CTSR - BACSU - GREMLIN Contacts

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CTSR - Transcriptional regulator CtsR

UniProt:	P37568	Sequences: MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQINYVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDIILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	154 (147)
Sequences:	572 (434)
Seq/√Len:	35.8

BACSU - CTSR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
120_M	147_M	6.042	1.00
91_N	141_A	4.669	1.00
94_L	144_M	4.594	1.00
32_I	48_N	3.923	1.00
123_V	143_M	3.472	1.00
123_V	147_M	2.902	1.00
39_V	47_I	2.734	1.00
26_E	70_R	2.567	1.00
27_I	52_T	2.134	0.99
73_K	107_L	2.075	0.99
12_Y	39_V	2.060	0.99
90_I	141_A	2.031	0.99
13_L	27_I	1.999	0.98
99_S	124_M	1.964	0.98
47_I	62_K	1.905	0.98
38_C	48_N	1.892	0.98
103_I	120_M	1.829	0.97
113_S	116_E	1.801	0.97
14_K	62_K	1.801	0.97
126_R	136_R	1.780	0.97
105_R	109_D	1.707	0.96
5_I	47_I	1.706	0.96
6_S	47_I	1.662	0.95
73_K	123_V	1.654	0.95
10_E	14_K	1.602	0.94
14_K	57_Y	1.593	0.94
96_Q	126_R	1.577	0.93
36_F	44_N	1.568	0.93
82_L	105_R	1.553	0.93
14_K	36_F	1.519	0.92
8_I	62_K	1.518	0.92
44_N	65_G	1.481	0.91
95_S	98_A	1.480	0.91
36_F	65_G	1.472	0.91
107_L	117_A	1.461	0.90
107_L	114_E	1.445	0.90
24_I	113_S	1.420	0.89
54_E	136_R	1.411	0.89
84_N	87_I	1.353	0.86
126_R	137_D	1.310	0.85
103_I	121_V	1.307	0.84
37_Q	49_T	1.291	0.84
16_V	48_N	1.280	0.83
112_I	117_A	1.268	0.83
4_N	12_Y	1.267	0.82
5_I	62_K	1.251	0.82
23_E	125_D	1.245	0.81
136_R	150_S	1.234	0.81
35_K	54_E	1.216	0.80
52_T	55_R	1.201	0.79
5_I	8_I	1.175	0.77
13_L	17_L	1.166	0.77
126_R	134_P	1.163	0.77
39_V	59_V	1.152	0.76
65_G	140_R	1.144	0.75
135_E	138_E	1.132	0.75
82_L	109_D	1.116	0.74
23_E	149_T	1.103	0.73
7_D	66_G	1.101	0.73
131_I	139_L	1.083	0.71
135_E	139_L	1.059	0.70
104_L	107_L	1.056	0.69
57_Y	141_A	1.054	0.69
59_V	70_R	1.036	0.68
16_V	47_I	1.019	0.67
103_I	124_M	1.015	0.66
37_Q	73_K	1.002	0.65
83_I	87_I	0.995	0.65
129_L	139_L	0.993	0.65
7_D	14_K	0.987	0.64
134_P	137_D	0.983	0.64
98_A	101_D	0.972	0.63
147_M	150_S	0.962	0.62
25_L	150_S	0.960	0.62
47_I	59_V	0.960	0.62
58_I	76_M	0.959	0.62
100_D	103_I	0.953	0.61
55_R	101_D	0.950	0.61
91_N	94_L	0.946	0.61
109_D	115_R	0.908	0.58
114_E	119_M	0.891	0.56
36_F	49_T	0.870	0.54
15_R	132_D	0.869	0.54
129_L	142_R	0.843	0.52
32_I	145_K	0.839	0.52
11_Q	110_K	0.828	0.51
9_I	116_E	0.822	0.50
5_I	16_V	0.820	0.50
38_C	54_E	0.818	0.50
94_L	141_A	0.813	0.49
87_I	142_R	0.805	0.49
25_L	131_I	0.799	0.48
19_Q	91_N	0.798	0.48
119_M	151_L	0.798	0.48
130_H	135_E	0.797	0.48
89_Q	105_R	0.797	0.48
112_I	147_M	0.794	0.48
93_H	114_E	0.794	0.48
82_L	106_L	0.794	0.48
6_S	62_K	0.790	0.47
130_H	143_M	0.789	0.47
84_N	90_I	0.788	0.47
4_N	14_K	0.787	0.47
73_K	142_R	0.785	0.47
127_S	137_D	0.780	0.47
65_G	141_A	0.771	0.46
48_N	62_K	0.771	0.46
81_V	149_T	0.768	0.45
8_I	25_L	0.764	0.45
5_I	39_V	0.756	0.44
107_L	121_V	0.754	0.44
12_Y	76_M	0.753	0.44
47_I	71_I	0.750	0.44
28_K	88_S	0.749	0.44
32_I	108_E	0.748	0.44
17_L	23_E	0.745	0.44
13_L	16_V	0.743	0.43
26_E	122_S	0.743	0.43
131_I	142_R	0.742	0.43
34_D	98_A	0.740	0.43
96_Q	100_D	0.737	0.43
88_S	132_D	0.737	0.43
79_E	103_I	0.737	0.43
100_D	104_L	0.732	0.42
13_L	112_I	0.730	0.42
10_E	116_E	0.721	0.41
10_E	49_T	0.714	0.41
102_I	145_K	0.708	0.40
28_K	101_D	0.707	0.40
20_N	151_L	0.700	0.40
38_C	105_R	0.698	0.40
8_I	84_N	0.696	0.39
143_M	146_A	0.695	0.39
6_S	66_G	0.689	0.39
20_N	138_E	0.689	0.39
134_P	138_E	0.686	0.39
59_V	66_G	0.684	0.38
32_I	121_V	0.681	0.38
12_Y	36_F	0.681	0.38
47_I	52_T	0.676	0.38
124_M	139_L	0.673	0.38
126_R	133_L	0.667	0.37
87_I	145_K	0.666	0.37
39_V	151_L	0.664	0.37
92_T	97_A	0.658	0.36
92_T	145_K	0.655	0.36
4_N	62_K	0.655	0.36
124_M	135_E	0.645	0.35
30_S	59_V	0.644	0.35
131_I	136_R	0.643	0.35
129_L	140_R	0.643	0.35
57_Y	148_L	0.642	0.35
9_I	49_T	0.633	0.34
107_L	118_K	0.631	0.34
92_T	138_E	0.624	0.34
39_V	65_G	0.621	0.33
6_S	103_I	0.620	0.33
65_G	99_S	0.609	0.32
117_A	139_L	0.606	0.32
119_M	147_M	0.606	0.32
103_I	135_E	0.604	0.32
14_K	129_L	0.603	0.32
139_L	143_M	0.603	0.32
122_S	147_M	0.603	0.32
18_D	94_L	0.600	0.32
22_K	37_Q	0.597	0.32
52_T	70_R	0.595	0.31
124_M	131_I	0.592	0.31
13_L	105_R	0.590	0.31
102_I	144_M	0.589	0.31
132_D	149_T	0.586	0.31
12_Y	49_T	0.585	0.31
63_R	69_I	0.583	0.31
28_K	109_D	0.582	0.30
57_Y	140_R	0.581	0.30
6_S	44_N	0.580	0.30
52_T	99_S	0.579	0.30
4_N	70_R	0.572	0.30
77_N	81_V	0.566	0.29
95_S	145_K	0.566	0.29
122_S	146_A	0.563	0.29
49_T	116_E	0.562	0.29
20_N	109_D	0.560	0.29
138_E	151_L	0.560	0.29
38_C	72_I	0.554	0.28
93_H	111_V	0.553	0.28
108_E	146_A	0.552	0.28
144_M	147_M	0.552	0.28
13_L	133_L	0.551	0.28
44_N	62_K	0.549	0.28
37_Q	136_R	0.547	0.28
23_E	75_K	0.547	0.28
112_I	130_H	0.546	0.28
95_S	111_V	0.546	0.28
43_I	59_V	0.544	0.28
106_L	137_D	0.543	0.28
61_S	71_I	0.539	0.27
8_I	27_I	0.539	0.27
15_R	79_E	0.538	0.27
86_I	131_I	0.538	0.27
53_S	105_R	0.538	0.27
80_V	118_K	0.538	0.27
28_K	126_R	0.538	0.27
81_V	90_I	0.536	0.27
137_D	140_R	0.532	0.27
103_I	117_A	0.531	0.27
32_I	77_N	0.531	0.27
86_I	106_L	0.530	0.27
47_I	69_I	0.527	0.27
93_H	128_V	0.526	0.26
112_I	120_M	0.518	0.26
44_N	140_R	0.518	0.26
16_V	19_Q	0.514	0.26
27_I	143_M	0.512	0.26
23_E	28_K	0.509	0.25
73_K	130_H	0.509	0.25
87_I	112_I	0.507	0.25
128_V	142_R	0.506	0.25
37_Q	52_T	0.504	0.25
24_I	136_R	0.500	0.25

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3h0dA	2	0.987	100	0.036	Contact Map
4u0yA	1	0.4351	83.5	0.925	Contact Map
4h0eA	2	0.4351	83.1	0.925	Contact Map
2ek5A	4	0.7013	82.2	0.926	Contact Map
1xd7A	2	0.7143	77.5	0.929	Contact Map
1ylfA	5	0.7597	77.5	0.929	Contact Map
3by6A	2	0.7143	75.4	0.931	Contact Map
4hamA	2	0.7727	74.5	0.931	Contact Map
3lmmA	1	0.4351	72.2	0.932	Contact Map
3ic7A	2	0.6623	72.1	0.932	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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