MCSB - BACSU - GREMLIN Contacts

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MCSB - Protein-arginine kinase

UniProt:	P37570	Sequences: MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTRYSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESPFGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQRGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVGNIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGVLSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRPNERDIRRAALIRERLHLEMNGKRQEDESI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	363 (338)
Sequences:	598 (463)
Seq/√Len:	25.2

BACSU - MCSB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
283_I	345_I	5.959	1.00
187_V	221_F	5.714	1.00
36_F	153_V	4.932	1.00
23_D	252_R	4.722	1.00
267_E	281_R	4.709	1.00
149_I	153_V	3.352	1.00
45_Y	50_A	3.208	1.00
271_Y	281_R	3.180	1.00
84_E	326_Q	2.994	1.00
49_E	52_S	2.985	1.00
281_R	346_R	2.908	1.00
81_Q	84_E	2.881	1.00
57_F	153_V	2.860	1.00
340_R	343_A	2.784	0.99
40_R	49_E	2.618	0.99
285_S	337_R	2.583	0.99
21_E	252_R	2.575	0.99
288_T	345_I	2.461	0.99
149_I	155_Y	2.387	0.98
136_L	241_N	2.347	0.98
130_F	138_A	2.319	0.98
20_P	134_Q	2.317	0.98
273_S	294_D	2.311	0.98
94_I	99_T	2.286	0.98
325_Q	337_R	2.258	0.98
121_E	167_C	2.238	0.97
125_R	207_R	2.230	0.97
207_R	222_Q	2.216	0.97
276_V	283_I	2.172	0.97
140_K	144_Q	2.153	0.97
76_R	79_D	2.127	0.96
54_I	105_G	2.117	0.96
58_E	76_R	2.029	0.95
279_N	282_M	2.017	0.95
33_A	125_R	1.803	0.91
234_Q	238_E	1.780	0.91
146_D	155_Y	1.763	0.90
182_H	293_S	1.749	0.90
297_L	301_L	1.731	0.90
125_R	176_R	1.731	0.90
274_Y	295_V	1.694	0.89
208_G	212_E	1.683	0.88
288_T	319_T	1.681	0.88
176_R	224_S	1.672	0.88
57_F	60_Q	1.624	0.86
139_M	237_V	1.624	0.86
88_L	106_C	1.605	0.86
167_C	176_R	1.605	0.86
134_Q	137_E	1.588	0.85
46_S	49_E	1.586	0.85
19_G	23_D	1.569	0.84
92_H	176_R	1.558	0.84
26_L	220_I	1.558	0.84
180_M	222_Q	1.554	0.84
176_R	212_E	1.543	0.83
150_E	163_Y	1.542	0.83
29_R	222_Q	1.538	0.83
343_A	347_E	1.522	0.83
167_C	180_M	1.519	0.82
109_S	113_E	1.518	0.82
60_Q	149_I	1.514	0.82
31_R	125_R	1.499	0.82
120_E	176_R	1.494	0.81
77_M	137_E	1.482	0.81
206_V	223_I	1.482	0.81
272_R	287_E	1.468	0.80
92_H	167_C	1.460	0.80
144_Q	151_E	1.453	0.79
125_R	211_G	1.442	0.79
139_M	175_L	1.435	0.79
264_I	339_I	1.433	0.78
83_L	325_Q	1.428	0.78
201_Q	244_A	1.406	0.77
126_I	145_V	1.392	0.76
37_E	154_D	1.391	0.76
29_R	211_G	1.381	0.76
180_M	212_E	1.379	0.76
169_T	211_G	1.375	0.75
168_P	225_N	1.372	0.75
95_S	120_E	1.361	0.75
269_R	294_D	1.336	0.73
72_F	114_V	1.335	0.73
53_I	57_F	1.331	0.73
95_S	121_E	1.330	0.73
121_E	214_S	1.329	0.73
167_C	207_R	1.327	0.73
155_Y	242_S	1.312	0.72
330_G	336_E	1.298	0.71
71_K	110_E	1.293	0.71
117_M	120_E	1.285	0.70
295_V	312_L	1.284	0.70
155_Y	192_I	1.283	0.70
169_T	176_R	1.274	0.70
125_R	222_Q	1.272	0.70
248_I	276_V	1.262	0.69
336_E	339_I	1.249	0.68
52_S	56_Q	1.245	0.68
27_S	178_S	1.241	0.68
231_K	239_D	1.239	0.67
259_Y	303_I	1.235	0.67
212_E	222_Q	1.232	0.67
125_R	170_N	1.226	0.67
33_A	224_S	1.223	0.66
120_E	170_N	1.218	0.66
288_T	303_I	1.215	0.66
282_M	339_I	1.205	0.65
126_I	322_G	1.198	0.65
273_S	291_C	1.193	0.64
33_A	117_M	1.189	0.64
207_R	211_G	1.188	0.64
91_K	323_F	1.178	0.63
101_S	104_G	1.177	0.63
31_R	167_C	1.177	0.63
180_M	207_R	1.174	0.63
120_E	167_C	1.169	0.63
318_L	344_L	1.167	0.63
176_R	180_M	1.156	0.62
315_L	349_L	1.154	0.62
168_P	228_T	1.151	0.62
167_C	212_E	1.147	0.61
57_F	283_I	1.146	0.61
280_C	283_I	1.144	0.61
92_H	180_M	1.132	0.60
24_I	312_L	1.132	0.60
189_T	192_I	1.131	0.60
33_A	211_G	1.128	0.60
48_E	175_L	1.125	0.60
19_G	252_R	1.120	0.59
332_L	336_E	1.120	0.59
52_S	61_F	1.114	0.59
167_C	211_G	1.109	0.59
167_C	178_S	1.105	0.58
167_C	222_Q	1.105	0.58
170_N	176_R	1.100	0.58
212_E	224_S	1.099	0.58
33_A	170_N	1.095	0.58
125_R	169_T	1.092	0.57
33_A	120_E	1.089	0.57
36_F	56_Q	1.076	0.56
109_S	202_L	1.075	0.56
114_V	145_V	1.075	0.56
241_N	306_G	1.071	0.56
181_M	223_I	1.069	0.56
125_R	167_C	1.069	0.56
167_C	224_S	1.066	0.56
169_T	207_R	1.066	0.56
54_I	74_L	1.060	0.55
231_K	235_D	1.058	0.55
106_C	115_S	1.057	0.55
207_R	212_E	1.057	0.55
30_I	177_A	1.050	0.54
121_E	170_N	1.047	0.54
130_F	134_Q	1.042	0.54
258_I	301_L	1.037	0.54
176_R	207_R	1.036	0.53
125_R	178_S	1.029	0.53
33_A	121_E	1.028	0.53
139_M	143_N	1.026	0.53
27_S	129_L	1.025	0.53
165_T	225_N	1.024	0.53
95_S	180_M	1.024	0.53
75_I	80_A	1.023	0.53
87_V	323_F	1.016	0.52
127_Q	169_T	1.014	0.52
120_E	207_R	1.013	0.52
95_S	117_M	1.013	0.52
185_A	188_L	1.010	0.52
15_M	288_T	1.008	0.51
127_Q	167_C	1.006	0.51
15_M	317_I	1.004	0.51
127_Q	176_R	1.002	0.51
31_R	211_G	1.001	0.51
176_R	222_Q	1.001	0.51
32_L	146_D	0.994	0.50
33_A	176_R	0.993	0.50
126_I	142_A	0.988	0.50
127_Q	177_A	0.985	0.50
169_T	226_Q	0.985	0.50
33_A	122_D	0.982	0.50
267_E	271_Y	0.975	0.49
100_E	104_G	0.971	0.49
121_E	212_E	0.963	0.48
86_R	322_G	0.963	0.48
176_R	213_G	0.963	0.48
274_Y	278_S	0.962	0.48
122_D	170_N	0.962	0.48
321_P	337_R	0.960	0.48
121_E	125_R	0.956	0.48
41_F	156_A	0.954	0.48
33_A	167_C	0.943	0.47
121_E	180_M	0.941	0.47
33_A	222_Q	0.941	0.47
36_F	156_A	0.941	0.47
30_I	128_C	0.940	0.47
243_V	286_K	0.939	0.46
29_R	176_R	0.935	0.46
334_P	337_R	0.931	0.46
92_H	96_P	0.930	0.46
29_R	33_A	0.928	0.46
29_R	169_T	0.927	0.46
121_E	222_Q	0.927	0.46
77_M	210_Y	0.926	0.45
125_R	212_E	0.926	0.45
31_R	207_R	0.922	0.45
95_S	167_C	0.918	0.45
27_S	31_R	0.914	0.45
33_A	127_Q	0.911	0.44
238_E	242_S	0.907	0.44
328_S	340_R	0.906	0.44
77_M	190_R	0.905	0.44
172_G	251_E	0.904	0.44
162_G	251_E	0.904	0.44
162_G	172_G	0.904	0.44
158_N	161_R	0.900	0.44
170_N	207_R	0.898	0.43
92_H	95_S	0.897	0.43
143_N	147_D	0.897	0.43
315_L	319_T	0.893	0.43
83_L	235_D	0.891	0.43
168_P	226_Q	0.885	0.43
163_Y	221_F	0.881	0.42
149_I	322_G	0.881	0.42
127_Q	211_G	0.878	0.42
39_I	53_I	0.877	0.42
95_S	212_E	0.876	0.42
26_L	280_C	0.874	0.42
48_E	247_L	0.872	0.42
106_C	232_S	0.871	0.42
257_A	261_T	0.871	0.42
40_R	239_D	0.867	0.41
191_Q	250_Q	0.863	0.41
169_T	208_G	0.860	0.41
116_V	185_A	0.859	0.41
209_I	291_C	0.859	0.41
92_H	222_Q	0.853	0.40
266_L	301_L	0.851	0.40
60_Q	148_W	0.847	0.40
13_S	16_K	0.844	0.40
273_S	276_V	0.843	0.40
176_R	211_G	0.838	0.39
34_R	41_F	0.837	0.39
118_L	223_I	0.837	0.39
259_Y	301_L	0.832	0.39
155_Y	261_T	0.832	0.39
271_Y	303_I	0.829	0.39
290_K	304_I	0.828	0.39
31_R	222_Q	0.814	0.38
31_R	176_R	0.814	0.38
299_I	311_I	0.813	0.38
71_K	339_I	0.812	0.37
276_V	291_C	0.811	0.37
267_E	345_I	0.809	0.37
121_E	211_G	0.807	0.37
34_R	162_G	0.805	0.37
34_R	172_G	0.805	0.37
34_R	251_E	0.805	0.37
211_G	222_Q	0.805	0.37
167_C	214_S	0.804	0.37
285_S	334_P	0.804	0.37
31_R	169_T	0.802	0.37
175_L	297_L	0.798	0.37
116_V	126_I	0.797	0.36
169_T	212_E	0.797	0.36
66_I	149_I	0.792	0.36
170_N	211_G	0.789	0.36
33_A	207_R	0.789	0.36
120_E	212_E	0.778	0.35
289_A	320_Q	0.778	0.35
196_I	291_C	0.774	0.35
92_H	125_R	0.773	0.35
29_R	207_R	0.770	0.35
28_S	43_T	0.770	0.35
51_S	76_R	0.767	0.34
107_L	238_E	0.764	0.34
105_G	287_E	0.762	0.34
288_T	292_L	0.759	0.34
212_E	226_Q	0.756	0.34
180_M	213_G	0.755	0.34
57_F	107_L	0.755	0.34
83_L	206_V	0.754	0.34
32_L	175_L	0.753	0.34
263_K	267_E	0.751	0.33
127_Q	212_E	0.749	0.33
116_V	163_Y	0.749	0.33
57_F	274_Y	0.749	0.33
208_G	218_G	0.746	0.33
43_T	166_S	0.746	0.33
105_G	221_F	0.744	0.33
283_I	288_T	0.743	0.33
54_I	149_I	0.743	0.33
63_E	151_E	0.742	0.33
256_E	261_T	0.742	0.33
248_I	273_S	0.739	0.33
125_R	180_M	0.735	0.32
149_I	234_Q	0.735	0.32
311_I	348_R	0.733	0.32
83_L	111_N	0.732	0.32
31_R	228_T	0.732	0.32
94_I	247_L	0.730	0.32
18_K	61_F	0.728	0.32
150_E	155_Y	0.728	0.32
270_V	298_G	0.727	0.32
127_Q	222_Q	0.722	0.32
55_Q	237_V	0.721	0.31
153_V	187_V	0.718	0.31
184_P	233_E	0.717	0.31
87_V	91_K	0.716	0.31
45_Y	49_E	0.715	0.31
56_Q	185_A	0.711	0.31
33_A	178_S	0.709	0.31
64_Q	151_E	0.704	0.30
157_F	160_Q	0.703	0.30
122_D	178_S	0.703	0.30
228_T	268_D	0.702	0.30
47_N	51_S	0.699	0.30
22_S	185_A	0.696	0.30
95_S	272_R	0.691	0.30
33_A	169_T	0.688	0.29
45_Y	247_L	0.688	0.29
141_A	253_S	0.686	0.29
161_R	256_E	0.685	0.29
90_E	321_P	0.683	0.29
104_G	263_K	0.683	0.29
31_R	122_D	0.683	0.29
167_C	226_Q	0.682	0.29
313_N	320_Q	0.681	0.29
123_H	162_G	0.679	0.29
123_H	172_G	0.679	0.29
123_H	251_E	0.679	0.29
170_N	224_S	0.678	0.29
225_N	229_L	0.678	0.29
99_T	295_V	0.676	0.29
63_E	152_K	0.676	0.29
295_V	302_G	0.676	0.29
48_E	108_L	0.671	0.28
241_N	330_G	0.670	0.28
187_V	192_I	0.668	0.28
178_S	207_R	0.667	0.28
244_A	330_G	0.664	0.28
33_A	180_M	0.663	0.28
210_Y	218_G	0.663	0.28
271_Y	279_N	0.662	0.28
121_E	169_T	0.662	0.28
135_L	241_N	0.660	0.28
239_D	331_A	0.658	0.28
125_R	210_Y	0.656	0.28
68_G	221_F	0.654	0.27
117_M	127_Q	0.653	0.27
135_L	177_A	0.653	0.27
127_Q	168_P	0.652	0.27
18_K	301_L	0.649	0.27
94_I	117_M	0.648	0.27
14_W	19_G	0.647	0.27
183_L	203_G	0.644	0.27
15_M	191_Q	0.644	0.27
284_E	291_C	0.642	0.27
115_S	177_A	0.639	0.27
69_I	270_V	0.639	0.27
177_A	203_G	0.639	0.27
190_R	270_V	0.637	0.26
33_A	214_S	0.635	0.26
276_V	279_N	0.634	0.26
92_H	212_E	0.634	0.26
92_H	178_S	0.633	0.26
23_D	294_D	0.631	0.26
193_N	243_V	0.630	0.26
14_W	23_D	0.627	0.26
229_L	236_I	0.627	0.26
136_L	234_Q	0.623	0.26
29_R	226_Q	0.622	0.26
69_I	151_E	0.622	0.26
256_E	260_Q	0.620	0.26
12_S	112_E	0.615	0.25
47_N	118_L	0.614	0.25
117_M	222_Q	0.613	0.25
173_T	225_N	0.613	0.25
28_S	283_I	0.611	0.25
233_E	275_G	0.611	0.25
233_E	272_R	0.611	0.25
167_C	170_N	0.610	0.25
90_E	322_G	0.609	0.25
95_S	208_G	0.609	0.25
120_E	222_Q	0.609	0.25
121_E	176_R	0.609	0.25
120_E	125_R	0.608	0.25
149_I	261_T	0.608	0.25
154_D	220_I	0.607	0.25
260_Q	333_R	0.606	0.25
61_F	140_K	0.605	0.25
81_Q	334_P	0.603	0.25
208_G	225_N	0.603	0.25
81_Q	331_A	0.603	0.25
38_H	84_E	0.598	0.24
32_L	156_A	0.598	0.24
74_L	105_G	0.597	0.24
135_L	179_V	0.595	0.24
167_C	321_P	0.594	0.24
12_S	15_M	0.594	0.24
263_K	269_R	0.593	0.24
99_T	337_R	0.592	0.24
258_I	297_L	0.591	0.24
92_H	121_E	0.589	0.24
299_I	348_R	0.589	0.24
223_I	247_L	0.587	0.24
333_R	336_E	0.587	0.24
29_R	167_C	0.584	0.24
202_L	296_R	0.582	0.23
13_S	26_L	0.580	0.23
95_S	170_N	0.580	0.23
99_T	157_F	0.579	0.23
31_R	120_E	0.578	0.23
120_E	180_M	0.578	0.23
55_Q	59_D	0.577	0.23
34_R	123_H	0.576	0.23
49_E	243_V	0.574	0.23
32_L	103_F	0.572	0.23
58_E	74_L	0.572	0.23
165_T	168_P	0.572	0.23
205_V	322_G	0.572	0.23
138_A	324_L	0.570	0.23
176_R	226_Q	0.569	0.23
61_F	305_K	0.569	0.23
213_G	224_S	0.567	0.23
324_L	332_L	0.567	0.23
27_S	125_R	0.566	0.23
195_I	261_T	0.566	0.23
107_L	158_N	0.565	0.23
285_S	325_Q	0.565	0.23
134_Q	175_L	0.562	0.22
74_L	237_V	0.562	0.22
151_E	193_N	0.562	0.22
133_F	179_V	0.561	0.22
334_P	338_D	0.557	0.22
30_I	237_V	0.557	0.22
13_S	247_L	0.555	0.22
130_F	274_Y	0.554	0.22
272_R	275_G	0.553	0.22
167_C	208_G	0.553	0.22
252_R	314_E	0.553	0.22
53_I	253_S	0.553	0.22
54_I	75_I	0.552	0.22
100_E	262_S	0.551	0.22
51_S	74_L	0.551	0.22
15_M	323_F	0.550	0.22
86_R	166_S	0.550	0.22
90_E	320_Q	0.549	0.22
62_S	110_E	0.548	0.22
116_V	260_Q	0.548	0.22
216_A	319_T	0.545	0.22
22_S	171_V	0.545	0.22
53_I	350_H	0.544	0.22
80_A	106_C	0.544	0.22
51_S	110_E	0.543	0.21
47_N	103_F	0.543	0.21
163_Y	203_G	0.543	0.21
181_M	250_Q	0.542	0.21
50_A	54_I	0.540	0.21
91_K	112_E	0.540	0.21
117_M	212_E	0.539	0.21
101_S	118_L	0.539	0.21
318_L	348_R	0.538	0.21
214_S	224_S	0.537	0.21
102_P	145_V	0.537	0.21
121_E	207_R	0.536	0.21
62_S	175_L	0.535	0.21
31_R	121_E	0.534	0.21
24_I	185_A	0.534	0.21
208_G	222_Q	0.533	0.21
206_V	224_S	0.532	0.21
146_D	233_E	0.531	0.21
248_I	262_S	0.531	0.21
64_Q	68_G	0.531	0.21
143_N	220_I	0.531	0.21
115_S	127_Q	0.530	0.21
41_F	164_L	0.530	0.21
237_V	276_V	0.530	0.21
29_R	180_M	0.528	0.21
52_S	55_Q	0.528	0.21
117_M	121_E	0.527	0.21
220_I	263_K	0.526	0.21
114_V	124_I	0.526	0.21
118_L	241_N	0.524	0.21
13_S	45_Y	0.523	0.21
187_V	250_Q	0.522	0.20
47_N	71_K	0.522	0.20
112_E	312_L	0.521	0.20
184_P	230_G	0.521	0.20
54_I	58_E	0.519	0.20
13_S	83_L	0.518	0.20
180_M	224_S	0.517	0.20
23_D	129_L	0.517	0.20
291_C	323_F	0.516	0.20
178_S	212_E	0.515	0.20
276_V	290_K	0.515	0.20
80_A	157_F	0.514	0.20
189_T	254_A	0.513	0.20
100_E	290_K	0.511	0.20
31_R	127_Q	0.509	0.20
166_S	274_Y	0.507	0.20
96_P	294_D	0.506	0.20
201_Q	311_I	0.505	0.20
168_P	218_G	0.505	0.20
231_K	236_I	0.504	0.20
31_R	170_N	0.503	0.20
81_Q	306_G	0.501	0.20
127_Q	225_N	0.501	0.20
28_S	241_N	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rf6A	1	0.9642	100	0.394	Contact Map
4wodA	1	0.6584	100	0.405	Contact Map
3jpzA	2	0.719	100	0.406	Contact Map
1qh4A	3	0.7245	100	0.407	Contact Map
3l2fA	6	0.719	100	0.407	Contact Map
4z9mA	5	0.719	100	0.409	Contact Map
3ju5A	2	0.7135	100	0.41	Contact Map
1m15A	1	0.6887	100	0.411	Contact Map
3ruiB	1	0.3085	19.2	0.974	Contact Map
3uv1A	2	0.4959	16.6	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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