GREMLIN Database
MCSA - Protein-arginine kinase activator protein
UniProt: P37569 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 185 (167)
Sequences: 574 (474)
Seq/√Len: 36.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_N163_H6.5681.00
83_K101_E5.3381.00
152_L164_V5.1461.00
141_Q167_Q5.1391.00
9_R31_Q4.3991.00
157_E160_N4.3931.00
146_K172_E4.1741.00
82_P105_T3.1201.00
148_E160_N2.9241.00
167_Q170_L2.6241.00
17_K38_D2.5361.00
4_Q27_H2.4851.00
5_E36_N2.3301.00
162_A166_D2.1600.99
88_F91_F2.1080.99
162_A165_R2.0800.99
8_E158_F1.7870.97
142_I168_I1.7810.97
88_F110_I1.7400.96
78_I89_Q1.7300.96
148_E164_V1.6910.96
16_T23_K1.6870.96
151_S155_Q1.6180.94
3_C6_C1.6080.94
118_H124_H1.6050.94
141_Q144_M1.5920.94
113_I117_V1.5610.93
150_E154_H1.5400.93
148_E167_Q1.4540.91
118_H121_N1.4330.90
163_H167_Q1.4290.90
86_M91_F1.4160.89
142_I171_L1.3950.89
14_H27_H1.3890.88
114_L118_H1.3840.88
101_E104_K1.3340.86
82_P101_E1.3270.86
2_I7_H1.3170.86
48_F57_L1.3160.86
91_F156_E1.2950.85
84_C99_C1.2790.84
124_H127_K1.2660.83
54_L124_H1.2610.83
109_N140_R1.2530.83
54_L133_G1.2250.81
144_M148_E1.1800.79
90_Q158_F1.1460.77
138_V174_S1.1260.75
6_C11_A1.1050.74
86_M94_I1.0960.73
115_R130_K1.0930.73
79_S105_T1.0920.73
33_A98_G1.0820.72
44_A50_I1.0770.72
138_V142_I1.0670.71
8_E172_E1.0480.70
154_H158_F1.0430.69
46_Q55_S1.0390.69
84_C126_G1.0260.68
99_C126_G1.0260.68
27_H97_F1.0240.68
147_K169_R1.0240.68
7_H85_G1.0140.67
14_H131_R1.0080.67
153_I174_S1.0070.67
3_C11_A0.9900.65
79_S109_N0.9850.65
138_V171_L0.9790.64
24_I94_I0.9740.64
34_K55_S0.9740.64
82_P85_G0.9720.64
29_C32_C0.9660.63
130_K174_S0.9640.63
95_G118_H0.9590.63
18_V113_I0.9350.61
13_F37_S0.9320.61
18_V88_F0.9250.60
12_T27_H0.9210.60
81_C84_C0.9200.60
81_C99_C0.9200.60
31_Q35_E0.9110.59
163_H170_L0.9060.58
2_I8_E0.9050.58
1_M6_C0.9030.58
16_T27_H0.8980.58
168_I172_E0.8950.57
100_S150_E0.8880.57
6_C29_C0.8800.56
16_T91_F0.8750.56
41_G44_A0.8710.55
35_E63_S0.8650.55
47_G51_H0.8590.54
92_R97_F0.8510.54
163_H169_R0.8430.53
145_L152_L0.8420.53
149_L158_F0.8390.53
95_G113_I0.8380.52
10_P118_H0.8300.52
152_L160_N0.8280.52
14_H25_E0.8280.52
133_G139_R0.8270.52
3_C29_C0.8260.51
17_K37_S0.8240.51
16_T97_F0.8140.50
25_E58_L0.8110.50
48_F56_G0.8060.50
25_E52_N0.8040.50
60_M96_R0.8030.49
149_L152_L0.8000.49
105_T109_N0.7940.49
134_G148_E0.7930.49
155_Q160_N0.7890.48
56_G116_K0.7850.48
22_E139_R0.7800.47
170_L173_Q0.7750.47
15_F36_N0.7660.46
95_G103_Y0.7650.46
13_F47_G0.7640.46
169_R173_Q0.7610.46
17_K50_I0.7600.46
1_M32_C0.7570.45
84_C102_C0.7530.45
99_C102_C0.7530.45
10_P138_V0.7520.45
9_R100_S0.7510.45
97_F107_H0.7490.45
170_L174_S0.7450.44
4_Q57_L0.7440.44
90_Q139_R0.7420.44
58_L96_R0.7410.44
1_M11_A0.7390.44
169_R172_E0.7340.43
115_R122_T0.7320.43
49_S88_F0.7220.42
116_K131_R0.7220.42
28_I152_L0.7190.42
58_L93_K0.7170.42
17_K24_I0.7150.42
93_K135_N0.7100.41
161_A165_R0.7090.41
104_K148_E0.7090.41
141_Q174_S0.7060.41
110_I114_L0.7040.41
7_H86_M0.7040.41
26_V90_Q0.7040.41
46_Q50_I0.7030.41
135_N163_H0.7010.41
19_V24_I0.7000.41
84_C98_G0.6960.40
12_T19_V0.6930.40
96_R105_T0.6900.40
142_I174_S0.6900.40
54_L139_R0.6880.39
144_M147_K0.6870.39
91_F118_H0.6870.39
51_H59_N0.6860.39
54_L61_D0.6860.39
81_C126_G0.6860.39
105_T108_S0.6860.39
37_S53_L0.6860.39
51_H114_L0.6830.39
35_E140_R0.6770.39
101_E105_T0.6770.39
141_Q170_L0.6760.38
94_I97_F0.6760.38
23_K55_S0.6710.38
145_L164_V0.6700.38
24_I171_L0.6630.37
107_H151_S0.6620.37
13_F28_I0.6620.37
79_S91_F0.6610.37
47_G88_F0.6590.37
64_F94_I0.6570.37
60_M90_Q0.6550.37
102_C115_R0.6470.36
83_K100_S0.6450.36
49_S129_P0.6420.36
96_R169_R0.6420.36
134_G153_I0.6400.36
24_I173_Q0.6400.36
93_K171_L0.6390.35
14_H118_H0.6360.35
16_T95_G0.6360.35
123_V167_Q0.6310.35
52_N57_L0.6290.35
25_E33_A0.6170.34
148_E151_S0.6150.34
113_I132_I0.6130.33
1_M10_P0.6030.33
8_E19_V0.6010.32
92_R107_H0.6000.32
104_K107_H0.5980.32
82_P107_H0.5950.32
86_M120_G0.5920.32
15_F124_H0.5920.32
33_A166_D0.5900.32
111_T114_L0.5900.32
66_N173_Q0.5880.31
46_Q114_L0.5880.31
41_G147_K0.5880.31
34_K146_K0.5860.31
147_K151_S0.5850.31
53_L122_T0.5780.31
81_C102_C0.5740.30
13_F156_E0.5670.30
94_I148_E0.5660.30
149_L168_I0.5660.30
65_Q143_D0.5650.30
63_S74_H0.5630.30
142_I155_Q0.5620.30
18_V83_K0.5620.30
89_Q164_V0.5620.30
6_C32_C0.5580.29
58_L92_R0.5560.29
97_F114_L0.5550.29
58_L151_S0.5530.29
88_F109_N0.5520.29
77_Q170_L0.5500.29
95_G100_S0.5500.29
10_P158_F0.5490.29
50_I57_L0.5470.28
4_Q12_T0.5470.28
88_F115_R0.5450.28
126_G129_P0.5410.28
53_L88_F0.5400.28
64_F137_H0.5390.28
73_S89_Q0.5390.28
59_N92_R0.5360.28
9_R59_N0.5360.28
132_I136_L0.5350.28
25_E120_G0.5340.28
108_S112_P0.5320.27
74_H125_A0.5300.27
34_K89_Q0.5260.27
112_P134_G0.5240.27
153_I162_A0.5200.27
86_M156_E0.5200.27
123_V170_L0.5200.27
29_C156_E0.5190.26
23_K35_E0.5180.26
34_K83_K0.5180.26
14_H95_G0.5140.26
73_S164_V0.5090.26
65_Q154_H0.5070.26
56_G131_R0.5070.26
32_C102_C0.5060.26
15_F117_V0.5060.26
3_C32_C0.5040.25
63_S92_R0.5020.25
8_E75_S0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e52A 2 0.2865 97.9 0.85 Contact Map
1c4oA 1 0.6973 97 0.873 Contact Map
2d7dA 2 0.5838 96.1 0.886 Contact Map
4kblA 2 0.827 76.5 0.924 Contact Map
4cgyA 1 0 72.8 0.926 Contact Map
1tfiA 1 0.2108 52.9 0.935 Contact Map
1vd4A 1 0.2973 52.4 0.936 Contact Map
2jtnA 1 0.5622 50.3 0.936 Contact Map
2i13A 1 0.5676 49.9 0.936 Contact Map
3w5kB 1 0.5081 49.7 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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