GREMLIN Database
COAX - Type III pantothenate kinase
UniProt: P37564 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 258 (245)
Sequences: 2838 (2105)
Seq/√Len: 134.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_D144_Q3.9121.00
238_D244_K3.5661.00
183_N186_S3.2971.00
120_L244_K3.2591.00
201_E233_C2.7121.00
110_R137_C2.6341.00
247_E251_E2.5731.00
17_Y22_L2.5101.00
117_A125_L2.4681.00
198_G202_G2.4461.00
101_D183_N2.4441.00
78_T84_E2.3291.00
161_L188_M2.3221.00
151_A199_Q2.2921.00
7_V73_L2.2751.00
113_N242_T2.2541.00
224_A237_V2.2521.00
62_I87_I2.1331.00
59_G250_Y2.0721.00
101_D182_K2.0671.00
88_V112_V2.0651.00
168_L188_M2.0651.00
97_N144_Q2.0501.00
110_R148_G2.0481.00
114_A139_I2.0451.00
64_S70_M2.0341.00
140_D146_M1.9961.00
102_N105_E1.9271.00
60_I77_C1.8961.00
4_V17_Y1.8761.00
120_L238_D1.8651.00
70_M87_I1.8501.00
118_I143_K1.8171.00
201_E231_S1.8121.00
130_F200_V1.8021.00
137_C145_Y1.8021.00
118_I123_N1.7751.00
205_K232_D1.7731.00
115_V249_I1.7571.00
116_A248_L1.7081.00
171_I188_M1.7001.00
201_E232_D1.6721.00
99_K144_Q1.6691.00
208_K214_E1.6581.00
158_T192_I1.6441.00
96_L118_I1.6441.00
53_M56_Q1.5801.00
133_A161_L1.5751.00
100_Y106_V1.5701.00
205_K233_C1.5341.00
61_I246_L1.5161.00
134_T196_Y1.5021.00
195_G199_Q1.5011.00
208_K233_C1.5011.00
159_E164_R1.4941.00
18_H21_K1.4921.00
11_N27_R1.4851.00
126_I215_P1.4841.00
202_G206_R1.4551.00
15_G243_L1.4311.00
20_G247_E1.4251.00
165_A169_P1.4201.00
186_S189_Q1.4131.00
228_A237_V1.4091.00
25_H240_F1.4091.00
216_K236_I1.4081.00
136_Y199_Q1.3851.00
117_A127_V1.3841.00
134_T223_L1.3801.00
204_V233_C1.3741.00
20_G251_E1.3511.00
196_Y199_Q1.3421.00
129_D220_T1.3391.00
201_E205_K1.3171.00
138_Y146_M1.3151.00
40_G80_Y1.3021.00
159_E163_S1.2921.00
122_G216_K1.2871.00
244_K247_E1.2821.00
138_Y211_A1.2811.00
92_M249_I1.2791.00
119_H248_L1.2771.00
198_G203_I1.2491.00
208_K235_D1.2431.00
169_P188_M1.2411.00
125_L218_I1.2221.00
16_V57_I1.2181.00
99_K146_M1.2171.00
138_Y207_M1.2091.00
100_Y148_G1.2071.00
18_H23_E1.2061.00
96_L115_V1.1981.00
145_Y148_G1.1961.00
149_A203_I1.1951.00
131_G222_G1.1860.99
175_R230_E1.1820.99
121_Y218_I1.1710.99
124_P140_D1.1590.99
206_R209_W1.1550.99
149_A207_M1.1400.99
219_A234_I1.1390.99
181_G187_A1.1360.99
91_G95_G1.1250.99
88_V249_I1.1230.99
8_G222_G1.1160.99
130_F227_I1.1070.99
17_Y244_K1.1040.99
125_L139_I1.1010.99
108_A112_V1.0970.99
219_A231_S1.0950.99
173_I193_L1.0870.99
60_I83_I1.0780.99
121_Y238_D1.0690.99
94_T111_I1.0650.99
69_I72_A1.0580.99
17_Y247_E1.0530.99
95_G252_R1.0500.99
11_N223_L1.0440.99
7_V12_T1.0400.99
208_K215_P1.0330.99
13_V27_R1.0290.99
91_G94_T1.0260.98
193_L230_E1.0230.98
8_G131_G1.0230.98
106_V111_I1.0170.98
126_I204_V1.0170.98
63_S108_A1.0170.98
100_Y110_R1.0160.98
137_C148_G1.0120.98
129_D135_T1.0120.98
197_V201_E1.0000.98
2_L250_Y0.9990.98
118_I122_G0.9940.98
138_Y180_I0.9940.98
209_W232_D0.9890.98
178_N210_Q0.9880.98
180_I211_A0.9810.98
63_S112_V0.9760.98
31_S34_K0.9730.98
4_V15_G0.9700.98
204_V217_V0.9670.98
128_V136_Y0.9650.98
141_E213_Q0.9520.98
100_Y145_Y0.9500.97
188_M192_I0.9460.97
156_I160_A0.9440.97
100_Y187_A0.9410.97
118_I125_L0.9390.97
112_V249_I0.9320.97
193_L197_V0.9320.97
114_A145_Y0.9310.97
219_A224_A0.8980.96
171_I189_Q0.8960.96
185_V189_Q0.8940.96
75_R78_T0.8940.96
240_F244_K0.8910.96
146_M182_K0.8900.96
195_G202_G0.8900.96
98_I111_I0.8830.96
197_V230_E0.8800.96
96_L114_A0.8800.96
175_R193_L0.8800.96
6_D13_V0.8780.96
110_R145_Y0.8620.96
106_V187_A0.8620.96
61_I86_Q0.8600.95
136_Y203_I0.8580.95
118_I124_P0.8570.95
91_G104_K0.8560.95
198_G206_R0.8540.95
112_V115_V0.8490.95
156_I164_R0.8490.95
124_P213_Q0.8450.95
130_F154_I0.8450.95
62_I85_P0.8340.95
133_A150_I0.8340.95
169_P185_V0.8320.95
150_I187_A0.8220.94
156_I165_A0.8210.94
12_T73_L0.8170.94
3_L14_L0.8160.94
124_P141_E0.8150.94
70_M74_E0.8140.94
116_A243_L0.8140.94
58_D83_I0.8130.94
154_I223_L0.8110.94
149_A179_I0.8080.94
2_L61_I0.8040.94
248_L251_E0.8010.93
225_P239_P0.7950.93
13_V129_D0.7910.93
28_I42_I0.7840.93
195_G203_I0.7780.92
130_F219_A0.7770.92
59_G83_I0.7740.92
90_P93_K0.7720.92
122_G125_L0.7640.92
157_S195_G0.7640.92
89_G93_K0.7600.92
136_Y151_A0.7540.91
15_G22_L0.7530.91
182_K186_S0.7520.91
128_V217_V0.7490.91
96_L143_K0.7490.91
135_T145_Y0.7480.91
197_V227_I0.7460.91
155_T223_L0.7430.91
36_E79_K0.7350.90
29_E38_E0.7340.90
177_D186_S0.7340.90
99_K106_V0.7330.90
88_V246_L0.7300.90
108_A167_K0.7270.90
2_L59_G0.7270.90
151_A195_G0.7250.90
95_G115_V0.7240.89
211_A215_P0.7230.89
181_G186_S0.7210.89
36_E71_F0.7170.89
119_H252_R0.7160.89
86_Q92_M0.7160.89
149_A190_S0.7160.89
17_Y243_L0.7150.89
135_T150_I0.7150.89
77_C85_P0.7120.89
149_A181_G0.7090.88
133_A165_A0.7000.88
219_A235_D0.6990.88
113_N137_C0.6990.88
30_T69_I0.6960.88
168_L171_I0.6940.87
106_V114_A0.6940.87
119_H122_G0.6940.87
217_V235_D0.6930.87
118_I139_I0.6910.87
159_E170_R0.6910.87
97_N142_N0.6910.87
90_P94_T0.6870.87
19_D23_E0.6860.87
203_I207_M0.6860.87
197_V202_G0.6860.87
4_V243_L0.6840.87
27_R30_T0.6770.86
127_V139_I0.6720.86
130_F196_Y0.6720.86
157_S199_Q0.6690.85
157_S160_A0.6680.85
162_Y170_R0.6670.85
36_E72_A0.6660.85
67_P166_A0.6610.85
57_I81_F0.6600.85
60_I85_P0.6600.85
126_I207_M0.6550.84
2_L247_E0.6550.84
126_I138_Y0.6530.84
162_Y168_L0.6530.84
68_P166_A0.6520.84
114_A187_A0.6510.84
165_A196_Y0.6490.84
180_I210_Q0.6480.84
71_F75_R0.6480.84
74_E84_E0.6410.83
196_Y223_L0.6410.83
74_E87_I0.6400.83
30_T66_V0.6370.83
208_K213_Q0.6370.83
106_V137_C0.6340.82
178_N190_S0.6330.82
129_D153_G0.6320.82
218_I241_L0.6310.82
14_L28_I0.6310.82
26_W46_L0.6280.82
11_N35_T0.6280.82
59_G86_Q0.6270.82
154_I196_Y0.6270.82
179_I194_F0.6250.81
147_G150_I0.6220.81
202_G205_K0.6210.81
74_E78_T0.6190.81
66_V166_A0.6170.80
27_R222_G0.6160.80
155_T159_E0.6150.80
130_F223_L0.6100.80
10_T29_E0.6090.80
198_G201_E0.6040.79
147_G181_G0.6000.79
53_M209_W0.5930.78
100_Y183_N0.5930.78
5_I14_L0.5930.78
14_L26_W0.5920.78
132_T156_I0.5890.77
193_L227_I0.5830.77
100_Y111_I0.5790.76
225_P237_V0.5780.76
116_A244_K0.5770.76
180_I207_M0.5770.76
37_D80_Y0.5750.76
194_F198_G0.5740.76
126_I136_Y0.5730.75
157_S223_L0.5720.75
162_Y187_A0.5720.75
98_I114_A0.5710.75
38_E42_I0.5710.75
14_L43_L0.5710.75
127_V241_L0.5700.75
123_N216_K0.5690.75
218_I238_D0.5650.74
23_E41_M0.5650.74
34_K42_I0.5650.74
116_A245_G0.5650.74
140_D143_K0.5620.74
136_Y218_I0.5600.74
61_I250_Y0.5600.74
198_G205_K0.5590.74
179_I203_I0.5580.73
10_T41_M0.5580.73
57_I60_I0.5570.73
197_V231_S0.5560.73
12_T39_F0.5500.72
241_L245_G0.5480.72
10_T131_G0.5480.72
1_M57_I0.5470.72
194_F206_R0.5460.72
6_D246_L0.5460.72
134_T154_I0.5440.72
106_V192_I0.5440.72
134_T137_C0.5430.71
38_E41_M0.5420.71
162_Y169_P0.5420.71
8_G132_T0.5390.71
20_G119_H0.5380.71
208_K212_K0.5380.71
231_S235_D0.5380.71
127_V137_C0.5380.71
104_K183_N0.5380.71
99_K145_Y0.5340.70
10_T222_G0.5340.70
93_K252_R0.5340.70
98_I187_A0.5330.70
76_M81_F0.5330.70
130_F231_S0.5320.70
106_V145_Y0.5310.70
109_D131_G0.5280.69
102_N106_V0.5280.69
12_T69_I0.5280.69
88_V111_I0.5270.69
151_A196_Y0.5250.69
20_G23_E0.5240.69
36_E75_R0.5230.69
2_L15_G0.5220.69
116_A119_H0.5210.68
201_E234_I0.5210.68
232_D235_D0.5200.68
28_I46_L0.5190.68
132_T165_A0.5190.68
18_H236_I0.5160.68
179_I210_Q0.5130.67
173_I224_A0.5130.67
135_T148_G0.5120.67
116_A125_L0.5110.67
2_L246_L0.5060.66
4_V61_I0.5060.66
39_F73_L0.5050.66
96_L249_I0.5050.66
30_T67_P0.5010.65
94_T97_N0.5000.65
42_I45_S0.5000.65
112_V245_G0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5b8hA 2 0.9341 100 0.104 Contact Map
4o5fA 2 0.9264 100 0.117 Contact Map
2f9wA 2 0.938 100 0.168 Contact Map
2h3gX 2 0.9574 100 0.207 Contact Map
3djcA 5 0.9806 100 0.26 Contact Map
3bexA 2 0.9496 100 0.274 Contact Map
2nrhA 2 0.7752 100 0.293 Contact Map
4ehuA 2 0.8566 98.7 0.847 Contact Map
1huxA 2 0.8566 98.2 0.867 Contact Map
1zxoA 4 0.8915 98.1 0.872 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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