PKN1 - BACSU - GREMLIN Contacts

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PKN1 - Probable serine/threonine-protein kinase YabT

UniProt:	P37562	Sequences: MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYLAETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQPIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYIIFFLI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	338 (258)
Sequences:	28329 (17708)
Seq/√Len:	1102.4

ECOLI - YEGI
BACSU - PKN1 PRKC YBDM YRZF
HALSA - Q9HR00
SULSO - Q97U18 Q97U41 Q97WD5 Q97ZY9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
251_N	256_S	3.642	1.00
129_M	210_M	3.389	1.00
155_I	166_I	3.202	1.00
44_L	51_H	3.160	1.00
45_A	54_L	2.979	1.00
45_A	52_V	2.920	1.00
32_K	44_L	2.739	1.00
137_S	141_Q	2.709	1.00
248_S	258_D	2.697	1.00
33_Q	41_I	2.633	1.00
137_S	261_K	2.609	1.00
203_L	249_A	2.474	1.00
29_T	46_E	2.328	1.00
29_T	48_S	2.256	1.00
136_L	206_V	2.254	1.00
106_E	164_R	2.219	1.00
81_M	87_D	2.199	1.00
33_Q	36_K	2.172	1.00
131_Q	162_R	2.123	1.00
109_K	158_G	2.092	1.00
214_V	242_Y	2.078	1.00
133_L	206_V	2.058	1.00
150_K	186_D	2.050	1.00
137_S	264_M	2.013	1.00
244_K	266_D	2.006	1.00
253_D	256_S	1.994	1.00
129_M	206_V	1.974	1.00
157_T	162_R	1.972	1.00
114_L	152_D	1.938	1.00
31_R	46_E	1.935	1.00
248_S	266_D	1.932	1.00
82_G	138_V	1.899	1.00
132_L	154_L	1.898	1.00
210_M	245_A	1.873	1.00
135_S	165_C	1.872	1.00
154_L	163_I	1.870	1.00
33_Q	43_Y	1.858	1.00
149_L	209_I	1.850	1.00
27_T	47_T	1.837	1.00
46_E	51_H	1.824	1.00
89_D	106_E	1.797	1.00
44_L	107_Y	1.780	1.00
133_L	263_D	1.779	1.00
131_Q	163_I	1.772	1.00
157_T	160_P	1.743	1.00
54_L	104_A	1.715	1.00
125_I	214_V	1.691	1.00
259_E	262_K	1.672	1.00
191_G	201_Y	1.638	1.00
249_A	263_D	1.629	1.00
46_E	49_D	1.616	1.00
112_L	115_K	1.582	1.00
203_L	260_M	1.530	1.00
52_V	104_A	1.527	1.00
120_K	124_W	1.508	1.00
56_V	102_F	1.470	1.00
136_L	149_L	1.460	1.00
244_K	248_S	1.459	1.00
245_A	249_A	1.442	1.00
141_Q	261_K	1.435	1.00
258_D	263_D	1.433	1.00
108_I	164_R	1.422	1.00
50_G	89_D	1.421	1.00
143_G	199_P	1.413	1.00
43_Y	56_V	1.406	1.00
154_L	209_I	1.403	1.00
248_S	251_N	1.377	1.00
31_R	44_L	1.368	1.00
200_S	259_E	1.361	1.00
185_Y	190_W	1.360	1.00
79_V	173_K	1.321	1.00
157_T	164_R	1.316	1.00
189_Y	212_N	1.315	1.00
151_P	189_Y	1.314	1.00
128_L	163_I	1.306	1.00
87_D	106_E	1.304	1.00
243_K	247_F	1.295	1.00
130_I	134_S	1.295	1.00
56_V	100_V	1.289	1.00
108_I	157_T	1.286	1.00
84_S	135_S	1.280	1.00
133_L	260_M	1.267	1.00
84_S	134_S	1.264	1.00
88_T	91_A	1.259	1.00
86_F	108_I	1.252	1.00
86_F	105_M	1.249	1.00
42_V	53_A	1.247	1.00
207_A	249_A	1.242	1.00
54_L	102_F	1.237	1.00
246_L	250_L	1.225	1.00
51_H	107_Y	1.218	1.00
144_W	171_T	1.216	1.00
36_K	41_I	1.211	1.00
52_V	89_D	1.209	1.00
245_A	266_D	1.205	1.00
170_G	184_F	1.186	1.00
125_I	213_S	1.184	1.00
126_P	271_A	1.183	1.00
59_D	96_A	1.180	1.00
136_L	260_M	1.174	1.00
133_L	264_M	1.172	1.00
114_L	118_S	1.159	1.00
134_S	264_M	1.141	1.00
134_S	137_S	1.137	1.00
28_Y	90_D	1.136	1.00
208_M	250_L	1.111	1.00
151_P	209_I	1.107	1.00
88_T	103_Y	1.088	1.00
241_K	267_A	1.087	1.00
266_D	269_Q	1.077	1.00
245_A	263_D	1.072	1.00
111_P	119_D	1.068	1.00
114_L	212_N	1.067	1.00
156_V	163_I	1.067	1.00
132_L	209_I	1.065	1.00
132_L	163_I	1.061	1.00
112_L	152_D	1.060	1.00
197_A	201_Y	1.058	1.00
138_V	142_Q	1.058	1.00
215_H	238_L	1.057	1.00
248_S	262_K	1.037	1.00
251_N	258_D	1.034	1.00
212_N	218_E	1.034	1.00
137_S	260_M	1.026	1.00
153_N	167_D	1.024	1.00
79_V	142_Q	1.023	1.00
147_G	197_A	1.018	1.00
47_T	50_G	1.016	1.00
228_Q	232_L	1.015	1.00
127_V	131_Q	1.014	1.00
222_T	227_E	1.008	1.00
230_R	234_E	1.002	1.00
116_Y	120_K	1.001	1.00
129_M	213_S	1.000	1.00
148_D	153_N	0.999	1.00
76_A	171_T	0.997	1.00
245_A	258_D	0.984	1.00
151_P	212_N	0.983	1.00
214_V	238_L	0.973	1.00
126_P	268_G	0.969	1.00
81_M	138_V	0.960	1.00
67_V	71_K	0.960	1.00
140_H	260_M	0.949	1.00
85_F	139_L	0.948	1.00
116_Y	156_V	0.948	1.00
30_L	45_A	0.945	1.00
24_N	27_T	0.944	1.00
146_F	149_L	0.936	1.00
92_Y	104_A	0.934	1.00
30_L	43_Y	0.933	1.00
86_F	166_I	0.932	1.00
66_E	69_V	0.924	1.00
144_W	173_K	0.918	1.00
258_D	266_D	0.918	1.00
127_V	162_R	0.916	1.00
258_D	262_K	0.915	1.00
117_V	212_N	0.913	1.00
222_T	231_S	0.912	1.00
69_V	73_F	0.908	1.00
222_T	228_Q	0.904	1.00
71_K	75_K	0.903	1.00
136_L	140_H	0.900	1.00
206_V	249_A	0.900	1.00
110_G	161_A	0.896	1.00
130_I	264_M	0.896	1.00
139_L	168_V	0.890	1.00
31_R	51_H	0.890	1.00
108_I	166_I	0.888	1.00
260_M	263_D	0.886	1.00
267_A	270_K	0.880	1.00
149_L	165_C	0.879	1.00
261_K	265_L	0.877	1.00
224_Q	227_E	0.866	1.00
203_L	258_D	0.863	1.00
204_F	250_L	0.858	1.00
239_L	242_Y	0.856	1.00
240_Q	243_K	0.856	1.00
28_Y	104_A	0.853	1.00
200_S	255_Q	0.850	1.00
125_I	210_M	0.849	1.00
192_Y	195_R	0.848	1.00
147_G	184_F	0.843	1.00
235_G	238_L	0.836	1.00
225_P	229_L	0.835	1.00
203_L	263_D	0.832	1.00
211_I	215_H	0.832	1.00
128_L	156_V	0.829	1.00
72_S	75_K	0.829	1.00
124_W	127_V	0.826	1.00
260_M	264_M	0.824	1.00
210_M	242_Y	0.821	1.00
150_K	153_N	0.820	1.00
51_H	109_K	0.819	1.00
227_E	231_S	0.814	1.00
34_L	107_Y	0.814	1.00
247_F	251_N	0.813	1.00
77_Q	105_M	0.812	1.00
83_P	134_S	0.810	1.00
108_I	156_V	0.808	1.00
227_E	230_R	0.807	1.00
188_G	228_Q	0.803	1.00
132_L	149_L	0.801	1.00
47_T	52_V	0.800	1.00
204_F	208_M	0.800	1.00
228_Q	231_S	0.799	1.00
262_K	265_L	0.798	1.00
108_I	155_I	0.797	1.00
124_W	161_A	0.796	1.00
238_L	242_Y	0.795	1.00
133_L	203_L	0.792	1.00
150_K	167_D	0.789	1.00
211_I	250_L	0.782	1.00
53_A	107_Y	0.781	1.00
69_V	72_S	0.781	1.00
75_K	78_S	0.775	1.00
138_V	141_Q	0.773	1.00
242_Y	268_G	0.773	1.00
85_F	138_V	0.771	1.00
80_T	139_L	0.770	1.00
45_A	104_A	0.764	1.00
90_D	104_A	0.761	1.00
123_E	126_P	0.761	1.00
41_I	56_V	0.759	1.00
30_L	54_L	0.756	1.00
80_T	138_V	0.755	1.00
218_E	221_K	0.753	1.00
148_D	186_D	0.750	1.00
215_H	235_G	0.746	1.00
181_Y	196_K	0.743	1.00
109_K	157_T	0.742	1.00
139_L	144_W	0.740	1.00
35_G	42_V	0.739	1.00
188_G	204_F	0.736	1.00
77_Q	88_T	0.730	1.00
226_K	229_L	0.729	1.00
230_R	233_I	0.729	1.00
229_L	233_I	0.723	1.00
225_P	228_Q	0.722	1.00
82_G	134_S	0.717	1.00
130_I	272_A	0.714	1.00
35_G	53_A	0.711	1.00
74_S	78_S	0.709	1.00
204_F	232_L	0.709	1.00
241_K	271_A	0.707	1.00
224_Q	228_Q	0.706	1.00
132_L	135_S	0.704	1.00
111_P	166_I	0.702	1.00
80_T	144_W	0.695	1.00
275_K	278_I	0.681	1.00
126_P	269_Q	0.681	1.00
21_G	24_N	0.673	1.00
132_L	206_V	0.672	1.00
37_G	40_G	0.671	1.00
82_G	85_F	0.667	1.00
183_E	190_W	0.666	1.00
273_Q	276_Q	0.666	1.00
30_L	56_V	0.666	1.00
83_P	162_R	0.663	1.00
76_A	144_W	0.663	1.00
47_T	90_D	0.659	1.00
92_Y	102_F	0.657	1.00
211_I	246_L	0.652	1.00
145_I	201_Y	0.652	1.00
28_Y	52_V	0.651	1.00
245_A	269_Q	0.650	1.00
130_I	268_G	0.646	1.00
128_L	161_A	0.644	1.00
208_M	211_I	0.643	1.00
37_G	53_A	0.643	1.00
201_Y	205_A	0.642	1.00
276_Q	279_K	0.641	1.00
206_V	210_M	0.640	1.00
157_T	161_A	0.639	1.00
73_F	80_T	0.635	1.00
172_T	180_E	0.635	1.00
128_L	132_L	0.633	1.00
187_R	225_P	0.630	1.00
193_G	233_I	0.626	1.00
277_P	280_A	0.624	1.00
40_G	57_S	0.622	1.00
147_G	172_T	0.621	1.00
229_L	232_L	0.621	1.00
113_L	213_S	0.619	1.00
187_R	229_L	0.618	1.00
206_V	263_D	0.618	1.00
121_G	216_K	0.618	1.00
188_G	218_E	0.616	1.00
74_S	103_Y	0.616	1.00
68_N	71_K	0.615	1.00
27_T	90_D	0.615	1.00
193_G	196_K	0.615	1.00
59_D	62_S	0.611	1.00
192_Y	196_K	0.610	1.00
117_V	151_P	0.608	1.00
211_I	219_F	0.608	1.00
249_A	258_D	0.604	1.00
175_G	178_I	0.602	1.00
129_M	133_L	0.600	1.00
91_A	101_S	0.599	1.00
84_S	131_Q	0.598	1.00
243_K	246_L	0.598	1.00
275_K	280_A	0.597	1.00
152_D	186_D	0.596	1.00
64_T	68_N	0.596	1.00
88_T	105_M	0.596	1.00
23_W	28_Y	0.593	1.00
116_Y	124_W	0.591	1.00
70_L	73_F	0.591	1.00
210_M	246_L	0.591	1.00
23_W	27_T	0.590	1.00
117_V	213_S	0.589	1.00
84_S	162_R	0.588	1.00
208_M	220_K	0.584	1.00
74_S	91_A	0.584	1.00
238_L	243_K	0.582	1.00
208_M	219_F	0.581	1.00
97_N	100_V	0.581	1.00
204_F	251_N	0.580	1.00
110_G	157_T	0.579	1.00
198_E	254_Y	0.578	1.00
148_D	169_G	0.578	1.00
129_M	136_L	0.578	1.00
208_M	218_E	0.576	1.00
114_L	151_P	0.575	1.00
55_K	167_D	0.573	1.00
148_D	167_D	0.572	1.00
106_E	157_T	0.572	1.00
28_Y	54_L	0.571	1.00
75_K	79_V	0.568	1.00
111_P	115_K	0.566	1.00
136_L	165_C	0.564	1.00
217_K	221_K	0.563	1.00
207_A	246_L	0.563	1.00
116_Y	128_L	0.562	1.00
185_Y	191_G	0.562	1.00
276_Q	280_A	0.562	1.00
129_M	245_A	0.560	1.00
73_F	76_A	0.559	1.00
211_I	220_K	0.554	1.00
254_Y	257_A	0.554	1.00
55_K	73_F	0.550	1.00
37_G	167_D	0.550	1.00
210_M	268_G	0.549	1.00
140_H	199_P	0.548	1.00
154_L	165_C	0.547	1.00
113_L	209_I	0.546	1.00
107_Y	111_P	0.544	1.00
207_A	250_L	0.544	1.00
24_N	54_L	0.542	1.00
115_K	118_S	0.542	1.00
130_I	269_Q	0.542	1.00
28_Y	47_T	0.542	1.00
131_Q	134_S	0.540	1.00
204_F	220_K	0.538	1.00
240_Q	244_K	0.537	1.00
174_E	199_P	0.536	1.00
203_L	259_E	0.536	1.00
86_F	164_R	0.536	1.00
113_L	154_L	0.533	1.00
145_I	199_P	0.531	1.00
30_L	33_Q	0.530	1.00
24_N	30_L	0.530	1.00
125_I	216_K	0.530	1.00
183_E	187_R	0.530	1.00
27_T	48_S	0.528	1.00
64_T	67_V	0.527	1.00
59_D	97_N	0.523	1.00
39_N	170_G	0.522	1.00
31_R	45_A	0.521	1.00
241_K	266_D	0.520	1.00
223_N	227_E	0.519	1.00
235_G	243_K	0.519	1.00
146_F	209_I	0.517	1.00
126_P	242_Y	0.516	1.00
228_Q	233_I	0.515	1.00
85_F	135_S	0.514	1.00
224_Q	232_L	0.512	1.00
73_F	77_Q	0.512	1.00
66_E	70_L	0.511	1.00
172_T	182_T	0.509	1.00
37_G	148_D	0.509	1.00
58_D	100_V	0.505	1.00
147_G	186_D	0.505	1.00
65_S	68_N	0.502	1.00
223_N	226_K	0.501	1.00
215_H	237_P	0.500	1.00
246_L	249_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2bdwA	2	0.8018	100	0.299	Contact Map
4ejnA	1	0.7663	100	0.305	Contact Map
4lqsA	1	0.8728	100	0.305	Contact Map
4qoxA	1	0.8994	100	0.306	Contact Map
4bgqA	1	0.6834	100	0.31	Contact Map
4cfeA	1	0.8373	100	0.31	Contact Map
3utoA	1	0.9675	100	0.312	Contact Map
4fr4A	1	0.9083	100	0.313	Contact Map
2yabA	2	0.7899	100	0.314	Contact Map
3soaA	5	0.9231	100	0.315	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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