GREMLIN Database
YABO - Uncharacterized protein YabO
UniProt: P37557 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 86 (79)
Sequences: 817 (478)
Seq/√Len: 53.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_Q77_T6.5921.00
30_I39_S4.0771.00
61_N77_T3.8381.00
48_T57_T2.6641.00
35_A39_S2.2421.00
29_S48_T2.1871.00
12_L58_V2.1481.00
24_D37_A2.1091.00
46_E57_T1.9921.00
32_G46_E1.6960.99
47_L60_V1.6400.98
3_L35_A1.6380.98
29_S50_R1.5920.98
68_K71_E1.5880.98
46_E59_Q1.5810.98
31_N45_D1.5050.97
30_I41_V1.3600.95
13_I22_V1.2570.93
20_K39_S1.2420.92
23_A28_I1.2180.91
23_A37_A1.2020.91
71_E74_N1.1970.91
3_L47_L1.1840.90
18_L55_L1.1720.90
41_V63_L1.1590.89
64_K67_T1.1540.89
10_S75_M1.1520.89
60_V63_L1.1490.89
64_K75_M1.0980.87
72_A76_Y1.0940.86
58_V78_I1.0920.86
27_R51_F1.0860.86
48_T55_L1.0730.85
47_L58_V1.0600.85
26_G34_Q1.0430.84
43_P62_E1.0400.83
18_L21_E1.0200.82
6_F63_L1.0000.81
56_V78_I0.9770.79
64_K71_E0.9720.79
50_R55_L0.9530.78
3_L38_S0.9520.78
36_K51_F0.9480.77
44_G59_Q0.9390.77
27_R52_G0.9360.76
37_A53_Q0.9350.76
5_K9_V0.9230.75
25_Q37_A0.9010.74
43_P63_L0.8830.72
27_R50_R0.8800.72
63_L67_T0.8630.70
34_Q40_D0.8480.69
71_E75_M0.8290.67
62_E71_E0.8070.65
29_S32_G0.7480.59
46_E79_L0.7430.59
20_K42_K0.7360.58
62_E74_N0.7300.57
8_K13_I0.7300.57
12_L56_V0.7250.57
49_V53_Q0.7250.57
28_I49_V0.7240.57
43_P73_A0.7000.54
59_Q79_L0.6950.54
23_A38_S0.6900.53
17_T21_E0.6890.53
29_S74_N0.6860.53
10_S72_A0.6850.53
57_T79_L0.6840.52
26_G47_L0.6840.52
8_K11_R0.6840.52
12_L78_I0.6810.52
63_L68_K0.6780.52
50_R53_Q0.6750.52
20_K36_K0.6740.51
10_S27_R0.6670.51
66_T70_E0.6660.51
62_E75_M0.6590.50
12_L47_L0.6560.50
34_Q55_L0.6480.49
25_Q50_R0.6460.48
32_G73_A0.6370.47
22_V53_Q0.6370.47
42_K79_L0.6230.46
48_T61_N0.6140.45
65_D68_K0.6110.45
24_D52_G0.6040.44
66_T71_E0.6020.44
20_K25_Q0.5880.42
22_V42_K0.5870.42
18_L37_A0.5840.42
13_I19_A0.5820.42
22_V28_I0.5810.42
11_R52_G0.5680.40
3_L41_V0.5670.40
11_R75_M0.5600.39
17_T26_G0.5590.39
19_A26_G0.5570.39
46_E61_N0.5560.39
6_F61_N0.5540.39
12_L25_Q0.5540.39
32_G48_T0.5510.39
36_K39_S0.5440.38
8_K17_T0.5430.38
39_S78_I0.5330.37
53_Q57_T0.5310.37
52_G58_V0.5280.36
25_Q34_Q0.5270.36
21_E38_S0.5240.36
7_L60_V0.5220.36
6_F40_D0.5210.36
36_K63_L0.5170.35
39_S66_T0.5130.35
20_K78_I0.5090.34
25_Q52_G0.5070.34
43_P61_N0.5050.34
46_E77_T0.5030.34
18_L22_V0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k6pA 1 0.9535 99.4 0.603 Contact Map
1dm9A 1 1 99.4 0.607 Contact Map
4bpeD 2 0.8605 98.8 0.694 Contact Map
3j80J 1 0.8837 98.8 0.699 Contact Map
3j7aE 1 0.9186 98.6 0.712 Contact Map
4tp8D 1 1 98.6 0.714 Contact Map
4rb5D 1 1 98.6 0.715 Contact Map
3bbnD 1 1 98.6 0.716 Contact Map
3j38J 1 0.8605 98.6 0.719 Contact Map
4ujpK 1 0.8372 98.5 0.722 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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