GREMLIN Database
TILS - tRNA(Ile)-lysidine synthase
UniProt: P37563 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 472 (407)
Sequences: 2956 (2554)
Seq/√Len: 126.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_M71_Y3.9221.00
60_E188_E3.8331.00
53_D62_E3.7891.00
193_D203_T3.6021.00
32_A177_C3.2011.00
193_D202_K2.9281.00
82_A111_E2.7771.00
170_K174_L2.7211.00
49_A72_C2.6841.00
209_K216_H2.6291.00
48_I80_E2.5961.00
128_D216_H2.5871.00
65_M69_Q2.5841.00
50_A108_F2.5661.00
405_K413_D2.4931.00
53_D61_S2.4691.00
131_V219_F2.4681.00
65_M81_T2.4621.00
49_A77_L2.4341.00
35_H176_Y2.4061.00
28_P177_C2.4001.00
53_D65_M2.3901.00
34_L49_A2.3611.00
24_V68_V2.3561.00
55_R83_Q2.3481.00
24_V49_A2.3311.00
186_T191_A2.2771.00
228_E269_R2.2331.00
69_Q73_K2.2071.00
235_S264_P2.2031.00
20_I122_A2.1951.00
113_M121_L2.1911.00
134_M223_S2.1571.00
268_Q296_L2.1561.00
395_R404_S2.0641.00
136_M196_T2.0401.00
35_H180_N2.0271.00
23_G109_F2.0171.00
72_C79_C1.9971.00
19_T46_N1.9501.00
24_V31_M1.9431.00
222_V226_L1.8781.00
64_D185_R1.8771.00
22_V37_L1.8651.00
122_A162_I1.8481.00
28_P173_I1.8401.00
56_F97_K1.8381.00
71_Y75_E1.8361.00
48_I118_A1.8331.00
28_P32_A1.8251.00
35_H75_E1.8021.00
411_F424_W1.7811.00
22_V33_L1.7591.00
134_M219_F1.7501.00
444_I447_D1.7441.00
63_E185_R1.7391.00
18_A120_Y1.7171.00
57_R60_E1.7111.00
229_D270_R1.6961.00
57_R188_E1.6951.00
232_F236_L1.6901.00
31_M182_L1.6871.00
236_L239_D1.6761.00
428_T434_I1.6751.00
387_I427_V1.6661.00
35_H182_L1.6651.00
396_I410_I1.6651.00
256_N259_Q1.6631.00
130_Q150_M1.6451.00
426_I434_I1.6451.00
388_R394_D1.6441.00
21_I118_A1.6361.00
99_A103_D1.6301.00
139_A208_L1.6271.00
390_R422_D1.6241.00
24_V71_Y1.6231.00
138_L222_V1.6121.00
66_R69_Q1.6081.00
56_F87_T1.6031.00
123_L161_I1.5971.00
145_T230_E1.5911.00
70_A74_A1.5831.00
408_K412_I1.5741.00
28_P186_T1.5731.00
65_M83_Q1.5541.00
38_H77_L1.5361.00
19_T48_I1.5301.00
254_E322_T1.5221.00
36_A165_F1.5221.00
238_K274_L1.5121.00
21_I48_I1.5041.00
52_V84_I1.5041.00
98_Q189_S1.4991.00
200_F204_V1.4971.00
36_A40_L1.4951.00
62_E83_Q1.4841.00
258_S321_Q1.4801.00
144_G226_L1.4691.00
35_H39_T1.4651.00
199_R211_E1.4541.00
50_A112_I1.4411.00
21_I112_I1.4381.00
18_A119_D1.4331.00
429_D433_E1.4301.00
203_T207_F1.4081.00
58_G64_D1.4071.00
32_A176_Y1.3981.00
435_I446_E1.3921.00
38_H75_E1.3921.00
351_L354_G1.3861.00
240_E267_L1.3831.00
131_V205_L1.3771.00
175_H179_E1.3711.00
407_V411_F1.3641.00
52_V82_A1.3631.00
34_L72_C1.3621.00
410_I437_I1.3601.00
37_L122_A1.3521.00
72_C77_L1.3451.00
433_E445_F1.3421.00
428_T432_G1.3351.00
225_A289_A1.3301.00
390_R393_G1.3241.00
86_V104_C1.3201.00
169_T172_E1.3101.00
50_A109_F1.3081.00
23_G123_L1.3081.00
127_G220_Q1.3061.00
103_D107_Q1.2981.00
31_M67_F1.2891.00
151_Q154_R1.2861.00
134_M149_G1.2861.00
131_V223_S1.2631.00
66_R70_A1.2561.00
69_Q79_C1.2561.00
174_L178_H1.2551.00
388_R428_T1.2311.00
110_E113_M1.2311.00
204_V208_L1.2280.99
241_M245_I1.2220.99
80_E115_K1.2210.99
153_V160_R1.2190.99
237_T271_G1.2170.99
257_S318_K1.2160.99
98_Q192_K1.2080.99
96_N99_A1.2060.99
98_Q195_Y1.2050.99
49_A79_C1.2020.99
106_Y123_L1.1990.99
177_C184_Y1.1980.99
230_E234_Q1.1940.99
171_E209_K1.1860.99
95_L103_D1.1800.99
147_L222_V1.1760.99
316_V325_F1.1660.99
177_C182_L1.1640.99
53_D83_Q1.1610.99
409_D412_I1.1600.99
389_T425_P1.1600.99
407_V437_I1.1590.99
28_P174_L1.1530.99
256_N321_Q1.1500.99
128_D209_K1.1480.99
426_I437_I1.1430.99
84_I104_C1.1380.99
86_V100_A1.1380.99
424_W440_L1.1340.99
131_V216_H1.1280.99
131_V220_Q1.1240.99
96_N100_A1.1210.99
176_Y180_N1.1180.99
214_D218_R1.1150.99
272_V295_F1.1110.99
126_H173_I1.1100.99
139_A219_F1.1100.99
143_L146_G1.1040.99
208_L215_V1.1020.99
97_K195_Y1.0970.99
69_Q81_T1.0950.99
225_A229_D1.0930.99
291_H311_P1.0880.99
67_F185_R1.0860.99
215_V219_F1.0780.99
390_R408_K1.0760.99
295_F316_V1.0700.99
142_T146_G1.0690.99
134_M138_L1.0620.99
165_F168_I1.0600.98
409_D413_D1.0580.98
320_Y415_K1.0560.98
139_A212_S1.0550.98
38_H41_C1.0520.98
21_I50_A1.0490.98
39_T180_N1.0450.98
144_G229_D1.0440.98
218_R221_K1.0410.98
63_E66_R1.0340.98
239_D243_K1.0340.98
57_R64_D1.0320.98
240_E263_L1.0320.98
384_P430_A1.0290.98
52_V108_F1.0290.98
171_E175_H1.0270.98
95_L100_A1.0250.98
376_T435_I1.0220.98
397_K404_S1.0170.98
36_A168_I1.0120.98
22_V47_V1.0120.98
294_Q298_W1.0120.98
410_I440_L1.0040.98
51_H65_M0.9970.98
231_Q264_P0.9950.98
104_C107_Q0.9950.98
113_M159_G0.9930.98
55_R62_E0.9930.98
425_P438_P0.9920.98
399_K447_D0.9890.98
203_T210_Q0.9880.98
315_K326_T0.9870.98
67_F184_Y0.9860.98
154_R159_G0.9860.98
31_M184_Y0.9850.98
80_E116_H0.9800.97
229_D233_L0.9790.97
82_A108_F0.9770.97
63_E188_E0.9760.97
390_R394_D0.9750.97
111_E115_K0.9740.97
49_A68_V0.9740.97
240_E244_V0.9720.97
148_A151_Q0.9710.97
152_P167_T0.9700.97
127_G216_H0.9670.97
233_L270_R0.9630.97
110_E160_R0.9630.97
28_P170_K0.9610.97
429_D435_I0.9610.97
68_V79_C0.9550.97
31_M75_E0.9550.97
390_R426_I0.9500.97
263_L271_G0.9470.97
204_V207_F0.9410.97
189_S192_K0.9410.97
309_D315_K0.9390.97
174_L186_T0.9360.97
381_V429_D0.9320.97
40_L45_A0.9290.97
135_L200_F0.9270.96
377_S381_V0.9240.96
34_L47_V0.9200.96
169_T216_H0.9190.96
107_Q111_E0.9190.96
123_L150_M0.9180.96
113_M118_A0.9180.96
120_Y162_I0.9120.96
134_M142_T0.9090.96
443_S446_E0.9080.96
256_N322_T0.9060.96
237_T274_L0.9020.96
70_A73_K0.9020.96
189_S198_N0.9020.96
28_P184_Y0.9010.96
385_L435_I0.9000.96
377_S380_K0.8990.96
269_R293_Q0.8980.96
60_E63_E0.8960.96
199_R202_K0.8960.96
19_T119_D0.8950.96
417_P420_E0.8930.96
214_D217_K0.8910.96
386_T428_T0.8900.96
442_K447_D0.8850.95
31_M68_V0.8830.95
150_M154_R0.8820.95
137_K142_T0.8810.95
414_K441_K0.8790.95
317_V326_T0.8720.95
216_H220_Q0.8710.95
50_A82_A0.8660.95
410_I441_K0.8650.95
126_H170_K0.8630.95
97_K101_A0.8620.95
21_I80_E0.8620.95
257_S323_C0.8590.95
48_I116_H0.8590.95
20_I162_I0.8570.95
135_L223_S0.8450.94
20_I37_L0.8420.94
151_Q227_T0.8410.94
142_T222_V0.8400.94
80_E112_I0.8390.94
390_R407_V0.8380.94
348_T351_L0.8340.94
82_A112_I0.8320.94
192_K202_K0.8320.94
98_Q194_D0.8300.94
192_K195_Y0.8280.93
41_C45_A0.8190.93
53_D188_E0.8150.93
110_E159_G0.8090.93
349_A352_P0.8080.93
394_D428_T0.8050.93
318_K321_Q0.8050.93
412_I415_K0.8000.92
352_P355_Y0.7980.92
37_L47_V0.7980.92
220_Q223_S0.7970.92
32_A165_F0.7960.92
127_G169_T0.7920.92
215_V218_R0.7910.92
32_A173_I0.7900.92
207_F210_Q0.7890.92
387_I425_P0.7880.92
234_Q274_L0.7870.92
168_I173_I0.7860.92
244_V259_Q0.7850.92
150_M166_L0.7840.92
397_K444_I0.7840.92
209_K215_V0.7800.91
134_M147_L0.7800.91
23_G61_S0.7770.91
238_K242_N0.7750.91
233_L237_T0.7730.91
265_M268_Q0.7730.91
424_W438_P0.7720.91
246_T256_N0.7720.91
420_E423_N0.7700.91
22_V49_A0.7680.91
351_L355_Y0.7670.91
385_L429_D0.7670.91
233_L236_L0.7640.90
136_M200_F0.7630.90
237_T270_R0.7610.90
376_T442_K0.7580.90
58_G185_R0.7580.90
241_M274_L0.7560.90
288_S291_H0.7550.90
294_Q297_D0.7530.90
20_I120_Y0.7520.90
205_L219_F0.7510.90
207_F211_E0.7510.90
26_G68_V0.7500.90
348_T352_P0.7500.90
383_F429_D0.7490.90
230_E233_L0.7480.89
84_I108_F0.7480.89
236_L240_E0.7470.89
297_D301_N0.7460.89
221_K225_A0.7450.89
410_I414_K0.7430.89
32_A182_L0.7410.89
135_L205_L0.7390.89
389_T426_I0.7360.89
396_I443_S0.7360.89
58_G61_S0.7350.89
24_V67_F0.7350.89
148_A227_T0.7350.89
276_L281_E0.7350.89
319_S419_Q0.7330.89
303_G306_G0.7330.89
320_Y421_R0.7330.89
306_G311_P0.7320.88
274_L277_N0.7320.88
436_W439_G0.7320.88
35_H38_H0.7290.88
67_F71_Y0.7280.88
403_G413_D0.7270.88
411_F426_I0.7270.88
196_T199_R0.7260.88
139_A204_V0.7260.88
48_I78_V0.7250.88
170_K173_I0.7240.88
189_S194_D0.7240.88
106_Y154_R0.7220.88
296_L300_E0.7220.88
32_A35_H0.7200.88
95_L99_A0.7190.88
406_K409_D0.7180.88
126_H165_F0.7180.88
130_Q166_L0.7160.87
411_F425_P0.7140.87
442_K446_E0.7120.87
196_T211_E0.7100.87
55_R86_V0.7090.87
27_G30_S0.7080.87
291_H294_Q0.7080.87
411_F437_I0.7060.87
134_M226_L0.7050.87
113_M160_R0.7050.87
237_T240_E0.7030.86
255_I275_I0.7010.86
355_Y360_R0.7010.86
260_L268_Q0.7000.86
398_L401_M0.6980.86
128_D171_E0.6970.86
270_R274_L0.6960.86
51_H64_D0.6960.86
33_L37_L0.6950.86
25_S30_S0.6940.86
25_S29_D0.6940.86
253_V275_I0.6940.86
229_D266_P0.6890.85
134_M222_V0.6880.85
109_F113_M0.6870.85
112_I116_H0.6850.85
383_F430_A0.6810.85
121_L159_G0.6810.85
67_F183_S0.6800.85
414_K440_L0.6760.84
433_E446_E0.6760.84
416_L421_R0.6750.84
60_E64_D0.6740.84
239_D242_N0.6740.84
199_R207_F0.6740.84
356_L360_R0.6730.84
176_Y182_L0.6710.84
128_D170_K0.6710.84
87_T189_S0.6710.84
110_E121_L0.6690.84
416_L424_W0.6690.84
315_K328_E0.6680.83
139_A211_E0.6670.83
264_P267_L0.6670.83
67_F182_L0.6650.83
80_E118_A0.6640.83
293_Q297_D0.6630.83
48_I119_D0.6630.83
298_W308_L0.6630.83
243_K259_Q0.6620.83
130_Q137_K0.6600.83
121_L161_I0.6590.83
109_F123_L0.6590.83
347_E350_V0.6570.82
240_E270_R0.6570.82
343_G346_D0.6560.82
131_V215_V0.6540.82
137_K222_V0.6540.82
406_K412_I0.6520.82
276_L287_F0.6490.82
37_L45_A0.6490.82
261_L300_E0.6470.82
22_V34_L0.6450.81
175_H178_H0.6450.81
139_A200_F0.6420.81
57_R61_S0.6380.81
109_F121_L0.6380.81
267_L270_R0.6360.80
274_L278_Y0.6350.80
139_A215_V0.6350.80
86_V96_N0.6350.80
436_W442_K0.6350.80
34_L71_Y0.6340.80
23_G106_Y0.6330.80
193_D199_R0.6300.80
320_Y412_I0.6300.80
61_S65_M0.6280.80
224_E289_A0.6270.79
56_F98_Q0.6270.79
228_E265_M0.6260.79
71_Y182_L0.6260.79
64_D68_V0.6230.79
177_C186_T0.6210.79
275_I299_A0.6200.79
305_S308_L0.6180.78
35_H177_C0.6150.78
58_G188_E0.6150.78
416_L440_L0.6150.78
395_R409_D0.6140.78
427_V438_P0.6090.77
64_D189_S0.6090.77
263_L267_L0.6070.77
148_A226_L0.6060.77
32_A180_N0.6040.77
382_R429_D0.6030.77
266_P270_R0.6030.77
61_S101_A0.6030.77
165_F173_I0.6010.77
130_Q149_G0.6010.77
31_M183_S0.6010.77
100_A104_C0.6000.76
65_M79_C0.6000.76
106_Y161_I0.6000.76
399_K403_G0.5990.76
145_T234_Q0.5980.76
180_N183_S0.5970.76
199_R210_Q0.5970.76
31_M177_C0.5960.76
368_E375_I0.5950.76
289_A293_Q0.5930.76
391_K394_D0.5930.76
143_L273_Q0.5900.75
268_Q300_E0.5900.75
101_A109_F0.5890.75
204_V211_E0.5860.75
189_S195_Y0.5840.74
429_D446_E0.5840.74
348_T358_E0.5790.74
307_V310_F0.5780.74
39_T176_Y0.5780.74
51_H79_C0.5780.74
178_H184_Y0.5780.74
273_Q408_K0.5710.73
385_L430_A0.5700.73
84_I101_A0.5690.73
378_E381_V0.5670.72
433_E443_S0.5660.72
35_H71_Y0.5660.72
386_T432_G0.5660.72
381_V384_P0.5650.72
34_L77_L0.5650.72
261_L268_Q0.5630.72
148_A230_E0.5630.72
68_V185_R0.5620.72
390_R412_I0.5620.72
26_G30_S0.5610.72
26_G29_D0.5610.72
52_V104_C0.5610.72
403_G406_K0.5600.71
339_Y342_S0.5590.71
265_M293_Q0.5590.71
199_R204_V0.5590.71
396_I407_V0.5530.70
236_L267_L0.5520.70
237_T241_M0.5520.70
307_V315_K0.5490.70
244_V263_L0.5480.70
430_A433_E0.5460.70
349_A354_G0.5460.70
147_L226_L0.5450.69
319_S324_L0.5430.69
131_V134_M0.5430.69
131_V135_L0.5400.69
24_V79_C0.5400.69
199_R208_L0.5390.69
390_R411_F0.5380.68
127_G217_K0.5380.68
195_Y390_R0.5370.68
112_I115_K0.5370.68
305_S310_F0.5370.68
60_E185_R0.5370.68
436_W441_K0.5370.68
203_T211_E0.5360.68
230_E270_R0.5360.68
314_L325_F0.5350.68
269_R296_L0.5350.68
437_I440_L0.5350.68
38_H182_L0.5350.68
143_L147_L0.5350.68
199_R212_S0.5340.68
396_I405_K0.5340.68
84_I100_A0.5330.68
348_T353_N0.5330.68
320_Y413_D0.5330.68
396_I440_L0.5330.68
138_L226_L0.5320.68
275_I279_L0.5320.68
37_L41_C0.5320.68
337_F343_G0.5300.67
22_V122_A0.5300.67
67_F177_C0.5300.67
55_R84_I0.5290.67
143_L225_A0.5280.67
425_P428_T0.5270.67
272_V292_I0.5260.67
379_K429_D0.5260.67
399_K444_I0.5250.67
308_L311_P0.5240.66
71_Y74_A0.5230.66
141_G146_G0.5230.66
54_H108_F0.5230.66
338_E341_I0.5220.66
28_P64_D0.5220.66
19_T118_A0.5220.66
127_G215_V0.5210.66
62_E66_R0.5210.66
134_M220_Q0.5210.66
205_L215_V0.5210.66
20_I45_A0.5210.66
61_S185_R0.5190.66
428_T435_I0.5190.66
376_T379_K0.5190.66
290_H294_Q0.5190.66
222_V225_A0.5180.66
104_C137_K0.5170.65
106_Y163_R0.5170.65
305_S311_P0.5160.65
32_A126_H0.5150.65
56_F62_E0.5140.65
135_L139_A0.5120.65
276_L325_F0.5100.64
407_V410_I0.5100.64
96_N403_G0.5100.64
237_T267_L0.5100.64
212_S218_R0.5090.64
314_L327_F0.5090.64
291_H298_W0.5090.64
305_S418_L0.5080.64
191_A194_D0.5080.64
31_M35_H0.5070.64
52_V109_F0.5060.64
275_I325_F0.5030.63
19_T117_Q0.5030.63
238_K278_Y0.5020.63
384_P429_D0.5020.63
113_M119_D0.5010.63
36_A39_T0.5010.63
313_G328_E0.5010.63
54_H84_I0.5010.63
339_Y343_G0.5000.63
144_G225_A0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a2kA 1 0.9725 100 0.214 Contact Map
1ni5A 2 0.9068 100 0.309 Contact Map
1wy5A 4 0.6398 100 0.45 Contact Map
3vrhA 2 0.5403 100 0.647 Contact Map
3rjzA 2 0.4322 100 0.735 Contact Map
3uowA 2 0.572 100 0.743 Contact Map
2vxoA 2 0.7182 100 0.744 Contact Map
2dplA 2 0.5657 100 0.748 Contact Map
1zunA 1 0.3581 100 0.753 Contact Map
1surA 2 0.3792 100 0.755 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0122 seconds.