GREMLIN Database
PKN1 - Probable serine/threonine-protein kinase YabT
UniProt: P37562 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (258)
Sequences: 28329 (17708)
Seq/√Len: 1102.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_N256_S3.6421.00
129_M210_M3.3891.00
155_I166_I3.2021.00
44_L51_H3.1601.00
45_A54_L2.9791.00
45_A52_V2.9201.00
32_K44_L2.7391.00
137_S141_Q2.7091.00
248_S258_D2.6971.00
33_Q41_I2.6331.00
137_S261_K2.6091.00
203_L249_A2.4741.00
29_T46_E2.3281.00
29_T48_S2.2561.00
136_L206_V2.2541.00
106_E164_R2.2191.00
81_M87_D2.1991.00
33_Q36_K2.1721.00
131_Q162_R2.1231.00
109_K158_G2.0921.00
214_V242_Y2.0781.00
133_L206_V2.0581.00
150_K186_D2.0501.00
137_S264_M2.0131.00
244_K266_D2.0061.00
253_D256_S1.9941.00
129_M206_V1.9741.00
157_T162_R1.9721.00
114_L152_D1.9381.00
31_R46_E1.9351.00
248_S266_D1.9321.00
82_G138_V1.8991.00
132_L154_L1.8981.00
210_M245_A1.8731.00
135_S165_C1.8721.00
154_L163_I1.8701.00
33_Q43_Y1.8581.00
149_L209_I1.8501.00
27_T47_T1.8371.00
46_E51_H1.8241.00
89_D106_E1.7971.00
44_L107_Y1.7801.00
133_L263_D1.7791.00
131_Q163_I1.7721.00
157_T160_P1.7431.00
54_L104_A1.7151.00
125_I214_V1.6911.00
259_E262_K1.6721.00
191_G201_Y1.6381.00
249_A263_D1.6291.00
46_E49_D1.6161.00
112_L115_K1.5821.00
203_L260_M1.5301.00
52_V104_A1.5271.00
120_K124_W1.5081.00
56_V102_F1.4701.00
136_L149_L1.4601.00
244_K248_S1.4591.00
245_A249_A1.4421.00
141_Q261_K1.4351.00
258_D263_D1.4331.00
108_I164_R1.4221.00
50_G89_D1.4211.00
143_G199_P1.4131.00
43_Y56_V1.4061.00
154_L209_I1.4031.00
248_S251_N1.3771.00
31_R44_L1.3681.00
200_S259_E1.3611.00
185_Y190_W1.3601.00
79_V173_K1.3211.00
157_T164_R1.3161.00
189_Y212_N1.3151.00
151_P189_Y1.3141.00
128_L163_I1.3061.00
87_D106_E1.3041.00
243_K247_F1.2951.00
130_I134_S1.2951.00
56_V100_V1.2891.00
108_I157_T1.2861.00
84_S135_S1.2801.00
133_L260_M1.2671.00
84_S134_S1.2641.00
88_T91_A1.2591.00
86_F108_I1.2521.00
86_F105_M1.2491.00
42_V53_A1.2471.00
207_A249_A1.2421.00
54_L102_F1.2371.00
246_L250_L1.2251.00
51_H107_Y1.2181.00
144_W171_T1.2161.00
36_K41_I1.2111.00
52_V89_D1.2091.00
245_A266_D1.2051.00
170_G184_F1.1861.00
125_I213_S1.1841.00
126_P271_A1.1831.00
59_D96_A1.1801.00
136_L260_M1.1741.00
133_L264_M1.1721.00
114_L118_S1.1591.00
134_S264_M1.1411.00
134_S137_S1.1371.00
28_Y90_D1.1361.00
208_M250_L1.1111.00
151_P209_I1.1071.00
88_T103_Y1.0881.00
241_K267_A1.0871.00
266_D269_Q1.0771.00
245_A263_D1.0721.00
111_P119_D1.0681.00
114_L212_N1.0671.00
156_V163_I1.0671.00
132_L209_I1.0651.00
132_L163_I1.0611.00
112_L152_D1.0601.00
197_A201_Y1.0581.00
138_V142_Q1.0581.00
215_H238_L1.0571.00
248_S262_K1.0371.00
251_N258_D1.0341.00
212_N218_E1.0341.00
137_S260_M1.0261.00
153_N167_D1.0241.00
79_V142_Q1.0231.00
147_G197_A1.0181.00
47_T50_G1.0161.00
228_Q232_L1.0151.00
127_V131_Q1.0141.00
222_T227_E1.0081.00
230_R234_E1.0021.00
116_Y120_K1.0011.00
129_M213_S1.0001.00
148_D153_N0.9991.00
76_A171_T0.9971.00
245_A258_D0.9841.00
151_P212_N0.9831.00
214_V238_L0.9731.00
126_P268_G0.9691.00
81_M138_V0.9601.00
67_V71_K0.9601.00
140_H260_M0.9491.00
85_F139_L0.9481.00
116_Y156_V0.9481.00
30_L45_A0.9451.00
24_N27_T0.9441.00
146_F149_L0.9361.00
92_Y104_A0.9341.00
30_L43_Y0.9331.00
86_F166_I0.9321.00
66_E69_V0.9241.00
144_W173_K0.9181.00
258_D266_D0.9181.00
127_V162_R0.9161.00
258_D262_K0.9151.00
117_V212_N0.9131.00
222_T231_S0.9121.00
69_V73_F0.9081.00
222_T228_Q0.9041.00
71_K75_K0.9031.00
136_L140_H0.9001.00
206_V249_A0.9001.00
110_G161_A0.8961.00
130_I264_M0.8961.00
139_L168_V0.8901.00
31_R51_H0.8901.00
108_I166_I0.8881.00
260_M263_D0.8861.00
267_A270_K0.8801.00
149_L165_C0.8791.00
261_K265_L0.8771.00
224_Q227_E0.8661.00
203_L258_D0.8631.00
204_F250_L0.8581.00
239_L242_Y0.8561.00
240_Q243_K0.8561.00
28_Y104_A0.8531.00
200_S255_Q0.8501.00
125_I210_M0.8491.00
192_Y195_R0.8481.00
147_G184_F0.8431.00
235_G238_L0.8361.00
225_P229_L0.8351.00
203_L263_D0.8321.00
211_I215_H0.8321.00
128_L156_V0.8291.00
72_S75_K0.8291.00
124_W127_V0.8261.00
260_M264_M0.8241.00
210_M242_Y0.8211.00
150_K153_N0.8201.00
51_H109_K0.8191.00
227_E231_S0.8141.00
34_L107_Y0.8141.00
247_F251_N0.8131.00
77_Q105_M0.8121.00
83_P134_S0.8101.00
108_I156_V0.8081.00
227_E230_R0.8071.00
188_G228_Q0.8031.00
132_L149_L0.8011.00
47_T52_V0.8001.00
204_F208_M0.8001.00
228_Q231_S0.7991.00
262_K265_L0.7981.00
108_I155_I0.7971.00
124_W161_A0.7961.00
238_L242_Y0.7951.00
133_L203_L0.7921.00
150_K167_D0.7891.00
211_I250_L0.7821.00
53_A107_Y0.7811.00
69_V72_S0.7811.00
75_K78_S0.7751.00
138_V141_Q0.7731.00
242_Y268_G0.7731.00
85_F138_V0.7711.00
80_T139_L0.7701.00
45_A104_A0.7641.00
90_D104_A0.7611.00
123_E126_P0.7611.00
41_I56_V0.7591.00
30_L54_L0.7561.00
80_T138_V0.7551.00
218_E221_K0.7531.00
148_D186_D0.7501.00
215_H235_G0.7461.00
181_Y196_K0.7431.00
109_K157_T0.7421.00
139_L144_W0.7401.00
35_G42_V0.7391.00
188_G204_F0.7361.00
77_Q88_T0.7301.00
226_K229_L0.7291.00
230_R233_I0.7291.00
229_L233_I0.7231.00
225_P228_Q0.7221.00
82_G134_S0.7171.00
130_I272_A0.7141.00
35_G53_A0.7111.00
74_S78_S0.7091.00
204_F232_L0.7091.00
241_K271_A0.7071.00
224_Q228_Q0.7061.00
132_L135_S0.7041.00
111_P166_I0.7021.00
80_T144_W0.6951.00
275_K278_I0.6811.00
126_P269_Q0.6811.00
21_G24_N0.6731.00
132_L206_V0.6721.00
37_G40_G0.6711.00
82_G85_F0.6671.00
183_E190_W0.6661.00
273_Q276_Q0.6661.00
30_L56_V0.6661.00
83_P162_R0.6631.00
76_A144_W0.6631.00
47_T90_D0.6591.00
92_Y102_F0.6571.00
211_I246_L0.6521.00
145_I201_Y0.6521.00
28_Y52_V0.6511.00
245_A269_Q0.6501.00
130_I268_G0.6461.00
128_L161_A0.6441.00
208_M211_I0.6431.00
37_G53_A0.6431.00
201_Y205_A0.6421.00
276_Q279_K0.6411.00
206_V210_M0.6401.00
157_T161_A0.6391.00
73_F80_T0.6351.00
172_T180_E0.6351.00
128_L132_L0.6331.00
187_R225_P0.6301.00
193_G233_I0.6261.00
277_P280_A0.6241.00
40_G57_S0.6221.00
147_G172_T0.6211.00
229_L232_L0.6211.00
113_L213_S0.6191.00
187_R229_L0.6181.00
206_V263_D0.6181.00
121_G216_K0.6181.00
188_G218_E0.6161.00
74_S103_Y0.6161.00
68_N71_K0.6151.00
27_T90_D0.6151.00
193_G196_K0.6151.00
59_D62_S0.6111.00
192_Y196_K0.6101.00
117_V151_P0.6081.00
211_I219_F0.6081.00
249_A258_D0.6041.00
175_G178_I0.6021.00
129_M133_L0.6001.00
91_A101_S0.5991.00
84_S131_Q0.5981.00
243_K246_L0.5981.00
275_K280_A0.5971.00
152_D186_D0.5961.00
64_T68_N0.5961.00
88_T105_M0.5961.00
23_W28_Y0.5931.00
116_Y124_W0.5911.00
70_L73_F0.5911.00
210_M246_L0.5911.00
23_W27_T0.5901.00
117_V213_S0.5891.00
84_S162_R0.5881.00
208_M220_K0.5841.00
74_S91_A0.5841.00
238_L243_K0.5821.00
208_M219_F0.5811.00
97_N100_V0.5811.00
204_F251_N0.5801.00
110_G157_T0.5791.00
198_E254_Y0.5781.00
148_D169_G0.5781.00
129_M136_L0.5781.00
208_M218_E0.5761.00
114_L151_P0.5751.00
55_K167_D0.5731.00
148_D167_D0.5721.00
106_E157_T0.5721.00
28_Y54_L0.5711.00
75_K79_V0.5681.00
111_P115_K0.5661.00
136_L165_C0.5641.00
217_K221_K0.5631.00
207_A246_L0.5631.00
116_Y128_L0.5621.00
185_Y191_G0.5621.00
276_Q280_A0.5621.00
129_M245_A0.5601.00
73_F76_A0.5591.00
211_I220_K0.5541.00
254_Y257_A0.5541.00
55_K73_F0.5501.00
37_G167_D0.5501.00
210_M268_G0.5491.00
140_H199_P0.5481.00
154_L165_C0.5471.00
113_L209_I0.5461.00
107_Y111_P0.5441.00
207_A250_L0.5441.00
24_N54_L0.5421.00
115_K118_S0.5421.00
130_I269_Q0.5421.00
28_Y47_T0.5421.00
131_Q134_S0.5401.00
204_F220_K0.5381.00
240_Q244_K0.5371.00
174_E199_P0.5361.00
203_L259_E0.5361.00
86_F164_R0.5361.00
113_L154_L0.5331.00
145_I199_P0.5311.00
30_L33_Q0.5301.00
24_N30_L0.5301.00
125_I216_K0.5301.00
183_E187_R0.5301.00
27_T48_S0.5281.00
64_T67_V0.5271.00
59_D97_N0.5231.00
39_N170_G0.5221.00
31_R45_A0.5211.00
241_K266_D0.5201.00
223_N227_E0.5191.00
235_G243_K0.5191.00
146_F209_I0.5171.00
126_P242_Y0.5161.00
228_Q233_I0.5151.00
85_F135_S0.5141.00
224_Q232_L0.5121.00
73_F77_Q0.5121.00
66_E70_L0.5111.00
172_T182_T0.5091.00
37_G148_D0.5091.00
58_D100_V0.5051.00
147_G186_D0.5051.00
65_S68_N0.5021.00
223_N226_K0.5011.00
215_H237_P0.5001.00
246_L249_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bdwA 2 0.8018 100 0.299 Contact Map
4ejnA 1 0.7663 100 0.305 Contact Map
4lqsA 1 0.8728 100 0.305 Contact Map
4qoxA 1 0.8994 100 0.306 Contact Map
4bgqA 1 0.6834 100 0.31 Contact Map
4cfeA 1 0.8373 100 0.31 Contact Map
3utoA 1 0.9675 100 0.312 Contact Map
4fr4A 1 0.9083 100 0.313 Contact Map
2yabA 2 0.7899 100 0.314 Contact Map
3soaA 5 0.9231 100 0.315 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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