26_P103_S1.5640.65
65_F184_E1.5520.64
171_D289_V1.5510.64
146_L164_E1.5500.64
65_F178_N1.5400.63
178_N183_E1.5110.62
183_E358_R1.5100.62
150_G154_T1.4950.61
48_N52_K1.4860.61
221_L339_R1.4650.59
190_D285_L1.4560.59
167_K171_D1.4310.58
30_G61_I1.4280.57
31_M275_K1.4250.57
233_M325_S1.3890.55
175_N357_D1.3880.55
30_G35_L1.3860.55
22_A137_L1.3810.55
21_V137_L1.3810.55
170_L346_G1.3710.54
126_I309_E1.3700.54
191_V325_S1.3700.54
54_V148_D1.3630.54
62_N88_K1.3600.54
184_E319_P1.3590.54
185_L342_K1.3320.52
41_G227_I1.3140.51
198_Y237_A1.3100.51
22_A186_V1.3060.51
197_R220_H1.3050.50
83_S203_R1.3020.50
180_L185_L1.3000.50
172_K357_D1.2950.50
195_M230_I1.2820.49
324_A332_V1.2800.49
17_I139_Q1.2780.49
54_V258_E1.2690.48
66_S276_L1.2690.48
163_L201_V1.2580.48
49_D99_D1.2560.48
122_G212_I1.2510.47
184_E290_L1.2510.47
157_N332_V1.2500.47
56_D109_M1.2470.47
80_I144_Y1.2450.47
132_R182_F1.2400.47
289_V326_A1.2380.47
126_I333_E1.2290.46
196_H270_D1.2240.46
126_I227_I1.2190.46
66_S69_H1.2110.45
221_L304_P1.2100.45
47_Y81_I1.2100.45
174_I212_I1.2090.45
56_D133_N1.2070.45
190_D356_L1.2060.45
83_S86_G1.2050.45
304_P337_E1.1960.44
316_G357_D1.1960.44
196_H342_K1.1930.44
18_L39_T1.1880.44
135_I326_A1.1830.44
94_T230_I1.1790.43
242_K318_L1.1790.43
12_L16_S1.1790.43
33_N71_Y1.1780.43
124_L132_R1.1760.43
230_I308_V1.1760.43
159_A166_Y1.1730.43
103_S292_R1.1700.43
267_L349_R1.1690.43
178_N354_H1.1690.43
74_A135_I1.1670.43
160_I275_K1.1660.43
126_I283_T1.1610.42
61_I322_I1.1590.42
81_I283_T1.1580.42
172_K355_Y1.1510.42
131_R169_I1.1500.42
16_S350_L1.1500.42
47_Y51_V1.1500.42
65_F104_S1.1460.42
83_S137_L1.1450.42
126_I235_E1.1410.41
44_V267_L1.1350.41
47_Y212_I1.1230.40
14_L258_E1.1190.40
138_Y346_G1.1110.40
86_G126_I1.1090.40
241_I259_L1.1050.39
71_Y124_L1.1050.39
212_I226_V1.1040.39
206_N266_D1.0990.39
41_G310_N1.0910.39
107_T212_I1.0890.39
86_G210_M1.0870.38
26_P66_S1.0840.38
29_A115_E1.0800.38
33_N131_R1.0780.38
152_I167_K1.0750.38
18_L146_L1.0750.38
143_K311_V1.0740.38
113_T117_V1.0740.38
39_T130_E1.0740.38
254_V257_K1.0720.38
49_D53_E1.0710.38
32_E36_R1.0700.38
53_E357_D1.0660.37
56_D104_S1.0640.37
96_L318_L1.0590.37
258_E261_D1.0590.37
197_R207_E1.0560.37
128_I169_I1.0540.37
33_N169_I1.0490.36
107_T202_L1.0470.36
269_D303_L1.0420.36
56_D82_L1.0420.36
93_N136_T1.0360.36
74_A326_A1.0350.36
31_M342_K1.0350.36
161_Q307_I1.0340.36
57_G83_S1.0330.36
185_L188_F1.0320.36
38_N83_S1.0240.35
332_V337_E1.0220.35
211_Y221_L1.0140.35
104_S262_M1.0120.35
81_I312_V1.0070.34
316_G335_I1.0020.34
285_L356_L1.0010.34
179_A354_H1.0000.34
80_I90_L0.9980.34
304_P333_E0.9970.34
109_M196_H0.9930.34
133_N154_T0.9920.34
188_F289_V0.9860.33
65_F358_R0.9840.33
231_T298_N0.9820.33
57_G203_R0.9810.33
74_A144_Y0.9780.33
285_L289_V0.9770.33
176_A185_L0.9750.33
119_K141_N0.9740.33
82_L86_G0.9700.32
186_V240_F0.9670.32
125_V297_L0.9660.32
121_T336_G0.9650.32
49_D269_D0.9580.32
34_V70_L0.9540.32
350_L357_D0.9540.32
52_K69_H0.9520.32
127_A274_Y0.9520.32
43_I168_T0.9470.31
61_I160_I0.9460.31
242_K309_E0.9410.31
64_A85_S0.9400.31
130_E146_L0.9400.31
132_R310_N0.9390.31
34_V195_M0.9390.31
183_E231_T0.9340.31
274_Y316_G0.9290.30
127_A138_Y0.9290.30
127_A319_P0.9280.30
185_L201_V0.9280.30
25_T54_V0.9270.30
262_M276_L0.9190.30
174_I338_V0.9180.30
241_I252_P0.9170.30
113_T339_R0.9170.30
122_G292_R0.9160.30
15_S210_M0.9110.30
113_T135_I0.9100.30
50_K88_K0.9080.29
212_I349_R0.9080.29
32_E355_Y0.9030.29
244_Y291_P0.9030.29
33_N132_R0.8980.29
247_E265_Y0.8930.29
126_I135_I0.8910.29
46_G152_I0.8830.28
132_R169_I0.8830.28
74_A161_Q0.8740.28
227_I286_D0.8720.28
26_P62_N0.8720.28
146_L236_E0.8710.28
126_I145_T0.8700.28
20_F137_L0.8680.28
62_N84_D0.8660.28
159_A211_Y0.8620.27
273_V294_Y0.8600.27
107_T353_K0.8580.27
136_T343_I0.8560.27
138_Y172_K0.8520.27
150_G259_L0.8520.27
294_Y311_V0.8470.27
54_V86_G0.8470.27
180_L221_L0.8470.27
167_K333_E0.8430.26
172_K179_A0.8400.26
274_Y350_L0.8400.26
68_A97_M0.8390.26
138_Y208_I0.8380.26
44_V67_P0.8350.26
313_E316_G0.8290.26
224_L310_N0.8280.26
43_I298_N0.8260.26
199_E208_I0.8230.26
310_N330_D0.8230.26
27_L348_K0.8220.26
86_G298_N0.8210.26
308_V312_V0.8170.25
85_S126_I0.8150.25
70_L155_K0.8070.25
164_E214_E0.8060.25
91_Y167_K0.8030.25
85_S88_K0.8030.25
81_I184_E0.8020.25
160_I213_K0.8010.25
162_T229_L0.7950.24
140_E254_V0.7910.24
175_N358_R0.7910.24
12_L258_E0.7910.24
69_H321_I0.7890.24
119_K140_E0.7880.24
329_L339_R0.7870.24
252_P312_V0.7840.24
286_D350_L0.7820.24
34_V55_V0.7790.24
204_I207_E0.7790.24
136_T191_V0.7770.24
85_S109_M0.7760.24
179_A185_L0.7760.24
314_A328_E0.7740.24
128_I330_D0.7740.24
262_M272_I0.7670.23
250_K259_L0.7660.23
294_Y312_V0.7640.23
45_V124_L0.7630.23
332_V336_G0.7620.23
132_R224_L0.7610.23
109_M342_K0.7600.23
185_L303_L0.7580.23
130_E299_K0.7550.23
204_I266_D0.7550.23
178_N311_V0.7530.23
170_L198_Y0.7520.23
117_V211_Y0.7520.23
210_M227_I0.7500.23
45_V313_E0.7500.23
69_H107_T0.7490.23
33_N124_L0.7440.22
124_L202_L0.7440.22
179_A313_E0.7420.22
38_N133_N0.7410.22
310_N332_V0.7390.22
23_P40_G0.7350.22
24_G40_G0.7350.22
163_L222_I0.7330.22
35_L332_V0.7320.22
312_V322_I0.7310.22
146_L291_P0.7300.22
311_V332_V0.7290.22
63_T143_K0.7290.22
104_S303_L0.7260.22
30_G196_H0.7230.22
56_D169_I0.7220.22
172_K358_R0.7210.21
83_S356_L0.7200.21
35_L184_E0.7190.21
116_R225_Q0.7180.21
81_I160_I0.7180.21
330_D333_E0.7140.21
71_Y165_K0.7140.21
91_Y154_T0.7130.21
54_V333_E0.7120.21
81_I121_T0.7120.21
204_I232_D0.7090.21
121_T257_K0.7090.21
22_A46_G0.7080.21
95_Q157_N0.7080.21
147_K222_I0.7060.21
149_I222_I0.7050.21
340_A343_I0.7050.21
128_I131_R0.7050.21
113_T221_L0.7030.21
196_H354_H0.7030.21
63_T328_E0.7030.21
323_E328_E0.7010.21
304_P340_A0.7000.21
242_K300_I0.6990.21
153_L163_L0.6930.20
132_R165_K0.6920.20
29_A34_V0.6910.20
289_V317_V0.6900.20
303_L308_V0.6890.20
227_I319_P0.6880.20
14_L313_E0.6880.20
88_K113_T0.6880.20
179_A183_E0.6870.20
148_D347_L0.6870.20
122_G126_I0.6860.20
99_D117_V0.6850.20
29_A233_M0.6840.20
69_H217_T0.6830.20
180_L264_S0.6810.20
154_T300_I0.6810.20
84_D312_V0.6750.20
172_K189_S0.6750.20
167_K338_V0.6720.20
235_E312_V0.6710.20
229_L239_L0.6700.20
153_L207_E0.6700.20
171_D267_L0.6670.20
64_A69_H0.6670.20
200_M211_Y0.6660.19
71_Y310_N0.6640.19
125_V138_Y0.6590.19
206_N292_R0.6590.19
218_E222_I0.6570.19
30_G169_I0.6570.19
236_E279_Y0.6570.19
279_Y289_V0.6560.19
188_F192_L0.6490.19
334_G340_A0.6470.19
196_H200_M0.6460.19
178_N358_R0.6450.19
16_S82_L0.6440.19
185_L264_S0.6430.19
173_T196_H0.6420.19
27_L86_G0.6410.19
151_F292_R0.6390.19
294_Y343_I0.6390.19
21_V167_K0.6390.19
35_L199_E0.6390.19
240_F259_L0.6370.18
304_P329_L0.6350.18
324_A346_G0.6330.18
204_I322_I0.6310.18
134_V288_Y0.6310.18
154_T167_K0.6310.18
184_E350_L0.6290.18
137_L346_G0.6280.18
171_D239_L0.6280.18
180_L339_R0.6270.18
203_R229_L0.6220.18
245_V255_L0.6210.18
329_L343_I0.6210.18
22_A292_R0.6190.18
191_V326_A0.6190.18
91_Y94_T0.6160.18
54_V259_L0.6160.18
27_L356_L0.6140.18
71_Y169_I0.6120.18
22_A275_K0.6120.18
151_F202_L0.6080.18
63_T160_I0.6070.17
41_G127_A0.6070.17
46_G146_L0.6050.17
179_A351_Q0.6020.17
95_Q182_F0.6010.17
80_I268_L0.6000.17
140_E325_S0.5980.17
310_N337_E0.5970.17
21_V350_L0.5940.17
68_A107_T0.5940.17
240_F248_K0.5930.17
59_F166_Y0.5920.17
46_G197_R0.5910.17
57_G156_A0.5900.17
346_G350_L0.5880.17
158_Q228_E0.5880.17
63_T124_L0.5880.17
62_N247_E0.5870.17
41_G275_K0.5870.17
65_F321_I0.5870.17
71_Y182_F0.5870.17
298_N311_V0.5860.17
26_P70_L0.5860.17
158_Q256_L0.5840.17
175_N356_L0.5830.17
37_A182_F0.5830.17
37_A319_P0.5810.17
74_A311_V0.5800.17
152_I302_R0.5800.17
90_L200_M0.5790.17
163_L211_Y0.5770.17
220_H345_K0.5760.16
188_F273_V0.5750.16
39_T162_T0.5750.16
304_P336_G0.5740.16
30_G157_N0.5740.16
85_S273_V0.5730.16
81_I332_V0.5730.16
170_L194_V0.5720.16
226_V303_L0.5690.16
88_K253_F0.5690.16
14_L252_P0.5690.16
142_M194_V0.5660.16
11_E184_E0.5650.16
47_Y143_K0.5650.16
147_K234_E0.5630.16
265_Y309_E0.5620.16
200_M347_L0.5620.16
80_I284_N0.5600.16
66_S123_C0.5590.16
35_L311_V0.5580.16
62_N189_S0.5580.16
314_A327_E0.5580.16
240_F345_K0.5570.16
81_I236_E0.5560.16
247_E257_K0.5540.16
80_I280_P0.5540.16
53_E137_L0.5540.16
121_T201_V0.5540.16
43_I263_S0.5480.16
83_S97_M0.5480.16
70_L245_V0.5450.16
240_F268_L0.5430.15
251_D257_K0.5430.15
267_L347_L0.5430.15
153_L353_K0.5420.15
37_A131_R0.5390.15
188_F210_M0.5390.15
184_E299_K0.5370.15
101_T317_V0.5350.15
49_D60_H0.5350.15
185_L356_L0.5300.15
161_Q183_E0.5300.15
33_N56_D0.5280.15
95_Q298_N0.5270.15
307_I337_E0.5270.15
65_F183_E0.5260.15
22_A32_E0.5260.15
149_I155_K0.5250.15
235_E288_Y0.5240.15
242_K355_Y0.5220.15
24_G28_R0.5210.15
23_P28_R0.5210.15
30_G199_E0.5210.15
112_R197_R0.5200.15
154_T328_E0.5190.15
99_D356_L0.5180.15
11_E253_F0.5170.15
58_G75_K0.5170.15
162_T226_V0.5160.15
145_T213_K0.5160.15
173_T270_D0.5140.15
11_E88_K0.5120.15
217_T288_Y0.5120.15
177_L347_L0.5120.15
205_K230_I0.5110.15
90_L186_V0.5100.15
74_A146_L0.5100.15
90_L242_K0.5070.14
107_T131_R0.5060.14
70_L271_S0.5060.14
168_T247_E0.5060.14
227_I326_A0.5040.14
195_M265_Y0.5040.14
13_D226_V0.5030.14
147_K152_I0.5030.14
344_K352_E0.5020.14
14_L306_P0.5020.14
54_V130_E0.5000.14
281_A351_Q0.5000.14
89_I93_N0.5000.14
62_N257_K0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c1yA 5 0.9528 100 0.328 Contact Map
2fb5A 3 0.4028 100 0.764 Contact Map
4rv7A 1 0.4222 100 0.774 Contact Map
4gfjA 1 0.6833 99.2 0.914 Contact Map
1vq8Y 1 0 98.2 0.938 Contact Map
2a1jB 2 0.2194 98.1 0.941 Contact Map
1z00A 1 0.2278 98 0.942 Contact Map
1z00B 1 0.225 97.7 0.945 Contact Map
1kftA 1 0.1556 97.7 0.946 Contact Map
1x2iA 2 0.1889 97.7 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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