GREMLIN Database
MCSB - Protein-arginine kinase
UniProt: P37570 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (338)
Sequences: 598 (463)
Seq/√Len: 25.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
283_I345_I5.9591.00
187_V221_F5.7141.00
36_F153_V4.9321.00
23_D252_R4.7221.00
267_E281_R4.7091.00
149_I153_V3.3521.00
45_Y50_A3.2081.00
271_Y281_R3.1801.00
84_E326_Q2.9941.00
49_E52_S2.9851.00
281_R346_R2.9081.00
81_Q84_E2.8811.00
57_F153_V2.8601.00
340_R343_A2.7840.99
40_R49_E2.6180.99
285_S337_R2.5830.99
21_E252_R2.5750.99
288_T345_I2.4610.99
149_I155_Y2.3870.98
136_L241_N2.3470.98
130_F138_A2.3190.98
20_P134_Q2.3170.98
273_S294_D2.3110.98
94_I99_T2.2860.98
325_Q337_R2.2580.98
121_E167_C2.2380.97
125_R207_R2.2300.97
207_R222_Q2.2160.97
276_V283_I2.1720.97
140_K144_Q2.1530.97
76_R79_D2.1270.96
54_I105_G2.1170.96
58_E76_R2.0290.95
279_N282_M2.0170.95
33_A125_R1.8030.91
234_Q238_E1.7800.91
146_D155_Y1.7630.90
182_H293_S1.7490.90
297_L301_L1.7310.90
125_R176_R1.7310.90
274_Y295_V1.6940.89
208_G212_E1.6830.88
288_T319_T1.6810.88
176_R224_S1.6720.88
57_F60_Q1.6240.86
139_M237_V1.6240.86
88_L106_C1.6050.86
167_C176_R1.6050.86
134_Q137_E1.5880.85
46_S49_E1.5860.85
19_G23_D1.5690.84
92_H176_R1.5580.84
26_L220_I1.5580.84
180_M222_Q1.5540.84
176_R212_E1.5430.83
150_E163_Y1.5420.83
29_R222_Q1.5380.83
343_A347_E1.5220.83
167_C180_M1.5190.82
109_S113_E1.5180.82
60_Q149_I1.5140.82
31_R125_R1.4990.82
120_E176_R1.4940.81
77_M137_E1.4820.81
206_V223_I1.4820.81
272_R287_E1.4680.80
92_H167_C1.4600.80
144_Q151_E1.4530.79
125_R211_G1.4420.79
139_M175_L1.4350.79
264_I339_I1.4330.78
83_L325_Q1.4280.78
201_Q244_A1.4060.77
126_I145_V1.3920.76
37_E154_D1.3910.76
29_R211_G1.3810.76
180_M212_E1.3790.76
169_T211_G1.3750.75
168_P225_N1.3720.75
95_S120_E1.3610.75
269_R294_D1.3360.73
72_F114_V1.3350.73
53_I57_F1.3310.73
95_S121_E1.3300.73
121_E214_S1.3290.73
167_C207_R1.3270.73
155_Y242_S1.3120.72
330_G336_E1.2980.71
71_K110_E1.2930.71
117_M120_E1.2850.70
295_V312_L1.2840.70
155_Y192_I1.2830.70
169_T176_R1.2740.70
125_R222_Q1.2720.70
248_I276_V1.2620.69
336_E339_I1.2490.68
52_S56_Q1.2450.68
27_S178_S1.2410.68
231_K239_D1.2390.67
259_Y303_I1.2350.67
212_E222_Q1.2320.67
125_R170_N1.2260.67
33_A224_S1.2230.66
120_E170_N1.2180.66
288_T303_I1.2150.66
282_M339_I1.2050.65
126_I322_G1.1980.65
273_S291_C1.1930.64
33_A117_M1.1890.64
207_R211_G1.1880.64
91_K323_F1.1780.63
101_S104_G1.1770.63
31_R167_C1.1770.63
180_M207_R1.1740.63
120_E167_C1.1690.63
318_L344_L1.1670.63
176_R180_M1.1560.62
315_L349_L1.1540.62
168_P228_T1.1510.62
167_C212_E1.1470.61
57_F283_I1.1460.61
280_C283_I1.1440.61
92_H180_M1.1320.60
24_I312_L1.1320.60
189_T192_I1.1310.60
33_A211_G1.1280.60
48_E175_L1.1250.60
19_G252_R1.1200.59
332_L336_E1.1200.59
52_S61_F1.1140.59
167_C211_G1.1090.59
167_C178_S1.1050.58
167_C222_Q1.1050.58
170_N176_R1.1000.58
212_E224_S1.0990.58
33_A170_N1.0950.58
125_R169_T1.0920.57
33_A120_E1.0890.57
36_F56_Q1.0760.56
109_S202_L1.0750.56
114_V145_V1.0750.56
241_N306_G1.0710.56
181_M223_I1.0690.56
125_R167_C1.0690.56
167_C224_S1.0660.56
169_T207_R1.0660.56
54_I74_L1.0600.55
231_K235_D1.0580.55
106_C115_S1.0570.55
207_R212_E1.0570.55
30_I177_A1.0500.54
121_E170_N1.0470.54
130_F134_Q1.0420.54
258_I301_L1.0370.54
176_R207_R1.0360.53
125_R178_S1.0290.53
33_A121_E1.0280.53
139_M143_N1.0260.53
27_S129_L1.0250.53
165_T225_N1.0240.53
95_S180_M1.0240.53
75_I80_A1.0230.53
87_V323_F1.0160.52
127_Q169_T1.0140.52
120_E207_R1.0130.52
95_S117_M1.0130.52
185_A188_L1.0100.52
15_M288_T1.0080.51
127_Q167_C1.0060.51
15_M317_I1.0040.51
127_Q176_R1.0020.51
31_R211_G1.0010.51
176_R222_Q1.0010.51
32_L146_D0.9940.50
33_A176_R0.9930.50
126_I142_A0.9880.50
127_Q177_A0.9850.50
169_T226_Q0.9850.50
33_A122_D0.9820.50
267_E271_Y0.9750.49
100_E104_G0.9710.49
121_E212_E0.9630.48
86_R322_G0.9630.48
176_R213_G0.9630.48
274_Y278_S0.9620.48
122_D170_N0.9620.48
321_P337_R0.9600.48
121_E125_R0.9560.48
41_F156_A0.9540.48
33_A167_C0.9430.47
121_E180_M0.9410.47
33_A222_Q0.9410.47
36_F156_A0.9410.47
30_I128_C0.9400.47
243_V286_K0.9390.46
29_R176_R0.9350.46
334_P337_R0.9310.46
92_H96_P0.9300.46
29_R33_A0.9280.46
29_R169_T0.9270.46
121_E222_Q0.9270.46
77_M210_Y0.9260.45
125_R212_E0.9260.45
31_R207_R0.9220.45
95_S167_C0.9180.45
27_S31_R0.9140.45
33_A127_Q0.9110.44
238_E242_S0.9070.44
328_S340_R0.9060.44
77_M190_R0.9050.44
172_G251_E0.9040.44
162_G251_E0.9040.44
162_G172_G0.9040.44
158_N161_R0.9000.44
170_N207_R0.8980.43
92_H95_S0.8970.43
143_N147_D0.8970.43
315_L319_T0.8930.43
83_L235_D0.8910.43
168_P226_Q0.8850.43
163_Y221_F0.8810.42
149_I322_G0.8810.42
127_Q211_G0.8780.42
39_I53_I0.8770.42
95_S212_E0.8760.42
26_L280_C0.8740.42
48_E247_L0.8720.42
106_C232_S0.8710.42
257_A261_T0.8710.42
40_R239_D0.8670.41
191_Q250_Q0.8630.41
169_T208_G0.8600.41
116_V185_A0.8590.41
209_I291_C0.8590.41
92_H222_Q0.8530.40
266_L301_L0.8510.40
60_Q148_W0.8470.40
13_S16_K0.8440.40
273_S276_V0.8430.40
176_R211_G0.8380.39
34_R41_F0.8370.39
118_L223_I0.8370.39
259_Y301_L0.8320.39
155_Y261_T0.8320.39
271_Y303_I0.8290.39
290_K304_I0.8280.39
31_R222_Q0.8140.38
31_R176_R0.8140.38
299_I311_I0.8130.38
71_K339_I0.8120.37
276_V291_C0.8110.37
267_E345_I0.8090.37
121_E211_G0.8070.37
34_R162_G0.8050.37
34_R172_G0.8050.37
34_R251_E0.8050.37
211_G222_Q0.8050.37
167_C214_S0.8040.37
285_S334_P0.8040.37
31_R169_T0.8020.37
175_L297_L0.7980.37
116_V126_I0.7970.36
169_T212_E0.7970.36
66_I149_I0.7920.36
170_N211_G0.7890.36
33_A207_R0.7890.36
120_E212_E0.7780.35
289_A320_Q0.7780.35
196_I291_C0.7740.35
92_H125_R0.7730.35
29_R207_R0.7700.35
28_S43_T0.7700.35
51_S76_R0.7670.34
107_L238_E0.7640.34
105_G287_E0.7620.34
288_T292_L0.7590.34
212_E226_Q0.7560.34
180_M213_G0.7550.34
57_F107_L0.7550.34
83_L206_V0.7540.34
32_L175_L0.7530.34
263_K267_E0.7510.33
127_Q212_E0.7490.33
116_V163_Y0.7490.33
57_F274_Y0.7490.33
208_G218_G0.7460.33
43_T166_S0.7460.33
105_G221_F0.7440.33
283_I288_T0.7430.33
54_I149_I0.7430.33
63_E151_E0.7420.33
256_E261_T0.7420.33
248_I273_S0.7390.33
125_R180_M0.7350.32
149_I234_Q0.7350.32
311_I348_R0.7330.32
83_L111_N0.7320.32
31_R228_T0.7320.32
94_I247_L0.7300.32
18_K61_F0.7280.32
150_E155_Y0.7280.32
270_V298_G0.7270.32
127_Q222_Q0.7220.32
55_Q237_V0.7210.31
153_V187_V0.7180.31
184_P233_E0.7170.31
87_V91_K0.7160.31
45_Y49_E0.7150.31
56_Q185_A0.7110.31
33_A178_S0.7090.31
64_Q151_E0.7040.30
157_F160_Q0.7030.30
122_D178_S0.7030.30
228_T268_D0.7020.30
47_N51_S0.6990.30
22_S185_A0.6960.30
95_S272_R0.6910.30
33_A169_T0.6880.29
45_Y247_L0.6880.29
141_A253_S0.6860.29
161_R256_E0.6850.29
90_E321_P0.6830.29
104_G263_K0.6830.29
31_R122_D0.6830.29
167_C226_Q0.6820.29
313_N320_Q0.6810.29
123_H162_G0.6790.29
123_H172_G0.6790.29
123_H251_E0.6790.29
170_N224_S0.6780.29
225_N229_L0.6780.29
99_T295_V0.6760.29
63_E152_K0.6760.29
295_V302_G0.6760.29
48_E108_L0.6710.28
241_N330_G0.6700.28
187_V192_I0.6680.28
178_S207_R0.6670.28
244_A330_G0.6640.28
33_A180_M0.6630.28
210_Y218_G0.6630.28
271_Y279_N0.6620.28
121_E169_T0.6620.28
135_L241_N0.6600.28
239_D331_A0.6580.28
125_R210_Y0.6560.28
68_G221_F0.6540.27
117_M127_Q0.6530.27
135_L177_A0.6530.27
127_Q168_P0.6520.27
18_K301_L0.6490.27
94_I117_M0.6480.27
14_W19_G0.6470.27
183_L203_G0.6440.27
15_M191_Q0.6440.27
284_E291_C0.6420.27
115_S177_A0.6390.27
69_I270_V0.6390.27
177_A203_G0.6390.27
190_R270_V0.6370.26
33_A214_S0.6350.26
276_V279_N0.6340.26
92_H212_E0.6340.26
92_H178_S0.6330.26
23_D294_D0.6310.26
193_N243_V0.6300.26
14_W23_D0.6270.26
229_L236_I0.6270.26
136_L234_Q0.6230.26
29_R226_Q0.6220.26
69_I151_E0.6220.26
256_E260_Q0.6200.26
12_S112_E0.6150.25
47_N118_L0.6140.25
117_M222_Q0.6130.25
173_T225_N0.6130.25
28_S283_I0.6110.25
233_E275_G0.6110.25
233_E272_R0.6110.25
167_C170_N0.6100.25
90_E322_G0.6090.25
95_S208_G0.6090.25
120_E222_Q0.6090.25
121_E176_R0.6090.25
120_E125_R0.6080.25
149_I261_T0.6080.25
154_D220_I0.6070.25
260_Q333_R0.6060.25
61_F140_K0.6050.25
81_Q334_P0.6030.25
208_G225_N0.6030.25
81_Q331_A0.6030.25
38_H84_E0.5980.24
32_L156_A0.5980.24
74_L105_G0.5970.24
135_L179_V0.5950.24
167_C321_P0.5940.24
12_S15_M0.5940.24
263_K269_R0.5930.24
99_T337_R0.5920.24
258_I297_L0.5910.24
92_H121_E0.5890.24
299_I348_R0.5890.24
223_I247_L0.5870.24
333_R336_E0.5870.24
29_R167_C0.5840.24
202_L296_R0.5820.23
13_S26_L0.5800.23
95_S170_N0.5800.23
99_T157_F0.5790.23
31_R120_E0.5780.23
120_E180_M0.5780.23
55_Q59_D0.5770.23
34_R123_H0.5760.23
49_E243_V0.5740.23
32_L103_F0.5720.23
58_E74_L0.5720.23
165_T168_P0.5720.23
205_V322_G0.5720.23
138_A324_L0.5700.23
176_R226_Q0.5690.23
61_F305_K0.5690.23
213_G224_S0.5670.23
324_L332_L0.5670.23
27_S125_R0.5660.23
195_I261_T0.5660.23
107_L158_N0.5650.23
285_S325_Q0.5650.23
134_Q175_L0.5620.22
74_L237_V0.5620.22
151_E193_N0.5620.22
133_F179_V0.5610.22
334_P338_D0.5570.22
30_I237_V0.5570.22
13_S247_L0.5550.22
130_F274_Y0.5540.22
272_R275_G0.5530.22
167_C208_G0.5530.22
252_R314_E0.5530.22
53_I253_S0.5530.22
54_I75_I0.5520.22
100_E262_S0.5510.22
51_S74_L0.5510.22
15_M323_F0.5500.22
86_R166_S0.5500.22
90_E320_Q0.5490.22
62_S110_E0.5480.22
116_V260_Q0.5480.22
216_A319_T0.5450.22
22_S171_V0.5450.22
53_I350_H0.5440.22
80_A106_C0.5440.22
51_S110_E0.5430.21
47_N103_F0.5430.21
163_Y203_G0.5430.21
181_M250_Q0.5420.21
50_A54_I0.5400.21
91_K112_E0.5400.21
117_M212_E0.5390.21
101_S118_L0.5390.21
318_L348_R0.5380.21
214_S224_S0.5370.21
102_P145_V0.5370.21
121_E207_R0.5360.21
62_S175_L0.5350.21
31_R121_E0.5340.21
24_I185_A0.5340.21
208_G222_Q0.5330.21
206_V224_S0.5320.21
146_D233_E0.5310.21
248_I262_S0.5310.21
64_Q68_G0.5310.21
143_N220_I0.5310.21
115_S127_Q0.5300.21
41_F164_L0.5300.21
237_V276_V0.5300.21
29_R180_M0.5280.21
52_S55_Q0.5280.21
117_M121_E0.5270.21
220_I263_K0.5260.21
114_V124_I0.5260.21
118_L241_N0.5240.21
13_S45_Y0.5230.21
187_V250_Q0.5220.20
47_N71_K0.5220.20
112_E312_L0.5210.20
184_P230_G0.5210.20
54_I58_E0.5190.20
13_S83_L0.5180.20
180_M224_S0.5170.20
23_D129_L0.5170.20
291_C323_F0.5160.20
178_S212_E0.5150.20
276_V290_K0.5150.20
80_A157_F0.5140.20
189_T254_A0.5130.20
100_E290_K0.5110.20
31_R127_Q0.5090.20
166_S274_Y0.5070.20
96_P294_D0.5060.20
201_Q311_I0.5050.20
168_P218_G0.5050.20
231_K236_I0.5040.20
31_R170_N0.5030.20
81_Q306_G0.5010.20
127_Q225_N0.5010.20
28_S241_N0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rf6A 1 0.9642 100 0.394 Contact Map
4wodA 1 0.6584 100 0.405 Contact Map
3jpzA 2 0.719 100 0.406 Contact Map
1qh4A 3 0.7245 100 0.407 Contact Map
3l2fA 6 0.719 100 0.407 Contact Map
4z9mA 5 0.719 100 0.409 Contact Map
3ju5A 2 0.7135 100 0.41 Contact Map
1m15A 1 0.6887 100 0.411 Contact Map
3ruiB 1 0.3085 19.2 0.974 Contact Map
3uv1A 2 0.4959 16.6 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.