COAX - BACSU - GREMLIN Contacts

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COAX - Type III pantothenate kinase

UniProt:	P37564	Sequences: MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILRSLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEALYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	258 (245)
Sequences:	2838 (2105)
Seq/√Len:	134.5

BACSU - COAX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
140_D	144_Q	3.912	1.00
238_D	244_K	3.566	1.00
183_N	186_S	3.297	1.00
120_L	244_K	3.259	1.00
201_E	233_C	2.712	1.00
110_R	137_C	2.634	1.00
247_E	251_E	2.573	1.00
17_Y	22_L	2.510	1.00
117_A	125_L	2.468	1.00
198_G	202_G	2.446	1.00
101_D	183_N	2.444	1.00
78_T	84_E	2.329	1.00
161_L	188_M	2.322	1.00
151_A	199_Q	2.292	1.00
7_V	73_L	2.275	1.00
113_N	242_T	2.254	1.00
224_A	237_V	2.252	1.00
62_I	87_I	2.133	1.00
59_G	250_Y	2.072	1.00
101_D	182_K	2.067	1.00
88_V	112_V	2.065	1.00
168_L	188_M	2.065	1.00
97_N	144_Q	2.050	1.00
110_R	148_G	2.048	1.00
114_A	139_I	2.045	1.00
64_S	70_M	2.034	1.00
140_D	146_M	1.996	1.00
102_N	105_E	1.927	1.00
60_I	77_C	1.896	1.00
4_V	17_Y	1.876	1.00
120_L	238_D	1.865	1.00
70_M	87_I	1.850	1.00
118_I	143_K	1.817	1.00
201_E	231_S	1.812	1.00
130_F	200_V	1.802	1.00
137_C	145_Y	1.802	1.00
118_I	123_N	1.775	1.00
205_K	232_D	1.773	1.00
115_V	249_I	1.757	1.00
116_A	248_L	1.708	1.00
171_I	188_M	1.700	1.00
201_E	232_D	1.672	1.00
99_K	144_Q	1.669	1.00
208_K	214_E	1.658	1.00
158_T	192_I	1.644	1.00
96_L	118_I	1.644	1.00
53_M	56_Q	1.580	1.00
133_A	161_L	1.575	1.00
100_Y	106_V	1.570	1.00
205_K	233_C	1.534	1.00
61_I	246_L	1.516	1.00
134_T	196_Y	1.502	1.00
195_G	199_Q	1.501	1.00
208_K	233_C	1.501	1.00
159_E	164_R	1.494	1.00
18_H	21_K	1.492	1.00
11_N	27_R	1.485	1.00
126_I	215_P	1.484	1.00
202_G	206_R	1.455	1.00
15_G	243_L	1.431	1.00
20_G	247_E	1.425	1.00
165_A	169_P	1.420	1.00
186_S	189_Q	1.413	1.00
228_A	237_V	1.409	1.00
25_H	240_F	1.409	1.00
216_K	236_I	1.408	1.00
136_Y	199_Q	1.385	1.00
117_A	127_V	1.384	1.00
134_T	223_L	1.380	1.00
204_V	233_C	1.374	1.00
20_G	251_E	1.351	1.00
196_Y	199_Q	1.342	1.00
129_D	220_T	1.339	1.00
201_E	205_K	1.317	1.00
138_Y	146_M	1.315	1.00
40_G	80_Y	1.302	1.00
159_E	163_S	1.292	1.00
122_G	216_K	1.287	1.00
244_K	247_E	1.282	1.00
138_Y	211_A	1.281	1.00
92_M	249_I	1.279	1.00
119_H	248_L	1.277	1.00
198_G	203_I	1.249	1.00
208_K	235_D	1.243	1.00
169_P	188_M	1.241	1.00
125_L	218_I	1.222	1.00
16_V	57_I	1.218	1.00
99_K	146_M	1.217	1.00
138_Y	207_M	1.209	1.00
100_Y	148_G	1.207	1.00
18_H	23_E	1.206	1.00
96_L	115_V	1.198	1.00
145_Y	148_G	1.196	1.00
149_A	203_I	1.195	1.00
131_G	222_G	1.186	0.99
175_R	230_E	1.182	0.99
121_Y	218_I	1.171	0.99
124_P	140_D	1.159	0.99
206_R	209_W	1.155	0.99
149_A	207_M	1.140	0.99
219_A	234_I	1.139	0.99
181_G	187_A	1.136	0.99
91_G	95_G	1.125	0.99
88_V	249_I	1.123	0.99
8_G	222_G	1.116	0.99
130_F	227_I	1.107	0.99
17_Y	244_K	1.104	0.99
125_L	139_I	1.101	0.99
108_A	112_V	1.097	0.99
219_A	231_S	1.095	0.99
173_I	193_L	1.087	0.99
60_I	83_I	1.078	0.99
121_Y	238_D	1.069	0.99
94_T	111_I	1.065	0.99
69_I	72_A	1.058	0.99
17_Y	247_E	1.053	0.99
95_G	252_R	1.050	0.99
11_N	223_L	1.044	0.99
7_V	12_T	1.040	0.99
208_K	215_P	1.033	0.99
13_V	27_R	1.029	0.99
91_G	94_T	1.026	0.98
193_L	230_E	1.023	0.98
8_G	131_G	1.023	0.98
106_V	111_I	1.017	0.98
126_I	204_V	1.017	0.98
63_S	108_A	1.017	0.98
100_Y	110_R	1.016	0.98
137_C	148_G	1.012	0.98
129_D	135_T	1.012	0.98
197_V	201_E	1.000	0.98
2_L	250_Y	0.999	0.98
118_I	122_G	0.994	0.98
138_Y	180_I	0.994	0.98
209_W	232_D	0.989	0.98
178_N	210_Q	0.988	0.98
180_I	211_A	0.981	0.98
63_S	112_V	0.976	0.98
31_S	34_K	0.973	0.98
4_V	15_G	0.970	0.98
204_V	217_V	0.967	0.98
128_V	136_Y	0.965	0.98
141_E	213_Q	0.952	0.98
100_Y	145_Y	0.950	0.97
188_M	192_I	0.946	0.97
156_I	160_A	0.944	0.97
100_Y	187_A	0.941	0.97
118_I	125_L	0.939	0.97
112_V	249_I	0.932	0.97
193_L	197_V	0.932	0.97
114_A	145_Y	0.931	0.97
219_A	224_A	0.898	0.96
171_I	189_Q	0.896	0.96
185_V	189_Q	0.894	0.96
75_R	78_T	0.894	0.96
240_F	244_K	0.891	0.96
146_M	182_K	0.890	0.96
195_G	202_G	0.890	0.96
98_I	111_I	0.883	0.96
197_V	230_E	0.880	0.96
96_L	114_A	0.880	0.96
175_R	193_L	0.880	0.96
6_D	13_V	0.878	0.96
110_R	145_Y	0.862	0.96
106_V	187_A	0.862	0.96
61_I	86_Q	0.860	0.95
136_Y	203_I	0.858	0.95
118_I	124_P	0.857	0.95
91_G	104_K	0.856	0.95
198_G	206_R	0.854	0.95
112_V	115_V	0.849	0.95
156_I	164_R	0.849	0.95
124_P	213_Q	0.845	0.95
130_F	154_I	0.845	0.95
62_I	85_P	0.834	0.95
133_A	150_I	0.834	0.95
169_P	185_V	0.832	0.95
150_I	187_A	0.822	0.94
156_I	165_A	0.821	0.94
12_T	73_L	0.817	0.94
3_L	14_L	0.816	0.94
124_P	141_E	0.815	0.94
70_M	74_E	0.814	0.94
116_A	243_L	0.814	0.94
58_D	83_I	0.813	0.94
154_I	223_L	0.811	0.94
149_A	179_I	0.808	0.94
2_L	61_I	0.804	0.94
248_L	251_E	0.801	0.93
225_P	239_P	0.795	0.93
13_V	129_D	0.791	0.93
28_I	42_I	0.784	0.93
195_G	203_I	0.778	0.92
130_F	219_A	0.777	0.92
59_G	83_I	0.774	0.92
90_P	93_K	0.772	0.92
122_G	125_L	0.764	0.92
157_S	195_G	0.764	0.92
89_G	93_K	0.760	0.92
136_Y	151_A	0.754	0.91
15_G	22_L	0.753	0.91
182_K	186_S	0.752	0.91
128_V	217_V	0.749	0.91
96_L	143_K	0.749	0.91
135_T	145_Y	0.748	0.91
197_V	227_I	0.746	0.91
155_T	223_L	0.743	0.91
36_E	79_K	0.735	0.90
29_E	38_E	0.734	0.90
177_D	186_S	0.734	0.90
99_K	106_V	0.733	0.90
88_V	246_L	0.730	0.90
108_A	167_K	0.727	0.90
2_L	59_G	0.727	0.90
151_A	195_G	0.725	0.90
95_G	115_V	0.724	0.89
211_A	215_P	0.723	0.89
181_G	186_S	0.721	0.89
36_E	71_F	0.717	0.89
119_H	252_R	0.716	0.89
86_Q	92_M	0.716	0.89
149_A	190_S	0.716	0.89
17_Y	243_L	0.715	0.89
135_T	150_I	0.715	0.89
77_C	85_P	0.712	0.89
149_A	181_G	0.709	0.88
133_A	165_A	0.700	0.88
219_A	235_D	0.699	0.88
113_N	137_C	0.699	0.88
30_T	69_I	0.696	0.88
168_L	171_I	0.694	0.87
106_V	114_A	0.694	0.87
119_H	122_G	0.694	0.87
217_V	235_D	0.693	0.87
118_I	139_I	0.691	0.87
159_E	170_R	0.691	0.87
97_N	142_N	0.691	0.87
90_P	94_T	0.687	0.87
19_D	23_E	0.686	0.87
203_I	207_M	0.686	0.87
197_V	202_G	0.686	0.87
4_V	243_L	0.684	0.87
27_R	30_T	0.677	0.86
127_V	139_I	0.672	0.86
130_F	196_Y	0.672	0.86
157_S	199_Q	0.669	0.85
157_S	160_A	0.668	0.85
162_Y	170_R	0.667	0.85
36_E	72_A	0.666	0.85
67_P	166_A	0.661	0.85
57_I	81_F	0.660	0.85
60_I	85_P	0.660	0.85
126_I	207_M	0.655	0.84
2_L	247_E	0.655	0.84
126_I	138_Y	0.653	0.84
162_Y	168_L	0.653	0.84
68_P	166_A	0.652	0.84
114_A	187_A	0.651	0.84
165_A	196_Y	0.649	0.84
180_I	210_Q	0.648	0.84
71_F	75_R	0.648	0.84
74_E	84_E	0.641	0.83
196_Y	223_L	0.641	0.83
74_E	87_I	0.640	0.83
30_T	66_V	0.637	0.83
208_K	213_Q	0.637	0.83
106_V	137_C	0.634	0.82
178_N	190_S	0.633	0.82
129_D	153_G	0.632	0.82
218_I	241_L	0.631	0.82
14_L	28_I	0.631	0.82
26_W	46_L	0.628	0.82
11_N	35_T	0.628	0.82
59_G	86_Q	0.627	0.82
154_I	196_Y	0.627	0.82
179_I	194_F	0.625	0.81
147_G	150_I	0.622	0.81
202_G	205_K	0.621	0.81
74_E	78_T	0.619	0.81
66_V	166_A	0.617	0.80
27_R	222_G	0.616	0.80
155_T	159_E	0.615	0.80
130_F	223_L	0.610	0.80
10_T	29_E	0.609	0.80
198_G	201_E	0.604	0.79
147_G	181_G	0.600	0.79
53_M	209_W	0.593	0.78
100_Y	183_N	0.593	0.78
5_I	14_L	0.593	0.78
14_L	26_W	0.592	0.78
132_T	156_I	0.589	0.77
193_L	227_I	0.583	0.77
100_Y	111_I	0.579	0.76
225_P	237_V	0.578	0.76
116_A	244_K	0.577	0.76
180_I	207_M	0.577	0.76
37_D	80_Y	0.575	0.76
194_F	198_G	0.574	0.76
126_I	136_Y	0.573	0.75
157_S	223_L	0.572	0.75
162_Y	187_A	0.572	0.75
98_I	114_A	0.571	0.75
38_E	42_I	0.571	0.75
14_L	43_L	0.571	0.75
127_V	241_L	0.570	0.75
123_N	216_K	0.569	0.75
218_I	238_D	0.565	0.74
23_E	41_M	0.565	0.74
34_K	42_I	0.565	0.74
116_A	245_G	0.565	0.74
140_D	143_K	0.562	0.74
136_Y	218_I	0.560	0.74
61_I	250_Y	0.560	0.74
198_G	205_K	0.559	0.74
179_I	203_I	0.558	0.73
10_T	41_M	0.558	0.73
57_I	60_I	0.557	0.73
197_V	231_S	0.556	0.73
12_T	39_F	0.550	0.72
241_L	245_G	0.548	0.72
10_T	131_G	0.548	0.72
1_M	57_I	0.547	0.72
194_F	206_R	0.546	0.72
6_D	246_L	0.546	0.72
134_T	154_I	0.544	0.72
106_V	192_I	0.544	0.72
134_T	137_C	0.543	0.71
38_E	41_M	0.542	0.71
162_Y	169_P	0.542	0.71
8_G	132_T	0.539	0.71
20_G	119_H	0.538	0.71
208_K	212_K	0.538	0.71
231_S	235_D	0.538	0.71
127_V	137_C	0.538	0.71
104_K	183_N	0.538	0.71
99_K	145_Y	0.534	0.70
10_T	222_G	0.534	0.70
93_K	252_R	0.534	0.70
98_I	187_A	0.533	0.70
76_M	81_F	0.533	0.70
130_F	231_S	0.532	0.70
106_V	145_Y	0.531	0.70
109_D	131_G	0.528	0.69
102_N	106_V	0.528	0.69
12_T	69_I	0.528	0.69
88_V	111_I	0.527	0.69
151_A	196_Y	0.525	0.69
20_G	23_E	0.524	0.69
36_E	75_R	0.523	0.69
2_L	15_G	0.522	0.69
116_A	119_H	0.521	0.68
201_E	234_I	0.521	0.68
232_D	235_D	0.520	0.68
28_I	46_L	0.519	0.68
132_T	165_A	0.519	0.68
18_H	236_I	0.516	0.68
179_I	210_Q	0.513	0.67
173_I	224_A	0.513	0.67
135_T	148_G	0.512	0.67
116_A	125_L	0.511	0.67
2_L	246_L	0.506	0.66
4_V	61_I	0.506	0.66
39_F	73_L	0.505	0.66
96_L	249_I	0.505	0.66
30_T	67_P	0.501	0.65
94_T	97_N	0.500	0.65
42_I	45_S	0.500	0.65
112_V	245_G	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
5b8hA	2	0.9341	100	0.104	Contact Map
4o5fA	2	0.9264	100	0.117	Contact Map
2f9wA	2	0.938	100	0.168	Contact Map
2h3gX	2	0.9574	100	0.207	Contact Map
3djcA	5	0.9806	100	0.26	Contact Map
3bexA	2	0.9496	100	0.274	Contact Map
2nrhA	2	0.7752	100	0.293	Contact Map
4ehuA	2	0.8566	98.7	0.847	Contact Map
1huxA	2	0.8566	98.2	0.867	Contact Map
1zxoA	4	0.8915	98.1	0.872	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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