HSLO - BACSU - GREMLIN Contacts

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HSLO - 33 kDa chaperonin

UniProt:	P37565	Sequences: MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGRTMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQGKLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVGVLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEVLGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYLFTKEELEGLRDQTTR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	291 (278)
Sequences:	2391 (1558)
Seq/√Len:	93.5

ECOLI - HSLO
BACSU - HSLO

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
80_N	84_E	4.603	1.00
69_G	113_N	4.583	1.00
255_Q	259_E	4.286	1.00
39_S	169_I	3.934	1.00
26_N	29_Q	3.664	1.00
21_T	47_T	3.465	1.00
256_D	260_E	2.906	1.00
246_I	254_I	2.875	1.00
49_S	77_A	2.864	1.00
86_R	236_P	2.754	1.00
84_E	232_R	2.687	1.00
239_K	281_E	2.509	1.00
251_K	255_Q	2.495	1.00
279_K	283_E	2.475	1.00
267_V	274_K	2.469	1.00
19_A	47_T	2.441	1.00
265_E	274_K	2.437	1.00
263_Q	276_L	2.279	1.00
253_E	256_D	2.270	1.00
72_I	89_V	2.261	1.00
33_G	93_Q	2.256	1.00
27_E	31_R	2.254	1.00
16_A	215_L	2.158	1.00
140_G	159_V	2.133	1.00
105_D	108_R	2.131	1.00
7_A	16_A	2.072	1.00
239_K	277_F	2.040	1.00
27_E	30_R	2.038	1.00
28_G	46_M	2.000	1.00
31_R	233_F	1.998	1.00
262_G	279_K	1.977	1.00
242_F	266_A	1.967	1.00
31_R	273_E	1.956	1.00
45_T	75_I	1.953	1.00
16_A	219_L	1.926	1.00
3_Y	228_T	1.917	1.00
116_L	132_V	1.908	1.00
46_M	87_A	1.831	1.00
84_E	234_H	1.827	1.00
210_T	213_E	1.819	1.00
170_L	206_Q	1.817	1.00
52_L	147_L	1.790	1.00
254_I	286_R	1.770	1.00
38_A	89_V	1.764	1.00
213_E	216_E	1.762	1.00
49_S	64_V	1.755	1.00
209_L	217_E	1.734	1.00
38_A	72_I	1.728	1.00
34_T	39_S	1.709	1.00
13_K	187_T	1.703	1.00
193_Q	196_S	1.702	1.00
194_R	221_E	1.690	1.00
265_E	276_L	1.664	1.00
247_L	250_G	1.634	1.00
147_L	155_S	1.634	1.00
237_C	268_C	1.592	1.00
193_Q	197_Q	1.582	1.00
68_G	111_G	1.580	1.00
78_D	86_R	1.558	1.00
255_Q	286_R	1.554	1.00
63_T	78_D	1.525	1.00
189_T	192_E	1.520	1.00
48_A	159_V	1.516	1.00
45_T	77_A	1.501	1.00
242_F	245_A	1.492	1.00
48_A	143_F	1.488	1.00
50_L	231_V	1.486	1.00
185_D	189_T	1.478	1.00
280_E	283_E	1.476	1.00
95_H	167_N	1.472	1.00
189_T	193_Q	1.464	1.00
117_S	129_T	1.452	1.00
235_C	271_C	1.448	1.00
255_Q	283_E	1.429	0.99
47_T	172_A	1.412	0.99
49_S	79_A	1.393	0.99
243_E	277_F	1.386	0.99
278_T	281_E	1.374	0.99
6_K	17_Y	1.373	0.99
14_V	179_L	1.372	0.99
2_D	24_M	1.368	0.99
136_S	141_D	1.348	0.99
5_V	211_P	1.347	0.99
237_C	271_C	1.319	0.99
51_M	174_G	1.314	0.99
144_T	148_V	1.311	0.99
66_I	134_I	1.310	0.99
268_C	271_C	1.308	0.99
209_L	214_I	1.308	0.99
42_L	87_A	1.262	0.99
61_K	78_D	1.252	0.99
243_E	284_G	1.250	0.99
252_K	256_D	1.230	0.98
3_Y	212_E	1.210	0.98
96_F	108_R	1.209	0.98
10_Y	224_E	1.203	0.98
239_K	243_E	1.179	0.98
4_L	54_A	1.177	0.98
45_T	66_I	1.169	0.98
281_E	284_G	1.163	0.98
12_G	224_E	1.163	0.98
243_E	247_L	1.162	0.98
204_L	214_I	1.155	0.98
245_A	266_A	1.150	0.98
94_V	109_A	1.134	0.97
8_L	226_L	1.133	0.97
164_N	170_L	1.132	0.97
209_L	213_E	1.132	0.97
122_L	125_R	1.129	0.97
193_Q	222_K	1.125	0.97
184_D	187_T	1.124	0.97
116_L	134_I	1.124	0.97
40_A	104_L	1.120	0.97
261_D	264_A	1.119	0.97
251_K	286_R	1.115	0.97
264_A	282_L	1.115	0.97
202_S	205_I	1.113	0.97
23_D	27_E	1.104	0.97
254_I	282_L	1.102	0.97
83_G	231_V	1.101	0.97
258_I	282_L	1.101	0.97
45_T	64_V	1.096	0.97
50_L	85_V	1.092	0.97
45_T	139_L	1.083	0.96
249_L	257_M	1.080	0.96
235_C	268_C	1.077	0.96
83_G	229_M	1.072	0.96
38_A	91_N	1.063	0.96
157_V	176_I	1.058	0.96
13_K	184_D	1.049	0.96
257_M	263_Q	1.047	0.96
179_L	188_I	1.033	0.95
3_Y	211_P	1.028	0.95
2_D	23_D	1.021	0.95
144_T	156_S	1.016	0.95
25_V	46_M	1.001	0.95
171_A	205_I	0.998	0.94
233_F	273_E	0.996	0.94
145_Y	149_S	0.988	0.94
250_G	253_E	0.984	0.94
74_A	90_S	0.982	0.94
137_G	141_D	0.968	0.93
5_V	225_I	0.965	0.93
175_F	198_V	0.963	0.93
14_V	191_I	0.953	0.93
26_N	30_R	0.943	0.93
18_A	211_P	0.939	0.92
166_D	170_L	0.936	0.92
138_E	141_D	0.934	0.92
77_A	87_A	0.921	0.92
42_L	233_F	0.920	0.92
66_I	139_L	0.916	0.91
69_G	111_G	0.905	0.91
64_V	116_L	0.901	0.91
58_G	81_A	0.895	0.91
41_A	110_V	0.887	0.90
158_G	175_F	0.887	0.90
242_F	248_G	0.881	0.90
201_I	214_I	0.880	0.90
64_V	143_F	0.879	0.90
52_L	55_M	0.869	0.89
22_T	171_A	0.867	0.89
247_L	285_L	0.865	0.89
25_V	47_T	0.860	0.89
258_I	263_Q	0.857	0.89
65_K	117_S	0.841	0.88
27_E	232_R	0.840	0.88
24_M	85_V	0.840	0.88
17_Y	55_M	0.838	0.87
55_M	176_I	0.838	0.87
200_P	203_K	0.832	0.87
70_G	111_G	0.832	0.87
263_Q	279_K	0.832	0.87
51_M	55_M	0.831	0.87
179_L	191_I	0.828	0.87
66_I	110_V	0.825	0.87
141_D	144_T	0.825	0.87
65_K	129_T	0.824	0.86
4_L	231_V	0.823	0.86
194_R	217_E	0.820	0.86
98_L	105_D	0.818	0.86
171_A	202_S	0.815	0.86
76_V	88_Y	0.814	0.86
188_I	192_E	0.813	0.86
156_S	195_L	0.813	0.86
67_E	90_S	0.811	0.86
194_R	220_G	0.804	0.85
51_M	176_I	0.804	0.85
19_A	231_V	0.804	0.85
148_V	154_P	0.802	0.85
186_E	190_K	0.802	0.85
48_A	51_M	0.801	0.85
67_E	74_A	0.799	0.85
68_G	110_V	0.789	0.84
216_E	220_G	0.788	0.84
67_E	115_T	0.787	0.84
212_E	225_I	0.783	0.84
199_E	224_E	0.782	0.83
40_A	103_K	0.780	0.83
194_R	197_Q	0.779	0.83
215_L	223_P	0.775	0.83
48_A	147_L	0.772	0.83
240_E	243_E	0.772	0.83
130_G	146_Y	0.770	0.83
97_D	105_D	0.768	0.82
155_S	178_Q	0.766	0.82
258_I	264_A	0.766	0.82
198_V	218_V	0.766	0.82
258_I	279_K	0.765	0.82
61_K	236_P	0.764	0.82
107_R	137_G	0.764	0.82
190_K	193_Q	0.763	0.82
207_K	217_E	0.759	0.82
40_A	106_V	0.757	0.81
34_T	89_V	0.755	0.81
242_F	269_H	0.755	0.81
136_S	145_Y	0.754	0.81
54_A	229_M	0.751	0.81
40_A	44_R	0.749	0.81
255_Q	258_I	0.749	0.81
46_M	49_S	0.744	0.80
55_M	153_V	0.743	0.80
53_G	79_A	0.740	0.80
66_I	116_L	0.740	0.80
183_T	188_I	0.740	0.80
216_E	221_E	0.739	0.80
78_D	236_P	0.735	0.80
119_V	129_T	0.733	0.79
50_L	147_L	0.730	0.79
215_L	225_I	0.727	0.79
180_M	231_V	0.724	0.79
5_V	228_T	0.722	0.78
35_W	93_Q	0.719	0.78
257_M	261_D	0.718	0.78
117_S	131_Q	0.718	0.78
19_A	50_L	0.718	0.78
156_S	199_E	0.718	0.78
51_M	215_L	0.712	0.77
269_H	272_N	0.711	0.77
250_G	270_F	0.711	0.77
187_T	190_K	0.710	0.77
258_I	286_R	0.709	0.77
96_F	105_D	0.708	0.77
41_A	72_I	0.705	0.77
203_K	206_Q	0.705	0.77
249_L	254_I	0.703	0.76
41_A	75_I	0.699	0.76
197_Q	217_E	0.698	0.76
149_S	272_N	0.697	0.76
28_G	34_T	0.697	0.76
11_D	222_K	0.697	0.76
121_D	124_L	0.695	0.76
235_C	238_S	0.692	0.75
20_R	211_P	0.691	0.75
74_A	77_A	0.690	0.75
147_L	176_I	0.688	0.75
55_M	147_L	0.687	0.75
147_L	157_V	0.684	0.74
201_I	211_P	0.683	0.74
212_E	228_T	0.682	0.74
9_A	219_L	0.680	0.74
17_Y	158_G	0.677	0.74
137_G	142_D	0.676	0.74
17_Y	54_A	0.676	0.74
261_D	279_K	0.674	0.73
164_N	167_N	0.673	0.73
15_R	215_L	0.671	0.73
2_D	20_R	0.668	0.73
177_I	198_V	0.668	0.73
25_V	161_V	0.665	0.72
238_S	268_C	0.663	0.72
181_P	226_L	0.661	0.72
139_L	190_K	0.661	0.72
59_D	81_A	0.659	0.72
263_Q	278_T	0.658	0.72
190_K	194_R	0.656	0.71
107_R	110_V	0.655	0.71
118_V	233_F	0.653	0.71
244_T	247_L	0.653	0.71
127_F	147_L	0.651	0.71
37_T	104_L	0.651	0.71
160_G	202_S	0.647	0.70
138_E	142_D	0.642	0.70
121_D	270_F	0.636	0.69
61_K	234_H	0.634	0.69
4_L	19_A	0.634	0.69
199_E	207_K	0.628	0.68
7_A	219_L	0.627	0.68
53_G	80_N	0.625	0.68
238_S	275_Y	0.624	0.68
192_E	196_S	0.624	0.68
18_A	223_P	0.622	0.67
197_Q	218_V	0.618	0.67
37_T	95_H	0.618	0.67
63_T	121_D	0.615	0.66
177_I	218_V	0.614	0.66
52_L	176_I	0.613	0.66
252_K	259_E	0.612	0.66
88_Y	266_A	0.612	0.66
97_D	108_R	0.610	0.66
29_Q	39_S	0.610	0.66
149_S	153_V	0.609	0.66
62_L	79_A	0.608	0.66
247_L	253_E	0.605	0.65
262_G	283_E	0.605	0.65
18_A	215_L	0.605	0.65
217_E	221_E	0.604	0.65
63_T	136_S	0.603	0.65
47_T	50_L	0.601	0.65
66_I	75_I	0.599	0.64
45_T	49_S	0.596	0.64
103_K	108_R	0.595	0.64
246_I	277_F	0.595	0.64
6_K	147_L	0.595	0.64
179_L	195_L	0.592	0.64
38_A	75_I	0.591	0.63
119_V	127_F	0.590	0.63
59_D	123_G	0.588	0.63
20_R	171_A	0.586	0.63
135_V	141_D	0.585	0.63
73_G	91_N	0.585	0.63
24_M	46_M	0.584	0.63
117_S	153_V	0.583	0.62
106_V	138_E	0.583	0.62
179_L	183_T	0.583	0.62
52_L	143_F	0.583	0.62
133_E	145_Y	0.583	0.62
71_P	111_G	0.582	0.62
10_Y	180_M	0.580	0.62
73_G	90_S	0.579	0.62
6_K	16_A	0.577	0.62
216_E	223_P	0.576	0.61
5_V	18_A	0.574	0.61
253_E	257_M	0.572	0.61
216_E	222_K	0.572	0.61
9_A	223_P	0.571	0.61
111_G	225_I	0.570	0.61
90_S	269_H	0.568	0.60
153_V	246_I	0.565	0.60
128_F	257_M	0.564	0.60
19_A	156_S	0.564	0.60
65_K	119_V	0.563	0.60
224_E	227_E	0.560	0.59
154_P	159_V	0.560	0.59
63_T	76_V	0.559	0.59
130_G	147_L	0.559	0.59
95_H	98_L	0.559	0.59
107_R	138_E	0.556	0.59
59_D	82_K	0.555	0.59
255_Q	279_K	0.555	0.59
180_M	226_L	0.553	0.58
222_K	280_E	0.553	0.58
68_G	77_A	0.551	0.58
50_L	81_A	0.551	0.58
44_R	138_E	0.550	0.58
63_T	106_V	0.549	0.58
34_T	38_A	0.549	0.58
249_L	253_E	0.548	0.58
105_D	137_G	0.548	0.58
215_L	219_L	0.547	0.58
189_T	196_S	0.546	0.57
180_M	236_P	0.545	0.57
253_E	258_I	0.544	0.57
67_E	113_N	0.544	0.57
186_E	189_T	0.542	0.57
6_K	227_E	0.542	0.57
133_E	272_N	0.542	0.57
37_T	94_V	0.541	0.57
118_V	224_E	0.539	0.56
193_Q	221_E	0.539	0.56
63_T	171_A	0.538	0.56
207_K	210_T	0.537	0.56
236_P	267_V	0.537	0.56
69_G	75_I	0.537	0.56
106_V	141_D	0.536	0.56
79_A	85_V	0.535	0.56
86_R	170_L	0.535	0.56
217_E	220_G	0.534	0.56
28_G	42_L	0.534	0.56
3_Y	230_P	0.533	0.56
233_F	237_C	0.531	0.55
103_K	106_V	0.530	0.55
20_R	72_I	0.530	0.55
175_F	218_V	0.528	0.55
38_A	92_P	0.526	0.55
7_A	198_V	0.526	0.55
241_R	248_G	0.526	0.55
61_K	123_G	0.526	0.55
196_S	199_E	0.525	0.54
246_I	285_L	0.524	0.54
152_Q	181_P	0.520	0.54
29_Q	169_I	0.520	0.54
167_N	171_A	0.520	0.54
13_K	182_G	0.520	0.54
33_G	167_N	0.519	0.54
35_W	167_N	0.519	0.54
154_P	174_G	0.517	0.53
161_V	172_A	0.514	0.53
16_A	119_V	0.514	0.53
21_T	172_A	0.513	0.53
250_G	286_R	0.513	0.53
261_D	282_L	0.512	0.53
29_Q	60_D	0.507	0.52
3_Y	20_R	0.507	0.52
200_P	217_E	0.507	0.52
150_S	181_P	0.507	0.52
16_A	60_D	0.507	0.52
235_C	275_Y	0.506	0.52
53_G	147_L	0.505	0.52
145_Y	148_V	0.505	0.52
237_C	275_Y	0.503	0.51
70_G	130_G	0.502	0.51
225_I	228_T	0.501	0.51
197_Q	221_E	0.501	0.51
46_M	50_L	0.501	0.51
76_V	245_A	0.500	0.51
204_L	217_E	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vzyA	3	0.9966	100	0.012	Contact Map
1vq0A	2	0.9863	100	0.053	Contact Map
1i7fA	2	0.7801	100	0.073	Contact Map
1hw7A	2	0.7835	100	0.202	Contact Map
2xigA	4	0.3643	41.1	0.959	Contact Map
3t7vA	1	0.2509	37.7	0.96	Contact Map
3iixA	1	0.299	33.7	0.961	Contact Map
1h67A	1	0.3436	26.6	0.963	Contact Map
2ds5A	2	0.0893	25.5	0.963	Contact Map
1ovxA	2	0.079	18.1	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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