GREMLIN Database
HSLO - 33 kDa chaperonin
UniProt: P37565 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 291 (278)
Sequences: 2391 (1558)
Seq/√Len: 93.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_N84_E4.6031.00
69_G113_N4.5831.00
255_Q259_E4.2861.00
39_S169_I3.9341.00
26_N29_Q3.6641.00
21_T47_T3.4651.00
256_D260_E2.9061.00
246_I254_I2.8751.00
49_S77_A2.8641.00
86_R236_P2.7541.00
84_E232_R2.6871.00
239_K281_E2.5091.00
251_K255_Q2.4951.00
279_K283_E2.4751.00
267_V274_K2.4691.00
19_A47_T2.4411.00
265_E274_K2.4371.00
263_Q276_L2.2791.00
253_E256_D2.2701.00
72_I89_V2.2611.00
33_G93_Q2.2561.00
27_E31_R2.2541.00
16_A215_L2.1581.00
140_G159_V2.1331.00
105_D108_R2.1311.00
7_A16_A2.0721.00
239_K277_F2.0401.00
27_E30_R2.0381.00
28_G46_M2.0001.00
31_R233_F1.9981.00
262_G279_K1.9771.00
242_F266_A1.9671.00
31_R273_E1.9561.00
45_T75_I1.9531.00
16_A219_L1.9261.00
3_Y228_T1.9171.00
116_L132_V1.9081.00
46_M87_A1.8311.00
84_E234_H1.8271.00
210_T213_E1.8191.00
170_L206_Q1.8171.00
52_L147_L1.7901.00
254_I286_R1.7701.00
38_A89_V1.7641.00
213_E216_E1.7621.00
49_S64_V1.7551.00
209_L217_E1.7341.00
38_A72_I1.7281.00
34_T39_S1.7091.00
13_K187_T1.7031.00
193_Q196_S1.7021.00
194_R221_E1.6901.00
265_E276_L1.6641.00
247_L250_G1.6341.00
147_L155_S1.6341.00
237_C268_C1.5921.00
193_Q197_Q1.5821.00
68_G111_G1.5801.00
78_D86_R1.5581.00
255_Q286_R1.5541.00
63_T78_D1.5251.00
189_T192_E1.5201.00
48_A159_V1.5161.00
45_T77_A1.5011.00
242_F245_A1.4921.00
48_A143_F1.4881.00
50_L231_V1.4861.00
185_D189_T1.4781.00
280_E283_E1.4761.00
95_H167_N1.4721.00
189_T193_Q1.4641.00
117_S129_T1.4521.00
235_C271_C1.4481.00
255_Q283_E1.4290.99
47_T172_A1.4120.99
49_S79_A1.3930.99
243_E277_F1.3860.99
278_T281_E1.3740.99
6_K17_Y1.3730.99
14_V179_L1.3720.99
2_D24_M1.3680.99
136_S141_D1.3480.99
5_V211_P1.3470.99
237_C271_C1.3190.99
51_M174_G1.3140.99
144_T148_V1.3110.99
66_I134_I1.3100.99
268_C271_C1.3080.99
209_L214_I1.3080.99
42_L87_A1.2620.99
61_K78_D1.2520.99
243_E284_G1.2500.99
252_K256_D1.2300.98
3_Y212_E1.2100.98
96_F108_R1.2090.98
10_Y224_E1.2030.98
239_K243_E1.1790.98
4_L54_A1.1770.98
45_T66_I1.1690.98
281_E284_G1.1630.98
12_G224_E1.1630.98
243_E247_L1.1620.98
204_L214_I1.1550.98
245_A266_A1.1500.98
94_V109_A1.1340.97
8_L226_L1.1330.97
164_N170_L1.1320.97
209_L213_E1.1320.97
122_L125_R1.1290.97
193_Q222_K1.1250.97
184_D187_T1.1240.97
116_L134_I1.1240.97
40_A104_L1.1200.97
261_D264_A1.1190.97
251_K286_R1.1150.97
264_A282_L1.1150.97
202_S205_I1.1130.97
23_D27_E1.1040.97
254_I282_L1.1020.97
83_G231_V1.1010.97
258_I282_L1.1010.97
45_T64_V1.0960.97
50_L85_V1.0920.97
45_T139_L1.0830.96
249_L257_M1.0800.96
235_C268_C1.0770.96
83_G229_M1.0720.96
38_A91_N1.0630.96
157_V176_I1.0580.96
13_K184_D1.0490.96
257_M263_Q1.0470.96
179_L188_I1.0330.95
3_Y211_P1.0280.95
2_D23_D1.0210.95
144_T156_S1.0160.95
25_V46_M1.0010.95
171_A205_I0.9980.94
233_F273_E0.9960.94
145_Y149_S0.9880.94
250_G253_E0.9840.94
74_A90_S0.9820.94
137_G141_D0.9680.93
5_V225_I0.9650.93
175_F198_V0.9630.93
14_V191_I0.9530.93
26_N30_R0.9430.93
18_A211_P0.9390.92
166_D170_L0.9360.92
138_E141_D0.9340.92
77_A87_A0.9210.92
42_L233_F0.9200.92
66_I139_L0.9160.91
69_G111_G0.9050.91
64_V116_L0.9010.91
58_G81_A0.8950.91
41_A110_V0.8870.90
158_G175_F0.8870.90
242_F248_G0.8810.90
201_I214_I0.8800.90
64_V143_F0.8790.90
52_L55_M0.8690.89
22_T171_A0.8670.89
247_L285_L0.8650.89
25_V47_T0.8600.89
258_I263_Q0.8570.89
65_K117_S0.8410.88
27_E232_R0.8400.88
24_M85_V0.8400.88
17_Y55_M0.8380.87
55_M176_I0.8380.87
200_P203_K0.8320.87
70_G111_G0.8320.87
263_Q279_K0.8320.87
51_M55_M0.8310.87
179_L191_I0.8280.87
66_I110_V0.8250.87
141_D144_T0.8250.87
65_K129_T0.8240.86
4_L231_V0.8230.86
194_R217_E0.8200.86
98_L105_D0.8180.86
171_A202_S0.8150.86
76_V88_Y0.8140.86
188_I192_E0.8130.86
156_S195_L0.8130.86
67_E90_S0.8110.86
194_R220_G0.8040.85
51_M176_I0.8040.85
19_A231_V0.8040.85
148_V154_P0.8020.85
186_E190_K0.8020.85
48_A51_M0.8010.85
67_E74_A0.7990.85
68_G110_V0.7890.84
216_E220_G0.7880.84
67_E115_T0.7870.84
212_E225_I0.7830.84
199_E224_E0.7820.83
40_A103_K0.7800.83
194_R197_Q0.7790.83
215_L223_P0.7750.83
48_A147_L0.7720.83
240_E243_E0.7720.83
130_G146_Y0.7700.83
97_D105_D0.7680.82
155_S178_Q0.7660.82
258_I264_A0.7660.82
198_V218_V0.7660.82
258_I279_K0.7650.82
61_K236_P0.7640.82
107_R137_G0.7640.82
190_K193_Q0.7630.82
207_K217_E0.7590.82
40_A106_V0.7570.81
34_T89_V0.7550.81
242_F269_H0.7550.81
136_S145_Y0.7540.81
54_A229_M0.7510.81
40_A44_R0.7490.81
255_Q258_I0.7490.81
46_M49_S0.7440.80
55_M153_V0.7430.80
53_G79_A0.7400.80
66_I116_L0.7400.80
183_T188_I0.7400.80
216_E221_E0.7390.80
78_D236_P0.7350.80
119_V129_T0.7330.79
50_L147_L0.7300.79
215_L225_I0.7270.79
180_M231_V0.7240.79
5_V228_T0.7220.78
35_W93_Q0.7190.78
257_M261_D0.7180.78
117_S131_Q0.7180.78
19_A50_L0.7180.78
156_S199_E0.7180.78
51_M215_L0.7120.77
269_H272_N0.7110.77
250_G270_F0.7110.77
187_T190_K0.7100.77
258_I286_R0.7090.77
96_F105_D0.7080.77
41_A72_I0.7050.77
203_K206_Q0.7050.77
249_L254_I0.7030.76
41_A75_I0.6990.76
197_Q217_E0.6980.76
149_S272_N0.6970.76
28_G34_T0.6970.76
11_D222_K0.6970.76
121_D124_L0.6950.76
235_C238_S0.6920.75
20_R211_P0.6910.75
74_A77_A0.6900.75
147_L176_I0.6880.75
55_M147_L0.6870.75
147_L157_V0.6840.74
201_I211_P0.6830.74
212_E228_T0.6820.74
9_A219_L0.6800.74
17_Y158_G0.6770.74
137_G142_D0.6760.74
17_Y54_A0.6760.74
261_D279_K0.6740.73
164_N167_N0.6730.73
15_R215_L0.6710.73
2_D20_R0.6680.73
177_I198_V0.6680.73
25_V161_V0.6650.72
238_S268_C0.6630.72
181_P226_L0.6610.72
139_L190_K0.6610.72
59_D81_A0.6590.72
263_Q278_T0.6580.72
190_K194_R0.6560.71
107_R110_V0.6550.71
118_V233_F0.6530.71
244_T247_L0.6530.71
127_F147_L0.6510.71
37_T104_L0.6510.71
160_G202_S0.6470.70
138_E142_D0.6420.70
121_D270_F0.6360.69
61_K234_H0.6340.69
4_L19_A0.6340.69
199_E207_K0.6280.68
7_A219_L0.6270.68
53_G80_N0.6250.68
238_S275_Y0.6240.68
192_E196_S0.6240.68
18_A223_P0.6220.67
197_Q218_V0.6180.67
37_T95_H0.6180.67
63_T121_D0.6150.66
177_I218_V0.6140.66
52_L176_I0.6130.66
252_K259_E0.6120.66
88_Y266_A0.6120.66
97_D108_R0.6100.66
29_Q39_S0.6100.66
149_S153_V0.6090.66
62_L79_A0.6080.66
247_L253_E0.6050.65
262_G283_E0.6050.65
18_A215_L0.6050.65
217_E221_E0.6040.65
63_T136_S0.6030.65
47_T50_L0.6010.65
66_I75_I0.5990.64
45_T49_S0.5960.64
103_K108_R0.5950.64
246_I277_F0.5950.64
6_K147_L0.5950.64
179_L195_L0.5920.64
38_A75_I0.5910.63
119_V127_F0.5900.63
59_D123_G0.5880.63
20_R171_A0.5860.63
135_V141_D0.5850.63
73_G91_N0.5850.63
24_M46_M0.5840.63
117_S153_V0.5830.62
106_V138_E0.5830.62
179_L183_T0.5830.62
52_L143_F0.5830.62
133_E145_Y0.5830.62
71_P111_G0.5820.62
10_Y180_M0.5800.62
73_G90_S0.5790.62
6_K16_A0.5770.62
216_E223_P0.5760.61
5_V18_A0.5740.61
253_E257_M0.5720.61
216_E222_K0.5720.61
9_A223_P0.5710.61
111_G225_I0.5700.61
90_S269_H0.5680.60
153_V246_I0.5650.60
128_F257_M0.5640.60
19_A156_S0.5640.60
65_K119_V0.5630.60
224_E227_E0.5600.59
154_P159_V0.5600.59
63_T76_V0.5590.59
130_G147_L0.5590.59
95_H98_L0.5590.59
107_R138_E0.5560.59
59_D82_K0.5550.59
255_Q279_K0.5550.59
180_M226_L0.5530.58
222_K280_E0.5530.58
68_G77_A0.5510.58
50_L81_A0.5510.58
44_R138_E0.5500.58
63_T106_V0.5490.58
34_T38_A0.5490.58
249_L253_E0.5480.58
105_D137_G0.5480.58
215_L219_L0.5470.58
189_T196_S0.5460.57
180_M236_P0.5450.57
253_E258_I0.5440.57
67_E113_N0.5440.57
186_E189_T0.5420.57
6_K227_E0.5420.57
133_E272_N0.5420.57
37_T94_V0.5410.57
118_V224_E0.5390.56
193_Q221_E0.5390.56
63_T171_A0.5380.56
207_K210_T0.5370.56
236_P267_V0.5370.56
69_G75_I0.5370.56
106_V141_D0.5360.56
79_A85_V0.5350.56
86_R170_L0.5350.56
217_E220_G0.5340.56
28_G42_L0.5340.56
3_Y230_P0.5330.56
233_F237_C0.5310.55
103_K106_V0.5300.55
20_R72_I0.5300.55
175_F218_V0.5280.55
38_A92_P0.5260.55
7_A198_V0.5260.55
241_R248_G0.5260.55
61_K123_G0.5260.55
196_S199_E0.5250.54
246_I285_L0.5240.54
152_Q181_P0.5200.54
29_Q169_I0.5200.54
167_N171_A0.5200.54
13_K182_G0.5200.54
33_G167_N0.5190.54
35_W167_N0.5190.54
154_P174_G0.5170.53
161_V172_A0.5140.53
16_A119_V0.5140.53
21_T172_A0.5130.53
250_G286_R0.5130.53
261_D282_L0.5120.53
29_Q60_D0.5070.52
3_Y20_R0.5070.52
200_P217_E0.5070.52
150_S181_P0.5070.52
16_A60_D0.5070.52
235_C275_Y0.5060.52
53_G147_L0.5050.52
145_Y148_V0.5050.52
237_C275_Y0.5030.51
70_G130_G0.5020.51
225_I228_T0.5010.51
197_Q221_E0.5010.51
46_M50_L0.5010.51
76_V245_A0.5000.51
204_L217_E0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vzyA 3 0.9966 100 0.012 Contact Map
1vq0A 2 0.9863 100 0.053 Contact Map
1i7fA 2 0.7801 100 0.073 Contact Map
1hw7A 2 0.7835 100 0.202 Contact Map
2xigA 4 0.3643 41.1 0.959 Contact Map
3t7vA 1 0.2509 37.7 0.96 Contact Map
3iixA 1 0.299 33.7 0.961 Contact Map
1h67A 1 0.3436 26.6 0.963 Contact Map
2ds5A 2 0.0893 25.5 0.963 Contact Map
1ovxA 2 0.079 18.1 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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