GREMLIN Database
CTSR - Transcriptional regulator CtsR
UniProt: P37568 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 154 (147)
Sequences: 572 (434)
Seq/√Len: 35.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_M147_M6.0421.00
91_N141_A4.6691.00
94_L144_M4.5941.00
32_I48_N3.9231.00
123_V143_M3.4721.00
123_V147_M2.9021.00
39_V47_I2.7341.00
26_E70_R2.5671.00
27_I52_T2.1340.99
73_K107_L2.0750.99
12_Y39_V2.0600.99
90_I141_A2.0310.99
13_L27_I1.9990.98
99_S124_M1.9640.98
47_I62_K1.9050.98
38_C48_N1.8920.98
103_I120_M1.8290.97
113_S116_E1.8010.97
14_K62_K1.8010.97
126_R136_R1.7800.97
105_R109_D1.7070.96
5_I47_I1.7060.96
6_S47_I1.6620.95
73_K123_V1.6540.95
10_E14_K1.6020.94
14_K57_Y1.5930.94
96_Q126_R1.5770.93
36_F44_N1.5680.93
82_L105_R1.5530.93
14_K36_F1.5190.92
8_I62_K1.5180.92
44_N65_G1.4810.91
95_S98_A1.4800.91
36_F65_G1.4720.91
107_L117_A1.4610.90
107_L114_E1.4450.90
24_I113_S1.4200.89
54_E136_R1.4110.89
84_N87_I1.3530.86
126_R137_D1.3100.85
103_I121_V1.3070.84
37_Q49_T1.2910.84
16_V48_N1.2800.83
112_I117_A1.2680.83
4_N12_Y1.2670.82
5_I62_K1.2510.82
23_E125_D1.2450.81
136_R150_S1.2340.81
35_K54_E1.2160.80
52_T55_R1.2010.79
5_I8_I1.1750.77
13_L17_L1.1660.77
126_R134_P1.1630.77
39_V59_V1.1520.76
65_G140_R1.1440.75
135_E138_E1.1320.75
82_L109_D1.1160.74
23_E149_T1.1030.73
7_D66_G1.1010.73
131_I139_L1.0830.71
135_E139_L1.0590.70
104_L107_L1.0560.69
57_Y141_A1.0540.69
59_V70_R1.0360.68
16_V47_I1.0190.67
103_I124_M1.0150.66
37_Q73_K1.0020.65
83_I87_I0.9950.65
129_L139_L0.9930.65
7_D14_K0.9870.64
134_P137_D0.9830.64
98_A101_D0.9720.63
147_M150_S0.9620.62
25_L150_S0.9600.62
47_I59_V0.9600.62
58_I76_M0.9590.62
100_D103_I0.9530.61
55_R101_D0.9500.61
91_N94_L0.9460.61
109_D115_R0.9080.58
114_E119_M0.8910.56
36_F49_T0.8700.54
15_R132_D0.8690.54
129_L142_R0.8430.52
32_I145_K0.8390.52
11_Q110_K0.8280.51
9_I116_E0.8220.50
5_I16_V0.8200.50
38_C54_E0.8180.50
94_L141_A0.8130.49
87_I142_R0.8050.49
25_L131_I0.7990.48
19_Q91_N0.7980.48
119_M151_L0.7980.48
130_H135_E0.7970.48
89_Q105_R0.7970.48
112_I147_M0.7940.48
93_H114_E0.7940.48
82_L106_L0.7940.48
6_S62_K0.7900.47
130_H143_M0.7890.47
84_N90_I0.7880.47
4_N14_K0.7870.47
73_K142_R0.7850.47
127_S137_D0.7800.47
65_G141_A0.7710.46
48_N62_K0.7710.46
81_V149_T0.7680.45
8_I25_L0.7640.45
5_I39_V0.7560.44
107_L121_V0.7540.44
12_Y76_M0.7530.44
47_I71_I0.7500.44
28_K88_S0.7490.44
32_I108_E0.7480.44
17_L23_E0.7450.44
13_L16_V0.7430.43
26_E122_S0.7430.43
131_I142_R0.7420.43
34_D98_A0.7400.43
96_Q100_D0.7370.43
88_S132_D0.7370.43
79_E103_I0.7370.43
100_D104_L0.7320.42
13_L112_I0.7300.42
10_E116_E0.7210.41
10_E49_T0.7140.41
102_I145_K0.7080.40
28_K101_D0.7070.40
20_N151_L0.7000.40
38_C105_R0.6980.40
8_I84_N0.6960.39
143_M146_A0.6950.39
6_S66_G0.6890.39
20_N138_E0.6890.39
134_P138_E0.6860.39
59_V66_G0.6840.38
32_I121_V0.6810.38
12_Y36_F0.6810.38
47_I52_T0.6760.38
124_M139_L0.6730.38
126_R133_L0.6670.37
87_I145_K0.6660.37
39_V151_L0.6640.37
92_T97_A0.6580.36
92_T145_K0.6550.36
4_N62_K0.6550.36
124_M135_E0.6450.35
30_S59_V0.6440.35
131_I136_R0.6430.35
129_L140_R0.6430.35
57_Y148_L0.6420.35
9_I49_T0.6330.34
107_L118_K0.6310.34
92_T138_E0.6240.34
39_V65_G0.6210.33
6_S103_I0.6200.33
65_G99_S0.6090.32
117_A139_L0.6060.32
119_M147_M0.6060.32
103_I135_E0.6040.32
14_K129_L0.6030.32
139_L143_M0.6030.32
122_S147_M0.6030.32
18_D94_L0.6000.32
22_K37_Q0.5970.32
52_T70_R0.5950.31
124_M131_I0.5920.31
13_L105_R0.5900.31
102_I144_M0.5890.31
132_D149_T0.5860.31
12_Y49_T0.5850.31
63_R69_I0.5830.31
28_K109_D0.5820.30
57_Y140_R0.5810.30
6_S44_N0.5800.30
52_T99_S0.5790.30
4_N70_R0.5720.30
77_N81_V0.5660.29
95_S145_K0.5660.29
122_S146_A0.5630.29
49_T116_E0.5620.29
20_N109_D0.5600.29
138_E151_L0.5600.29
38_C72_I0.5540.28
93_H111_V0.5530.28
108_E146_A0.5520.28
144_M147_M0.5520.28
13_L133_L0.5510.28
44_N62_K0.5490.28
37_Q136_R0.5470.28
23_E75_K0.5470.28
112_I130_H0.5460.28
95_S111_V0.5460.28
43_I59_V0.5440.28
106_L137_D0.5430.28
61_S71_I0.5390.27
8_I27_I0.5390.27
15_R79_E0.5380.27
86_I131_I0.5380.27
53_S105_R0.5380.27
80_V118_K0.5380.27
28_K126_R0.5380.27
81_V90_I0.5360.27
137_D140_R0.5320.27
103_I117_A0.5310.27
32_I77_N0.5310.27
86_I106_L0.5300.27
47_I69_I0.5270.27
93_H128_V0.5260.26
112_I120_M0.5180.26
44_N140_R0.5180.26
16_V19_Q0.5140.26
27_I143_M0.5120.26
23_E28_K0.5090.25
73_K130_H0.5090.25
87_I112_I0.5070.25
128_V142_R0.5060.25
37_Q52_T0.5040.25
24_I136_R0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h0dA 2 0.987 100 0.036 Contact Map
4u0yA 1 0.4351 83.5 0.925 Contact Map
4h0eA 2 0.4351 83.1 0.925 Contact Map
2ek5A 4 0.7013 82.2 0.926 Contact Map
1xd7A 2 0.7143 77.5 0.929 Contact Map
1ylfA 5 0.7597 77.5 0.929 Contact Map
3by6A 2 0.7143 75.4 0.931 Contact Map
4hamA 2 0.7727 74.5 0.931 Contact Map
3lmmA 1 0.4351 72.2 0.932 Contact Map
3ic7A 2 0.6623 72.1 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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