GREMLIN Database
DUS1 - Probable tRNA-dihydrouridine synthase 1
UniProt: P37567 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (304)
Sequences: 6668 (3993)
Seq/√Len: 229.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_E263_L4.5971.00
192_K221_D4.4201.00
207_T210_D3.3111.00
88_D135_N3.2331.00
206_K210_D2.9881.00
131_V166_K2.8721.00
213_R217_E2.6921.00
66_K94_D2.6201.00
161_E196_S2.6171.00
127_V165_G2.4531.00
189_K193_Q2.4481.00
186_D217_E2.4271.00
128_S132_D2.3691.00
80_L98_I2.3521.00
307_T310_E2.2691.00
212_K216_D2.2301.00
201_G214_M2.2181.00
118_L146_W2.2071.00
26_F30_V2.1221.00
84_A134_V2.0811.00
144_M187_I2.0291.00
124_Y163_A2.0091.00
212_K242_Y2.0011.00
190_E193_Q1.9761.00
205_V214_M1.9641.00
161_E197_I1.8971.00
100_M123_I1.8891.00
82_E85_K1.8751.00
119_D122_K1.8691.00
134_V138_V1.8601.00
262_K312_V1.8601.00
266_D312_V1.8571.00
78_E82_E1.8501.00
184_N187_I1.8271.00
124_Y159_A1.8101.00
177_Q184_N1.8041.00
213_R216_D1.7961.00
188_I201_G1.7861.00
210_D213_R1.7731.00
123_I156_N1.7541.00
69_S95_I1.7521.00
206_K228_A1.7241.00
111_D119_D1.7151.00
300_N304_H1.7121.00
121_D125_E1.7111.00
85_K133_A1.7101.00
70_L87_V1.6991.00
158_Q194_S1.6791.00
80_L130_V1.6571.00
264_H288_Y1.6491.00
211_A223_V1.6421.00
153_A191_V1.6411.00
37_L69_S1.6401.00
262_K316_D1.6381.00
81_V133_A1.6371.00
76_K79_T1.6181.00
142_M170_L1.6171.00
310_E313_Q1.5931.00
124_Y162_R1.5851.00
241_Q245_T1.5821.00
241_Q249_K1.5791.00
155_K158_Q1.5791.00
124_Y128_S1.5771.00
195_V199_V1.5591.00
121_D159_A1.5541.00
14_V200_I1.5511.00
36_G240_V1.5491.00
201_G205_V1.5371.00
77_K81_V1.5361.00
200_I222_G1.5331.00
187_I190_E1.5321.00
167_A200_I1.5311.00
209_Q213_R1.5281.00
200_I224_M1.5191.00
154_V194_S1.5131.00
189_K214_M1.4951.00
183_A204_D1.4881.00
125_E128_S1.4791.00
98_I130_V1.4741.00
122_K125_E1.4611.00
88_D136_K1.4381.00
74_G80_L1.4371.00
192_K199_V1.4281.00
88_D134_V1.4241.00
158_Q161_E1.4231.00
232_N238_R1.4171.00
189_K217_E1.4091.00
297_N300_N1.3961.00
312_V316_D1.3911.00
11_N36_G1.3891.00
128_S163_A1.3861.00
87_V96_I1.3741.00
237_Y256_E1.3731.00
140_V160_V1.3721.00
46_K79_T1.3351.00
201_G220_V1.3091.00
13_V223_V1.2951.00
172_G188_I1.2801.00
263_L267_R1.2731.00
253_Q256_E1.2541.00
305_C310_E1.2511.00
157_A195_V1.2491.00
305_C314_L1.2431.00
16_A226_G1.2281.00
13_V239_T1.2271.00
266_D270_D1.2251.00
139_T167_A1.2211.00
158_Q162_R1.2141.00
117_L142_M1.2091.00
127_V163_A1.2071.00
39_C169_A1.2051.00
28_L32_E1.1901.00
114_A175_R1.1821.00
48_I86_F1.1761.00
157_A191_V1.1731.00
144_M184_N1.1721.00
225_I239_T1.1631.00
258_M262_K1.1621.00
190_E194_S1.1621.00
39_C69_S1.1611.00
77_K122_K1.1591.00
309_E313_Q1.1561.00
31_K65_E1.1481.00
155_K159_A1.1451.00
37_L95_I1.1361.00
148_E177_Q1.1301.00
211_A239_T1.1221.00
117_L156_N1.1201.00
140_V165_G1.1101.00
306_E310_E1.1081.00
33_F260_V1.1081.00
261_C285_A1.1071.00
241_Q247_K1.1061.00
242_Y245_T1.1011.00
14_V37_L1.0931.00
161_E195_V1.0931.00
117_L152_F1.0931.00
156_N160_V1.0921.00
240_V244_E1.0881.00
271_L276_V1.0811.00
154_V190_E1.0771.00
144_M172_G1.0741.00
214_M220_V1.0711.00
127_V160_V1.0661.00
170_L191_V1.0641.00
208_P238_R1.0621.00
45_D83_A1.0481.00
46_K50_Y1.0451.00
131_V138_V1.0421.00
264_H268_L1.0411.00
185_W214_M1.0411.00
28_L267_R1.0411.00
80_L126_M1.0391.00
15_L30_V1.0361.00
127_V140_V1.0351.00
28_L64_R1.0301.00
214_M218_T1.0261.00
24_S28_L1.0261.00
297_N301_E1.0201.00
123_I160_V1.0201.00
116_W126_M1.0191.00
85_K89_Q1.0181.00
28_L62_D1.0151.00
242_Y246_G1.0131.00
154_V195_V1.0041.00
308_R312_V1.0001.00
153_A187_I0.9981.00
159_A163_A0.9971.00
205_V211_A0.9971.00
142_M156_N0.9901.00
209_Q242_Y0.9871.00
189_K219_G0.9851.00
120_P155_K0.9811.00
256_E259_A0.9801.00
81_V85_K0.9731.00
52_N55_T0.9711.00
275_N279_R0.9601.00
305_C311_F0.9591.00
78_E129_A0.9531.00
267_R270_D0.9521.00
254_V257_K0.9471.00
111_D115_K0.9451.00
15_L229_A0.9381.00
257_K292_V0.9371.00
31_K67_P0.9351.00
229_A235_M0.9301.00
144_M151_I0.9271.00
289_L295_N0.9261.00
301_E305_C0.9241.00
33_F237_Y0.9221.00
229_A236_I0.9171.00
154_V191_V0.9151.00
128_S162_R0.9121.00
85_K88_D0.9101.00
262_K266_D0.9040.99
156_N159_A0.9040.99
84_A130_V0.9040.99
264_H285_A0.9000.99
279_R282_R0.8980.99
169_A224_M0.8940.99
228_A232_N0.8930.99
129_A132_D0.8930.99
165_G168_V0.8810.99
121_D124_Y0.8750.99
158_Q195_V0.8730.99
205_V223_V0.8720.99
69_S139_T0.8660.99
79_T82_E0.8640.99
264_H281_M0.8630.99
25_A267_R0.8560.99
160_V165_G0.8550.99
104_V107_I0.8550.99
49_L82_E0.8510.99
234_W257_K0.8490.99
273_G277_A0.8460.99
123_I127_V0.8420.99
24_S60_Y0.8380.99
252_P256_E0.8370.99
14_V39_C0.8370.99
77_K125_E0.8350.99
108_T115_K0.8330.99
167_A198_P0.8330.99
170_L199_V0.8290.99
309_E312_V0.8250.99
61_I68_L0.8240.99
25_A271_L0.8190.99
177_Q181_G0.8130.99
87_V93_A0.8090.99
60_Y91_T0.8050.99
208_P212_K0.8040.99
204_D227_R0.7970.99
21_V287_W0.7960.99
81_V129_A0.7960.99
289_L298_V0.7950.99
77_K126_M0.7930.99
86_F89_Q0.7920.99
296_A300_N0.7920.99
101_G202_N0.7910.99
255_R259_A0.7900.99
13_V236_I0.7900.99
82_E86_F0.7890.99
266_D269_I0.7860.99
149_D152_F0.7850.99
272_K280_E0.7850.99
142_M153_A0.7850.99
148_E151_I0.7830.98
57_G60_Y0.7820.98
259_A263_L0.7810.98
215_L223_V0.7810.98
261_C264_H0.7750.98
265_L269_I0.7740.98
12_R36_G0.7700.98
15_L22_C0.7680.98
95_I139_T0.7670.98
269_I312_V0.7640.98
16_A224_M0.7600.98
97_D169_A0.7570.98
230_L287_W0.7560.98
131_V165_G0.7550.98
100_M140_V0.7540.98
49_L79_T0.7530.98
30_V229_A0.7500.98
209_Q212_K0.7490.98
283_K287_W0.7480.98
269_I273_G0.7460.98
81_V134_V0.7400.98
257_K261_C0.7380.98
53_A57_G0.7330.98
188_I199_V0.7320.98
245_T249_K0.7310.98
271_L274_E0.7300.98
40_A68_L0.7270.98
157_A168_V0.7240.98
147_D174_T0.7220.97
215_L220_V0.7220.97
168_V197_I0.7210.97
30_V35_A0.7180.97
263_L266_D0.7180.97
272_K276_V0.7160.97
186_D190_E0.7140.97
241_Q246_G0.7010.97
142_M157_A0.7000.97
208_P242_Y0.7000.97
89_Q92_T0.7000.97
75_G111_D0.6990.97
45_D80_L0.6980.97
234_W252_P0.6970.97
189_K220_V0.6960.97
210_D214_M0.6960.97
161_E168_V0.6950.97
208_P211_A0.6940.97
154_V158_Q0.6930.97
44_S73_F0.6930.97
19_A42_M0.6920.97
310_E314_L0.6920.97
311_F314_L0.6890.97
276_V280_E0.6870.97
299_R303_N0.6860.97
130_V138_V0.6850.97
29_T267_R0.6840.96
37_L167_A0.6800.96
115_K118_L0.6790.96
72_I80_L0.6780.96
31_K38_V0.6780.96
61_I65_E0.6780.96
137_P166_K0.6760.96
212_K243_L0.6750.96
266_D308_R0.6700.96
96_I134_V0.6650.96
12_R222_G0.6630.96
105_P109_K0.6630.96
45_D79_T0.6570.96
129_A133_A0.6570.96
159_A162_R0.6540.95
92_T136_K0.6540.95
108_T146_W0.6530.95
13_V211_A0.6520.95
118_L152_F0.6470.95
30_V33_F0.6460.95
117_L123_I0.6450.95
111_D122_K0.6430.95
55_T58_M0.6430.95
105_P178_M0.6410.95
152_F156_N0.6410.95
24_S62_D0.6380.95
48_I91_T0.6380.95
276_V281_M0.6370.95
189_K218_T0.6360.95
21_V230_L0.6360.95
199_V220_V0.6350.95
212_K215_L0.6340.95
147_D176_V0.6340.95
239_T243_L0.6340.95
169_A200_I0.6320.95
168_V195_V0.6290.94
258_M261_C0.6270.94
142_M168_V0.6260.94
120_P159_A0.6250.94
258_M315_L0.6240.94
157_A170_L0.6240.94
25_A28_L0.6230.94
30_V236_I0.6220.94
167_A222_G0.6210.94
154_V157_A0.6210.94
185_W201_G0.6200.94
225_I235_M0.6200.94
208_P239_T0.6200.94
40_A70_L0.6200.94
32_E64_R0.6190.94
289_L299_R0.6190.94
206_K226_G0.6180.94
238_R251_E0.6180.94
84_A96_I0.6130.94
75_G112_A0.6120.94
131_V163_A0.6090.93
53_A58_M0.6080.93
81_V132_D0.6080.93
191_V194_S0.6060.93
14_V167_A0.6020.93
225_I236_I0.5990.93
286_A303_N0.5950.93
179_Y204_D0.5950.93
189_K205_V0.5950.93
48_I53_A0.5950.93
313_Q316_D0.5930.93
61_I66_K0.5910.92
269_I308_R0.5910.92
257_K260_V0.5910.92
14_V169_A0.5900.92
70_L93_A0.5830.92
154_V187_I0.5830.92
105_P108_T0.5820.92
44_S47_A0.5800.92
247_K250_E0.5790.92
151_I154_V0.5760.91
104_V178_M0.5710.91
98_I127_V0.5710.91
265_L308_R0.5690.91
100_M160_V0.5680.91
117_L145_G0.5680.91
118_L147_D0.5680.91
165_G197_I0.5660.91
237_Y241_Q0.5650.91
49_L83_A0.5650.91
241_Q250_E0.5650.91
185_W217_E0.5640.91
232_N235_M0.5640.91
188_I220_V0.5630.90
18_M21_V0.5570.90
298_V301_E0.5560.90
54_R91_T0.5560.90
295_N299_R0.5540.90
119_D125_E0.5530.90
148_E176_V0.5530.90
225_I229_A0.5520.90
24_S61_I0.5520.90
13_V240_V0.5510.90
188_I214_M0.5500.89
39_C139_T0.5490.89
22_C30_V0.5480.89
35_A38_V0.5460.89
126_M129_A0.5440.89
81_V130_V0.5440.89
235_M239_T0.5380.88
285_A311_F0.5380.88
172_G183_A0.5340.88
130_V134_V0.5340.88
275_N306_E0.5330.88
161_E198_P0.5330.88
282_R306_E0.5320.88
153_A170_L0.5310.88
157_A194_S0.5310.88
268_L272_K0.5300.88
307_T311_F0.5300.88
101_G224_M0.5300.88
107_I112_A0.5290.88
32_E267_R0.5280.87
301_E310_E0.5270.87
84_A88_D0.5260.87
308_R311_F0.5260.87
239_T242_Y0.5250.87
274_E307_T0.5240.87
60_Y63_E0.5240.87
187_I194_S0.5240.87
234_W237_Y0.5230.87
13_V36_G0.5230.87
179_Y183_A0.5230.87
61_I94_D0.5220.87
259_A262_K0.5200.87
29_T33_F0.5190.87
72_I130_V0.5190.87
147_D151_I0.5180.86
211_A215_L0.5170.86
124_Y160_V0.5150.86
144_M153_A0.5140.86
185_W213_R0.5130.86
121_D155_K0.5130.86
246_G249_K0.5130.86
265_L268_L0.5120.86
54_R60_Y0.5120.86
36_G225_I0.5110.86
194_S199_V0.5110.86
250_E253_Q0.5110.86
122_K126_M0.5090.86
85_K132_D0.5070.85
289_L315_L0.5060.85
145_G226_G0.5050.85
186_D189_K0.5050.85
263_L270_D0.5030.85
39_C95_I0.5030.85
51_N56_M0.5030.85
277_A280_E0.5020.85
146_W175_R0.5020.85
193_Q219_G0.5010.85
84_A138_V0.5010.85
19_A43_V0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhnA 1 0.9159 100 0.35 Contact Map
3b0pA 1 0.8979 100 0.371 Contact Map
4bfaA 1 0.9219 100 0.373 Contact Map
4xp7A 1 0.8919 100 0.397 Contact Map
1gteA 4 0.97 100 0.589 Contact Map
3tjlA 2 0.8529 100 0.615 Contact Map
3l5aA 1 0.8228 100 0.619 Contact Map
4gbuA 2 0.8168 100 0.619 Contact Map
4tmbA 2 0.8258 100 0.625 Contact Map
1o94A 2 0.8859 100 0.627 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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