GREMLIN Database
CLPC - Negative regulator of genetic competence ClpC/MecB
UniProt: P37571 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 810 (784)
Sequences: 4966 (2505)
Seq/√Len: 89.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_A176_E6.5151.00
169_D238_R5.8821.00
724_S748_K5.5731.00
744_T795_D5.4701.00
720_T749_A4.9221.00
167_A240_M4.8811.00
716_K753_E4.6641.00
347_S375_V4.3761.00
780_E785_N4.1811.00
746_A795_D4.1681.00
501_N504_N3.9991.00
344_V375_V3.7411.00
507_H514_D3.6331.00
420_L446_E3.6071.00
505_I508_S3.5481.00
245_G299_I3.4441.00
656_M705_I3.4411.00
348_I371_I3.3301.00
638_R646_T3.3201.00
168_R173_I3.1161.00
472_T475_D2.9731.00
269_R308_E2.9481.00
252_K256_E2.8881.00
423_V442_L2.8781.00
522_K775_D2.8771.00
192_V337_I2.8451.00
540_S634_L2.8391.00
502_M561_S2.8321.00
195_V337_I2.8201.00
413_L453_V2.7681.00
715_E718_H2.6951.00
160_T164_D2.6711.00
744_T793_V2.6711.00
511_I725_L2.6701.00
419_K445_T2.6621.00
366_I399_G2.6501.00
161_P164_D2.6311.00
522_K779_E2.6031.00
343_S346_E2.5961.00
750_K796_V2.5471.00
205_V281_L2.5321.00
542_I705_I2.4741.00
344_V379_D2.4381.00
493_Q501_N2.3891.00
266_D270_Q2.3311.00
503_E518_V2.3251.00
716_K749_A2.3131.00
247_V264_V2.3061.00
728_D731_T2.2901.00
281_L324_I2.2841.00
232_E235_R2.2811.00
503_E525_R2.2251.00
424_R450_R2.1681.00
349_Q352_Q2.1581.00
773_V794_L2.1561.00
660_V696_A2.1491.00
797_E800_E2.1391.00
797_E801_F2.1331.00
372_E376_K2.1311.00
786_I792_I2.1131.00
754_E772_H2.1081.00
730_L769_I2.0811.00
172_A175_K2.0811.00
173_I178_S2.0791.00
505_I561_S2.0641.00
798_D801_F2.0541.00
544_L658_S2.0481.00
742_E793_V2.0401.00
719_L752_A2.0351.00
633_V654_L2.0271.00
169_D240_M2.0161.00
87_V111_G2.0081.00
179_L223_Q2.0071.00
580_K625_D1.9971.00
515_E686_K1.9941.00
693_L702_I1.9931.00
169_D172_A1.9911.00
394_L480_V1.9871.00
726_M766_R1.9811.00
555_A655_I1.9751.00
742_E791_H1.9751.00
562_I653_I1.9701.00
340_D609_K1.9681.00
727_S743_L1.9611.00
63_E66_S1.9351.00
581_H590_P1.9251.00
509_R557_A1.9251.00
50_L55_L1.9241.00
410_P460_W1.9201.00
509_R553_E1.9151.00
344_V376_K1.9091.00
750_K754_E1.9091.00
735_K740_S1.9011.00
509_R560_E1.8961.00
451_E455_D1.8911.00
660_V693_L1.8871.00
712_H718_H1.8831.00
517_V554_L1.8751.00
285_I330_L1.8671.00
373_A473_V1.8661.00
420_L449_L1.8561.00
402_V471_V1.8551.00
450_R454_E1.8541.00
427_K443_R1.8521.00
509_R566_E1.8511.00
690_M693_L1.8501.00
747_A796_V1.8421.00
445_T448_R1.8291.00
426_E438_K1.8151.00
36_L65_E1.8111.00
751_V768_A1.8031.00
338_Q609_K1.7931.00
500_L783_R1.7911.00
570_I612_S1.7891.00
768_A772_H1.7831.00
682_H685_M1.7721.00
162_T263_K1.7711.00
34_I84_A1.7671.00
606_V652_T1.7671.00
225_I239_V1.7541.00
374_A395_I1.7521.00
244_M247_V1.7441.00
228_N235_R1.7371.00
352_Q368_D1.7351.00
665_L685_M1.7291.00
266_D269_R1.7101.00
747_A801_F1.7061.00
720_T745_D1.7051.00
534_P733_R1.7031.00
740_S791_H1.7011.00
420_L453_V1.6991.00
416_L449_L1.6931.00
278_I311_C1.6871.00
365_S470_E1.6711.00
581_H584_S1.6641.00
438_K441_S1.6561.00
500_L782_L1.6491.00
507_H517_V1.6451.00
427_K439_A1.6451.00
354_L357_R1.6431.00
630_L633_V1.6421.00
435_E438_K1.6391.00
460_W463_K1.6291.00
457_K461_K1.6201.00
436_F439_A1.6171.00
417_E457_K1.6161.00
322_K598_E1.6141.00
344_V348_I1.5921.00
63_E126_N1.5881.00
448_R452_Q1.5861.00
356_D360_A1.5761.00
787_H790_Q1.5731.00
616_L633_V1.5481.00
31_T87_V1.5341.00
777_L792_I1.5281.00
578_M582_S1.5191.00
738_D788_K1.5121.00
502_M521_A1.5091.00
10_A108_I1.5021.00
739_L792_I1.4991.00
352_Q372_E1.4831.00
355_R368_D1.4811.00
26_H68_I1.4801.00
35_L120_A1.4801.00
417_E453_V1.4751.00
579_E590_P1.4731.00
265_M303_S1.4731.00
419_K452_Q1.4701.00
515_E712_H1.4670.99
692_E695_R1.4670.99
726_M729_Q1.4640.99
175_K238_R1.4630.99
718_H721_E1.4590.99
750_K772_H1.4550.99
723_V748_K1.4410.99
569_M613_V1.4400.99
721_E724_S1.4400.99
430_A439_A1.4360.99
371_I395_I1.4340.99
369_D473_V1.4330.99
376_K736_E1.4310.99
578_M625_D1.4200.99
737_Q788_K1.4190.99
780_E783_R1.4130.99
633_V639_L1.4060.99
542_I693_L1.4060.99
568_S609_K1.4020.99
347_S387_L1.4010.99
382_I480_V1.4000.99
281_L313_G1.3960.99
378_S387_L1.3920.99
635_E766_R1.3920.99
720_T748_K1.3870.99
743_L748_K1.3850.99
728_D732_K1.3790.99
570_I606_V1.3700.99
501_N505_I1.3680.99
261_L264_V1.3680.99
543_F655_I1.3650.99
584_S587_V1.3560.99
164_D172_A1.3540.99
744_T747_A1.3520.99
454_E458_K1.3490.99
20_E37_G1.3490.99
348_I372_E1.3470.99
410_P413_L1.3440.99
723_V752_A1.3360.99
289_G293_A1.3340.99
191_R397_E1.3340.99
447_Q451_E1.3310.99
57_S61_Q1.3220.99
727_S769_I1.3220.99
746_A796_V1.3200.99
743_L747_A1.3170.99
419_K422_E1.3160.99
224_Q229_E1.3150.99
130_S133_K1.3140.99
664_E692_E1.3010.99
415_E419_K1.2930.99
739_L786_I1.2910.99
56_G59_K1.2900.99
161_P267_E1.2860.99
418_Q422_E1.2830.99
60_I123_V1.2820.99
428_D431_V1.2810.99
158_A161_P1.2800.99
746_A749_A1.2790.99
129_V134_A1.2790.99
80_Y84_A1.2770.99
444_D448_R1.2750.99
409_T417_E1.2750.99
776_R780_E1.2750.99
686_K690_M1.2700.99
503_E507_H1.2680.99
682_H712_H1.2660.98
217_I339_V1.2660.98
747_A795_D1.2570.98
223_Q227_N1.2560.98
743_L773_V1.2540.98
427_K446_E1.2530.98
720_T724_S1.2490.98
180_D199_R1.2470.98
755_G765_L1.2450.98
775_D779_E1.2440.98
451_E454_E1.2420.98
24_L69_G1.2390.98
542_I619_I1.2350.98
685_M712_H1.2320.98
9_R12_K1.2270.98
557_A560_E1.2220.98
437_E441_S1.2200.98
684_D687_D1.2190.98
514_D718_H1.2160.98
352_Q355_R1.2140.98
387_L391_A1.2080.98
506_L510_V1.2060.98
355_R371_I1.2060.98
209_E317_L1.2040.98
36_L61_Q1.2010.98
663_S667_R1.1990.98
422_E426_E1.1990.98
702_I708_I1.1970.98
13_V38_L1.1950.98
724_S745_D1.1950.98
223_Q226_I1.1920.98
46_A109_L1.1910.98
367_T470_E1.1890.98
497_D501_N1.1850.98
83_R115_E1.1830.98
754_E768_A1.1820.98
518_V522_K1.1800.98
686_K710_V1.1800.98
527_A532_K1.1730.98
171_T179_L1.1710.97
747_A794_L1.1700.97
519_A709_I1.1690.97
191_R194_E1.1690.97
452_Q455_D1.1690.97
192_V218_A1.1650.97
210_P331_E1.1630.97
458_K462_E1.1620.97
271_A274_I1.1620.97
796_V799_G1.1540.97
378_S390_K1.1530.97
194_E400_S1.1530.97
687_D691_G1.1510.97
531_L730_L1.1490.97
367_T472_T1.1440.97
16_L37_G1.1430.97
572_I586_L1.1430.97
341_Q379_D1.1420.97
750_K801_F1.1420.97
114_R131_L1.1400.97
589_S616_L1.1400.97
769_I773_V1.1340.97
796_V801_F1.1320.97
436_F443_R1.1290.97
321_R643_K1.1280.97
94_E97_K1.1240.97
730_L774_E1.1200.97
583_T626_V1.1190.97
441_S445_T1.1180.97
197_S233_I1.1160.97
318_D321_R1.1160.97
251_T264_V1.1150.97
26_H71_G1.1150.97
20_E24_L1.1130.97
409_T457_K1.1050.96
122_R126_N1.1030.96
44_G105_T1.1010.96
434_Q444_D1.1010.96
45_I104_G1.1000.96
755_G768_A1.0980.96
577_Y601_Q1.0970.96
27_N74_M1.0970.96
587_V629_I1.0950.96
437_E440_A1.0930.96
41_E44_G1.0910.96
94_E111_G1.0890.96
367_T370_A1.0860.96
171_T226_I1.0850.96
424_R446_E1.0840.96
533_D733_R1.0820.96
322_K597_D1.0810.96
38_L44_G1.0810.96
431_V443_R1.0800.96
578_M628_N1.0780.96
91_S108_I1.0770.96
572_I616_L1.0760.96
772_H776_R1.0690.96
348_I375_V1.0650.96
453_V457_K1.0610.95
500_L779_E1.0590.95
660_V692_E1.0590.95
121_A125_N1.0580.95
606_V649_F1.0550.95
28_N81_T1.0550.95
194_E401_K1.0540.95
744_T796_V1.0540.95
268_I276_L1.0530.95
55_L60_I1.0520.95
131_L135_R1.0520.95
745_D749_A1.0510.95
423_V449_L1.0470.95
290_A294_I1.0460.95
596_Y642_S1.0420.95
87_V112_L1.0410.95
207_I336_P1.0400.95
360_A363_R1.0400.95
190_Q405_R1.0390.95
440_A444_D1.0380.95
786_I790_Q1.0370.95
439_A443_R1.0370.95
352_Q371_I1.0350.95
210_P328_A1.0340.95
663_S692_E1.0330.95
199_R358_Y1.0320.95
412_N452_Q1.0310.95
402_V475_D1.0290.95
747_A773_V1.0280.95
681_N684_D1.0280.95
478_M489_S1.0270.95
174_A179_L1.0270.95
65_E69_G1.0220.94
780_E786_I1.0190.94
723_V769_I1.0190.94
162_T267_E1.0170.94
750_K753_E1.0160.94
684_D688_K1.0140.94
495_E528_R1.0130.94
351_L374_A1.0120.94
506_L557_A1.0120.94
124_L127_L1.0120.94
682_H710_V1.0110.94
94_E131_L1.0110.94
40_R61_Q1.0100.94
199_R357_R1.0090.94
517_V520_V1.0090.94
690_M710_V1.0080.94
189_I220_G1.0070.94
115_E118_G1.0070.94
583_T629_I1.0050.94
210_P386_F1.0020.94
455_D459_S1.0010.94
416_L453_V1.0010.94
480_V488_V1.0000.94
423_V446_E0.9980.94
244_M284_L0.9960.94
693_L708_I0.9960.94
419_K449_L0.9930.94
6_F92_M0.9920.94
423_V445_T0.9910.94
20_E36_L0.9910.94
536_R766_R0.9900.93
168_R269_R0.9820.93
635_E701_F0.9810.93
424_R427_K0.9810.93
603_T647_V0.9770.93
757_D764_P0.9750.93
729_Q732_K0.9750.93
265_M300_L0.9740.93
348_I376_K0.9700.93
87_V115_E0.9690.93
507_H718_H0.9690.93
532_K538_I0.9650.93
378_S394_L0.9650.93
438_K445_T0.9640.93
619_I660_V0.9610.92
580_K585_R0.9600.92
61_Q65_E0.9600.92
171_T174_A0.9600.92
166_L251_T0.9590.92
430_A442_L0.9580.92
648_D651_N0.9560.92
346_E349_Q0.9530.92
427_K431_V0.9510.92
514_D518_V0.9460.92
553_E557_A0.9450.92
424_R428_D0.9450.92
683_K686_K0.9420.92
94_E98_L0.9410.92
697_F701_F0.9400.92
439_A446_E0.9380.92
504_N508_S0.9370.91
81_T84_A0.9360.91
224_Q418_Q0.9350.91
10_A105_T0.9310.91
616_L656_M0.9300.91
197_S400_S0.9260.91
481_S488_V0.9250.91
373_A376_K0.9240.91
52_A140_Q0.9230.91
507_H518_V0.9220.91
417_E421_D0.9200.91
52_A137_Q0.9190.91
525_R779_E0.9180.91
192_V339_V0.9180.91
543_F711_F0.9180.91
449_L453_V0.9170.91
719_L756_V0.9150.90
731_T741_I0.9150.90
20_E23_R0.9140.90
201_K393_D0.9130.90
242_L264_V0.9120.90
8_E11_Q0.9100.90
186_S224_Q0.9090.90
631_L700_E0.9090.90
518_V521_A0.9090.90
403_R407_F0.9050.90
544_L693_L0.9050.90
94_E114_R0.9040.90
261_L300_L0.9030.90
436_F440_A0.9030.90
137_Q140_Q0.9020.90
207_I317_L0.9010.90
257_F296_A0.8990.90
371_I375_V0.8980.90
731_T735_K0.8960.90
504_N507_H0.8950.89
554_L711_F0.8950.89
517_V521_A0.8930.89
732_K735_K0.8930.89
182_V189_I0.8920.89
370_A473_V0.8920.89
84_A108_I0.8910.89
206_L339_V0.8910.89
13_V41_E0.8900.89
475_D478_M0.8900.89
749_A753_E0.8890.89
317_L338_Q0.8880.89
553_E726_M0.8880.89
682_H686_K0.8880.89
421_D424_R0.8880.89
401_K478_M0.8870.89
524_V653_I0.8870.89
731_T743_L0.8870.89
82_P86_K0.8840.89
420_L450_R0.8840.89
14_L88_I0.8820.89
510_V571_R0.8810.89
748_K765_L0.8810.89
511_I721_E0.8790.89
499_L528_R0.8790.89
268_I271_A0.8780.89
724_S743_L0.8760.88
7_T102_Y0.8760.88
6_F10_A0.8760.88
446_E450_R0.8760.88
251_T261_L0.8740.88
459_S463_K0.8730.88
205_V324_I0.8730.88
691_G695_R0.8720.88
90_L115_E0.8710.88
55_L129_V0.8710.88
430_A436_F0.8690.88
437_E444_D0.8690.88
284_L297_S0.8680.88
503_E521_A0.8680.88
532_K648_D0.8670.88
739_L781_L0.8640.88
420_L424_R0.8630.88
521_A525_R0.8620.88
741_I794_L0.8620.88
734_L738_D0.8610.88
437_E443_R0.8600.88
724_S728_D0.8590.87
429_A433_S0.8590.87
357_R360_A0.8580.87
456_T459_S0.8560.87
7_T104_G0.8550.87
35_L112_L0.8550.87
218_A223_Q0.8500.87
31_T84_A0.8490.87
743_L794_L0.8490.87
444_D447_Q0.8480.87
606_V614_V0.8480.87
265_M299_I0.8460.87
707_E770_Q0.8460.87
20_E61_Q0.8440.87
30_G81_T0.8430.86
607_R645_R0.8420.86
473_V490_K0.8420.86
589_S598_E0.8410.86
182_V354_L0.8400.86
426_E429_A0.8390.86
32_E36_L0.8390.86
179_L182_V0.8380.86
727_S731_T0.8360.86
525_R775_D0.8360.86
344_V347_S0.8350.86
90_L111_G0.8350.86
701_F705_I0.8350.86
13_V37_G0.8340.86
7_T10_A0.8340.86
199_R531_L0.8340.86
443_R446_E0.8340.86
398_A479_V0.8330.86
153_G159_N0.8330.86
187_K482_S0.8300.86
585_R642_S0.8290.86
135_R138_V0.8280.86
605_K609_K0.8270.85
774_E778_S0.8270.85
402_V405_R0.8270.85
13_V105_T0.8260.85
751_V755_G0.8260.85
727_S773_V0.8250.85
733_R774_E0.8240.85
90_L116_G0.8220.85
716_K756_V0.8210.85
594_V597_D0.8190.85
18_Q29_I0.8180.85
352_Q426_E0.8160.85
36_L40_R0.8160.85
431_V439_A0.8140.85
717_K720_T0.8120.84
18_Q22_L0.8120.84
395_I476_I0.8110.84
372_E473_V0.8100.84
507_H712_H0.8100.84
14_L80_Y0.8100.84
535_K566_E0.8090.84
115_E121_A0.8080.84
90_L94_E0.8070.84
603_T639_L0.8040.84
88_I103_V0.8040.84
382_I390_K0.8030.84
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169_D299_I0.5060.50
249_A262_K0.5060.50
224_Q782_L0.5050.50
192_V312_I0.5050.50
162_T361_H0.5050.50
161_P240_M0.5040.50
706_D770_Q0.5040.50
685_M710_V0.5040.50
51_Q57_S0.5040.50
372_E736_E0.5040.50
179_L192_V0.5030.50
100_H104_G0.5030.50
251_T254_R0.5030.50
451_E462_E0.5030.50
587_V665_L0.5030.50
35_L109_L0.5020.50
247_V311_C0.5020.50
162_T274_I0.5020.50
585_R628_N0.5020.50
373_A394_L0.5020.50
15_A73_E0.5020.50
690_M760_Y0.5020.50
560_E732_K0.5020.50
355_R359_E0.5010.50
85_K92_M0.5010.50
262_K266_D0.5010.50
727_S741_I0.5010.50
795_D801_F0.5000.49
194_E737_Q0.5000.49
590_P593_Y0.5000.49
528_R531_L0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qvrA 3 0.9123 100 0.441 Contact Map
4d2uA 3 0.9086 100 0.443 Contact Map
1r6bX 1 0.858 100 0.451 Contact Map
3pxiA 3 0.8827 100 0.466 Contact Map
4ciuA 1 0.7383 100 0.582 Contact Map
3pxgA 3 0.5469 100 0.71 Contact Map
3vkgA 2 0.8506 100 0.76 Contact Map
4hseA 1 0.384 100 0.797 Contact Map
4lj9A 1 0.4099 100 0.815 Contact Map
4akgA 2 0.8309 100 0.827 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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