GREMLIN Database
YABS - Uncharacterized protein YabS
UniProt: P37561 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (195)
Sequences: 3275 (1918)
Seq/√Len: 137.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_I201_F4.5461.00
144_S210_T3.4881.00
141_T176_I3.3371.00
139_V156_L2.8131.00
174_M185_E2.7401.00
30_A35_I2.7241.00
173_A187_V2.6031.00
185_E190_W2.5801.00
28_A32_E2.5481.00
161_V197_L2.3841.00
176_I184_V2.1871.00
39_V60_A2.1521.00
217_R221_L2.0991.00
139_V152_V2.0301.00
148_K205_S1.9991.00
31_K61_L1.9441.00
17_S55_E1.9301.00
61_L65_G1.9101.00
160_S200_L1.8081.00
137_V156_L1.8021.00
117_R120_V1.7511.00
137_V159_L1.7491.00
23_P27_A1.7451.00
141_T149_L1.7391.00
150_P153_K1.6991.00
198_S202_A1.6971.00
24_L58_G1.6861.00
118_G121_M1.6821.00
190_W199_T1.6771.00
120_V123_V1.6761.00
47_Q57_E1.6731.00
39_V56_V1.6621.00
192_P195_Q1.6511.00
118_G123_V1.6331.00
160_S196_S1.6161.00
218_E222_Q1.6071.00
136_L173_A1.5841.00
138_L219_A1.5821.00
116_K121_M1.5661.00
181_K218_E1.5371.00
177_F212_T1.5221.00
146_A205_S1.4911.00
179_G209_I1.4901.00
224_E229_R1.4871.00
116_K119_E1.4711.00
11_L39_V1.4641.00
121_M124_V1.4611.00
141_T206_T1.4601.00
71_Y74_Q1.4581.00
185_E196_S1.4391.00
160_S172_F1.4291.00
190_W195_Q1.4111.00
183_E186_L1.3921.00
41_G75_L1.3911.00
136_L187_V1.3621.00
9_I37_V1.3561.00
181_K214_P1.3521.00
186_L189_N1.3481.00
116_K120_V1.3381.00
9_I35_I1.3301.00
60_A66_V1.2871.00
61_L64_G1.2801.00
196_S200_L1.2691.00
138_L175_C1.2671.00
156_L200_L1.2611.00
193_K197_L1.2461.00
117_R121_M1.2391.00
117_R124_V1.2261.00
175_C219_A1.2211.00
9_I30_A1.1951.00
74_Q77_Q1.1901.00
140_D144_S1.1861.00
119_E123_V1.1470.99
164_N193_K1.1390.99
7_N229_R1.1350.99
122_E125_D1.1310.99
11_L59_I1.1260.99
116_K122_E1.1140.99
69_V78_T1.1120.99
75_L87_M1.1110.99
205_S212_T1.1090.99
116_K124_V1.1050.99
164_N169_N1.1030.99
157_I197_L1.1010.99
67_H85_K1.1000.99
24_L28_A1.0940.99
136_L219_A1.0790.99
23_P26_M1.0630.99
27_A31_K1.0560.99
167_I171_E1.0450.99
175_C181_K1.0450.99
27_A34_G1.0380.99
118_G124_V1.0340.99
171_E229_R1.0290.99
119_E124_V1.0240.99
153_K157_I1.0160.98
201_F204_L1.0130.98
136_L175_C1.0130.98
224_E228_S1.0110.98
174_M203_K1.0080.98
183_E218_E1.0060.98
41_G56_V0.9950.98
154_E201_F0.9930.98
196_S204_L0.9850.98
12_I39_V0.9850.98
17_S23_P0.9820.98
155_A159_L0.9780.98
9_I61_L0.9640.98
57_E61_L0.9580.98
200_L204_L0.9570.98
180_K214_P0.9560.98
143_A208_G0.9560.98
15_G56_V0.9550.98
10_L86_A0.9540.98
154_E157_I0.9480.98
118_G122_E0.9470.98
82_V87_M0.9390.97
182_Q206_T0.9350.97
74_Q78_T0.9260.97
120_V124_V0.9250.97
165_S212_T0.9140.97
13_T41_G0.9120.97
72_A75_L0.9090.97
177_F210_T0.9070.97
137_V173_A0.9070.97
14_D210_T0.9010.97
139_V174_M0.8960.97
117_R122_E0.8940.97
138_L213_G0.8880.96
71_Y87_M0.8870.96
119_E122_E0.8860.96
19_H23_P0.8770.96
178_P210_T0.8700.96
217_R220_T0.8630.96
41_G45_E0.8620.96
206_T220_T0.8620.96
14_D18_N0.8590.96
160_S163_L0.8510.95
148_K151_T0.8410.95
171_E188_L0.8360.95
139_V203_K0.8330.95
73_S76_S0.8310.95
16_C46_N0.8310.95
163_L175_C0.8310.95
26_M29_F0.8250.95
143_A210_T0.8240.95
117_R123_V0.8190.94
134_Q171_E0.8190.94
41_G60_A0.8190.94
144_S209_I0.8150.94
65_G68_Q0.8150.94
197_L201_F0.8140.94
153_K204_L0.8090.94
185_E199_T0.8090.94
47_Q82_V0.8030.94
145_M152_V0.8020.94
29_F67_H0.7990.94
46_N54_K0.7920.93
27_A37_V0.7820.93
57_E63_G0.7800.93
40_I58_G0.7790.93
56_V60_A0.7780.93
145_M151_T0.7700.92
42_I72_A0.7650.92
213_G218_E0.7640.92
200_L203_K0.7620.92
224_E227_R0.7590.92
76_S82_V0.7590.92
27_A59_I0.7580.92
152_V156_L0.7570.92
72_A78_T0.7570.92
54_K57_E0.7560.92
153_K200_L0.7500.91
145_M210_T0.7490.91
29_F32_E0.7440.91
196_S201_F0.7400.91
140_D210_T0.7380.91
67_H71_Y0.7350.91
142_S210_T0.7340.91
138_L215_A0.7240.90
225_K228_S0.7230.90
138_L177_F0.7220.90
7_N34_G0.7220.90
7_N30_A0.7210.90
176_I206_T0.7140.89
138_L141_T0.7090.89
85_K88_T0.7090.89
146_A207_G0.7080.89
4_G7_N0.7070.89
19_H26_M0.7060.89
149_L205_S0.7050.89
188_L228_S0.7030.89
32_E62_A0.6990.88
41_G59_I0.6940.88
145_M149_L0.6930.88
180_K206_T0.6930.88
42_I71_Y0.6920.88
43_M69_V0.6920.88
10_L87_M0.6890.88
67_H78_T0.6870.87
41_G72_A0.6850.87
196_S199_T0.6800.87
82_V85_K0.6780.87
153_K203_K0.6750.86
135_V157_I0.6720.86
16_C55_E0.6700.86
14_D42_I0.6670.86
193_K198_S0.6590.85
198_S201_F0.6580.85
14_D87_M0.6580.85
184_V203_K0.6580.85
145_M177_F0.6540.85
196_S203_K0.6510.84
133_L170_N0.6500.84
14_D66_V0.6440.84
165_S172_F0.6440.84
138_L155_A0.6430.84
142_S145_M0.6410.84
143_A209_I0.6410.84
65_G70_V0.6400.83
138_L176_I0.6390.83
143_A178_P0.6390.83
184_V199_T0.6340.83
176_I218_E0.6320.83
129_E162_S0.6290.82
146_A152_V0.6280.82
36_T58_G0.6120.81
29_F73_S0.6110.81
138_L149_L0.6100.80
141_T205_S0.6080.80
64_G67_H0.6080.80
167_I170_N0.6030.80
116_K123_V0.6000.79
43_M47_Q0.5980.79
179_G211_P0.5970.79
77_Q85_K0.5950.79
171_E225_K0.5940.79
205_S210_T0.5900.78
77_Q84_K0.5880.78
216_I220_T0.5880.78
132_H177_F0.5860.78
9_I64_G0.5840.78
134_Q230_R0.5820.77
211_P214_P0.5800.77
186_L227_R0.5800.77
83_T87_M0.5770.77
143_A180_K0.5750.76
177_F215_A0.5730.76
19_H45_E0.5730.76
151_T177_F0.5680.76
8_Q82_V0.5660.75
25_A29_F0.5630.75
209_I221_L0.5620.75
122_E126_E0.5590.74
196_S224_E0.5560.74
72_A87_M0.5520.74
165_S185_E0.5510.73
85_K90_T0.5500.73
142_S149_L0.5460.73
70_V88_T0.5450.73
25_A40_I0.5450.73
135_V172_F0.5430.72
42_I75_L0.5430.72
158_D219_A0.5420.72
120_V125_D0.5410.72
62_A67_H0.5390.72
172_F176_I0.5390.72
65_G82_V0.5390.72
173_A209_I0.5380.72
31_K87_M0.5340.71
144_S212_T0.5310.71
187_V228_S0.5310.71
194_L198_S0.5300.70
62_A73_S0.5300.70
173_A188_L0.5300.70
166_R170_N0.5270.70
47_Q68_Q0.5260.70
14_D74_Q0.5260.70
161_V193_K0.5220.69
148_K155_A0.5190.69
165_S193_K0.5170.69
18_N23_P0.5130.68
43_M72_A0.5130.68
11_L60_A0.5100.68
85_K89_Q0.5080.67
141_T183_E0.5060.67
165_S171_E0.5040.67
150_P216_I0.5040.67
189_N199_T0.5040.67
198_S217_R0.5040.67
84_K88_T0.5020.66
38_N85_K0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cn9A 1 0.8163 100 0.431 Contact Map
3ragA 1 0.9224 100 0.438 Contact Map
3zqkA 1 0.4694 99.8 0.636 Contact Map
4igiA 1 0.4653 99.7 0.643 Contact Map
4bj3A 1 0.4612 99.7 0.643 Contact Map
4okrA 1 0.4939 99.7 0.647 Contact Map
2xggA 2 0.4816 99.7 0.647 Contact Map
1ijbA 1 0.5061 99.7 0.651 Contact Map
1v7pC 1 0.4612 99.7 0.654 Contact Map
1atzA 1 0.4776 99.7 0.655 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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